Details for: FER

Gene ID: 2241

Symbol: FER

Ensembl ID: ENSG00000151422

Description: FER tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.88
    Marker Score: 164945
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.99
    Marker Score: 5366
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.64
    Marker Score: 4402
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.45
    Marker Score: 18094
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.38
    Marker Score: 7411
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.34
    Marker Score: 4162
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.22
    Marker Score: 13496
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.98
    Marker Score: 13783
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.84
    Marker Score: 2185
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.83
    Marker Score: 5437
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.82
    Marker Score: 3974
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.81
    Marker Score: 59900
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.79
    Marker Score: 21035
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.77
    Marker Score: 11538.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.77
    Marker Score: 1538
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.71
    Marker Score: 14556
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.71
    Marker Score: 9083
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.69
    Marker Score: 1338
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.68
    Marker Score: 2317
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.68
    Marker Score: 783
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.67
    Marker Score: 3075
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.61
    Marker Score: 20033
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.58
    Marker Score: 51346
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.57
    Marker Score: 1493
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.57
    Marker Score: 1934
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.56
    Marker Score: 97327
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.54
    Marker Score: 1374
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.53
    Marker Score: 37868
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.53
    Marker Score: 1332
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.49
    Marker Score: 10335
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.49
    Marker Score: 5720
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.48
    Marker Score: 2366
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.37
    Marker Score: 5673
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.35
    Marker Score: 86788
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.32
    Marker Score: 1354
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.32
    Marker Score: 973
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.3
    Marker Score: 731
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.28
    Marker Score: 1500
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.28
    Marker Score: 822.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.27
    Marker Score: 6483
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.2
    Marker Score: 696
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.19
    Marker Score: 8455
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.18
    Marker Score: 1275
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.17
    Marker Score: 2457
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.17
    Marker Score: 1215
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20202
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.13
    Marker Score: 820
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.11
    Marker Score: 2330.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.1
    Marker Score: 1252
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.05
    Marker Score: 3450
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125552
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.02
    Marker Score: 973
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2
    Marker Score: 1318
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19922
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.92
    Marker Score: 698
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.92
    Marker Score: 34067
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18109
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.86
    Marker Score: 29874
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15768
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.83
    Marker Score: 606
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.83
    Marker Score: 1625
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.83
    Marker Score: 1583
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.81
    Marker Score: 2237
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.8
    Marker Score: 467
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.79
    Marker Score: 885
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7215
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.76
    Marker Score: 2200
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.76
    Marker Score: 482
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.75
    Marker Score: 1887
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.74
    Marker Score: 38916
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.71
    Marker Score: 955
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.68
    Marker Score: 1798.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2476
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.6
    Marker Score: 6667
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.6
    Marker Score: 591
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.57
    Marker Score: 686
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.56
    Marker Score: 1084
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.54
    Marker Score: 580
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.51
    Marker Score: 5827
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.46
    Marker Score: 2558
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.46
    Marker Score: 2127
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.44
    Marker Score: 414
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.43
    Marker Score: 435
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.4
    Marker Score: 356
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.36
    Marker Score: 427
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.33
    Marker Score: 4732.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.33
    Marker Score: 485
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.33
    Marker Score: 1089
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 788
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.31
    Marker Score: 1578
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.27
    Marker Score: 4515.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.27
    Marker Score: 432
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.27
    Marker Score: 2989
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.25
    Marker Score: 403
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.25
    Marker Score: 647
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.23
    Marker Score: 1739
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19208
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.2
    Marker Score: 449.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.17
    Marker Score: 2372
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.16
    Marker Score: 368

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The FER gene is a member of the FER family of tyrosine kinases, which are involved in a wide range of cellular processes. * It is widely expressed in epithelial cells, where it is important for cell adhesion, migration, and growth. * In neurons, FER is involved in synaptic plasticity, neuroprotection, and apoptosis. * It is also expressed in immune cells, where it plays a role in regulating immune responses. **Pathways and functions:** * FER is a key regulator of cell adhesion by binding to cadherins and facilitating their interaction with each other. * It is also involved in cell migration by binding to extracellular matrix proteins and promoting their migration. * In the skin, FER is essential for the formation of the epithelial barrier and the maintenance of skin integrity. * It is also involved in the regulation of epithelial cell proliferation, differentiation, and migration. * In neurons, FER is crucial for synaptic development, plasticity, and disease. * In immune cells, FER plays a role in regulating immune responses, including inflammation, migration, and cytotoxicity. **Clinical significance:** * Mutations in the FER gene have been linked to several human diseases, including cancer, cardiovascular disease, and diabetes. * Inhibition of FER signaling has been shown to suppress cell growth and proliferation, and can be used as a therapeutic strategy in cancer and other diseases. * Therefore, understanding the role of FER in cell growth and survival is important for the development of new therapeutic strategies.

Genular Protein ID: 567500370

Symbol: FER_HUMAN

Name: Tyrosine-protein kinase Fer

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2725517

Title: Isolation and sequence analysis of a novel human tyrosine kinase gene.

PubMed ID: 2725517

DOI: 10.1128/mcb.9.4.1587-1593.1989

PubMed ID: 22223638

Title: Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells.

