Details for: FHL1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.13
Marker Score: 2450 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.88
Marker Score: 3748 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.84
Marker Score: 63477 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.76
Marker Score: 5187 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.73
Marker Score: 3368.5 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.71
Marker Score: 7094 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.65
Marker Score: 1003 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.58
Marker Score: 33981 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.42
Marker Score: 5304 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.38
Marker Score: 1323 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.32
Marker Score: 3358 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.22
Marker Score: 4520.5 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.19
Marker Score: 5147.5 - Cell Name: muscle cell (CL0000187)
Fold Change: 2.18
Marker Score: 616 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.09
Marker Score: 1378 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.09
Marker Score: 2526.5 - Cell Name: Mueller cell (CL0000636)
Fold Change: 2.05
Marker Score: 2839 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.9
Marker Score: 1797 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.9
Marker Score: 1379 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.88
Marker Score: 457 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.84
Marker Score: 582 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.8
Marker Score: 46018 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.77
Marker Score: 518 - Cell Name: fat cell (CL0000136)
Fold Change: 1.76
Marker Score: 981 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.74
Marker Score: 7520 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.74
Marker Score: 557 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.72
Marker Score: 4364 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.71
Marker Score: 58275 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.67
Marker Score: 611 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.67
Marker Score: 4184.5 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.67
Marker Score: 6923 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.66
Marker Score: 102343 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.64
Marker Score: 1587 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.57
Marker Score: 6570.5 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.55
Marker Score: 438 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.53
Marker Score: 1164 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.52
Marker Score: 5401.5 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.52
Marker Score: 55942 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 168051 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.46
Marker Score: 5653 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.44
Marker Score: 6013 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.42
Marker Score: 28219 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.41
Marker Score: 5443 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.39
Marker Score: 13087 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.37
Marker Score: 3741 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.37
Marker Score: 52022 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.37
Marker Score: 13005 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.33
Marker Score: 13748 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.32
Marker Score: 303 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.32
Marker Score: 713 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.3
Marker Score: 760 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.3
Marker Score: 436 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.29
Marker Score: 557 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.27
Marker Score: 18970 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.27
Marker Score: 365 - Cell Name: neuron (CL0000540)
Fold Change: 1.26
Marker Score: 5131 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.21
Marker Score: 18998 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.21
Marker Score: 299 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.2
Marker Score: 316 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.2
Marker Score: 1853 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.19
Marker Score: 1481 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.17
Marker Score: 297 - Cell Name: pericyte (CL0000669)
Fold Change: 1.16
Marker Score: 679 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.16
Marker Score: 2202 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.16
Marker Score: 11725 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4743 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.12
Marker Score: 1206.5 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.11
Marker Score: 1059 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.11
Marker Score: 5113 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.08
Marker Score: 12207 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.07
Marker Score: 1004 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.05
Marker Score: 235 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.04
Marker Score: 8000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251702 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.03
Marker Score: 1593.5 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.03
Marker Score: 8849 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.03
Marker Score: 338 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.03
Marker Score: 329 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.03
Marker Score: 874 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.02
Marker Score: 307 - Cell Name: theca cell (CL0000503)
Fold Change: 1.01
Marker Score: 727 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1
Marker Score: 1068 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1
Marker Score: 417.5 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71724 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47949 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.99
Marker Score: 222 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.98
Marker Score: 925 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30400 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.98
Marker Score: 258 - Cell Name: motor neuron (CL0000100)
Fold Change: 0.97
Marker Score: 578 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.97
Marker Score: 1137 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.96
Marker Score: 455 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.96
Marker Score: 1160 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.96
Marker Score: 333 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.95
Marker Score: 679 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.95
Marker Score: 1337 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.95
Marker Score: 1826 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 489 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.94
Marker Score: 591
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Other Information
Genular Protein ID: 3901787642
Symbol: FHL1_HUMAN
Name: Four and a half LIM domains protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8753811
Title: Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
PubMed ID: 8753811
PubMed ID: 9714789
Title: Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1).
PubMed ID: 9714789
PubMed ID: 10352231
Title: Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1.
