FOXO1 | ENSG00000150907 | NCBI 2308

Details for: FOXO1

Gene ID: 2308

Symbol: FOXO1

Ensembl ID: ENSG00000150907

Description: forkhead box O1

Associated with

Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Apoptotic process
(GO:0006915)
Autophagy
(GO:0006914)
Beta-catenin binding
(GO:0008013)
Blood vessel development
(GO:0001568)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to cold
(GO:0070417)
Cellular response to hyperoxia
(GO:0071455)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to starvation
(GO:0009267)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna damage response
(GO:0006974)
Energy homeostasis
(GO:0097009)
Fat cell differentiation
(GO:0045444)
Gene expression
(GO:0010467)
Insulin receptor signaling pathway
(GO:0008286)
Intracellular glucose homeostasis
(GO:0001678)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cardiac muscle hypertrophy in response to stress
(GO:1903243)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of stress-activated mapk cascade
(GO:0032873)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein acetylation
(GO:0006473)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transcription initiation by rna polymerase ii
(GO:0060260)
Response to fatty acid
(GO:0070542)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Temperature homeostasis
(GO:0001659)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 277.4113
Cell Significance Index: -43.1500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 170.3179
Cell Significance Index: -43.2000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 85.3062
Cell Significance Index: -40.2800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 82.1155
Cell Significance Index: -33.3600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 76.2269
Cell Significance Index: -39.2100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.4650
Cell Significance Index: -33.8600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.1513
Cell Significance Index: -43.3400
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 27.8647
Cell Significance Index: 121.3000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.1911
Cell Significance Index: -44.1900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.5808
Cell Significance Index: -39.0600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.4078
Cell Significance Index: -38.1100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.0668
Cell Significance Index: -43.6700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 10.2619
Cell Significance Index: 69.5300
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 9.9442
Cell Significance Index: 125.2200
Cell Name: type II muscle cell (CL0002212)
Fold Change: 8.9881
Cell Significance Index: 145.0300
Cell Name: type I muscle cell (CL0002211)
Fold Change: 8.1855
Cell Significance Index: 199.7200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 7.8246
Cell Significance Index: 131.8100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 6.7993
Cell Significance Index: 182.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: 5.2041
Cell Significance Index: 101.5700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 4.8276
Cell Significance Index: 69.3300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 4.5245
Cell Significance Index: 116.3000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.2755
Cell Significance Index: 47.1100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.1666
Cell Significance Index: 119.9100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1070
Cell Significance Index: 137.4300
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.1012
Cell Significance Index: 43.3700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.8015
Cell Significance Index: 555.9600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.5849
Cell Significance Index: 145.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.9632
Cell Significance Index: 150.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8736
Cell Significance Index: 257.3000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.8161
Cell Significance Index: 38.8200
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.7157
Cell Significance Index: 15.2300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1.6005
Cell Significance Index: 9.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2891
Cell Significance Index: 86.6800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.2330
Cell Significance Index: 18.5800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9814
Cell Significance Index: 352.0200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9739
Cell Significance Index: 879.3300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.7589
Cell Significance Index: 21.2100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7480
Cell Significance Index: 38.9600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5979
Cell Significance Index: 17.1400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5702
Cell Significance Index: 92.7400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5492
Cell Significance Index: 59.7400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5285
Cell Significance Index: 13.2100
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.5175
Cell Significance Index: 5.3600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4767
Cell Significance Index: 28.6200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4374
Cell Significance Index: 83.2400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4296
Cell Significance Index: 9.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4068
Cell Significance Index: 222.1400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3792
Cell Significance Index: 46.6200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3029
Cell Significance Index: 54.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2950
Cell Significance Index: 130.4400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2698
Cell Significance Index: 7.1000
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2656
Cell Significance Index: 3.9200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2515
Cell Significance Index: 17.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2061
Cell Significance Index: 24.3000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1774
Cell Significance Index: 2.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1621
Cell Significance Index: 16.0400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1418
Cell Significance Index: 16.1900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1334
Cell Significance Index: 26.7500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1271
Cell Significance Index: 8.9900
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.0967
Cell Significance Index: 1.0100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0964
Cell Significance Index: 4.5300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0823
Cell Significance Index: 14.0500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0587
Cell Significance Index: 108.3400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0580
Cell Significance Index: 2.6300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0421
Cell Significance Index: 64.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0359
Cell Significance Index: 22.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0240
Cell Significance Index: 10.8900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0097
Cell Significance Index: 18.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0076
Cell Significance Index: -0.2200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0111
Cell Significance Index: -0.3900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0125
Cell Significance Index: -0.2700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0210
Cell Significance Index: -15.5700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0216
Cell Significance Index: -29.3600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0237
Cell Significance Index: -14.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0267
Cell Significance Index: -19.5400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0365
Cell Significance Index: -5.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0416
Cell Significance Index: -23.4700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0528
Cell Significance Index: -39.9500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0711
Cell Significance Index: -9.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0814
Cell Significance Index: -17.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1162
Cell Significance Index: -13.3100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1258
Cell Significance Index: -36.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1267
Cell Significance Index: -14.7700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1307
Cell Significance Index: -1.9300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1380
Cell Significance Index: -14.1000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1922
Cell Significance Index: -12.4000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2018
Cell Significance Index: -3.4900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2226
Cell Significance Index: -6.0600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2441
Cell Significance Index: -11.3800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2534
Cell Significance Index: -32.4900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2789
Cell Significance Index: -17.1000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3733
Cell Significance Index: -38.8700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4106
Cell Significance Index: -25.8800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4114
Cell Significance Index: -30.6700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4226
Cell Significance Index: -33.4700
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.4383
Cell Significance Index: -3.4600
Cell Name: peg cell (CL4033014)
Fold Change: -0.4421
Cell Significance Index: -10.2200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4597
Cell Significance Index: -23.8800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4802
Cell Significance Index: -15.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FOXO1 has several key characteristics that distinguish it from other transcription factors. These include: 1. **Multifunctional**: FOXO1 has been shown to regulate a wide range of cellular processes, including metabolism, stress response, apoptosis, and immune system regulation. 2. **Cellular localization**: FOXO1 is primarily localized to the nucleus, where it regulates gene expression by binding to specific DNA sequences. 3. **Phosphorylation**: FOXO1 is phosphorylated by various kinases, including Akt, which inactivates FOXO1 and prevents it from regulating gene expression. 4. **Acetylation**: FOXO1 can also be acetylated, which regulates its transcriptional activity and stability. **Pathways and Functions** FOXO1 is involved in several key pathways and functions, including: 1. **Akt-mediated inactivation**: FOXO1 is inactivated by phosphorylation by Akt, which prevents it from regulating gene expression. 2. **Apoptotic process**: FOXO1 regulates apoptosis by activating pro-apoptotic genes and inhibiting anti-apoptotic genes. 3. **Autophagy**: FOXO1 regulates autophagy by activating autophagy-related genes. 4. **Insulin signaling pathway**: FOXO1 is regulated by the insulin signaling pathway, which inhibits its activity in response to high glucose levels. 5. **DNA damage response**: FOXO1 regulates the DNA damage response by activating genes involved in DNA repair and apoptosis. **Clinical Significance** FOXO1 has been implicated in various diseases, including: 1. **Diabetes**: FOXO1 is involved in the regulation of insulin secretion and glucose homeostasis, making it a potential target for the treatment of diabetes. 2. **Cancer**: FOXO1 is involved in the regulation of cell cycle and apoptosis, making it a potential target for the treatment of cancer. 3. **Neurodegenerative diseases**: FOXO1 is involved in the regulation of neuronal function and survival, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. 4. **Immune system disorders**: FOXO1 is involved in the regulation of immune system function, making it a potential target for the treatment of immune system disorders such as autoimmune diseases. In conclusion, FOXO1 is a multifaceted regulator of cellular processes that plays a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, making it a potential target for the treatment of these diseases. Further research is needed to fully understand the role of FOXO1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Forkhead box protein O1A

