Details for: ACSL3

Gene ID: 2181

Symbol: ACSL3

Ensembl ID: ENSG00000123983

Description: acyl-CoA synthetase long chain family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 470.5384
    Cell Significance Index: -73.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 296.4201
    Cell Significance Index: -75.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 181.3823
    Cell Significance Index: -74.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 158.9417
    Cell Significance Index: -75.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 155.4434
    Cell Significance Index: -63.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.7263
    Cell Significance Index: -70.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.1906
    Cell Significance Index: -63.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.1109
    Cell Significance Index: -76.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.8207
    Cell Significance Index: -69.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.4021
    Cell Significance Index: -74.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.4955
    Cell Significance Index: -76.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3439
    Cell Significance Index: -35.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.7903
    Cell Significance Index: 674.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.0415
    Cell Significance Index: 159.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.6017
    Cell Significance Index: 32.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3303
    Cell Significance Index: 462.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1465
    Cell Significance Index: 430.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7094
    Cell Significance Index: 95.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6821
    Cell Significance Index: 603.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3333
    Cell Significance Index: 163.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3073
    Cell Significance Index: 235.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1477
    Cell Significance Index: 59.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1075
    Cell Significance Index: 120.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0513
    Cell Significance Index: 28.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9383
    Cell Significance Index: 72.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9045
    Cell Significance Index: 493.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8790
    Cell Significance Index: 41.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8296
    Cell Significance Index: 61.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7994
    Cell Significance Index: 552.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7530
    Cell Significance Index: 16.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7468
    Cell Significance Index: 16.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7292
    Cell Significance Index: 19.8500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.6059
    Cell Significance Index: 4.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6013
    Cell Significance Index: 542.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5472
    Cell Significance Index: 25.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4766
    Cell Significance Index: 16.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4080
    Cell Significance Index: 11.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4025
    Cell Significance Index: 39.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3957
    Cell Significance Index: 729.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3878
    Cell Significance Index: 49.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3545
    Cell Significance Index: 21.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3539
    Cell Significance Index: 156.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3113
    Cell Significance Index: 40.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3068
    Cell Significance Index: 21.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2633
    Cell Significance Index: 36.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2139
    Cell Significance Index: 329.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1784
    Cell Significance Index: 242.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1607
    Cell Significance Index: 4.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1553
    Cell Significance Index: 10.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1419
    Cell Significance Index: 64.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0989
    Cell Significance Index: 62.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0950
    Cell Significance Index: 18.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0890
    Cell Significance Index: 167.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0879
    Cell Significance Index: 3.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0762
    Cell Significance Index: 2.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0245
    Cell Significance Index: 17.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0121
    Cell Significance Index: 0.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0321
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0366
    Cell Significance Index: -27.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0412
    Cell Significance Index: -1.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0588
    Cell Significance Index: -44.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0615
    Cell Significance Index: -38.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0960
    Cell Significance Index: -5.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1122
    Cell Significance Index: -63.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1318
    Cell Significance Index: -13.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1359
    Cell Significance Index: -9.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1437
    Cell Significance Index: -5.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1879
    Cell Significance Index: -1.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1960
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2150
    Cell Significance Index: -34.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2349
    Cell Significance Index: -67.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2531
    Cell Significance Index: -53.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2566
    Cell Significance Index: -37.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2665
    Cell Significance Index: -1.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3455
    Cell Significance Index: -7.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3485
    Cell Significance Index: -41.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4190
    Cell Significance Index: -7.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4426
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4562
    Cell Significance Index: -52.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4742
    Cell Significance Index: -6.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4899
    Cell Significance Index: -30.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5358
    Cell Significance Index: -17.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5663
    Cell Significance Index: -12.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5892
    Cell Significance Index: -14.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6031
    Cell Significance Index: -68.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6301
    Cell Significance Index: -65.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6423
    Cell Significance Index: -10.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6513
    Cell Significance Index: -42.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6913
    Cell Significance Index: -8.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7118
    Cell Significance Index: -11.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7873
    Cell Significance Index: -6.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8196
    Cell Significance Index: -64.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9586
    Cell Significance Index: -25.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0008
    Cell Significance Index: -21.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0504
    Cell Significance Index: -20.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0915
    Cell Significance Index: -66.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1128
    Cell Significance Index: -29.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1705
    Cell Significance Index: -29.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1802
    Cell Significance Index: -14.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACSL3 belongs to the acyl-CoA synthetase long chain family, which is a group of enzymes responsible for activating fatty acids for various cellular processes. ACSL3 is specifically involved in the synthesis of long-chain fatty acyl-CoAs, which are essential for energy production, lipid metabolism, and cell signaling. The enzyme exhibits a high degree of specificity, preferentially activating long-chain fatty acids, and has a unique catalytic mechanism that involves the formation of a high-energy acyl-CoA intermediate. **Pathways and Functions** ACSL3 is involved in a wide range of cellular processes, including: 1. **Fatty Acid Metabolism**: ACSL3 plays a key role in the synthesis and degradation of long-chain fatty acids, which are essential for energy production, lipid storage, and cell signaling. 2. **Insulin Secretion**: ACSL3 regulates the secretion of insulin by pancreatic beta-cells, which is critical for maintaining glucose homeostasis. 3. **Energy Metabolism**: ACSL3 contributes to the regulation of energy metabolism by influencing the levels of fatty acids in the cell, which in turn affects ATP production and oxidative stress. 4. **Cell Differentiation**: ACSL3 is involved in the regulation of cell differentiation, particularly in the development of neurons and adipocytes. 5. **Lipid Droplet Formation**: ACSL3 is required for the formation of lipid droplets, which are essential for the storage of fatty acids in adipocytes. **Clinical Significance** Dysregulation of ACSL3 has been implicated in various diseases, including: 1. **Type 2 Diabetes**: ACSL3 deficiency has been linked to impaired insulin secretion and glucose metabolism, highlighting its importance in the regulation of glucose homeostasis. 2. **Obesity**: ACSL3 plays a role in regulating lipid metabolism and energy balance, making it a potential target for the treatment of obesity. 3. **Neurodegenerative Diseases**: ACSL3 has been implicated in the regulation of neuronal function and survival, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. 4. **Cardiovascular Disease**: ACSL3 regulates fatty acid metabolism, which is critical for cardiovascular health, making it a potential target for the treatment of cardiovascular disease. In conclusion, ACSL3 is a critical enzyme involved in the biosynthesis and metabolism of long-chain fatty acids, which has significant implications for various cellular processes, including energy metabolism, insulin secretion, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 1001636921

