Details for: FBLN2

Gene ID: 2199

Symbol: FBLN2

Ensembl ID: ENSG00000163520

Description: fibulin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.38
    Marker Score: 2477
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.06
    Marker Score: 2012
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.39
    Marker Score: 10308
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.21
    Marker Score: 5792
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.05
    Marker Score: 471
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.03
    Marker Score: 2792
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9
    Marker Score: 3312
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.79
    Marker Score: 772
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.63
    Marker Score: 403
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.63
    Marker Score: 679
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.6
    Marker Score: 13504
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.52
    Marker Score: 17115
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.49
    Marker Score: 50854
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169129
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1365
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.31
    Marker Score: 1120
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.29
    Marker Score: 321
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.28
    Marker Score: 321
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.12
    Marker Score: 408
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16894.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.07
    Marker Score: 344
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.05
    Marker Score: 298
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.05
    Marker Score: 1770
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.03
    Marker Score: 6177
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.99
    Marker Score: 1143
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.97
    Marker Score: 251
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1880
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.92
    Marker Score: 220
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.9
    Marker Score: 191
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.86
    Marker Score: 1072
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.82
    Marker Score: 793
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.8
    Marker Score: 430
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.76
    Marker Score: 653
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.74
    Marker Score: 191
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.72
    Marker Score: 1035
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.71
    Marker Score: 259
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.71
    Marker Score: 1089
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.71
    Marker Score: 534
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 330
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2822.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.65
    Marker Score: 820.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.64
    Marker Score: 481.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.63
    Marker Score: 739
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 349
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.62
    Marker Score: 560
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.62
    Marker Score: 274
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 649
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.61
    Marker Score: 182
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.6
    Marker Score: 1700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.59
    Marker Score: 338
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.58
    Marker Score: 131
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.57
    Marker Score: 474
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.54
    Marker Score: 134
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1280
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.54
    Marker Score: 667
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.52
    Marker Score: 3092
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.51
    Marker Score: 505
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.5
    Marker Score: 122
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.49
    Marker Score: 871.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.48
    Marker Score: 302
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.48
    Marker Score: 430
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.45
    Marker Score: 420
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.44
    Marker Score: 642
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.43
    Marker Score: 198.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.42
    Marker Score: 94
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.41
    Marker Score: 258.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.41
    Marker Score: 272
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.4
    Marker Score: 399
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.39
    Marker Score: 429
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.39
    Marker Score: 135
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.38
    Marker Score: 765
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.38
    Marker Score: 185
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.38
    Marker Score: 383
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.36
    Marker Score: 3621

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Other Information

**Key characteristics:** - FBLN2 is a secreted protein that is expressed in high levels in embryonic and adult tissues. - It is a glycoprotein with a molecular weight of approximately 140 kDa. - FBLN2 is a member of the immunoglobulin superfamily, which are proteins that are involved in cell adhesion, migration, and signaling. - It is a key regulator of cell-substrate adhesion, as it is essential for the formation of stable cell-matrix complexes. - It is also involved in the formation and maintenance of the ECM, as it helps to assemble and maintain the collagen fibers that provide structural support for cells. **Pathways and functions:** - FBLN2 is involved in a variety of cellular processes, including cell migration, cell adhesion, and cell signaling. - It is essential for the migration of fibroblasts and endothelial cells, as it is a major component of cell adhesion to extracellular matrix proteins. - It is also involved in the formation of the ECM, as it is a key component of collagen fibers. - It is involved in cell signaling pathways, as it is a key component of cell adhesion receptors and signaling complexes. **Clinical significance:** - Mutations in FBLN2 have been linked to a number of human diseases, including pulmonary fibrosis, osteoarthritis, and cancer. - FBLN2 is a potential target for therapeutic intervention in these diseases, as it is a key component of the ECM that is involved in the development and progression of these conditions.

Genular Protein ID: 1405521687

Symbol: FBLN2_HUMAN

Name: Fibulin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7806230

Title: Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.

PubMed ID: 7806230

DOI: 10.1006/geno.1994.1404

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8737292

Title: The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo.

PubMed ID: 8737292

DOI: 10.1007/bf02331415

PubMed ID: 17255108

Title: Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

PubMed ID: 17255108

DOI: 10.1074/jbc.m608204200

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

Sequence Information:

