FOXO1 | ENSG00000150907 | NCBI 2308

Details for: FOXO1

Gene ID: 2308

Symbol: FOXO1

Ensembl ID: ENSG00000150907

Description: forkhead box O1

Associated with

Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Apoptotic process
(GO:0006915)
Autophagy
(GO:0006914)
Beta-catenin binding
(GO:0008013)
Blood vessel development
(GO:0001568)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to cold
(GO:0070417)
Cellular response to hyperoxia
(GO:0071455)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to starvation
(GO:0009267)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna damage response
(GO:0006974)
Energy homeostasis
(GO:0097009)
Fat cell differentiation
(GO:0045444)
Gene expression
(GO:0010467)
Insulin receptor signaling pathway
(GO:0008286)
Intracellular glucose homeostasis
(GO:0001678)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cardiac muscle hypertrophy in response to stress
(GO:1903243)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of stress-activated mapk cascade
(GO:0032873)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein acetylation
(GO:0006473)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transcription initiation by rna polymerase ii
(GO:0060260)
Response to fatty acid
(GO:0070542)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Temperature homeostasis
(GO:0001659)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac neuron (CL0010022)
Fold Change: 6.13
Marker Score: 7,634
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.89
Marker Score: 14,743
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 4.96
Marker Score: 1,815
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.5
Marker Score: 2,503
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.37
Marker Score: 77,488
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 4.24
Marker Score: 2,791
Cell Name: fat cell (CL0000136)
Fold Change: 3.57
Marker Score: 1,995
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 3
Marker Score: 1,580
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.96
Marker Score: 1,531
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.91
Marker Score: 62,190
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.6
Marker Score: 3,778
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.42
Marker Score: 1,365
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.39
Marker Score: 1,575
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.37
Marker Score: 1,826
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.28
Marker Score: 2,436
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.17
Marker Score: 564
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.14
Marker Score: 4,120
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.11
Marker Score: 1,263
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.04
Marker Score: 2,189
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.92
Marker Score: 600
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.8
Marker Score: 1,599
Cell Name: decidual cell (CL2000002)
Fold Change: 1.79
Marker Score: 7,713
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.75
Marker Score: 39,194
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.68
Marker Score: 5,975
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.67
Marker Score: 973
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.67
Marker Score: 528
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.65
Marker Score: 720
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.62
Marker Score: 10,395
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.6
Marker Score: 8,604
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.6
Marker Score: 3,759
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.59
Marker Score: 770
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.57
Marker Score: 452
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.55
Marker Score: 17,421
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.53
Marker Score: 576
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.51
Marker Score: 4,955
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.47
Marker Score: 6,358
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,172
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.45
Marker Score: 382
Cell Name: germ cell (CL0000586)
Fold Change: 1.42
Marker Score: 2,474
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.4
Marker Score: 1,510
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.39
Marker Score: 503
Cell Name: astrocyte (CL0000127)
Fold Change: 1.38
Marker Score: 1,195
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.37
Marker Score: 376
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.34
Marker Score: 342
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.33
Marker Score: 429
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.32
Marker Score: 400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.31
Marker Score: 1,489
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.31
Marker Score: 4,833
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.29
Marker Score: 9,914
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.29
Marker Score: 774
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.27
Marker Score: 1,465
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.26
Marker Score: 42,997
Cell Name: keratocyte (CL0002363)
Fold Change: 1.25
Marker Score: 288
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.23
Marker Score: 371
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.22
Marker Score: 19,115
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.21
Marker Score: 1,048
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.19
Marker Score: 824
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.18
Marker Score: 291
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.17
Marker Score: 1,291
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.17
Marker Score: 436
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.16
Marker Score: 572
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.16
Marker Score: 4,475
Cell Name: contractile cell (CL0000183)
Fold Change: 1.14
Marker Score: 619
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.14
Marker Score: 1,615
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.13
Marker Score: 562
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.11
Marker Score: 1,062
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.08
Marker Score: 374
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.06
Marker Score: 330
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.05
Marker Score: 522
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.05
Marker Score: 1,034
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.04
Marker Score: 2,087
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.04
Marker Score: 15,569
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.04
Marker Score: 933
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.04
Marker Score: 938
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.04
Marker Score: 2,108
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.03
Marker Score: 371
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.03
Marker Score: 1,342
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.02
Marker Score: 246
Cell Name: lactocyte (CL0002325)
Fold Change: 1.02
Marker Score: 16,411
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.01
Marker Score: 2,427
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1
Marker Score: 1,064
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,667
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,893
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.98
Marker Score: 904
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,387
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.97
Marker Score: 8,520
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.97
Marker Score: 5,818
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.96
Marker Score: 1,474
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.95
Marker Score: 2,498
Cell Name: podocyte (CL0000653)
Fold Change: 0.95
Marker Score: 350
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,395
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 484
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.94
Marker Score: 641
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.94
Marker Score: 3,333
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.94
Marker Score: 2,670
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.93
Marker Score: 1,253
Cell Name: basal cell (CL0000646)
Fold Change: 0.91
Marker Score: 1,176
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.91
Marker Score: 1,997
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.91
Marker Score: 220

