Details for: FGR

Gene ID: 2268

Symbol: FGR

Ensembl ID: ENSG00000000938

Description: FGR proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.8680
    Cell Significance Index: -8.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.1675
    Cell Significance Index: -8.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.3226
    Cell Significance Index: -11.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.6752
    Cell Significance Index: -10.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.6366
    Cell Significance Index: -11.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.3016
    Cell Significance Index: 326.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.9058
    Cell Significance Index: 146.1200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.7514
    Cell Significance Index: 20.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.0319
    Cell Significance Index: -8.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7054
    Cell Significance Index: 92.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4978
    Cell Significance Index: -9.3700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.7901
    Cell Significance Index: 18.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2833
    Cell Significance Index: -9.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0561
    Cell Significance Index: -4.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9358
    Cell Significance Index: 29.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9378
    Cell Significance Index: 178.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9305
    Cell Significance Index: 92.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6831
    Cell Significance Index: 616.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4227
    Cell Significance Index: 7.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3552
    Cell Significance Index: 57.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3150
    Cell Significance Index: 6.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2975
    Cell Significance Index: 6.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2898
    Cell Significance Index: 31.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2306
    Cell Significance Index: 12.0100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1433
    Cell Significance Index: 1.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1261
    Cell Significance Index: 4.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1241
    Cell Significance Index: 8.5900
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1021
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0588
    Cell Significance Index: 36.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0219
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0108
    Cell Significance Index: -2.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0158
    Cell Significance Index: -7.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0162
    Cell Significance Index: -10.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0163
    Cell Significance Index: -8.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0170
    Cell Significance Index: -1.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0201
    Cell Significance Index: -0.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0210
    Cell Significance Index: -6.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0221
    Cell Significance Index: -10.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0224
    Cell Significance Index: -8.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0266
    Cell Significance Index: -3.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0276
    Cell Significance Index: -3.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0296
    Cell Significance Index: -5.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0317
    Cell Significance Index: -6.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0338
    Cell Significance Index: -0.6600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0426
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0496
    Cell Significance Index: -5.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0598
    Cell Significance Index: -8.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0599
    Cell Significance Index: -3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0616
    Cell Significance Index: -7.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0657
    Cell Significance Index: -9.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0704
    Cell Significance Index: -1.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0715
    Cell Significance Index: -9.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0757
    Cell Significance Index: -3.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0800
    Cell Significance Index: -4.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0808
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0811
    Cell Significance Index: -9.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0823
    Cell Significance Index: -8.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0824
    Cell Significance Index: -1.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0916
    Cell Significance Index: -1.3400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1007
    Cell Significance Index: -0.8800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1016
    Cell Significance Index: -0.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1078
    Cell Significance Index: -8.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1082
    Cell Significance Index: -7.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1106
    Cell Significance Index: -5.2000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1128
    Cell Significance Index: -1.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1203
    Cell Significance Index: -7.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1264
    Cell Significance Index: -9.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1282
    Cell Significance Index: -6.6600
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.1299
    Cell Significance Index: -1.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1347
    Cell Significance Index: -9.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1385
    Cell Significance Index: -3.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1434
    Cell Significance Index: -5.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1476
    Cell Significance Index: -9.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1499
    Cell Significance Index: -3.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1505
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1520
    Cell Significance Index: -9.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1549
    Cell Significance Index: -1.7600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1555
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1702
    Cell Significance Index: -9.5500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1751
    Cell Significance Index: -1.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1767
    Cell Significance Index: -2.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1872
    Cell Significance Index: -9.8300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1909
    Cell Significance Index: -1.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1945
    Cell Significance Index: -9.0700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2073
    Cell Significance Index: -3.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2082
    Cell Significance Index: -9.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2131
    Cell Significance Index: -5.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2278
    Cell Significance Index: -7.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The FGR proto-oncogene is a member of the Src family of tyrosine kinases, which are characterized by their ability to autophosphorylate and phosphorylate tyrosine residues on target proteins. The FGR proto-oncogene is specifically expressed in immune cells, where it plays a key role in regulating immune responses. The gene is also implicated in the regulation of various cellular processes, including cell shape, migration, and phagocytosis. **Pathways and Functions:** The FGR proto-oncogene is involved in several signaling pathways, including: 1. **Fcγ receptor signaling pathway**: The FGR proto-oncogene is involved in the regulation of Fcγ receptor-mediated phagocytosis and the production of anti-inflammatory cytokines, such as IL-10. 2. **Phosphatidylinositol 3-kinase/protein kinase B signaling pathway**: The FGR proto-oncogene is involved in the regulation of this pathway, which is crucial for cell migration and survival. 3. **Immune response-regulating cell surface receptor signaling pathway**: The FGR proto-oncogene is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Leishmania infection**: The FGR proto-oncogene is specifically expressed in cells infected with Leishmania parasites and is involved in the regulation of parasite growth and survival. **Clinical Significance:** The FGR proto-oncogene has been implicated in various diseases, including: 1. **Leishmaniasis**: The FGR proto-oncogene is specifically expressed in cells infected with Leishmania parasites and is involved in the regulation of parasite growth and survival. 2. **Autoimmune diseases**: The FGR proto-oncogene is involved in the regulation of immune responses and has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis. 3. **Cancer**: The FGR proto-oncogene is involved in the regulation of cell migration and survival and has been implicated in the pathogenesis of various cancers, including leukemia and lymphoma. In conclusion, the FGR proto-oncogene is a key player in immune regulation and Leishmania infection, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of the FGR proto-oncogene in human disease and to develop targeted therapies for the treatment of these diseases.