PubMed ID: 10352231
PubMed ID: 10524257
Title: Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1.
PubMed ID: 10524257
PubMed ID: 10480922
Title: Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication.
PubMed ID: 10480922
PubMed ID: 11400158
Title: Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1).
PubMed ID: 11400158
DOI: 10.1002/jcb.1110
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7626119
Title: The developmental regulation of a novel muscle LIM-protein.
PubMed ID: 7626119
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 26933038
Title: Exome sequencing identified a splice site mutation in FHL1 that causes Uruguay Syndrome, an X-linked disorder with skeletal muscle hypertrophy and premature cardiac death.
PubMed ID: 26933038
PubMed ID: 18179888
Title: An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1.
PubMed ID: 18179888
PubMed ID: 18179901
Title: X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1.
PubMed ID: 18179901
PubMed ID: 18274675
Title: Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
PubMed ID: 18274675
DOI: 10.1172/jci34450
PubMed ID: 19716112
Title: Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy.
PubMed ID: 19716112
PubMed ID: 19181672
Title: Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1.
PubMed ID: 19181672
DOI: 10.1093/brain/awn325
PubMed ID: 31554973
Title: FHL1 is a major host factor for chikungunya virus infection.
PubMed ID: 31554973
PubMed ID: 33055253
Title: Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
PubMed ID: 33055253
DOI: 10.1128/jvi.01672-20
PubMed ID: 19171836
Title: Novel FHL1 mutations in fatal and benign reducing body myopathy.
PubMed ID: 19171836
PubMed ID: 19687455
Title: Consequences of mutations within the C terminus of the FHL1 gene.
PubMed ID: 19687455
PubMed ID: 20186852
Title: Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation.
PubMed ID: 20186852
DOI: 10.1002/ana.21839
PubMed ID: 23169582
Title: Novel FHL1 mutation in a family with reducing body myopathy.
PubMed ID: 23169582
DOI: 10.1002/mus.23500
PubMed ID: 27234031
Title: Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.
PubMed ID: 27234031
DOI: 10.1111/cge.12810
Sequence Information:
- Length: 323
- Mass: 36263
- Checksum: 50FD17F7B2606823
- Sequence:
MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG KRTVSRVSHP VSKARKPPVC HGKRLPLTLF PSANLRGRHP GGERTCPSWV VVLYRKNRSL AAPRGPGLVK APVWWPMKDN PGTTTASTAK NAP
Genular Protein ID: 1941463317
Symbol: Q5JXI2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15772651
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
Sequence Information:
- Length: 210
- Mass: 23701
- Checksum: 2C54446BBABB394B
- Sequence:
MASHRHSGPS SYKVGTMAEK FDCHYCRDPL QGKKYVQKDG HHCCLKCFDK FCANTCVECR KPIGADSKEV HYKNRFWHDT CFRCAKCLHP LANETFVAKD NKILCNKCTT REDSPKCKGC FKAIVAGDQN VEYKGTVWHK DCFTCSNCKQ VIGTGSFFPK GEDFYCVTCH ETKFAKHCVK CNKGLVKAPV WWPMKDNPGT TTASTAKNAP
Genular Protein ID: 3728444563
Symbol: B7Z9A1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 319
- Mass: 36203
- Checksum: DDE5223FAC920CBD
- Sequence:
MCEFLRHLGS CFQPYPAFAE YILSATHPAW GPSSYKVGTM AEKFDCHYCR DPLQGKKYVQ KDGHHCCLKC FDKFCANTCV ECRKPIGADS KEVHYKNRFW HDTCFRCAKC LHPSANETFV AKDNKILCNK CTTREDSPKC KGCFKATVAG DQNVEYKGTV WHKDCFTCSN CKQVIGTGSF FPKGEDFYCV TCHETKFAKH CVKCNKAITS GGITYQDQPW HADCFVCVTC SKKLAGQRFT AVEDQYYCVD CYKNFVAKKC AGCKNPITGF GKGSSVVAYE GQSWHDYCFH CKKCSVNLAN KRFVFHQEQV YCPDCAKKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.