Details for: EZH1

Gene ID: 2145

Symbol: EZH1

Ensembl ID: ENSG00000108799

Description: enhancer of zeste 1 polycomb repressive complex 2 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.8101
    Cell Significance Index: -36.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.8634
    Cell Significance Index: -36.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.4418
    Cell Significance Index: -29.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.9088
    Cell Significance Index: -29.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0781
    Cell Significance Index: -37.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8264
    Cell Significance Index: -34.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9595
    Cell Significance Index: -30.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6451
    Cell Significance Index: -38.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3753
    Cell Significance Index: -18.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 5.4771
    Cell Significance Index: 65.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.9711
    Cell Significance Index: 124.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5228
    Cell Significance Index: 305.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4633
    Cell Significance Index: 28.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4284
    Cell Significance Index: 11.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3476
    Cell Significance Index: 16.7200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.0154
    Cell Significance Index: 6.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9097
    Cell Significance Index: 19.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8549
    Cell Significance Index: 306.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7260
    Cell Significance Index: 55.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7202
    Cell Significance Index: 44.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6800
    Cell Significance Index: 110.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6598
    Cell Significance Index: 71.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6384
    Cell Significance Index: 10.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6061
    Cell Significance Index: 419.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5440
    Cell Significance Index: 28.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5424
    Cell Significance Index: 32.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5220
    Cell Significance Index: 15.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4763
    Cell Significance Index: 47.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4173
    Cell Significance Index: 75.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3988
    Cell Significance Index: 9.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3418
    Cell Significance Index: 67.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3089
    Cell Significance Index: 7.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2941
    Cell Significance Index: 20.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2766
    Cell Significance Index: 37.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2674
    Cell Significance Index: 12.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2634
    Cell Significance Index: 7.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2591
    Cell Significance Index: 14.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2360
    Cell Significance Index: 15.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2186
    Cell Significance Index: 25.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2149
    Cell Significance Index: 26.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2119
    Cell Significance Index: 9.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2116
    Cell Significance Index: 4.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1957
    Cell Significance Index: 106.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1891
    Cell Significance Index: 118.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1493
    Cell Significance Index: 10.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1455
    Cell Significance Index: 64.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1408
    Cell Significance Index: 5.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1039
    Cell Significance Index: 5.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1018
    Cell Significance Index: 46.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0992
    Cell Significance Index: 18.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0907
    Cell Significance Index: 170.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0589
    Cell Significance Index: 1.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0499
    Cell Significance Index: 31.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0445
    Cell Significance Index: 5.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0283
    Cell Significance Index: 52.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0241
    Cell Significance Index: 37.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0189
    Cell Significance Index: 25.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0063
    Cell Significance Index: 0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0202
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0408
    Cell Significance Index: -1.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0479
    Cell Significance Index: -27.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1059
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1088
    Cell Significance Index: -22.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1097
    Cell Significance Index: -31.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1217
    Cell Significance Index: -1.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1227
    Cell Significance Index: -14.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1272
    Cell Significance Index: -18.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1312
    Cell Significance Index: -13.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1373
    Cell Significance Index: -6.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1401
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1404
    Cell Significance Index: -16.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1488
    Cell Significance Index: -3.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1547
    Cell Significance Index: -19.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1868
    Cell Significance Index: -4.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2258
    Cell Significance Index: -6.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2287
    Cell Significance Index: -11.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2404
    Cell Significance Index: -17.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2432
    Cell Significance Index: -27.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2719
    Cell Significance Index: -7.4000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2732
    Cell Significance Index: -3.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2753
    Cell Significance Index: -5.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2802
    Cell Significance Index: -29.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2813
    Cell Significance Index: -5.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3264
    Cell Significance Index: -24.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3720
    Cell Significance Index: -29.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3934
    Cell Significance Index: -4.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4044
    Cell Significance Index: -5.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4259
    Cell Significance Index: -26.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4962
    Cell Significance Index: -7.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5042
    Cell Significance Index: -16.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5043
    Cell Significance Index: -14.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5602
    Cell Significance Index: -7.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5914
    Cell Significance Index: -14.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6299
    Cell Significance Index: -9.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6581
    Cell Significance Index: -20.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6669
    Cell Significance Index: -14.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EZH1 is a histone-lysine N-methyltransferase enzyme that belongs to the Polycomb group of proteins. It is a key player in the PRC2 complex, which is responsible for maintaining the repressive chromatin state of target genes. EZH1 is characterized by its ability to catalyze the trimethylation of H3K27, a process that is essential for silencing gene expression. This enzyme is also known for its role in the maintenance of heterochromatin, a compact, transcriptionally inactive chromatin state. EZH1 has been shown to interact with various transcription factors and chromatin-modifying enzymes, further highlighting its regulatory role in gene expression. **Pathways and Functions** EZH1 is involved in several key pathways, including: 1. **Chromatin remodeling**: EZH1 plays a crucial role in maintaining the repressive chromatin state of target genes by catalyzing the trimethylation of H3K27. 2. **Heterochromatin formation**: EZH1 is essential for the maintenance of heterochromatin, a compact, transcriptionally inactive chromatin state. 3. **Transcriptional regulation**: EZH1 regulates gene expression by interacting with transcription factors and chromatin-modifying enzymes, thereby influencing the transcriptional activity of target genes. 4. **Cell differentiation**: EZH1 is involved in the regulation of cell differentiation, particularly in the development of neurons and other cell types. **Clinical Significance** Dysregulation of EZH1 has been implicated in several diseases, including: 1. **Cancer**: EZH1 overexpression has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Neurological disorders**: EZH1 has been implicated in the regulation of neuronal development and function, and its dysregulation has been linked to neurological disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Metabolic disorders**: EZH1 has been shown to regulate glucose and lipid metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and type 2 diabetes. 4. **Immune responses**: EZH1 is involved in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In conclusion, EZH1 is a critical regulator of gene expression and chromatin structure, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the role of EZH1 in human disease and to explore potential therapeutic strategies for targeting this gene.