PubMed ID: 22223638

DOI: 10.1074/jbc.m111.327106

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 2156206

Title: Identification and chromosomal mapping of new human tyrosine kinase genes.

PubMed ID: 2156206

PubMed ID: 1990274

Title: Nuclear and cytoplasmic location of the FER tyrosine kinase.

PubMed ID: 1990274

DOI: 10.1128/mcb.11.2.1180-1183.1991

PubMed ID: 7623846

Title: The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.

PubMed ID: 7623846

DOI: 10.1128/mcb.15.8.4553

PubMed ID: 9722593

Title: Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.

PubMed ID: 9722593

DOI: 10.1074/jbc.273.36.23542

PubMed ID: 12972546

Title: Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.

PubMed ID: 12972546

DOI: 10.1091/mbc.e03-02-0080

PubMed ID: 14517306

Title: Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.

PubMed ID: 14517306

DOI: 10.1128/mcb.23.20.7391-7402.2003

PubMed ID: 16418535

Title: Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.

PubMed ID: 16418535

DOI: 10.1083/jcb.200508091

PubMed ID: 18985748

Title: Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.

PubMed ID: 18985748

DOI: 10.1002/dvdy.21789

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19339212

Title: Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.

PubMed ID: 19339212

DOI: 10.1016/j.bbamcr.2009.01.015

PubMed ID: 19159681

Title: Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity.

PubMed ID: 19159681

DOI: 10.1016/j.cellsig.2008.12.011

PubMed ID: 19147545

Title: The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.

PubMed ID: 19147545

DOI: 10.1158/1541-7786.mcr-08-0117

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19738202

Title: The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.

PubMed ID: 19738202

DOI: 10.1126/scisignal.2000393

PubMed ID: 20111072

Title: FES kinases are required for oncogenic FLT3 signaling.

PubMed ID: 20111072

DOI: 10.1038/leu.2009.301

PubMed ID: 21518868

Title: FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.

PubMed ID: 21518868

DOI: 10.1073/pnas.1105369108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11994747

Title: Closing in on the biological functions of Fps/Fes and Fer.

PubMed ID: 11994747

DOI: 10.1038/nrm783

PubMed ID: 1651563

Title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

PubMed ID: 1651563

DOI: 10.1126/science.1651563

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 822
  • Mass: 94638
  • Checksum: BD42DF6C03419C76
  • Sequence:
  • MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKESTVQ 
    MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ 
    IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KEKYKEALAK GKETEKAKER YDKATMKLHM 
    LHNQYVLALK GAQLHQNQYY DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI 
    VNVHKEIQMS VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL 
    TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI VLLLSQKQAL 
    EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV NYEEDARSVT SMERKERLSK 
    FESIRHSIAG IIRSPKSALG SSALSDMISI SEKPLAEQDW YHGAIPRIEA QELLKKQGDF 
    LVRESHGKPG EYVLSVYSDG QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK 
    KSGVVLLNPI PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE 
    LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR RKKDELKLKQ 
    LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI SDFGMSRQED GGVYSSSGLK 
    QIPIKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGVCP YPGMTNQQAR EQVERGYRMS 
    APQHCPEDIS KIMMKCWDYK PENRPKFSEL QKELTIIKRK LT

Genular Protein ID: 2830150207

Symbol: Q6PEJ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 163
  • Mass: 18865
  • Checksum: 651BF0961098ECCE
  • Sequence:
  • MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKGSTVQ 
    MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ 
    IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KGKYKEALAK VKK

Genular Protein ID: 582616497

Symbol: W0S1B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 647
  • Mass: 74266
  • Checksum: F05F6497716D7D36
  • Sequence:
  • MKLHMLHNQY VLALKGAQLH QNQYYDITLP LLLDSLQKMQ EEMIKALKGI FDEYSQITSL 
    VTEEIVNVHK EIQMSVEQID PSTEYNNFID VHRTTAAKEQ EIEFDTSLLE ENENLQANEI 
    MWNNLTAESL QVMLKTLAEE LMQTQQMLLN KEEAVLELEK RIEESSETCE KKSDIVLLLS 
    QKQALEELKQ SVQQLRCTEA KFSAQKELLE QKVQENDGKE PPPVVNYEED ARSVTSMERK 
    ERLSKFESIR HSIAGIIRSP KSALGSSALS DMISISEKPL AEQDWYHGAI PRIEAQELLK 
    KQGDFLVRES HGKPGEYVLS VYSDGQRRHF IIQYVDNMYR FEGTGFSNIP QLIDHHYTTK 
    QVITKKSGVV LLNPIPKDKK WILSHEDVIL GELLGKGNFG EVYKGTLKDK TSVAVKTCKE 
    DLPQELKIKF LQEAKILKQY DHPNIVKLIG VCTQRQPVYI IMELVSGGDF LTFLRRKKDE 
    LKLKQLVKFS LDAAAGMLYL ESKNCIHRDL AARNCLVGEN NVLKISDFGM SRQEDGGVYS 
    SSGLKQIPIK WTAPEALNYG RYSSESDVWS FGILLWETFS LGVCPYPGMT NQQAREQVER 
    GYRMSAPQHC PEDISKIMMK CWDYKPENRP KFSELQKELT IIKRKLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.