Details for: FOXO1
Gene ID: 2308
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: FOXO1
Ensembl ID: ENSG00000150907
Description: forkhead box O1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 70.71rCSI 90.79%PRS 36.24
-
CSI 30.4rCSI 97.27%PRS 36.81
-
CSI 27.64rCSI 44.46%PRS 27.78
-
CSI 23.54rCSI 76.61%PRS 42.32
-
CSI 22.2rCSI 49.77%PRS 26.35
-
CSI 21.42rCSI 34.06%PRS 33.66
-
CSI 20.98rCSI 36.29%PRS 31.31
-
CSI 20.49rCSI 26.41%PRS 26.67
-
CSI 19.47rCSI 13.12%PRS 49.02
-
CSI 19.15rCSI 36.53%PRS 56.09
-
CSI 18.81rCSI 30.8%PRS 31.46
-
CSI 18.09rCSI 13.44%PRS 52.14
-
CSI 15.58rCSI 26.15%PRS 25.78
-
CSI 14.82rCSI 10.41%PRS 63.16
-
CSI 13.98rCSI 14.99%PRS 37.57
-
CSI 13.34rCSI 14.61%PRS 43.42
-
CSI 13.32rCSI 41.03%PRS 51.64
-
CSI 13.28rCSI 11.68%PRS 29.97
-
CSI 13.06rCSI 35.88%PRS 55.29
-
CSI 13.06rCSI 10.15%PRS 55.57
-
CSI 12.94rCSI 48.48%PRS 33.79
-
CSI 11.76rCSI 10.09%PRS 48.92
-
CSI 11.36rCSI 16.3%PRS 32.09
-
CSI 10.81rCSI 28.09%PRS 45.28
-
CSI 10.38rCSI 25.34%PRS 36.42
-
CSI 10.12rCSI 51.81%PRS 43.01
-
CSI 10.01rCSI 52.63%PRS 49.33
-
CSI 9.93rCSI 22.71%PRS 39.12
-
CSI 9.93rCSI 48.93%PRS 50.86
-
CSI 9.9rCSI 15.64%PRS 40.58
-
CSI 9.36rCSI 22.31%PRS 42.24
-
CSI 8.97rCSI 21.05%PRS 49.14
-
CSI 8.86rCSI 11.85%PRS 47.58
-
CSI 8.86rCSI 6.16%PRS 47.49
-
CSI 8.67rCSI 15.32%PRS 24.87
-
CSI 8.49rCSI 11.75%PRS 45.38
-
CSI 8.33rCSI 6.23%PRS 53.76
-
CSI 8.25rCSI 19.84%PRS 50.11
-
CSI 7.93rCSI 5.52%PRS 51.93
-
CSI 7.92rCSI 18.08%PRS 34.07
-
CSI 7.67rCSI 36.71%PRS 41.74
-
CSI 7.66rCSI 6.34%PRS 40.5
-
CSI 7.49rCSI 52.99%PRS 35.04
-
CSI 7.43rCSI 8.71%PRS 54.3
-
CSI 7.38rCSI 6.87%PRS 39.48
-
CSI 7.35rCSI 5.28%PRS 51.81
-
CSI 7.17rCSI 6.18%PRS 49.06
-
CSI 7.14rCSI 12.78%PRS 38.11
-
CSI 6.85rCSI 5.15%PRS 42.62
-
CSI 6.79rCSI 6.67%PRS 54.45
-
CSI 6.77rCSI 32.46%PRS 37.89
-
CSI 6.7rCSI 5.87%PRS 49.08
-
CSI 6.7rCSI 8.34%PRS 50.58
-
CSI 6.22rCSI 15.4%PRS 37.79
-
CSI 6.05rCSI 12.5%PRS 46.97
-
CSI 5.88rCSI 4.75%PRS 50.78
-
CSI 5.87rCSI 7.02%PRS 25.74
-
CSI 5.68rCSI 11.79%PRS 38.02
-
CSI 5.61rCSI 14.65%PRS 48.71
-
CSI 5.57rCSI 12.86%PRS 32.64
-
CSI 5.47rCSI 14.62%PRS 33.55
-
CSI 5.25rCSI 23.34%PRS 38.22
-
CSI 5.23rCSI 4.06%PRS 39.79
-
CSI 5.13rCSI 19.95%PRS 48.93
-
CSI 5.11rCSI 27.14%PRS 41
-
CSI 5.03rCSI 14.29%PRS 39.86
-
CSI 4.91rCSI 8.61%PRS 32.77
-
CSI 4.86rCSI 19%PRS 18.53
-
CSI 4.77rCSI 26.06%PRS 44.14
-
CSI 4.74rCSI 7.56%PRS 42.96
-
CSI 4.72rCSI 11.97%PRS 31.31
-
CSI 4.52rCSI 4.27%PRS 40.82
-
CSI 4.43rCSI 13.15%PRS 50.98
-
CSI 4.4rCSI 10.69%PRS 25
-
CSI 4.4rCSI 11.46%PRS 38.8
-
CSI 4.36rCSI 14.15%PRS 43.09
-
CSI 4.32rCSI 6.51%PRS 41.2
-
CSI 4.24rCSI 4.09%PRS 31.19
-
CSI 4.18rCSI 7.36%PRS 38.54
-
CSI 4.17rCSI 9.96%PRS 50.75
-
CSI 4.16rCSI 10.77%PRS 36.3
-
CSI 4.15rCSI 9.19%PRS 36.99
-
CSI 4.02rCSI 6.63%PRS 44.77
-
CSI 3.99rCSI 20.07%PRS 50.72
-
CSI 3.9rCSI 13.84%PRS 53.13
-
CSI 3.66rCSI 21.96%PRS 54.75
-
CSI 3.66rCSI 5%PRS 44.18
-
CSI 3.57rCSI 7.86%PRS 43.41
-
CSI 3.5rCSI 3.67%PRS 42.03
-
CSI 3.5rCSI 3.21%PRS 46.49
-
CSI 3.46rCSI 8.66%PRS 70.71
