Details for: FER
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 530.6495
Cell Significance Index: -82.5400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 326.2849
Cell Significance Index: -82.7600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 175.3570
Cell Significance Index: -82.7900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 159.0372
Cell Significance Index: -64.6100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.7146
Cell Significance Index: -64.6500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 67.2855
Cell Significance Index: -82.9600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 24.4510
Cell Significance Index: -75.1000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.8047
Cell Significance Index: -49.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 21.0616
Cell Significance Index: -83.1100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 5.4475
Cell Significance Index: 106.3200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 4.0275
Cell Significance Index: 96.5900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.5563
Cell Significance Index: 199.5600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.4870
Cell Significance Index: 214.3300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 3.4030
Cell Significance Index: 72.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.8992
Cell Significance Index: 1039.8800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8043
Cell Significance Index: 562.5300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.6774
Cell Significance Index: 58.6300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.6083
Cell Significance Index: 175.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2122
Cell Significance Index: 439.0100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.0236
Cell Significance Index: 1399.5900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.8897
Cell Significance Index: 83.5900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.7209
Cell Significance Index: 49.1100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.7198
Cell Significance Index: 131.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6499
Cell Significance Index: 46.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6465
Cell Significance Index: 62.3500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.0509
Cell Significance Index: 1938.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0108
Cell Significance Index: 1903.2600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.9866
Cell Significance Index: 14.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.9639
Cell Significance Index: 1483.8400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9533
Cell Significance Index: 23.8300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9396
Cell Significance Index: 12.8200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9316
Cell Significance Index: 841.1800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.7067
Cell Significance Index: 320.7600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6059
Cell Significance Index: 384.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4104
Cell Significance Index: 66.7500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3495
Cell Significance Index: 5.9900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3487
Cell Significance Index: 62.8600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2965
Cell Significance Index: 36.4600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2187
Cell Significance Index: 3.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1978
Cell Significance Index: 268.9800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0689
Cell Significance Index: 7.5000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0669
Cell Significance Index: 36.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0612
Cell Significance Index: 27.0400 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.0067
Cell Significance Index: -0.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0188
Cell Significance Index: -2.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0597
Cell Significance Index: -5.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0828
Cell Significance Index: -60.7300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0953
Cell Significance Index: -70.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1131
Cell Significance Index: -85.6400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1457
Cell Significance Index: -3.7500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1468
Cell Significance Index: -82.8100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1475
Cell Significance Index: -92.1200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1503
Cell Significance Index: -15.6500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1782
Cell Significance Index: -3.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1796
Cell Significance Index: -24.6600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2389
Cell Significance Index: -10.8300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2478
Cell Significance Index: -71.2900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.3268
Cell Significance Index: -62.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3747
Cell Significance Index: -19.5200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4161
Cell Significance Index: -87.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4163
Cell Significance Index: -71.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4282
Cell Significance Index: -54.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4616
Cell Significance Index: -53.8000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4620
Cell Significance Index: -52.9300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4691
Cell Significance Index: -5.8500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4915
Cell Significance Index: -50.2100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.5262
Cell Significance Index: -15.1600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5385
Cell Significance Index: -32.3300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.5591
Cell Significance Index: -72.2300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.6076
Cell Significance Index: -71.6600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7586
Cell Significance Index: -52.4600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7876
Cell Significance Index: -49.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.8276
Cell Significance Index: -38.9000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.8490
Cell Significance Index: -10.7200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8779
Cell Significance Index: -40.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8780
Cell Significance Index: -69.5400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8837
Cell Significance Index: -54.1800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.8886
Cell Significance Index: -17.5700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9146
Cell Significance Index: -24.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.9412
Cell Significance Index: -70.1500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0218
Cell Significance Index: -65.9200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.0230
Cell Significance Index: -72.3500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0283
Cell Significance Index: -32.7500 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -1.0806
Cell Significance Index: -15.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0948
Cell Significance Index: -57.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.1019
Cell Significance Index: -57.2400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.1029
Cell Significance Index: -36.1100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.1115
Cell Significance Index: -16.4100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1313
Cell Significance Index: -24.0100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -1.1478
Cell Significance Index: -14.8900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.1641
Cell Significance Index: -23.3700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1777
Cell Significance Index: -37.7200 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -1.1850
Cell Significance Index: -12.9100 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -1.2226
Cell Significance Index: -18.6000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.3334
Cell Significance Index: -19.1000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.5884
Cell Significance Index: -12.9500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.6518
Cell Significance Index: -9.9800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6762
Cell Significance Index: -58.7200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.7251
Cell Significance Index: -46.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.8582
Cell Significance Index: -64.5700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 567500370
Symbol: FER_HUMAN
Name: Tyrosine-protein kinase Fer
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2725517
Title: Isolation and sequence analysis of a novel human tyrosine kinase gene.
