Details for: FOXL1

Gene ID: 2300

Symbol: FOXL1

Ensembl ID: ENSG00000176678

Description: forkhead box L1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.51
    Marker Score: 4320
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.21
    Marker Score: 4028.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1519
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.16
    Marker Score: 1504
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7679
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2481
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.97
    Marker Score: 462
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 799
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1209
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.61
    Marker Score: 978
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1144
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.53
    Marker Score: 640
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8250
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 201
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 436
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.36
    Marker Score: 399
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.35
    Marker Score: 400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 244
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.25
    Marker Score: 240
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.23
    Marker Score: 237
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.22
    Marker Score: 415
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1206
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 212
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.16
    Marker Score: 105
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.15
    Marker Score: 251
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.14
    Marker Score: 97
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 49
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 564
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 115
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.08
    Marker Score: 1103
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.08
    Marker Score: 101
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 225
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.05
    Marker Score: 94
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.05
    Marker Score: 182
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.05
    Marker Score: 100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.05
    Marker Score: 13

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Other Information

**Key characteristics:** - Regulates gene expression through DNA binding and transcriptional regulation. - Involves the formation of a heterodimeric complex with FOXL2. - Essential for the development of the heart, as it is expressed in heart-related tissues and plays a role in regulating cardiac development. - Also involved in the development of the immune system, where it is expressed in immune cells and regulates the expression of immune-related genes. **Pathways and functions:** - **Heart development:** FOXL1 is essential for the development of the heart, as it is expressed in heart-related tissues and plays a role in regulating cardiac development. - **Immune responses:** FOXL1 is expressed in immune cells and plays a role in regulating immune responses. - **Tissue morphogenesis:** FOXL1 is involved in tissue morphogenesis, as it is expressed in cells that give rise to various tissues, including the heart, immune system, and endoderm. - **RNA polymerase II-specific:** FOXL1 is a key regulator of RNA polymerase II-mediated transcription. **Clinical significance:** - Mutations in FOXL1 have been linked to a number of human diseases, including autism, heart defects, and immune disorders. - Therefore, FOXL1 is a potential therapeutic target for a variety of diseases that are characterized by abnormal gene expression or function. **Additional notes:** - FOXL1 is a highly conserved protein, with similar sequences found in organisms from flies to humans. - It is a member of the forkhead box protein family of transcription factors. - FOXL1 is a highly dynamic protein, with its expression and function being regulated by a variety of factors, including growth factors, cytokines, and microRNAs.

Genular Protein ID: 2173511779

Symbol: FOXL1_HUMAN

Name: Forkhead box protein L1

UniProtKB Accession Codes:

Q12952 Q17RR1 Q9H242

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11078474

Title: Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.

PubMed ID: 11078474

DOI: 10.1086/316915

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

Sequence Information:

  • Length: 345
  • Mass: 36490
  • Checksum: 015D86B57DF3BBC6
  • Sequence:
    • MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM 
AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG 
SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG 
PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP 
GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA 
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ

Genular Protein ID: 1512530256

Symbol: Q498Y4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q498Y4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 345
  • Mass: 36520
  • Checksum: 015446A17DF3BBD2
  • Sequence:
    • MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM 
AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG 
SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG 
PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQSAAAVAV GQAARTGDGP 
GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA 
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.