Genular Protein ID: 125490149

Symbol: EZH1_HUMAN

Name: Histone-lysine N-methyltransferase EZH1

UniProtKB Accession Codes:

Q92800 A6NCH6 B4DIJ1 B4DIZ7 B4DSS2 B4E3R7 O43287 Q14459 Q53XP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 14 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 12 EMDB 5 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 4 Rhea 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921387

Title: Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.

PubMed ID: 8921387

DOI: 10.1006/geno.1996.0537

PubMed ID: 9473645

Title: Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.

PubMed ID: 9473645

DOI: 10.1016/s0167-4781(97)00156-5

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 19026781

Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

PubMed ID: 19026781

DOI: 10.1016/j.molcel.2008.11.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31451685

Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

PubMed ID: 31451685

DOI: 10.1038/s41467-019-11800-x

Sequence Information:

  • Length: 747
  • Mass: 85271
  • Checksum: 7CFC52269CDA011B
  • Sequence:
    • MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 
KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN 
FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV 
DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI 
ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 
RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR 
RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP 
QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK 
LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT 
QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 
SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD 
KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG 
EELFFDYRYS QADALKYVGI ERETDVL

Genular Protein ID: 824689760

Symbol: A0A0A0MSY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSY9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 738
  • Mass: 84277
  • Checksum: C6FD469BFE9D340A
  • Sequence:
    • MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 
KKLRVQPVQS MKPCTIESIF PGFASQHMLM RSLNTVALVP IMYSWSPLQQ NFMVEDETVL 
CNIPYMGDEV KEEDETFIEE LINNYDGKVH GEEEMIPGSV LISDAVFLEL VDALNQYSDE 
EEEGHNDTSD GKQDDSKEDL PVTRKRKRHA IEGNKKSSKK QFPNDMIFSA IASMFPENGV 
PDDMKERYRE LTEMSDPNAL PPQCTPNIDG PNAKSVQREQ SLHSFHTLFC RRCFKYDCFL 
HPFHATPNVY KRKNKEIKIE PEPCGTDCFL LLEGAKEYAM LHNPRSKCSG RRRRRHHIVS 
ASCSNASASA VAETKEGDSD RDTGNDWASS SSEANSRCQT PTKQKASPAP PQLCVVEAPS 
EPVEWTGAEE SLFRVFHGTY FNNFCSIARL LGTKTCKQVF QFAVKESLIL KLPTDELMNP 
SQKKKRKHRL WAAHCRKIQL KKDNSSTQVY NYQPCDHPDR PCDSTCPCIM TQNFCEKFCQ 
CNPDCQNRFP GCRCKTQCNT KQCPCYLAVR ECDPDLCLTC GASEHWDCKV VSCKNCSIQR 
GLKKHLLLAP SDVAGWGTFI KESVQKNEFI SEYCGELISQ DEADRRGKVY DKYMSSFLFN 
LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK VVMVNGDHRI GIFAKRAIQA GEELFFDYRY 
SQADALKYVG IERETDVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.