PubMed ID: 2725517
PubMed ID: 22223638
Title: Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells.
PubMed ID: 22223638
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 8247543
Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
PubMed ID: 8247543
PubMed ID: 2156206
Title: Identification and chromosomal mapping of new human tyrosine kinase genes.
PubMed ID: 2156206
PubMed ID: 1990274
Title: Nuclear and cytoplasmic location of the FER tyrosine kinase.
PubMed ID: 1990274
PubMed ID: 7623846
Title: The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.
PubMed ID: 7623846
PubMed ID: 9722593
Title: Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.
PubMed ID: 9722593
PubMed ID: 12972546
Title: Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.
PubMed ID: 12972546
PubMed ID: 14517306
Title: Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.
PubMed ID: 14517306
PubMed ID: 16418535
Title: Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.
PubMed ID: 16418535
PubMed ID: 18985748
Title: Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.
PubMed ID: 18985748
DOI: 10.1002/dvdy.21789
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19339212
Title: Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.
PubMed ID: 19339212
PubMed ID: 19159681
Title: Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity.
PubMed ID: 19159681
PubMed ID: 19147545
Title: The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.
PubMed ID: 19147545
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19738202
Title: The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
PubMed ID: 19738202
PubMed ID: 20111072
Title: FES kinases are required for oncogenic FLT3 signaling.
PubMed ID: 20111072
DOI: 10.1038/leu.2009.301
PubMed ID: 21518868
Title: FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.
PubMed ID: 21518868
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 11994747
Title: Closing in on the biological functions of Fps/Fes and Fer.
PubMed ID: 11994747
DOI: 10.1038/nrm783
PubMed ID: 1651563
Title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
PubMed ID: 1651563
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 822
- Mass: 94638
- Checksum: BD42DF6C03419C76
- Sequence:
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK PENRPKFSEL QKELTIIKRK LT
Genular Protein ID: 582616497
Symbol: W0S1B5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 647
- Mass: 74266
- Checksum: F05F6497716D7D36
- Sequence:
MKLHMLHNQY VLALKGAQLH QNQYYDITLP LLLDSLQKMQ EEMIKALKGI FDEYSQITSL VTEEIVNVHK EIQMSVEQID PSTEYNNFID VHRTTAAKEQ EIEFDTSLLE ENENLQANEI MWNNLTAESL QVMLKTLAEE LMQTQQMLLN KEEAVLELEK RIEESSETCE KKSDIVLLLS QKQALEELKQ SVQQLRCTEA KFSAQKELLE QKVQENDGKE PPPVVNYEED ARSVTSMERK ERLSKFESIR HSIAGIIRSP KSALGSSALS DMISISEKPL AEQDWYHGAI PRIEAQELLK KQGDFLVRES HGKPGEYVLS VYSDGQRRHF IIQYVDNMYR FEGTGFSNIP QLIDHHYTTK QVITKKSGVV LLNPIPKDKK WILSHEDVIL GELLGKGNFG EVYKGTLKDK TSVAVKTCKE DLPQELKIKF LQEAKILKQY DHPNIVKLIG VCTQRQPVYI IMELVSGGDF LTFLRRKKDE LKLKQLVKFS LDAAAGMLYL ESKNCIHRDL AARNCLVGEN NVLKISDFGM SRQEDGGVYS SSGLKQIPIK WTAPEALNYG RYSSESDVWS FGILLWETFS LGVCPYPGMT NQQAREQVER GYRMSAPQHC PEDISKIMMK CWDYKPENRP KFSELQKELT IIKRKLT
Genular Protein ID: 2830150207
Symbol: Q6PEJ9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 163
- Mass: 18865
- Checksum: 651BF0961098ECCE
- Sequence:
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKGSTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KGKYKEALAK VKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.