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** FOXO1 has several key characteristics that distinguish it from other transcription factors. These include: 1. **Multifunctional**: FOXO1 has been shown to regulate a wide range of cellular processes, including metabolism, stress response, apoptosis, and immune system regulation. 2. **Cellular localization**: FOXO1 is primarily localized to the nucleus, where it regulates gene expression by binding to specific DNA sequences. 3. **Phosphorylation**: FOXO1 is phosphorylated by various kinases, including Akt, which inactivates FOXO1 and prevents it from regulating gene expression. 4. **Acetylation**: FOXO1 can also be acetylated, which regulates its transcriptional activity and stability. **Pathways and Functions** FOXO1 is involved in several key pathways and functions, including: 1. **Akt-mediated inactivation**: FOXO1 is inactivated by phosphorylation by Akt, which prevents it from regulating gene expression. 2. **Apoptotic process**: FOXO1 regulates apoptosis by activating pro-apoptotic genes and inhibiting anti-apoptotic genes. 3. **Autophagy**: FOXO1 regulates autophagy by activating autophagy-related genes. 4. **Insulin signaling pathway**: FOXO1 is regulated by the insulin signaling pathway, which inhibits its activity in response to high glucose levels. 5. **DNA damage response**: FOXO1 regulates the DNA damage response by activating genes involved in DNA repair and apoptosis. **Clinical Significance** FOXO1 has been implicated in various diseases, including: 1. **Diabetes**: FOXO1 is involved in the regulation of insulin secretion and glucose homeostasis, making it a potential target for the treatment of diabetes. 2. **Cancer**: FOXO1 is involved in the regulation of cell cycle and apoptosis, making it a potential target for the treatment of cancer. 3. **Neurodegenerative diseases**: FOXO1 is involved in the regulation of neuronal function and survival, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. 4. **Immune system disorders**: FOXO1 is involved in the regulation of immune system function, making it a potential target for the treatment of immune system disorders such as autoimmune diseases. In conclusion, FOXO1 is a multifaceted regulator of cellular processes that plays a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, making it a potential target for the treatment of these diseases. Further research is needed to fully understand the role of FOXO1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Forkhead box protein O1A

Genular Protein ID: 2634259510

Symbol: FOXO1_HUMAN

Name: Forkhead box protein O1A

UniProtKB Accession Codes:

Q12778 O43523 Q5VYC7 Q6NSK6

Database IDs:

Citations:

PubMed ID: 8275086

Title: Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.

PubMed ID: 8275086

DOI: 10.1038/ng1193-230

PubMed ID: 9479491

Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.

PubMed ID: 9479491

DOI: 10.1006/geno.1997.5122

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8187070

Title: Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

PubMed ID: 8187070

PubMed ID: 10358075

Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.

PubMed ID: 10358075

DOI: 10.1074/jbc.274.24.17179

PubMed ID: 10358076

Title: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.

PubMed ID: 10358076

DOI: 10.1074/jbc.274.24.17184

PubMed ID: 11311120

Title: The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

PubMed ID: 11311120

DOI: 10.1042/bj3550597

PubMed ID: 11237865

Title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

PubMed ID: 11237865

DOI: 10.1042/0264-6021:3540605

PubMed ID: 11980723

Title: Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

PubMed ID: 11980723

DOI: 10.1093/emboj/21.9.2263

PubMed ID: 12228231

Title: Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.

PubMed ID: 12228231

DOI: 10.1074/jbc.m208063200

PubMed ID: 15220471

Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.

PubMed ID: 15220471

DOI: 10.1073/pnas.0400593101

PubMed ID: 15890677

Title: The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.

PubMed ID: 15890677

DOI: 10.1210/me.2004-0292

PubMed ID: 15668399

Title: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

PubMed ID: 15668399

DOI: 10.1073/pnas.0406789102

PubMed ID: 17024043

Title: Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.

PubMed ID: 17024043

DOI: 10.1038/nature05288

PubMed ID: 18951090

Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

PubMed ID: 18951090

DOI: 10.1016/j.molcel.2008.09.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18356527

Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

PubMed ID: 18356527

DOI: 10.1126/science.1152337

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19221179

Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.

PubMed ID: 19221179

DOI: 10.1074/jbc.m900461200

PubMed ID: 20543840

Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.

PubMed ID: 20543840

DOI: 10.1038/ncb2069

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21245099

Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

PubMed ID: 21245099

DOI: 10.1158/0008-5472.can-10-2203

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25009184

Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

PubMed ID: 25009184

DOI: 10.1073/pnas.1411026111

PubMed ID: 31063815

Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.

PubMed ID: 31063815

DOI: 10.1016/j.cellsig.2019.04.014

PubMed ID: 18786403

Title: Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.

PubMed ID: 18786403

DOI: 10.1016/j.str.2008.06.013

Sequence Information:

Length: 655
Mass: 69662
Checksum: 6DEF6C994BDFDBAB
Sequence:

MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS 
ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP 
APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR 
LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN 
PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG 
SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP 
SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN 
YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV 
DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP 
HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS 
DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOXO1

Associated with

Cells (max top 100)

Other Information

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. PubMed ID: 8275086

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. PubMed ID: 9479491

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. PubMed ID: 8187070

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. PubMed ID: 10358075

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. PubMed ID: 10358076

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. PubMed ID: 11311120

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. PubMed ID: 11237865

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. PubMed ID: 11980723

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. PubMed ID: 12228231

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. PubMed ID: 15220471

The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. PubMed ID: 15890677

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. PubMed ID: 15668399

Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection. PubMed ID: 17024043

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. PubMed ID: 18951090

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. PubMed ID: 18356527

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Regulation of neuronal cell death by MST1-FOXO1 signaling. PubMed ID: 19221179

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. PubMed ID: 20543840

KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PubMed ID: 20668652

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner. PubMed ID: 21245099

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. PubMed ID: 25009184

Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis. PubMed ID: 31063815

Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. PubMed ID: 18786403