Details for: FCAR

Gene ID: 2204

Symbol: FCAR

Ensembl ID: ENSG00000186431

Description: Fc alpha receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.4436
    Cell Significance Index: -1.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.9783
    Cell Significance Index: -1.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 4.8491
    Cell Significance Index: -1.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.0843
    Cell Significance Index: -1.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.4275
    Cell Significance Index: -1.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4770
    Cell Significance Index: 12.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4685
    Cell Significance Index: 8.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3038
    Cell Significance Index: -0.6700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1819
    Cell Significance Index: 2.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1347
    Cell Significance Index: 3.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1071
    Cell Significance Index: 2.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1015
    Cell Significance Index: 1.7400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.0995
    Cell Significance Index: 0.7800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0509
    Cell Significance Index: 0.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0170
    Cell Significance Index: 3.4100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0100
    Cell Significance Index: 0.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0067
    Cell Significance Index: 0.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0063
    Cell Significance Index: 1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0053
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0011
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0016
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0029
    Cell Significance Index: -0.3300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0035
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0038
    Cell Significance Index: -0.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0048
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0061
    Cell Significance Index: -1.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0077
    Cell Significance Index: -0.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0083
    Cell Significance Index: -0.3600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0109
    Cell Significance Index: -1.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0113
    Cell Significance Index: -1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0146
    Cell Significance Index: -1.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0146
    Cell Significance Index: -1.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0159
    Cell Significance Index: -1.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0163
    Cell Significance Index: -1.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0197
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0199
    Cell Significance Index: -0.9300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0244
    Cell Significance Index: -1.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0253
    Cell Significance Index: -1.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0274
    Cell Significance Index: -0.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0275
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0280
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0285
    Cell Significance Index: -0.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0295
    Cell Significance Index: -1.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0297
    Cell Significance Index: -0.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0299
    Cell Significance Index: -1.9300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0331
    Cell Significance Index: -0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0335
    Cell Significance Index: -1.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0340
    Cell Significance Index: -1.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0351
    Cell Significance Index: -1.3300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0359
    Cell Significance Index: -1.8900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0361
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0368
    Cell Significance Index: -0.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0381
    Cell Significance Index: -0.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0389
    Cell Significance Index: -0.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0393
    Cell Significance Index: -0.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0399
    Cell Significance Index: -1.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0401
    Cell Significance Index: -1.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0403
    Cell Significance Index: -1.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0407
    Cell Significance Index: -1.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0436
    Cell Significance Index: -1.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0438
    Cell Significance Index: -0.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0446
    Cell Significance Index: -1.1900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0458
    Cell Significance Index: -0.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0470
    Cell Significance Index: -0.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0473
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0473
    Cell Significance Index: -0.7800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0514
    Cell Significance Index: -0.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0517
    Cell Significance Index: -1.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0518
    Cell Significance Index: -1.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0520
    Cell Significance Index: -1.3300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0529
    Cell Significance Index: -0.6300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0558
    Cell Significance Index: -0.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0585
    Cell Significance Index: -1.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0595
    Cell Significance Index: -1.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0598
    Cell Significance Index: -1.7600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0608
    Cell Significance Index: -0.6500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0608
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Fc alpha receptor structure**: The FCAR is a type of Fc receptor that binds to the Fc region of IgA antibodies, which is distinct from other Fc receptors that bind to IgG or IgM antibodies. 2. **Cell surface localization**: The FCAR is expressed on the surface of various immune cells, including enterocytes, monocytes, and goblet cells, allowing it to interact with its ligand, IgA antibodies. 3. **Functional diversity**: The FCAR can modulate immune responses in different ways, including the regulation of phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and the activation of immune cells. 4. **Tissue-specific expression**: The FCAR is expressed in various tissues, including the gastrointestinal tract, where it plays a role in the clearance of pathogens and the regulation of immune responses in the gut. **Pathways and Functions:** 1. **Immune response regulation**: The FCAR modulates immune responses by regulating the clearance of pathogens and the activation of immune cells. 2. **IgA-mediated immunity**: The FCAR plays a crucial role in IgA-mediated immunity, allowing it to recognize and bind to IgA antibodies, which are essential for the clearance of pathogens in the gut. 3. **Neutrophil degranulation**: The FCAR can regulate neutrophil degranulation, which is essential for the clearance of pathogens and the regulation of immune responses in the gut. 4. **Innate immune system**: The FCAR is part of the innate immune system, which provides the first line of defense against pathogens. **Clinical Significance:** 1. **Immunodeficiency disorders**: Mutations in the FCAR gene can lead to immunodeficiency disorders, such as IgA deficiency, which increases the risk of infections and autoimmune diseases. 2. **Inflammatory bowel disease**: The FCAR plays a role in the regulation of immune responses in the gut, and dysregulation of the FCAR has been implicated in inflammatory bowel disease (IBD). 3. **Cancer therapy**: The FCAR can be targeted by cancer therapies, such as immunotherapy, which can enhance the effectiveness of cancer treatments. 4. **Vaccine development**: The FCAR can be used as a target for vaccine development, allowing for the creation of vaccines that can induce immune responses against specific pathogens. In conclusion, the Fc alpha receptor (FCAR) is a critical component of the innate immune system, playing a pivotal role in the regulation of immune responses and the clearance of pathogens. Its dysregulation has been implicated in various diseases, including immunodeficiency disorders, inflammatory bowel disease, and cancer. Further research on the FCAR is necessary to fully understand its role in the immune system and to develop effective therapeutic strategies.

Genular Protein ID: 3831858662

Symbol: FCAR_HUMAN

Name: Immunoglobulin alpha Fc receptor

UniProtKB Accession Codes:

P24071 Q13603 Q13604 Q15727 Q15728 Q1AJL7 Q1AJL8 Q1AJL9 Q53X38 Q53X39 Q92587 Q92588 Q92590 Q92592 Q92593 Q9UEK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 27 EMDB 1 Ensembl 100 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2258698

Title: Expression cloning of a human Fc receptor for IgA.

PubMed ID: 2258698

DOI: 10.1084/jem.172.6.1665

PubMed ID: 7636188

Title: Structure of the gene for the human myeloid IgA Fc receptor (CD89).

PubMed ID: 7636188

PubMed ID: 8666819

Title: Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages.

PubMed ID: 8666819

PubMed ID: 8836118

Title: Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils.

PubMed ID: 8836118

DOI: 10.1042/bj3180771

PubMed ID: 9367406

Title: IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells.

PubMed ID: 9367406

DOI: 10.1111/j.1365-2249.1997.tb08321.x

PubMed ID: 17548632

Title: Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.

PubMed ID: 17548632

DOI: 10.4049/jimmunol.178.12.7943

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522255

Title: Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.

PubMed ID: 7522255

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18045383

Title: The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.

PubMed ID: 18045383

DOI: 10.1111/j.1365-2958.2007.05989.x

PubMed ID: 12783876

Title: Crystal structure of the ectodomain of human FcalphaRI.

PubMed ID: 12783876

DOI: 10.1074/jbc.c300223200

PubMed ID: 12768205

Title: Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.

PubMed ID: 12768205

DOI: 10.1038/nature01685

Sequence Information:

  • Length: 287
  • Mass: 32265
  • Checksum: A2CCA68467CD45F7
  • Sequence:
    • MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 
MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 
GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 
GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA 
LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.