-
CSI 3.45rCSI 9.08%PRS 62.66
-
CSI 3.32rCSI 2.94%PRS 38.91
-
CSI 3.29rCSI 2.61%PRS 61.01
-
CSI 3.13rCSI 8.27%PRS 46.59
-
CSI 3.12rCSI 3.62%PRS 63.42
-
CSI 3.09rCSI 7.34%PRS 45.36
-
CSI 3.09rCSI 8.51%PRS 36.89
-
CSI 3.08rCSI 3.19%PRS 45.13
-
CSI 3.03rCSI 4.3%PRS 37.07
-
CSI 0.3rCSI 1.9%PRS 50.8%
-
CSI 0.3rCSI 5.1%PRS 66.0%
-
CSI 0.4rCSI 2.7%PRS 58.7%
-
CSI 0.4rCSI 2.4%PRS 33.1%
-
CSI 0.5rCSI 0.7%PRS 43.9%
-
CSI 0.5rCSI 0.6%PRS 35.7%
-
CSI 0.5rCSI 3.9%PRS 28.9%
-
CSI 0.6rCSI 6.7%PRS 41.9%
-
CSI 0.6rCSI 2.9%PRS 62.6%
-
CSI 0.7rCSI 3.4%PRS 54.9%
-
CSI 0.7rCSI 1.2%PRS 63.6%
-
CSI 0.8rCSI 1.4%PRS 49.0%
-
CSI 0.8rCSI 5.6%PRS 67.0%
-
CSI 0.8rCSI 5.8%PRS 60.2%
-
CSI 0.8rCSI 4.6%PRS 64.4%
-
CSI 0.9rCSI 2.1%PRS 30.3%
-
CSI 0.9rCSI 7.2%PRS 35.2%
-
CSI 0.9rCSI 3.7%PRS 55.4%
-
CSI 1.0rCSI 3.4%PRS 24.7%
-
CSI 1.0rCSI 4.5%PRS 59.7%
-
CSI 1.0rCSI 3.2%PRS 39.4%
-
CSI 1.1rCSI 4.6%PRS 37.2%
-
CSI 1.1rCSI 2.4%PRS 38.6%
-
CSI 1.1rCSI 5.0%PRS 38.1%
-
CSI 1.1rCSI 3.2%PRS 57.4%
-
CSI 1.2rCSI 1.4%PRS 46.6%
-
CSI 1.2rCSI 3.0%PRS 70.9%
-
CSI 1.2rCSI 10.2%PRS 42.3%
-
CSI 1.2rCSI 1.7%PRS 49.0%
-
CSI 1.2rCSI 3.8%PRS 28.9%
-
CSI 1.2rCSI 1.2%PRS 41.9%
-
CSI 1.2rCSI 2.5%PRS 62.2%
-
CSI 1.2rCSI 1.4%PRS 30.7%
-
CSI 1.2rCSI 6.1%PRS 40.0%
-
CSI 1.3rCSI 1.7%PRS 37.0%
-
CSI 1.3rCSI 1.9%PRS 55.2%
-
CSI 1.3rCSI 2.1%PRS 46.1%
-
CSI 1.4rCSI 2.5%PRS 34.3%
-
CSI 1.4rCSI 3.8%PRS 48.4%
-
CSI 1.4rCSI 9.5%PRS 77.0%
-
CSI 1.5rCSI 4.9%PRS 29.6%
-
CSI 1.5rCSI 4.3%PRS 56.3%
-
CSI 1.5rCSI 1.4%PRS 54.2%
-
CSI 1.6rCSI 1.2%PRS 38.2%
-
CSI 1.6rCSI 1.6%PRS 68.1%
-
CSI 1.6rCSI 3.6%PRS 45.6%
-
CSI 1.6rCSI 1.3%PRS 45.6%
-
CSI 1.6rCSI 6.4%PRS 59.3%
-
CSI 1.6rCSI 6.4%PRS 52.4%
-
CSI 1.7rCSI 3.2%PRS 41.4%
-
CSI 1.7rCSI 2.2%PRS 44.2%
-
CSI 1.7rCSI 9.4%PRS 60.2%
-
CSI 1.7rCSI 7.8%PRS 60.4%
-
CSI 1.7rCSI 1.5%PRS 44.8%
-
CSI 1.8rCSI 7.9%PRS 65.2%
-
CSI 1.8rCSI 3.9%PRS 60.9%
-
CSI 1.9rCSI 4.6%PRS 56.2%
-
CSI 2.0rCSI 1.5%PRS 51.2%
-
CSI 2.0rCSI 2.4%PRS 58.2%
-
CSI 2.0rCSI 4.0%PRS 64.8%
-
CSI 2.0rCSI 3.4%PRS 60.3%
-
CSI 2.0rCSI 2.1%PRS 37.2%
-
CSI 2.1rCSI 4.8%PRS 66.1%
-
CSI 2.2rCSI 4.3%PRS 39.5%
-
CSI 2.3rCSI 5.7%PRS 47.4%
-
CSI 2.4rCSI 4.5%PRS 30.6%
-
CSI 2.4rCSI 3.7%PRS 48.3%
-
CSI 2.4rCSI 2.3%PRS 59.8%
-
CSI 2.5rCSI 3.1%PRS 42.1%
-
CSI 2.5rCSI 3.4%PRS 52.2%
-
CSI 2.5rCSI 1.5%PRS 53.5%
-
CSI 2.5rCSI 18.1%PRS 46.5%
-
CSI 2.6rCSI 4.1%PRS 31.5%
-
CSI 2.6rCSI 2.5%PRS 63.4%
-
CSI 2.6rCSI 1.9%PRS 34.0%
-
CSI 2.6rCSI 10.6%PRS 38.4%
-
CSI 2.7rCSI 7.5%PRS 41.2%
-
CSI 2.7rCSI 3.6%PRS 52.4%
-
CSI 2.8rCSI 4.3%PRS 49.8%
-
CSI 2.8rCSI 4.1%PRS 42.4%
-
CSI 2.8rCSI 4.3%PRS 40.2%
-
CSI 2.8rCSI 5.6%PRS 57.5%
-
CSI 2.8rCSI 2.3%PRS 40.6%
-
CSI 2.9rCSI 2.3%PRS 28.7%
-
CSI 2.9rCSI 2.5%PRS 48.1%
-
CSI 2.9rCSI 70.4%PRS 26.1%
-
CSI 2.9rCSI 8.7%PRS 38.3%
-
CSI 3.0rCSI 70.7%PRS 25.2%
-
CSI 3.0rCSI 4.0%PRS 41.4%
-
CSI 3.0rCSI 12.7%PRS 38.1%
-
CSI 3.0rCSI 2.8%PRS 40.7%
-
CSI 3.0rCSI 5.3%PRS 47.9%
-
CSI 3.0rCSI 4.3%PRS 37.1%
-
CSI 3.1rCSI 3.2%PRS 45.1%
-
CSI 3.1rCSI 8.5%PRS 36.9%
-
CSI 3.1rCSI 7.3%PRS 45.4%
-
