Details for: FANCG

Gene ID: 2189

Symbol: FANCG

Ensembl ID: ENSG00000221829

Description: FA complementation group G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.6809
    Cell Significance Index: -5.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.3793
    Cell Significance Index: -5.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 18.5825
    Cell Significance Index: -7.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8558
    Cell Significance Index: -7.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5011
    Cell Significance Index: -6.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8994
    Cell Significance Index: -7.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9404
    Cell Significance Index: 93.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7579
    Cell Significance Index: 12.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7230
    Cell Significance Index: 7.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6842
    Cell Significance Index: 130.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6501
    Cell Significance Index: 39.0300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5556
    Cell Significance Index: 4.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5496
    Cell Significance Index: 59.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4673
    Cell Significance Index: 7.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4653
    Cell Significance Index: 75.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4490
    Cell Significance Index: 11.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3789
    Cell Significance Index: 7.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3284
    Cell Significance Index: 7.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3051
    Cell Significance Index: 15.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2690
    Cell Significance Index: 31.3500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2683
    Cell Significance Index: 1.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2655
    Cell Significance Index: 9.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2580
    Cell Significance Index: 7.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2419
    Cell Significance Index: 6.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2084
    Cell Significance Index: 24.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1724
    Cell Significance Index: 155.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1611
    Cell Significance Index: 11.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1359
    Cell Significance Index: 6.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1286
    Cell Significance Index: 1.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1143
    Cell Significance Index: 22.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1107
    Cell Significance Index: 6.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0925
    Cell Significance Index: 18.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0791
    Cell Significance Index: 43.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0757
    Cell Significance Index: 2.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0753
    Cell Significance Index: 10.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0717
    Cell Significance Index: 31.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0628
    Cell Significance Index: 1.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0620
    Cell Significance Index: 1.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0550
    Cell Significance Index: 19.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0531
    Cell Significance Index: 1.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0496
    Cell Significance Index: 1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0447
    Cell Significance Index: 12.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0438
    Cell Significance Index: 5.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0297
    Cell Significance Index: 20.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0283
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0216
    Cell Significance Index: 3.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0213
    Cell Significance Index: 2.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0203
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0053
    Cell Significance Index: 0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0029
    Cell Significance Index: 0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0023
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0096
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0130
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0194
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0244
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0298
    Cell Significance Index: -1.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0322
    Cell Significance Index: -2.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0389
    Cell Significance Index: -4.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0405
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0411
    Cell Significance Index: -8.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0449
    Cell Significance Index: -3.3500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0483
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0697
    Cell Significance Index: -7.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0705
    Cell Significance Index: -0.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0741
    Cell Significance Index: -4.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0760
    Cell Significance Index: -5.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0842
    Cell Significance Index: -5.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0902
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0924
    Cell Significance Index: -7.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1119
    Cell Significance Index: -4.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1205
    Cell Significance Index: -1.7300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1264
    Cell Significance Index: -0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1287
    Cell Significance Index: -2.2100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1294
    Cell Significance Index: -1.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1334
    Cell Significance Index: -2.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1402
    Cell Significance Index: -5.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1469
    Cell Significance Index: -4.2100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1502
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1528
    Cell Significance Index: -3.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1545
    Cell Significance Index: -4.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1577
    Cell Significance Index: -2.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1641
    Cell Significance Index: -5.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1650
    Cell Significance Index: -4.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1729
    Cell Significance Index: -2.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FANCG is a 28-kilodalton protein that belongs to the FA protein family, which consists of eight subunits (A, B, C, D, E, F, G, and I). FANCG is specifically involved in the repair of interstrand cross-links, a type of DNA damage that can be caused by environmental mutagens, such as radiation and certain chemicals. The protein interacts with other FA proteins to form a complex that binds to DNA, facilitating the repair of interstrand cross-links. **Pathways and Functions:** FANCG is involved in several cellular pathways, including: 1. **Antiviral mechanism by interferon-stimulated genes**: FANCG has been shown to interact with interferon-stimulated genes, which are crucial for the induction of antiviral responses. 2. **DNA damage response**: FANCG is a key component of the FA pathway, which is responsible for repairing DNA damage caused by interstrand cross-links. 3. **Cytokine signaling in the immune system**: FANCG has been implicated in the regulation of cytokine signaling, which is essential for the proper functioning of the immune system. 4. **Spermatogenesis**: FANCG is required for the normal development of spermatids, suggesting its importance in male reproductive health. **Clinical Significance:** FANCG mutations have been associated with various human diseases, including: 1. **Fanconi anemia**: A rare genetic disorder characterized by bone marrow failure, anemia, and congenital abnormalities. 2. **Cancer**: FANCG mutations have been linked to an increased risk of cancer, particularly leukemia and lymphoma. 3. **Neurological disorders**: FANCG mutations have been associated with neurological disorders, such as ataxia and dementia. 4. **Immunodeficiency**: FANCG mutations can impair the functioning of the immune system, leading to recurrent infections and autoimmune diseases. In conclusion, FANCG is a multifunctional protein that plays a critical role in maintaining genomic integrity and regulating immune responses. Its dysregulation can lead to various human diseases, highlighting the importance of understanding the molecular mechanisms underlying FANCG function. Further research is necessary to elucidate the complex relationships between FANCG and other cellular pathways, and to develop novel therapeutic strategies for the treatment of FANCG-related diseases.

