Details for: FGR
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 55.8680
Cell Significance Index: -8.6900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 35.1675
Cell Significance Index: -8.9200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 27.3226
Cell Significance Index: -11.1000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 20.6752
Cell Significance Index: -10.6400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.6366
Cell Significance Index: -11.1100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 9.3016
Cell Significance Index: 326.8500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 7.9058
Cell Significance Index: 146.1200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 7.7514
Cell Significance Index: 20.7700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.0319
Cell Significance Index: -8.6700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.7054
Cell Significance Index: 92.6300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.4978
Cell Significance Index: -9.3700 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.7901
Cell Significance Index: 18.5100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.2833
Cell Significance Index: -9.0100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0561
Cell Significance Index: -4.5000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.9358
Cell Significance Index: 29.9500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9378
Cell Significance Index: 178.4700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9305
Cell Significance Index: 92.0500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6831
Cell Significance Index: 616.7500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4227
Cell Significance Index: 7.4700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3552
Cell Significance Index: 57.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3150
Cell Significance Index: 6.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2975
Cell Significance Index: 6.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2898
Cell Significance Index: 31.5300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2306
Cell Significance Index: 12.0100 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.1433
Cell Significance Index: 1.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1261
Cell Significance Index: 4.0400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1241
Cell Significance Index: 8.5900 - Cell Name: blood cell (CL0000081)
Fold Change: 0.1021
Cell Significance Index: 0.8700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0588
Cell Significance Index: 36.6900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0219
Cell Significance Index: 0.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0000
Cell Significance Index: 0.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0014
Cell Significance Index: -0.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0021
Cell Significance Index: -0.3800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0027
Cell Significance Index: -5.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0051
Cell Significance Index: -9.4600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0062
Cell Significance Index: -0.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0062
Cell Significance Index: -9.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0073
Cell Significance Index: -5.5300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0073
Cell Significance Index: -9.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0108
Cell Significance Index: -2.2700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0109
Cell Significance Index: -0.6700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0150
Cell Significance Index: -10.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0156
Cell Significance Index: -2.6700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0158
Cell Significance Index: -7.0000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0162
Cell Significance Index: -10.3000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0163
Cell Significance Index: -8.9200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0170
Cell Significance Index: -1.7400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0201
Cell Significance Index: -0.9100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0210
Cell Significance Index: -6.0400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0221
Cell Significance Index: -10.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0224
Cell Significance Index: -8.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0266
Cell Significance Index: -3.2700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0276
Cell Significance Index: -3.2600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0296
Cell Significance Index: -5.9400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0317
Cell Significance Index: -6.3000 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0338
Cell Significance Index: -0.6600 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0426
Cell Significance Index: -0.3500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0496
Cell Significance Index: -5.6600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0598
Cell Significance Index: -8.2100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0599
Cell Significance Index: -3.0300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0616
Cell Significance Index: -7.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0657
Cell Significance Index: -9.5600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0704
Cell Significance Index: -1.7100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0715
Cell Significance Index: -9.2400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0757
Cell Significance Index: -3.2900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0800
Cell Significance Index: -4.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0808
Cell Significance Index: -9.4200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0811
Cell Significance Index: -9.2900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0823
Cell Significance Index: -8.5700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0824
Cell Significance Index: -1.7100 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0916
Cell Significance Index: -1.3400 - Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.1007
Cell Significance Index: -0.8800 - Cell Name: activated type II NK T cell (CL0000931)
Fold Change: -0.1016
Cell Significance Index: -0.2600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1078
Cell Significance Index: -8.2700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1082
Cell Significance Index: -7.6500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1106
Cell Significance Index: -5.2000 - Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1128
Cell Significance Index: -1.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1203
Cell Significance Index: -7.7600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1264
Cell Significance Index: -9.4200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1282
Cell Significance Index: -6.6600 - Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: -0.1299
Cell Significance Index: -1.2500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1347
Cell Significance Index: -9.0600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1385
Cell Significance Index: -3.8700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1434
Cell Significance Index: -5.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1476
Cell Significance Index: -9.3000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1499
Cell Significance Index: -3.8300 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1505
Cell Significance Index: -2.0000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1520
Cell Significance Index: -9.3400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1549
Cell Significance Index: -1.7600 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1555
Cell Significance Index: -1.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1702
Cell Significance Index: -9.5500 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.1751
Cell Significance Index: -1.7100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1767
Cell Significance Index: -2.4800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1872
Cell Significance Index: -9.8300 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.1909
Cell Significance Index: -1.7000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1945
Cell Significance Index: -9.0700 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2073
Cell Significance Index: -3.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2082
Cell Significance Index: -9.2100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2131
Cell Significance Index: -5.7000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2278
Cell Significance Index: -7.9800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1297010885
Symbol: FGR_HUMAN
Name: Tyrosine-protein kinase Fgr
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3275868
Title: Primary structure of the human fgr proto-oncogene product p55c-fgr.
PubMed ID: 3275868
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2852026
Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.
PubMed ID: 2852026
DOI: 10.1038/bjc.1988.294
PubMed ID: 3330776
Title: Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.
PubMed ID: 3330776
PubMed ID: 1690869
Title: Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.
PubMed ID: 1690869
PubMed ID: 3023853
Title: Structure, expression, and chromosomal location of the human c-fgr gene.
PubMed ID: 3023853
PubMed ID: 2181286
Title: Specific expression of human c-fgr in natural immunity effector cells.
PubMed ID: 2181286
PubMed ID: 1737799
Title: Diverse biologic properties imparted by the c-fgr proto-oncogene.
PubMed ID: 1737799
PubMed ID: 8327512
Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.
PubMed ID: 8327512
PubMed ID: 7519620
Title: Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.
PubMed ID: 7519620
PubMed ID: 8603737
Title: Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity.
PubMed ID: 8603737
PubMed ID: 10739672
Title: Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.
PubMed ID: 10739672
PubMed ID: 11078731
Title: Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.
PubMed ID: 11078731
PubMed ID: 12435267
Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.
PubMed ID: 12435267
DOI: 10.1042/bj20021201
PubMed ID: 17164290
Title: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.
PubMed ID: 17164290
DOI: 10.1242/jcs.03315
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 529
- Mass: 59479
- Checksum: 6B8C1E08414E0F9C
- Sequence:
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF PIKWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT
Genular Protein ID: 3208359896
Symbol: P78453_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2852026
Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.
PubMed ID: 2852026
Sequence Information:
- Length: 177
- Mass: 19354
- Checksum: 11ACD7F3BAF3D43E
- Sequence:
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.