Details for: FHL1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 319.0069
Cell Significance Index: -49.6200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 159.3182
Cell Significance Index: -40.4100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.6076
Cell Significance Index: -43.2500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 84.1339
Cell Significance Index: -34.1800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.1406
Cell Significance Index: -39.6800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.3015
Cell Significance Index: -49.6900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.8631
Cell Significance Index: -34.2400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.3652
Cell Significance Index: -43.8400 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 14.7727
Cell Significance Index: 238.3600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 14.6295
Cell Significance Index: 356.9500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.5011
Cell Significance Index: -49.3300 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 10.0303
Cell Significance Index: 62.0600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.9474
Cell Significance Index: -24.4100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.0695
Cell Significance Index: 130.3100 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 4.9753
Cell Significance Index: 26.1800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 4.8617
Cell Significance Index: 61.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.1299
Cell Significance Index: 240.1800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.9209
Cell Significance Index: 28.3600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8988
Cell Significance Index: 380.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.6603
Cell Significance Index: 87.1700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6002
Cell Significance Index: 45.8700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.5863
Cell Significance Index: 30.9600 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.2829
Cell Significance Index: 164.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2730
Cell Significance Index: 85.6000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8539
Cell Significance Index: 117.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8501
Cell Significance Index: 304.9200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7776
Cell Significance Index: 50.1700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.6881
Cell Significance Index: 12.1600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6297
Cell Significance Index: 13.4600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5394
Cell Significance Index: 11.2900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5288
Cell Significance Index: 32.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2996
Cell Significance Index: 135.9600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2932
Cell Significance Index: 4.2100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2559
Cell Significance Index: 113.1300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2315
Cell Significance Index: 16.3700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.2250
Cell Significance Index: 1.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1400
Cell Significance Index: 263.6000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1377
Cell Significance Index: 3.9300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0789
Cell Significance Index: 3.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0384
Cell Significance Index: 24.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0348
Cell Significance Index: 47.3300 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0138
Cell Significance Index: 0.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0079
Cell Significance Index: 12.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0023
Cell Significance Index: 2.1200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0088
Cell Significance Index: -0.2100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0137
Cell Significance Index: -8.5800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0148
Cell Significance Index: -0.5600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0154
Cell Significance Index: -28.3200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0194
Cell Significance Index: -14.3500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0356
Cell Significance Index: -2.0000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0380
Cell Significance Index: -1.3200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0428
Cell Significance Index: -7.7100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0476
Cell Significance Index: -26.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0496
Cell Significance Index: -36.4000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0600
Cell Significance Index: -45.4200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0651
Cell Significance Index: -1.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0783
Cell Significance Index: -42.7500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0876
Cell Significance Index: -16.6700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0907
Cell Significance Index: -14.7500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1071
Cell Significance Index: -22.5500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1208
Cell Significance Index: -2.0700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1291
Cell Significance Index: -37.1500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1542
Cell Significance Index: -26.3300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1591
Cell Significance Index: -23.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1622
Cell Significance Index: -8.4500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1646
Cell Significance Index: -17.1400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1830
Cell Significance Index: -6.4300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1849
Cell Significance Index: -20.1100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1890
Cell Significance Index: -23.2400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1953
Cell Significance Index: -19.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2055
Cell Significance Index: -20.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2162
Cell Significance Index: -42.9100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2923
Cell Significance Index: -6.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3003
Cell Significance Index: -18.0300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3149
Cell Significance Index: -40.6800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3221
Cell Significance Index: -9.2800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3290
Cell Significance Index: -37.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3487
Cell Significance Index: -39.9500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3492
Cell Significance Index: -40.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3536
Cell Significance Index: -41.7000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.3654
Cell Significance Index: -25.2700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3939
Cell Significance Index: -17.8600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4030
Cell Significance Index: -25.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4117
Cell Significance Index: -25.2400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4310
Cell Significance Index: -8.9400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4694
Cell Significance Index: -37.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5312
Cell Significance Index: -39.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5595
Cell Significance Index: -17.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5600
Cell Significance Index: -26.3200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.5733
Cell Significance Index: -9.1000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6113
Cell Significance Index: -7.5800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6571
Cell Significance Index: -14.2400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.6690
Cell Significance Index: -10.3500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6999
Cell Significance Index: -19.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7483
Cell Significance Index: -18.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.7876
Cell Significance Index: -20.7100 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.7900
Cell Significance Index: -10.1300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8216
Cell Significance Index: -24.1300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.8499
Cell Significance Index: -9.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.8570
Cell Significance Index: -44.5200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3901787642
Symbol: FHL1_HUMAN
Name: Four and a half LIM domains protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8753811
Title: Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
PubMed ID: 8753811
PubMed ID: 9714789
Title: Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1).
