Details for: FOXL1

Gene ID: 2300

Symbol: FOXL1

Ensembl ID: ENSG00000176678

Description: forkhead box L1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.3018
    Cell Significance Index: 26.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4941
    Cell Significance Index: 366.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4152
    Cell Significance Index: 87.4600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3671
    Cell Significance Index: 3.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3442
    Cell Significance Index: 194.1300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3295
    Cell Significance Index: 2.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2732
    Cell Significance Index: 2.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1596
    Cell Significance Index: 18.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0686
    Cell Significance Index: 42.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0449
    Cell Significance Index: 0.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0352
    Cell Significance Index: 0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0308
    Cell Significance Index: 0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0248
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0043
    Cell Significance Index: 0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0018
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0006
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0030
    Cell Significance Index: -0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0033
    Cell Significance Index: -1.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0088
    Cell Significance Index: -3.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0105
    Cell Significance Index: -1.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0153
    Cell Significance Index: -1.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0157
    Cell Significance Index: -3.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0161
    Cell Significance Index: -3.1900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0187
    Cell Significance Index: -0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0201
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0209
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0222
    Cell Significance Index: -2.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0244
    Cell Significance Index: -3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0280
    Cell Significance Index: -3.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0285
    Cell Significance Index: -1.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0301
    Cell Significance Index: -3.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0444
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0462
    Cell Significance Index: -0.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0471
    Cell Significance Index: -0.9400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0478
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0486
    Cell Significance Index: -3.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0494
    Cell Significance Index: -2.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0497
    Cell Significance Index: -1.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0539
    Cell Significance Index: -4.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0574
    Cell Significance Index: -0.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0619
    Cell Significance Index: -2.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0620
    Cell Significance Index: -3.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0646
    Cell Significance Index: -3.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0652
    Cell Significance Index: -1.9200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0727
    Cell Significance Index: -1.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0798
    Cell Significance Index: -2.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0844
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0860
    Cell Significance Index: -2.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0888
    Cell Significance Index: -3.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0910
    Cell Significance Index: -2.2700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0910
    Cell Significance Index: -1.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0922
    Cell Significance Index: -2.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0944
    Cell Significance Index: -3.0900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0954
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0960
    Cell Significance Index: -2.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0981
    Cell Significance Index: -3.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1001
    Cell Significance Index: -3.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1005
    Cell Significance Index: -3.2000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1024
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1041
    Cell Significance Index: -3.0000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1043
    Cell Significance Index: -1.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1045
    Cell Significance Index: -2.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1085
    Cell Significance Index: -2.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1088
    Cell Significance Index: -2.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1102
    Cell Significance Index: -2.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1140
    Cell Significance Index: -3.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1149
    Cell Significance Index: -3.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1172
    Cell Significance Index: -3.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1240
    Cell Significance Index: -3.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1253
    Cell Significance Index: -3.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1258
    Cell Significance Index: -1.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1288
    Cell Significance Index: -1.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1299
    Cell Significance Index: -3.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1332
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1336
    Cell Significance Index: -3.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1338
    Cell Significance Index: -3.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1359
    Cell Significance Index: -3.2600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1409
    Cell Significance Index: -1.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1409
    Cell Significance Index: -1.7800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1425
    Cell Significance Index: -1.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1448
    Cell Significance Index: -3.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1521
    Cell Significance Index: -2.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1527
    Cell Significance Index: -3.2400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1528
    Cell Significance Index: -1.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1533
    Cell Significance Index: -3.7400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1541
    Cell Significance Index: -1.9500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1544
    Cell Significance Index: -2.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1559
    Cell Significance Index: -3.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1566
    Cell Significance Index: -2.7000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1576
    Cell Significance Index: -1.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1588
    Cell Significance Index: -3.1400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1620
    Cell Significance Index: -1.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1647
    Cell Significance Index: -3.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Activity:** FOXL1 is a member of the forkhead box family of transcription factors, which play a critical role in regulating gene expression. Its ability to bind to specific DNA sequences enables it to control the transcription of target genes. 2. **Cell-Specific Expression:** FOXL1 is expressed in a wide range of cell types, including T cells, microglial cells, and goblet cells. This cell-specific expression suggests that FOXL1 plays distinct roles in different tissues and cell types. 3. **Immunomodulatory Functions:** FOXL1 has been implicated in immune regulation, particularly in the context of T cell development and function. Its expression in T cells and other immune cells highlights its potential role in modulating immune responses. **Pathways and Functions:** 1. **Anatomical Structure Morphogenesis:** FOXL1 is involved in the development of various anatomical structures, including the heart, Peyer's patches, and visceral mesoderm. Its expression in these tissues suggests that FOXL1 plays a critical role in tissue development and patterning. 2. **Cell Differentiation:** FOXL1 regulates the differentiation of various cell types, including T cells, microglial cells, and goblet cells. Its ability to control cell fate decisions highlights its importance in tissue development and homeostasis. 3. **Chromatin Regulation:** FOXL1 interacts with chromatin to regulate gene expression. Its binding to specific DNA sequences enables it to control the transcription of target genes, influencing cellular processes such as cell differentiation and survival. 4. **RNA Polymerase II Activity:** FOXL1 interacts with RNA polymerase II to regulate transcription. Its ability to control the transcription of target genes highlights its importance in cellular processes such as cell differentiation and survival. **Clinical Significance:** 1. **Autoimmune Diseases:** FOXL1 has been implicated in various autoimmune diseases, including lupus and rheumatoid arthritis. Its expression in immune cells and tissues highlights its potential role in modulating immune responses and contributing to disease pathogenesis. 2. **Cancer:** FOXL1 has been identified as a potential oncogene in certain types of cancer, including ovarian and breast cancer. Its expression in cancer cells suggests that FOXL1 may contribute to tumorigenesis and cancer progression. 3. **Reproductive Health:** FOXL1 is essential for female reproductive health, particularly in the context of ovarian development and function. Its expression in ovarian cells highlights its potential role in regulating reproductive processes and contributing to infertility. In conclusion, the FOXL1 gene is a complex and multifunctional gene that plays critical roles in various cellular processes, including cell differentiation, chromatin regulation, and immune response. Its expression in multiple cell types and tissues highlights its importance in tissue development, homeostasis, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which FOXL1 regulates cellular processes and to explore its potential therapeutic applications in autoimmune and cancer diseases.

Genular Protein ID: 2173511779

Symbol: FOXL1_HUMAN

Name: Forkhead box protein L1

UniProtKB Accession Codes:

Q12952 Q17RR1 Q9H242

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11078474

Title: Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.

PubMed ID: 11078474

DOI: 10.1086/316915

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 34633540

Title: A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) gene.

PubMed ID: 34633540

DOI: 10.1007/s00439-021-02381-1

Sequence Information:

  • Length: 345
  • Mass: 36490
  • Checksum: 015D86B57DF3BBC6
  • Sequence:
    • MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM 
AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG 
SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG 
PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP 
GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA 
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ

Genular Protein ID: 1512530256

Symbol: Q498Y4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q498Y4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 345
  • Mass: 36520
  • Checksum: 015446A17DF3BBD2
  • Sequence:
    • MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM 
AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG 
SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG 
PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQSAAAVAV GQAARTGDGP 
GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA 
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.