Details for: ETV1

Gene ID: 2115

Symbol: ETV1

Ensembl ID: ENSG00000006468

Description: ETS variant transcription factor 1

Associated with

  • Axon guidance
    (GO:0007411)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mechanosensory behavior
    (GO:0007638)
  • Muscle organ development
    (GO:0007517)
  • Nucleus
    (GO:0005634)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.48
    Marker Score: 2998
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.2
    Marker Score: 739
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.9
    Marker Score: 899
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.9
    Marker Score: 7346
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.87
    Marker Score: 1094
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.79
    Marker Score: 4085
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.79
    Marker Score: 6629
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.77
    Marker Score: 16674
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.71
    Marker Score: 11155
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.56
    Marker Score: 2503
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.5
    Marker Score: 834
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.47
    Marker Score: 31474
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.41
    Marker Score: 25052
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.36
    Marker Score: 1685
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.31
    Marker Score: 11269
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3
    Marker Score: 20863
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12194
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.27
    Marker Score: 19040
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.26
    Marker Score: 1732
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2536
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.23
    Marker Score: 1421
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 719
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18624
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1749
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.09
    Marker Score: 378
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.06
    Marker Score: 4430.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.05
    Marker Score: 237
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251778
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.04
    Marker Score: 23141
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.01
    Marker Score: 1225
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.01
    Marker Score: 61990
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.93
    Marker Score: 1049
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.93
    Marker Score: 1576
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5472
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.9
    Marker Score: 296
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5122
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 530.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.83
    Marker Score: 2951
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 802
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.8
    Marker Score: 1670
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.78
    Marker Score: 2049
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1812
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.77
    Marker Score: 253
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.75
    Marker Score: 494.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3133.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 354
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.73
    Marker Score: 1403
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.72
    Marker Score: 289
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.69
    Marker Score: 1065
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.67
    Marker Score: 709
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.66
    Marker Score: 573
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.65
    Marker Score: 8603
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.65
    Marker Score: 1069
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.64
    Marker Score: 235
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 199
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.63
    Marker Score: 354
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 778
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.62
    Marker Score: 1419
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.62
    Marker Score: 168
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.61
    Marker Score: 3202
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.61
    Marker Score: 647
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.59
    Marker Score: 631
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.59
    Marker Score: 2385
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.57
    Marker Score: 583
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.57
    Marker Score: 333
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.57
    Marker Score: 293
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 178
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.55
    Marker Score: 240
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.54
    Marker Score: 1679
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.54
    Marker Score: 948
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 199.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.53
    Marker Score: 494
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 499
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 222
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5
    Marker Score: 247
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5
    Marker Score: 264
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5
    Marker Score: 6599

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Other Information

**Key characteristics** * The ETV1 gene is a member of the ETS family of transcription factors. * It is expressed in a variety of cell types, including neurons, epithelial cells, and immune cells. * ETV1 is a key regulator of gene expression in these cells. * It is involved in a variety of cellular processes, including axon guidance, cell differentiation, and the regulation of transcription. **Pathways and functions** * ETV1 is a key regulator of axon guidance. * It is required for the migration and guidance of neurons during development. * It also plays a role in the regulation of axonal branching and survival. * In addition to its role in axon guidance, ETV1 is also involved in cell differentiation. * It is required for the development of various tissues, including the nervous system, the cardiovascular system, and the immune system. * ETV1 is also involved in the regulation of transcription. * It is a key regulator of the expression of a variety of genes, including those involved in cell differentiation, proliferation, and survival. **Clinical significance** Mutations in the ETV1 gene have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * In autism, mutations in ETV1 are thought to be responsible for the developmental abnormalities that occur in the brain of individuals with autism. * In schizophrenia, mutations in ETV1 are thought to be responsible for the cognitive deficits that occur in this disorder. * In cancer, mutations in ETV1 are associated with the development of aggressive tumors. **Conclusion** The ETV1 gene is a key regulator of gene expression in a variety of cell types. It is involved in a variety of cellular processes, including axon guidance, cell differentiation, and the regulation of transcription. Mutations in the ETV1 gene have been linked to a number of human diseases, including autism, schizophrenia, and cancer.

Genular Protein ID: 3378639973

Symbol: ETV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P50549 A4D118 B2R768 B7Z2I4 B7Z618 B7Z9P2 C9JT37 E9PHB1 F5GXR2 O75849 Q4KMQ6 Q59GA7 Q6AI30 Q9UQ71 Q9Y636

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 37 Ensembl 8 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 6 RNAct 1 RefSeq 10 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7700648

Title: A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

PubMed ID: 7700648

PubMed ID: 7651741

Title: Molecular characterization of the ets-related human transcription factor ER81.

PubMed ID: 7651741

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213813

Title: Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.

PubMed ID: 12213813

DOI: 10.1074/jbc.m205501200

PubMed ID: 12569367

Title: Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).

PubMed ID: 12569367

DOI: 10.1038/sj.onc.1206185

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 477
  • Mass: 55131
  • Checksum: BE95FA3F07196F06
  • Sequence:
    • MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 
AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS SACSQEQPFK FSYGEKCLYN 
VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY 
PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT 
MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG 
MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA 
LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM PEGGCCNPHP YNEGYVY

Genular Protein ID: 1719729245

Symbol: B7Z2C9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2C9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 437
  • Mass: 50233
  • Checksum: 3D9857741AE8A67C
  • Sequence:
    • MLQDLSASVF FPPCSQHRTL AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS 
SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK 
PDRAFPAHLP PSQSIPDSSY PMDRRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI 
PFPPQGFKQE YHDPVYEHNT MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE 
GFLAHPSRTE GCMFEKGPRR FYDDTCVVPE KFDGDIKLEP GMYREGPTYQ RRGSLQLWQF 
LVALLDDPSN SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG 
IMQKVAGERY VYKFVCDPEA PFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM 
PEGGCCNPHP YNEGYVY

Genular Protein ID: 1338222778

Symbol: B5MCT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B5MCT2

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 491
  • Mass: 56510
  • Checksum: 8F86FC4A0753581F
  • Sequence:
    • MSGRGDGGQQ QLLHSKFLAG FVCHIEKNES QRGRNCNEKP TNVRKRKFIN RDLAHDSEEL 
FQDLSQLQET WLAEAQVPDN DEQFVPDYQA ESLAFHGLPL KIKKEPHSPC SEISSACSQE 
QPFKFSYGEK CLYNVSAYDQ KPQVGMRPSN PPTPSSTPVS PLHHASPNST HTPKPDRAFP 
AHLPPSQSIP DSSYPMDHRF RRQLSEPCNS FPPLPTMPRE GRPMYQRQMS EPNIPFPPQG 
FKQEYHDPVY EHNTMVGSAA SQSFPPPLMI KQEPRDFAYD SEVPSCHSIY MRQEGFLAHP 
SRTEGCMFEK GPRQFYDDTC VVPEKFDGDI KQEPGMYREG PTYQRRGSLQ LWQFLVALLD 
DPSNSHFIAW TGRGMEFKLI EPEEVARRWG IQKNRPAMNY DKLSRSLRYY YEKGIMQKVA 
GERYVYKFVC DPEALFSMAF PDNQRPLLKT DMERHINEED TVPLSHFDES MAYMPEGGCC 
NPHPYNEGYV Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.