Details for: EZH1

Gene ID: 2145

Symbol: EZH1

Ensembl ID: ENSG00000108799

Description: enhancer of zeste 1 polycomb repressive complex 2 subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.94
    Marker Score: 4252.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.8
    Marker Score: 755
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.72
    Marker Score: 514
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.63
    Marker Score: 100546
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.59
    Marker Score: 16452
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.54
    Marker Score: 1774
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.51
    Marker Score: 14317
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.49
    Marker Score: 14027
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.49
    Marker Score: 56420.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12556
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.45
    Marker Score: 5602
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.45
    Marker Score: 30914
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.44
    Marker Score: 393
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.43
    Marker Score: 28364
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.43
    Marker Score: 5804
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.41
    Marker Score: 52166
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.41
    Marker Score: 10833
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.35
    Marker Score: 3849
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.34
    Marker Score: 20044
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.33
    Marker Score: 2712
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.33
    Marker Score: 656
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2030
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.25
    Marker Score: 1562
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.24
    Marker Score: 5136
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.23
    Marker Score: 690
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.18
    Marker Score: 4937.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.13
    Marker Score: 745
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.08
    Marker Score: 344
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.03
    Marker Score: 539
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.02
    Marker Score: 598.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.02
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71689.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47914
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.97
    Marker Score: 1699
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.91
    Marker Score: 391
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2703
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 995
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9
    Marker Score: 30474
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.89
    Marker Score: 261
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.89
    Marker Score: 2138
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.88
    Marker Score: 4078
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.86
    Marker Score: 928
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 195
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.85
    Marker Score: 18905.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4822
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.83
    Marker Score: 1005
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12863
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.82
    Marker Score: 655
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.81
    Marker Score: 773
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 791
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.8
    Marker Score: 291
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.79
    Marker Score: 747.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.79
    Marker Score: 473
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.78
    Marker Score: 193
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.78
    Marker Score: 772
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.78
    Marker Score: 2763
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.77
    Marker Score: 1483
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.77
    Marker Score: 819.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.76
    Marker Score: 661
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.75
    Marker Score: 1015
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3133
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.74
    Marker Score: 416
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.73
    Marker Score: 674
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1028
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.72
    Marker Score: 190
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.71
    Marker Score: 263
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.71
    Marker Score: 272
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7
    Marker Score: 853
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7
    Marker Score: 23723
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.7
    Marker Score: 243
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.69
    Marker Score: 150
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.69
    Marker Score: 342
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.69
    Marker Score: 391
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.68
    Marker Score: 461
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 702
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.68
    Marker Score: 6842
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.67
    Marker Score: 2779
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.66
    Marker Score: 705
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 439
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.66
    Marker Score: 1175
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1562
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.66
    Marker Score: 820
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.66
    Marker Score: 358

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Other Information

**Key characteristics:** * EZH1 is a member of the EZH family of histone-modifying enzymes, which are responsible for adding or removing methyl groups to histone proteins. * It is a highly conserved gene, with a similar sequence found in organisms from yeast to humans. * EZH1 is a key regulator of gene expression in the CNS, and its mutations have been linked to a variety of neurological disorders. **Pathways and functions:** * EZH1 is involved in multiple pathways that are essential for the development and function of the CNS. * In the developing brain, EZH1 is expressed in neural stem cells and proliferating neurons, where it helps to regulate their differentiation and survival. * In adults, EZH1 is expressed in a variety of cell types, including ciliary muscle cells, retinal ganglion cells, and neurons. * It plays a critical role in the development and function of the eye, where it is expressed in photoreceptor cells and retinal ganglion cells. * EZH1 is also involved in the development and function of the hippocampus, where it is expressed in neurons and astrocytes. **Clinical significance:** * Mutations in EZH1 have been linked to a variety of neurological disorders, including autism, schizophrenia, and Alzheimer's disease. * These disorders are characterized by a variety of cognitive deficits, including difficulties with attention, memory, and learning. * Understanding the role of EZH1 in the CNS has potential implications for the development of new treatments for these disorders. **Additional notes:** * EZH1 is a highly dynamic gene, and its expression levels can vary depending on the cellular context. * It is also a target for post-translational modifications, which can further regulate its activity. * EZH1 is a promising target for cancer therapy, as it is frequently methylated in cancer cells and is involved in their survival and proliferation.

Genular Protein ID: 125490149

Symbol: EZH1_HUMAN

Name: Histone-lysine N-methyltransferase EZH1

UniProtKB Accession Codes:

Q92800 A6NCH6 B4DIJ1 B4DIZ7 B4DSS2 B4E3R7 O43287 Q14459 Q53XP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 14 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 12 EMDB 5 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 4 Rhea 3 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921387

Title: Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.

PubMed ID: 8921387

DOI: 10.1006/geno.1996.0537

PubMed ID: 9473645

Title: Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.

PubMed ID: 9473645

DOI: 10.1016/s0167-4781(97)00156-5

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 19026781

Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

PubMed ID: 19026781

DOI: 10.1016/j.molcel.2008.11.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31451685

Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

PubMed ID: 31451685

DOI: 10.1038/s41467-019-11800-x

Sequence Information:

  • Length: 747
  • Mass: 85271
  • Checksum: 7CFC52269CDA011B
  • Sequence:
    • MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 
KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN 
FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV 
DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI 
ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 
RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR 
RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP 
QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK 
LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT 
QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 
SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD 
KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG 
EELFFDYRYS QADALKYVGI ERETDVL

Genular Protein ID: 824689760

Symbol: A0A0A0MSY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSY9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 11 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 5 Proteomes 2 RefSeq 1 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 738
  • Mass: 84277
  • Checksum: C6FD469BFE9D340A
  • Sequence:
    • MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 
KKLRVQPVQS MKPCTIESIF PGFASQHMLM RSLNTVALVP IMYSWSPLQQ NFMVEDETVL 
CNIPYMGDEV KEEDETFIEE LINNYDGKVH GEEEMIPGSV LISDAVFLEL VDALNQYSDE 
EEEGHNDTSD GKQDDSKEDL PVTRKRKRHA IEGNKKSSKK QFPNDMIFSA IASMFPENGV 
PDDMKERYRE LTEMSDPNAL PPQCTPNIDG PNAKSVQREQ SLHSFHTLFC RRCFKYDCFL 
HPFHATPNVY KRKNKEIKIE PEPCGTDCFL LLEGAKEYAM LHNPRSKCSG RRRRRHHIVS 
ASCSNASASA VAETKEGDSD RDTGNDWASS SSEANSRCQT PTKQKASPAP PQLCVVEAPS 
EPVEWTGAEE SLFRVFHGTY FNNFCSIARL LGTKTCKQVF QFAVKESLIL KLPTDELMNP 
SQKKKRKHRL WAAHCRKIQL KKDNSSTQVY NYQPCDHPDR PCDSTCPCIM TQNFCEKFCQ 
CNPDCQNRFP GCRCKTQCNT KQCPCYLAVR ECDPDLCLTC GASEHWDCKV VSCKNCSIQR 
GLKKHLLLAP SDVAGWGTFI KESVQKNEFI SEYCGELISQ DEADRRGKVY DKYMSSFLFN 
LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK VVMVNGDHRI GIFAKRAIQA GEELFFDYRY 
SQADALKYVG IERETDVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.