CSI 3.1rCSI 3.6%PRS 63.4%
-
CSI 3.1rCSI 8.3%PRS 46.6%
-
CSI 3.3rCSI 2.6%PRS 61.0%
-
CSI 3.3rCSI 2.9%PRS 38.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2634259510
Symbol: FOXO1_HUMAN
Name: Forkhead box protein O1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8275086
Title: Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
PubMed ID: 8275086
DOI: 10.1038/ng1193-230
PubMed ID: 9479491
Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
PubMed ID: 9479491
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8187070
Title: Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.
PubMed ID: 8187070
PubMed ID: 10358075
Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
PubMed ID: 10358075
PubMed ID: 10358076
Title: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.
PubMed ID: 10358076
PubMed ID: 11311120
Title: The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
PubMed ID: 11311120
DOI: 10.1042/bj3550597
PubMed ID: 11237865
Title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
PubMed ID: 11237865
PubMed ID: 11980723
Title: Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
PubMed ID: 11980723
PubMed ID: 12228231
Title: Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
PubMed ID: 12228231
PubMed ID: 15220471
Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
PubMed ID: 15220471
PubMed ID: 15890677
Title: The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
PubMed ID: 15890677
DOI: 10.1210/me.2004-0292
PubMed ID: 15668399
Title: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
PubMed ID: 15668399
PubMed ID: 17024043
Title: Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.
PubMed ID: 17024043
DOI: 10.1038/nature05288
PubMed ID: 18951090
Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
PubMed ID: 18951090
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18356527
Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
PubMed ID: 18356527
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19483080
Title: C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.
PubMed ID: 19483080
PubMed ID: 19221179
Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.
PubMed ID: 19221179
PubMed ID: 20543840
Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
PubMed ID: 20543840
DOI: 10.1038/ncb2069
PubMed ID: 20668652
Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
PubMed ID: 20668652
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21245099
Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
PubMed ID: 21245099
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25009184
Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
PubMed ID: 25009184
PubMed ID: 31063815
Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.
PubMed ID: 31063815
PubMed ID: 18786403
Title: Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.
PubMed ID: 18786403
Sequence Information:
- Length: 655
- Mass: 69662
- Checksum: 6DEF6C994BDFDBAB
- Sequence:
MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG