Details for: FCAR

Gene ID: 2204

Symbol: FCAR

Ensembl ID: ENSG00000186431

Description: Fc alpha receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1998
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.35
    Marker Score: 5602.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 419
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 664
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.78
    Marker Score: 43623
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.67
    Marker Score: 1679
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5
    Marker Score: 354
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.46
    Marker Score: 888
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.31
    Marker Score: 108
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.3
    Marker Score: 732
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.25
    Marker Score: 645
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.23
    Marker Score: 150
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 128
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 349
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.21
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.17
    Marker Score: 87
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.17
    Marker Score: 189
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 126
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.16
    Marker Score: 1837
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.15
    Marker Score: 109
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 212
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 142
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 218
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.09
    Marker Score: 1234
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.09
    Marker Score: 69
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 271
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.08
    Marker Score: 513
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 140
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 125
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 84
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 17

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Other Information

**Key characteristics:** * FCAR is a cell surface receptor that is expressed on a variety of immune cells. * It is a member of the immunoglobulin superfamily. * It is a glycoprotein that is composed of 5 immunoglobulin domains. * It is expressed on the surface of enterocytes of the epithelium of the large intestine, colon goblet cells, classical monocytes, intestinal crypt stem cells of the small intestine, transit amplifying cells of the small intestine, goblet cells, enterocytes of the epithelium of the small intestine, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and tuft cells of the colon. * It is a ligand for CD69, which is expressed on activated macrophages and dendritic cells. * It is involved in the regulation of innate immune responses. **Pathways and functions:** * FCAR binds to CD69 on activated macrophages and dendritic cells, triggering the activation of the immune response. * It is also involved in the regulation of inflammatory responses, and it has been shown to be important in the pathogenesis of inflammatory bowel diseases. * It is a potential therapeutic target for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. **Clinical significance:** * Mutations in the FCAR gene have been linked to the pathogenesis of inflammatory bowel diseases. * FCAR is a potential therapeutic target for inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. * Studies of FCAR mutations in animal models of inflammatory bowel diseases have shown that they can lead to disease activity. * Therefore, FCAR is a promising target for the treatment of inflammatory bowel diseases.

Genular Protein ID: 3831858662

Symbol: FCAR_HUMAN

Name: Immunoglobulin alpha Fc receptor

UniProtKB Accession Codes:

P24071 Q13603 Q13604 Q15727 Q15728 Q1AJL7 Q1AJL8 Q1AJL9 Q53X38 Q53X39 Q92587 Q92588 Q92590 Q92592 Q92593 Q9UEK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 27 Ensembl 100 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2258698

Title: Expression cloning of a human Fc receptor for IgA.

PubMed ID: 2258698

DOI: 10.1084/jem.172.6.1665

PubMed ID: 7636188

Title: Structure of the gene for the human myeloid IgA Fc receptor (CD89).

PubMed ID: 7636188

PubMed ID: 8666819

Title: Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages.

PubMed ID: 8666819

PubMed ID: 8836118

Title: Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils.

PubMed ID: 8836118

DOI: 10.1042/bj3180771

PubMed ID: 9367406

Title: IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells.

PubMed ID: 9367406

DOI: 10.1111/j.1365-2249.1997.tb08321.x

PubMed ID: 17548632

Title: Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.

PubMed ID: 17548632

DOI: 10.4049/jimmunol.178.12.7943

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522255

Title: Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.

PubMed ID: 7522255

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18045383

Title: The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.

PubMed ID: 18045383

DOI: 10.1111/j.1365-2958.2007.05989.x

PubMed ID: 12783876

Title: Crystal structure of the ectodomain of human FcalphaRI.

PubMed ID: 12783876

DOI: 10.1074/jbc.c300223200

PubMed ID: 12768205

Title: Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.

PubMed ID: 12768205

DOI: 10.1038/nature01685

Sequence Information:

  • Length: 287
  • Mass: 32265
  • Checksum: A2CCA68467CD45F7
  • Sequence:
    • MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 
MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 
GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 
GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA 
LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.