Genular Protein ID: 2142429782

Symbol: FANCG_HUMAN

Name: Fanconi anemia group G protein

UniProtKB Accession Codes:

O15287

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256465

Title: The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

PubMed ID: 9256465

DOI: 10.1073/pnas.94.17.9232

PubMed ID: 9806548

Title: The Fanconi anaemia group G gene FANCG is identical with XRCC9.

PubMed ID: 9806548

DOI: 10.1038/3093

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373536

Title: Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.

PubMed ID: 10373536

DOI: 10.1128/mcb.19.7.4866

PubMed ID: 12724401

Title: A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.

PubMed ID: 12724401

DOI: 10.1128/mcb.23.10.3417-3426.2003

PubMed ID: 15299030

Title: The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).

PubMed ID: 15299030

DOI: 10.1074/jbc.m403884200

PubMed ID: 15502827

Title: X-linked inheritance of Fanconi anemia complementation group B.

PubMed ID: 15502827

DOI: 10.1038/ng1458

PubMed ID: 16116422

Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

PubMed ID: 16116422

DOI: 10.1038/ng1626

PubMed ID: 18212739

Title: FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.

PubMed ID: 18212739

DOI: 10.1038/sj.onc.1211034

PubMed ID: 22343915

Title: FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.

PubMed ID: 22343915

DOI: 10.1182/blood-2011-10-385963

PubMed ID: 22705371

Title: A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

PubMed ID: 22705371

DOI: 10.1016/j.molcel.2012.05.026

PubMed ID: 22266823

Title: Regulation of Rev1 by the Fanconi anemia core complex.

PubMed ID: 22266823

DOI: 10.1038/nsmb.2222

PubMed ID: 11093276

Title: Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.

PubMed ID: 11093276

DOI: 10.1038/sj.ejhg.5200552

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18550849

Title: HES1 is a novel interactor of the Fanconi anemia core complex.

PubMed ID: 18550849

DOI: 10.1182/blood-2008-04-152710

Sequence Information:

  • Length: 622
  • Mass: 68554
  • Checksum: 4BC7475472AC3C84
  • Sequence:
    • MSRQTTSVGS SCLDLWREKN DRLVRQAKVA QNSGLTLRRQ QLAQDALEGL RGLLHSLQGL 
PAAVPVLPLE LTVTCNFIIL RASLAQGFTE DQAQDIQRSL ERVLETQEQQ GPRLEQGLRE 
LWDSVLRASC LLPELLSALH RLVGLQAALW LSADRLGDLA LLLETLNGSQ SGASKDLLLL 
LKTWSPPAEE LDAPLTLQDA QGLKDVLLTA FAYRQGLQEL ITGNPDKALS SLHEAASGLC 
PRPVLVQVYT ALGSCHRKMG NPQRALLYLV AALKEGSAWG PPLLEASRLY QQLGDTTAEL 
ESLELLVEAL NVPCSSKAPQ FLIEVELLLP PPDLASPLHC GTQSQTKHIL ASRCLQTGRA 
GDAAEHYLDL LALLLDSSEP RFSPPPSPPG PCMPEVFLEA AVALIQAGRA QDALTLCEEL 
LSRTSSLLPK MSRLWEDARK GTKELPYCPL WVSATHLLQG QAWVQLGAQK VAISEFSRCL 
ELLFRATPEE KEQGAAFNCE QGCKSDAALQ QLRAAALISR GLEWVASGQD TKALQDFLLS 
VQMCPGNRDT YFHLLQTLKR LDRRDEATAL WWRLEAQTKG SHEDALWSLP LYLESYLSWI 
RPSDRDAFLE EFRTSLPKSC DL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.