Genular Protein ID: 1297010885

Symbol: FGR_HUMAN

Name: Tyrosine-protein kinase Fgr

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3275868

Title: Primary structure of the human fgr proto-oncogene product p55c-fgr.

PubMed ID: 3275868

DOI: 10.1128/mcb.8.1.259-266.1988

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2852026

Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.

PubMed ID: 2852026

DOI: 10.1038/bjc.1988.294

PubMed ID: 3330776

Title: Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.

PubMed ID: 3330776

PubMed ID: 1690869

Title: Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.

PubMed ID: 1690869

PubMed ID: 3023853

Title: Structure, expression, and chromosomal location of the human c-fgr gene.

PubMed ID: 3023853

DOI: 10.1128/mcb.6.2.511-517.1986

PubMed ID: 2181286

Title: Specific expression of human c-fgr in natural immunity effector cells.

PubMed ID: 2181286

DOI: 10.1128/mcb.10.4.1789-1792.1990

PubMed ID: 1737799

Title: Diverse biologic properties imparted by the c-fgr proto-oncogene.

PubMed ID: 1737799

DOI: 10.1016/s0021-9258(19)50753-0

PubMed ID: 8327512

Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

PubMed ID: 8327512

DOI: 10.1073/pnas.90.13.6305

PubMed ID: 7519620

Title: Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.

PubMed ID: 7519620

DOI: 10.1083/jcb.126.4.1111

PubMed ID: 8603737

Title: Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity.

PubMed ID: 8603737

DOI: 10.1016/0014-5793(96)00029-4

PubMed ID: 10739672

Title: Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.

PubMed ID: 10739672

DOI: 10.1006/excr.2000.4816

PubMed ID: 11078731

Title: Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.

PubMed ID: 11078731

DOI: 10.1074/jbc.m006571200

PubMed ID: 12435267

Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.

PubMed ID: 12435267

DOI: 10.1042/bj20021201

PubMed ID: 17164290

Title: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

PubMed ID: 17164290

DOI: 10.1242/jcs.03315

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 529
  • Mass: 59479
  • Checksum: 6B8C1E08414E0F9C
  • Sequence:
  • MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 
    INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 
    SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY 
    SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP 
    CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP 
    KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV 
    DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF 
    PIKWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP 
    PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT

Genular Protein ID: 3208359896

Symbol: P78453_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2852026

Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.

PubMed ID: 2852026

Sequence Information:

  • Length: 177
  • Mass: 19354
  • Checksum: 11ACD7F3BAF3D43E
  • Sequence:
  • MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 
    INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 
    SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.