Details for: FANCG

Gene ID: 2189

Symbol: FANCG

Ensembl ID: ENSG00000221829

Description: FA complementation group G

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.29
    Marker Score: 2188
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.24
    Marker Score: 1105
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.12
    Marker Score: 1615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5127
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1687
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13558
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.85
    Marker Score: 572
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.83
    Marker Score: 785
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.82
    Marker Score: 2235
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.81
    Marker Score: 651
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 564
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.72
    Marker Score: 908
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 521
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.67
    Marker Score: 717
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2723
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.61
    Marker Score: 611
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.49
    Marker Score: 140
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.48
    Marker Score: 300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.48
    Marker Score: 1867
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.47
    Marker Score: 629
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 970
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.46
    Marker Score: 314
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.45
    Marker Score: 222.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.44
    Marker Score: 323
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.43
    Marker Score: 1265
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.42
    Marker Score: 1737
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.42
    Marker Score: 5495
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.41
    Marker Score: 218
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 251
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.38
    Marker Score: 356
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 361
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 119
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1004
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.36
    Marker Score: 181
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.36
    Marker Score: 846
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.35
    Marker Score: 194
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.35
    Marker Score: 1299
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.32
    Marker Score: 2068
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.31
    Marker Score: 198
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.31
    Marker Score: 77
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 127
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 707
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.3
    Marker Score: 88
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.29
    Marker Score: 206
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.27
    Marker Score: 651
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.27
    Marker Score: 1042
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.26
    Marker Score: 258
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.26
    Marker Score: 279
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.26
    Marker Score: 271
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.25
    Marker Score: 291
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.25
    Marker Score: 158
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.25
    Marker Score: 164
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.24
    Marker Score: 52
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.24
    Marker Score: 48
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 367
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.24
    Marker Score: 59
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 114
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.23
    Marker Score: 262
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.23
    Marker Score: 406
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.23
    Marker Score: 945
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.23
    Marker Score: 122
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 153.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.23
    Marker Score: 449
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.23
    Marker Score: 227
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.23
    Marker Score: 238
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.22
    Marker Score: 366
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.22
    Marker Score: 138

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Other Information

**Key characteristics:** - FANCG is a protein of the Fanconi anemia group G family. - It is a transmembrane protein that is expressed in high levels in cells that are repairing DNA damage. - FANCG is a key regulator of the Fanconi anemia pathway, which is a rare genetic disorder that is caused by mutations in genes that repair DNA damage. **Pathways and functions:** - FANCG is involved in the repair of DNA damage in cells. - It is a key regulator of the Fanconi anemia pathway, a rare genetic disorder that is caused by mutations in genes that repair DNA damage. - FANCG is also involved in the regulation of cell cycle progression, apoptosis, and differentiation. **Clinical significance:** - Mutations in the FANCG gene have been linked to the development of Fanconi anemia. - FANCG is a promising target for the treatment of Fanconi anemia. - There are currently clinical trials underway to develop drugs that target FANCG to treat Fanconi anemia.

Genular Protein ID: 2142429782

Symbol: FANCG_HUMAN

Name: Fanconi anemia group G protein

UniProtKB Accession Codes:

O15287

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256465

Title: The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

PubMed ID: 9256465

DOI: 10.1073/pnas.94.17.9232

PubMed ID: 9806548

Title: The Fanconi anaemia group G gene FANCG is identical with XRCC9.

PubMed ID: 9806548

DOI: 10.1038/3093

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373536

Title: Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.

PubMed ID: 10373536

DOI: 10.1128/mcb.19.7.4866

PubMed ID: 12724401

Title: A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.

PubMed ID: 12724401

DOI: 10.1128/mcb.23.10.3417-3426.2003

PubMed ID: 15299030

Title: The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).

PubMed ID: 15299030

DOI: 10.1074/jbc.m403884200

PubMed ID: 15502827

Title: X-linked inheritance of Fanconi anemia complementation group B.

PubMed ID: 15502827

DOI: 10.1038/ng1458

PubMed ID: 16116422

Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

PubMed ID: 16116422

DOI: 10.1038/ng1626

PubMed ID: 18212739

Title: FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.

PubMed ID: 18212739

DOI: 10.1038/sj.onc.1211034

PubMed ID: 22343915

Title: FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.

PubMed ID: 22343915

DOI: 10.1182/blood-2011-10-385963

PubMed ID: 22705371

Title: A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

PubMed ID: 22705371

DOI: 10.1016/j.molcel.2012.05.026

PubMed ID: 22266823

Title: Regulation of Rev1 by the Fanconi anemia core complex.

PubMed ID: 22266823

DOI: 10.1038/nsmb.2222

PubMed ID: 11093276

Title: Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.

PubMed ID: 11093276

DOI: 10.1038/sj.ejhg.5200552

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18550849

Title: HES1 is a novel interactor of the Fanconi anemia core complex.

PubMed ID: 18550849

DOI: 10.1182/blood-2008-04-152710

Sequence Information:

  • Length: 622
  • Mass: 68554
  • Checksum: 4BC7475472AC3C84
  • Sequence:
    • MSRQTTSVGS SCLDLWREKN DRLVRQAKVA QNSGLTLRRQ QLAQDALEGL RGLLHSLQGL 
PAAVPVLPLE LTVTCNFIIL RASLAQGFTE DQAQDIQRSL ERVLETQEQQ GPRLEQGLRE 
LWDSVLRASC LLPELLSALH RLVGLQAALW LSADRLGDLA LLLETLNGSQ SGASKDLLLL 
LKTWSPPAEE LDAPLTLQDA QGLKDVLLTA FAYRQGLQEL ITGNPDKALS SLHEAASGLC 
PRPVLVQVYT ALGSCHRKMG NPQRALLYLV AALKEGSAWG PPLLEASRLY QQLGDTTAEL 
ESLELLVEAL NVPCSSKAPQ FLIEVELLLP PPDLASPLHC GTQSQTKHIL ASRCLQTGRA 
GDAAEHYLDL LALLLDSSEP RFSPPPSPPG PCMPEVFLEA AVALIQAGRA QDALTLCEEL 
LSRTSSLLPK MSRLWEDARK GTKELPYCPL WVSATHLLQG QAWVQLGAQK VAISEFSRCL 
ELLFRATPEE KEQGAAFNCE QGCKSDAALQ QLRAAALISR GLEWVASGQD TKALQDFLLS 
VQMCPGNRDT YFHLLQTLKR LDRRDEATAL WWRLEAQTKG SHEDALWSLP LYLESYLSWI 
RPSDRDAFLE EFRTSLPKSC DL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.