Details for: FGR

Gene ID: 2268

Symbol: FGR

Ensembl ID: ENSG00000000938

Description: FGR proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.43
    Marker Score: 191704
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.41
    Marker Score: 6649
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.81
    Marker Score: 6774
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.68
    Marker Score: 6664.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.66
    Marker Score: 7359
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.21
    Marker Score: 25737
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.15
    Marker Score: 55126
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.05
    Marker Score: 2087
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.99
    Marker Score: 5801
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.77
    Marker Score: 7359
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.59
    Marker Score: 9657
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.52
    Marker Score: 2245
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.52
    Marker Score: 656
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.5
    Marker Score: 4738
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168626
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.46
    Marker Score: 1666
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.28
    Marker Score: 324
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.21
    Marker Score: 724
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.21
    Marker Score: 625
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.19
    Marker Score: 496
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.16
    Marker Score: 3011
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 352
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.08
    Marker Score: 1302
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 494
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251763
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.03
    Marker Score: 620
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16106
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.99
    Marker Score: 870
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.95
    Marker Score: 2417
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 392
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.94
    Marker Score: 648
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.93
    Marker Score: 1033
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5265
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.92
    Marker Score: 1194
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.9
    Marker Score: 319
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.89
    Marker Score: 732.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.88
    Marker Score: 513
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 277
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.86
    Marker Score: 215
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.85
    Marker Score: 1234
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.85
    Marker Score: 470
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.83
    Marker Score: 272
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.77
    Marker Score: 747
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.7
    Marker Score: 908
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.69
    Marker Score: 696
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.68
    Marker Score: 1095
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.68
    Marker Score: 638
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.67
    Marker Score: 521
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.66
    Marker Score: 1109
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.65
    Marker Score: 226
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.64
    Marker Score: 628
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 709
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 383
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.62
    Marker Score: 140
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.61
    Marker Score: 444
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.58
    Marker Score: 501
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.57
    Marker Score: 390
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.56
    Marker Score: 816
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.55
    Marker Score: 385
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.53
    Marker Score: 531
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.53
    Marker Score: 228
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.52
    Marker Score: 155
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.51
    Marker Score: 697
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.5
    Marker Score: 1003
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.5
    Marker Score: 251
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.48
    Marker Score: 642
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.48
    Marker Score: 457
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.48
    Marker Score: 1170
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.48
    Marker Score: 309
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.48
    Marker Score: 996
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.47
    Marker Score: 415
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.46
    Marker Score: 449
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.46
    Marker Score: 225
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.45
    Marker Score: 1270
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.44
    Marker Score: 106

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Other Information

**Key characteristics:** - FGR is a single-pass membrane protein with a molecular weight of approximately 120 kDa. - It is a member of the Src family of tyrosine kinases, which are involved in a variety of cellular processes, including cell growth, differentiation, and signaling. - FGR is phosphorylated by various cytokines and growth factors, which regulates its activity. **Pathways and functions:** - FGR is primarily involved in the regulation of the inflammatory response against Leishmania parasites. - It is crucial for the recruitment and activation of immune cells, including macrophages and dendritic cells, which are key players in the innate immune response against Leishmania. - FGR signaling promotes the production of anti-inflammatory cytokines, such as IL-10, which helps to suppress the inflammatory response and promote tissue repair. - It also modulates the function of platelets, which can influence the inflammatory response. **Clinical significance:** - Mutations in FGR have been linked to an increased susceptibility to Leishmania infection. - Targeting FGR with small molecule inhibitors has shown promising results in preclinical models of leishmaniasis, indicating its potential as a therapeutic agent. - However, further research is needed to develop effective FGR inhibitors for clinical use.

Genular Protein ID: 1297010885

Symbol: FGR_HUMAN

Name: Tyrosine-protein kinase Fgr

UniProtKB Accession Codes:

P09769 D3DPL7 Q9UIQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 ELM 1 EMBL 14 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 43 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 5 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3275868

Title: Primary structure of the human fgr proto-oncogene product p55c-fgr.

PubMed ID: 3275868

DOI: 10.1128/mcb.8.1.259-266.1988

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2852026

Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.

PubMed ID: 2852026

DOI: 10.1038/bjc.1988.294

PubMed ID: 3330776

Title: Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.

PubMed ID: 3330776

PubMed ID: 1690869

Title: Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.

PubMed ID: 1690869

PubMed ID: 3023853

Title: Structure, expression, and chromosomal location of the human c-fgr gene.

PubMed ID: 3023853

DOI: 10.1128/mcb.6.2.511-517.1986

PubMed ID: 2181286

Title: Specific expression of human c-fgr in natural immunity effector cells.

PubMed ID: 2181286

DOI: 10.1128/mcb.10.4.1789-1792.1990

PubMed ID: 1737799

Title: Diverse biologic properties imparted by the c-fgr proto-oncogene.

PubMed ID: 1737799

DOI: 10.1016/s0021-9258(19)50753-0

PubMed ID: 8327512

Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

PubMed ID: 8327512

DOI: 10.1073/pnas.90.13.6305

PubMed ID: 7519620

Title: Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.

PubMed ID: 7519620

DOI: 10.1083/jcb.126.4.1111

PubMed ID: 8603737

Title: Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity.

PubMed ID: 8603737

DOI: 10.1016/0014-5793(96)00029-4

PubMed ID: 10739672

Title: Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.

PubMed ID: 10739672

DOI: 10.1006/excr.2000.4816

PubMed ID: 11078731

Title: Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.

PubMed ID: 11078731

DOI: 10.1074/jbc.m006571200

PubMed ID: 12435267

Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.

PubMed ID: 12435267

DOI: 10.1042/bj20021201

PubMed ID: 17164290

Title: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

PubMed ID: 17164290

DOI: 10.1242/jcs.03315

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 529
  • Mass: 59479
  • Checksum: 6B8C1E08414E0F9C
  • Sequence:
    • MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 
INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 
SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY 
SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP 
CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP 
KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV 
DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF 
PIKWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP 
PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT

Genular Protein ID: 3208359896

Symbol: P78453_HUMAN

Name: N/A

UniProtKB Accession Codes:

P78453

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 2852026

Title: Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.

PubMed ID: 2852026

Sequence Information:

  • Length: 177
  • Mass: 19354
  • Checksum: 11ACD7F3BAF3D43E
  • Sequence:
    • MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 
INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 
SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.