Symbol: ACSL3_HUMAN

Name: Long-chain acyl-CoA synthetase 3

UniProtKB Accession Codes:

O95573 Q60I92 Q8IUM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 Ensembl 11 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 41 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177793

Title: Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35.

PubMed ID: 9177793

DOI: 10.1006/geno.1997.4710

PubMed ID: 11707336

Title: Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene.

PubMed ID: 11707336

DOI: 10.1016/s0378-1119(01)00714-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18003621

Title: Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.

PubMed ID: 18003621

DOI: 10.1074/jbc.m706160200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 720
  • Mass: 80420
  • Checksum: AAC4B0B4543EC8DD
  • Sequence:
    • MNNHVSSKPS TMKLKHTINP ILLYFIHFLI SLYTILTYIP FYFFSESRQE KSNRIKAKPV 
NSKPDSAYRS VNSLDGLASV LYPGCDTLDK VFTYAKNKFK NKRLLGTREV LNEEDEVQPN 
GKIFKKVILG QYNWLSYEDV FVRAFNFGNG LQMLGQKPKT NIAIFCETRA EWMIAAQACF 
MYNFQLVTLY ATLGGPAIVH ALNETEVTNI ITSKELLQTK LKDIVSLVPR LRHIITVDGK 
PPTWSEFPKG IIVHTMAAVE ALGAKASMEN QPHSKPLPSD IAVIMYTSGS TGLPKGVMIS 
HSNIIAGITG MAERIPELGE EDVYIGYLPL AHVLELSAEL VCLSHGCRIG YSSPQTLADQ 
SSKIKKGSKG DTSMLKPTLM AAVPEIMDRI YKNVMNKVSE MSSFQRNLFI LAYNYKMEQI 
SKGRNTPLCD SFVFRKVRSL LGGNIRLLLC GGAPLSATTQ RFMNICFCCP VGQGYGLTES 
AGAGTISEVW DYNTGRVGAP LVCCEIKLKN WEEGGYFNTD KPHPRGEILI GGQSVTMGYY 
KNEAKTKADF FEDENGQRWL CTGDIGEFEP DGCLKIIDRK KDLVKLQAGE YVSLGKVEAA 
LKNLPLVDNI CAYANSYHSY VIGFVVPNQK ELTELARKKG LKGTWEELCN SCEMENEVLK 
VLSEAAISAS LEKFEIPVKI RLSPEPWTPE TGLVTDAFKL KRKELKTHYQ ADIERMYGRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.