PubMed ID: 9714789
PubMed ID: 10352231
Title: Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1.
PubMed ID: 10352231
PubMed ID: 10524257
Title: Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1.
PubMed ID: 10524257
PubMed ID: 10480922
Title: Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication.
PubMed ID: 10480922
PubMed ID: 11400158
Title: Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1).
PubMed ID: 11400158
DOI: 10.1002/jcb.1110
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7626119
Title: The developmental regulation of a novel muscle LIM-protein.
PubMed ID: 7626119
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 26933038
Title: Exome sequencing identified a splice site mutation in FHL1 that causes Uruguay Syndrome, an X-linked disorder with skeletal muscle hypertrophy and premature cardiac death.
PubMed ID: 26933038
PubMed ID: 18179888
Title: An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1.
PubMed ID: 18179888
PubMed ID: 18179901
Title: X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1.
PubMed ID: 18179901
PubMed ID: 18274675
Title: Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
PubMed ID: 18274675
DOI: 10.1172/jci34450
PubMed ID: 19716112
Title: Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy.
PubMed ID: 19716112
PubMed ID: 19181672
Title: Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1.
PubMed ID: 19181672
DOI: 10.1093/brain/awn325
PubMed ID: 31554973
Title: FHL1 is a major host factor for chikungunya virus infection.
PubMed ID: 31554973
PubMed ID: 33055253
Title: Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
PubMed ID: 33055253
DOI: 10.1128/jvi.01672-20
PubMed ID: 19171836
Title: Novel FHL1 mutations in fatal and benign reducing body myopathy.
PubMed ID: 19171836
PubMed ID: 19687455
Title: Consequences of mutations within the C terminus of the FHL1 gene.
PubMed ID: 19687455
PubMed ID: 20186852
Title: Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation.
PubMed ID: 20186852
DOI: 10.1002/ana.21839
PubMed ID: 23169582
Title: Novel FHL1 mutation in a family with reducing body myopathy.
PubMed ID: 23169582
DOI: 10.1002/mus.23500
PubMed ID: 27234031
Title: Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.
PubMed ID: 27234031
DOI: 10.1111/cge.12810
Sequence Information:
- Length: 323
- Mass: 36263
- Checksum: 50FD17F7B2606823
- Sequence:
MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG KRTVSRVSHP VSKARKPPVC HGKRLPLTLF PSANLRGRHP GGERTCPSWV VVLYRKNRSL AAPRGPGLVK APVWWPMKDN PGTTTASTAK NAP
Genular Protein ID: 1941463317
Symbol: Q5JXI2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15772651
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
Sequence Information:
- Length: 210
- Mass: 23701
- Checksum: 2C54446BBABB394B
- Sequence:
MASHRHSGPS SYKVGTMAEK FDCHYCRDPL QGKKYVQKDG HHCCLKCFDK FCANTCVECR KPIGADSKEV HYKNRFWHDT CFRCAKCLHP LANETFVAKD NKILCNKCTT REDSPKCKGC FKAIVAGDQN VEYKGTVWHK DCFTCSNCKQ VIGTGSFFPK GEDFYCVTCH ETKFAKHCVK CNKGLVKAPV WWPMKDNPGT TTASTAKNAP
Genular Protein ID: 3728444563
Symbol: B7Z9A1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 319
- Mass: 36203
- Checksum: DDE5223FAC920CBD
- Sequence:
MCEFLRHLGS CFQPYPAFAE YILSATHPAW GPSSYKVGTM AEKFDCHYCR DPLQGKKYVQ KDGHHCCLKC FDKFCANTCV ECRKPIGADS KEVHYKNRFW HDTCFRCAKC LHPSANETFV AKDNKILCNK CTTREDSPKC KGCFKATVAG DQNVEYKGTV WHKDCFTCSN CKQVIGTGSF FPKGEDFYCV TCHETKFAKH CVKCNKAITS GGITYQDQPW HADCFVCVTC SKKLAGQRFT AVEDQYYCVD CYKNFVAKKC AGCKNPITGF GKGSSVVAYE GQSWHDYCFH CKKCSVNLAN KRFVFHQEQV YCPDCAKKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.