Details for: ACSL3

Gene ID: 2181

Symbol: ACSL3

Ensembl ID: ENSG00000123983

Description: acyl-CoA synthetase long chain family member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.58
    Marker Score: 3467
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.42
    Marker Score: 11183
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.39
    Marker Score: 51033
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.35
    Marker Score: 1367
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.33
    Marker Score: 2677
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.24
    Marker Score: 2703
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.21
    Marker Score: 4500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.1
    Marker Score: 1977
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.07
    Marker Score: 30900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.05
    Marker Score: 1201
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.05
    Marker Score: 75602
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.03
    Marker Score: 851
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.99
    Marker Score: 2094
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.98
    Marker Score: 66826
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.97
    Marker Score: 4722
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.95
    Marker Score: 14981
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.95
    Marker Score: 2361
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.93
    Marker Score: 5180
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.93
    Marker Score: 4240
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.93
    Marker Score: 38404
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.91
    Marker Score: 1142
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.89
    Marker Score: 7833
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.85
    Marker Score: 70363
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.84
    Marker Score: 7123.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.84
    Marker Score: 113262
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.82
    Marker Score: 4133
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.82
    Marker Score: 1215
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2655
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.78
    Marker Score: 18366.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.77
    Marker Score: 739
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.74
    Marker Score: 1923
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.73
    Marker Score: 498
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.68
    Marker Score: 1784
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.68
    Marker Score: 1105
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.68
    Marker Score: 1454
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14393.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.67
    Marker Score: 6165
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.66
    Marker Score: 3022
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.65
    Marker Score: 523
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15653
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.62
    Marker Score: 6597
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.61
    Marker Score: 3107
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.61
    Marker Score: 1986
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6
    Marker Score: 54599
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.59
    Marker Score: 460
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.59
    Marker Score: 5202
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.59
    Marker Score: 924
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.58
    Marker Score: 2042
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.58
    Marker Score: 1562
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.57
    Marker Score: 6054
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.57
    Marker Score: 760.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.56
    Marker Score: 493
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.54
    Marker Score: 721
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.53
    Marker Score: 24565
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.52
    Marker Score: 415
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14253
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.51
    Marker Score: 791
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.51
    Marker Score: 1308
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.51
    Marker Score: 1765
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.5
    Marker Score: 1427
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.49
    Marker Score: 1175
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.49
    Marker Score: 1244
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.48
    Marker Score: 2052
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.47
    Marker Score: 1687
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.45
    Marker Score: 50352
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.44
    Marker Score: 3637
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.43
    Marker Score: 2372
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.43
    Marker Score: 794
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.41
    Marker Score: 3455
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2172
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.41
    Marker Score: 958
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.4
    Marker Score: 689
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.38
    Marker Score: 24533.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.38
    Marker Score: 11877
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.38
    Marker Score: 519
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.38
    Marker Score: 844
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.34
    Marker Score: 1195
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.33
    Marker Score: 10409.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.33
    Marker Score: 29693
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.32
    Marker Score: 2245
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.29
    Marker Score: 3279
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.29
    Marker Score: 637
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.29
    Marker Score: 880
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.28
    Marker Score: 1282.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.28
    Marker Score: 8146
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.27
    Marker Score: 11020
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.27
    Marker Score: 1822
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.26
    Marker Score: 1835
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.26
    Marker Score: 470
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1276
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.25
    Marker Score: 6561
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.25
    Marker Score: 318
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19305
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.22
    Marker Score: 2777.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.21
    Marker Score: 2532
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.21
    Marker Score: 753.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.21
    Marker Score: 446
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 816
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.2
    Marker Score: 4123
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.2
    Marker Score: 1445

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Other Information

**Key characteristics:** * ACSL3 is a transmembrane protein that is localized to the cell surface. * It is a key enzyme in the biosynthesis of very long-chain fatty acids (VLCFAAs). * It is also involved in the regulation of insulin secretion. **Pathways and functions:** * ACSL3 is involved in the synthesis of VLCFAAs, which are a class of fatty acids that are essential for a variety of cellular processes. * VLCFAAs are also involved in the regulation of insulin secretion. * They are produced by the liver and transported to the cells. * Once in the cells, VLCFAAs are used to synthesize other lipids, such as choline and sphingolipids. * They are also used to regulate the activity of other enzymes, such as lipase enzymes. **Clinical significance:** * Mutations in ACSL3 have been linked to the development of several eye diseases, including age-related macular degeneration (AMD). * In AMD, the protein is expressed in the retinal pigment epithelial cells, which are responsible for producing the pigment that gives the eyes their color. * Mutations in ACSL3 can lead to the accumulation of VLCFAAs in the retina, which can damage the pigment epithelial cells and lead to the development of AMD. * Therefore, ACSL3 is a promising target for the treatment of AMD.

Genular Protein ID: 1001636921

Symbol: ACSL3_HUMAN

Name: Long-chain acyl-CoA synthetase 3

UniProtKB Accession Codes:

O95573 Q60I92 Q8IUM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 EPD 1 Ensembl 11 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 41 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177793

Title: Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35.

PubMed ID: 9177793

DOI: 10.1006/geno.1997.4710

PubMed ID: 11707336

Title: Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene.

PubMed ID: 11707336

DOI: 10.1016/s0378-1119(01)00714-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18003621

Title: Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.

PubMed ID: 18003621

DOI: 10.1074/jbc.m706160200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 720
  • Mass: 80420
  • Checksum: AAC4B0B4543EC8DD
  • Sequence:
    • MNNHVSSKPS TMKLKHTINP ILLYFIHFLI SLYTILTYIP FYFFSESRQE KSNRIKAKPV 
NSKPDSAYRS VNSLDGLASV LYPGCDTLDK VFTYAKNKFK NKRLLGTREV LNEEDEVQPN 
GKIFKKVILG QYNWLSYEDV FVRAFNFGNG LQMLGQKPKT NIAIFCETRA EWMIAAQACF 
MYNFQLVTLY ATLGGPAIVH ALNETEVTNI ITSKELLQTK LKDIVSLVPR LRHIITVDGK 
PPTWSEFPKG IIVHTMAAVE ALGAKASMEN QPHSKPLPSD IAVIMYTSGS TGLPKGVMIS 
HSNIIAGITG MAERIPELGE EDVYIGYLPL AHVLELSAEL VCLSHGCRIG YSSPQTLADQ 
SSKIKKGSKG DTSMLKPTLM AAVPEIMDRI YKNVMNKVSE MSSFQRNLFI LAYNYKMEQI 
SKGRNTPLCD SFVFRKVRSL LGGNIRLLLC GGAPLSATTQ RFMNICFCCP VGQGYGLTES 
AGAGTISEVW DYNTGRVGAP LVCCEIKLKN WEEGGYFNTD KPHPRGEILI GGQSVTMGYY 
KNEAKTKADF FEDENGQRWL CTGDIGEFEP DGCLKIIDRK KDLVKLQAGE YVSLGKVEAA 
LKNLPLVDNI CAYANSYHSY VIGFVVPNQK ELTELARKKG LKGTWEELCN SCEMENEVLK 
VLSEAAISAS LEKFEIPVKI RLSPEPWTPE TGLVTDAFKL KRKELKTHYQ ADIERMYGRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.