  • Length: 1184
  • Mass: 126573
  • Checksum: D46890D93518B343
  • Sequence:
  • MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE PGACCATCVQ 
    QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC PPGGGKISCQ FMLCPELPPN 
    CIEAVVVADS CPQCGQVGCV HAGHKYAAGH TVHLPPCRAC HCPDAGGELI CYQLPGCHGN 
    FSDAEEGDPE RHYEDPYSYD QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS 
    TIQAPPWPAV LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG 
    HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS TGPEGVTHAP 
    SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP PTREVPRKPQ VLPHSHVEED 
    TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ QWAIDNDECL EIPESGTEDN VCRTAQRHCC 
    VSYLQEKSCM AGVLGAKEGE TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN 
    LGYPCNHVML SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL 
    PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP PQPEAPQEPA 
    LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA ICSCFPGYAI MADGVSCEDI 
    NECVTDLHTC SRGEHCVNTL GSFHCYKALT CEPGYALKDG ECEDVDECAM GTHTCQPGFL 
    CQNTKGSFYC QARQRCMDGF LQDPEGNCVD INECTSLSEP CRPGFSCINT VGSYTCQRNP 
    LICARGYHAS DDGTKCVDVN ECETGVHRCG EGQVCHNLPG SYRCDCKAGF QRDAFGRGCI 
    DVNECWASPG RLCQHTCENT LGSYRCSCAS GFLLAADGKR CEDVNECEAQ RCSQECANIY 
    GSYQCYCRQG YQLAEDGHTC TDIDECAQGA GILCTFRCLN VPGSYQCACP EQGYTMTANG 
    RSCKDVDECA LGTHNCSEAE TCHNIQGSFR CLRFECPPNY VQVSKTKCER TTCHDFLECQ 
    NSPARITHYQ LNFQTGLLVP AHIFRIGPAP AFTGDTIALN IIKGNEEGYF GTRRLNAYTG 
    VVYLQRAVLE PRDFALDVEM KLWRQGSVTT FLAKMHIFFT TFAL

Genular Protein ID: 4078909286

Symbol: Q9Y3V7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 576
  • Mass: 63274
  • Checksum: FF2F0E9B185D8AC3
  • Sequence:
  • PQEPALKSEF SQVASNTIPL PLPQPNTCKD NGPCKQVCST VGGSAICSCF PGYAIMADGV 
    SCEDQDECLM GAHDCSRRQF CVNTLGSFYC VNHTVLCADG YILNAHRKCV DINECVTDLH 
    TCSRGEHCVN TLGSFHCYKA LTCEPGYALK DGECEDVDEC AMGTHTCQPG FLCQNTKGSF 
    YCQARQRCMD GFLQDPEGNC VDINECTSLS EPCRPGFSCI NTVGSYTCQR NPLICARGYH 
    ASDDGTKCVD VNECETGVHR CGEGQVCHNL PGSYRCDCKA GFQRDAFGRG CIDVNECWAS 
    PGRLCQHTCE NTLGSYRCSC ASGFLLAADG KRCEDVNECE AQRCSQECAN IYGSYQCYCR 
    QGYQLAEDGH TCTDIDECAQ GAGILCTFRC LNVPGSYQCA CPEQGYTMTA NGRSCKDVDE 
    CALGTHNCSE AETCHNIQGS FRCLRFECPP NYVQVSKTKC ERTTCHDFLE CQNSPARITH 
    YQLNFQTGLL VPAHIFRIGP APAFTGDTIA LNIIKGNEEG YFGTRRLNAY TGVVYLQRAV 
    LEPRDFALDV EMKLWRQGSV TTFLAKMHIF FTTFAL

Genular Protein ID: 3142409099

Symbol: Q86V58_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1184
  • Mass: 126509
  • Checksum: 4240CD6ADBB9EC5D
  • Sequence:
  • MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE PGACCATCVQ 
    QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC PPGGGKISCQ FMLCPELPPN 
    CIEAVVVADS CPQCGQVGCV HAGHKYAAGH TVHLPPCRAC HCPDAGGELI CYQLPGCHGN 
    FSDAEEGDPE RHYEDPYSYD QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS 
    TIQAPPWPAV LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG 
    HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS TGPEGVTHAP 
    SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP PTREVPRKPQ VLPHSHVEED 
    TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ QWAIDNDECL EIPESGTEDN VCRTAQRHCC 
    VSYLQEKSCM AGVLGAKEGE TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN 
    LGYPCNHVML SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL 
    PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP PQPEAPQEPA 
    LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA ICSCFPGYAI MADGVSCEDI 
    NECVTDLHTC SRGEHCVNTL GSFHCYKALT CEPGYALKDG ECEDVDECAM GTHTCQPGFL 
    CQNTKGSFYC QARQRCMDGF LQDPEGNCVD INECTSLSEP CRPGFSCINT VGSYTCQRNP 
    LICARGYHAS DDGAKCVDVN ECETGVHRCG EGQVCHNLPG SYRCDCKAGF QRDAFGRGCI 
    DVNECWASPG RLCQHTCENT LGSYRCSCAS GFLLAADGKR CEDVNECEAQ RCSQECANIY 
    GSYQCYCRQG YQLAEDGHTC TDIDECAQGA GILCTFRCLN VPGSYQCACP EQGYTMTANG 
    RSCKDVDECA LGTHNCSEAE TCHNIQGSFR CLRLECPPNY VQVSKTKCER TTCHDFLECQ 
    NSPARITHYQ LNFQTGLLVP AHIFRIGPAP AFTGDTIALN IIKGNEEGYF GTRRLNAYTG 
    VVYLQRAVLE PRDFALDVEM KLWRQGSVTT FLAKMHIFFT TFAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.