Genular Protein ID: 2634259510

Symbol: FOXO1_HUMAN

Name: Forkhead box protein O1A

UniProtKB Accession Codes:

Q12778 O43523 Q5VYC7 Q6NSK6

Database IDs:

Citations:

PubMed ID: 8275086

Title: Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.

PubMed ID: 8275086

DOI: 10.1038/ng1193-230

PubMed ID: 9479491

Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.

PubMed ID: 9479491

DOI: 10.1006/geno.1997.5122

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8187070

Title: Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

PubMed ID: 8187070

PubMed ID: 10358075

Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.

PubMed ID: 10358075

DOI: 10.1074/jbc.274.24.17179

PubMed ID: 10358076

Title: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.

PubMed ID: 10358076

DOI: 10.1074/jbc.274.24.17184

PubMed ID: 11311120

Title: The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

PubMed ID: 11311120

DOI: 10.1042/bj3550597

PubMed ID: 11237865

Title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

PubMed ID: 11237865

DOI: 10.1042/0264-6021:3540605

PubMed ID: 11980723

Title: Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

PubMed ID: 11980723

DOI: 10.1093/emboj/21.9.2263

PubMed ID: 12228231

Title: Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.

PubMed ID: 12228231

DOI: 10.1074/jbc.m208063200

PubMed ID: 15220471

Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.

PubMed ID: 15220471

DOI: 10.1073/pnas.0400593101

PubMed ID: 15890677

Title: The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.

PubMed ID: 15890677

DOI: 10.1210/me.2004-0292

PubMed ID: 15668399

Title: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

PubMed ID: 15668399

DOI: 10.1073/pnas.0406789102

PubMed ID: 17024043

Title: Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.

PubMed ID: 17024043

DOI: 10.1038/nature05288

PubMed ID: 18951090

Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

PubMed ID: 18951090

DOI: 10.1016/j.molcel.2008.09.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18356527

Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

PubMed ID: 18356527

DOI: 10.1126/science.1152337

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19483080

Title: C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.

PubMed ID: 19483080

DOI: 10.1074/jbc.m109.017046

PubMed ID: 19221179

Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.

PubMed ID: 19221179

DOI: 10.1074/jbc.m900461200

PubMed ID: 20543840

Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.

PubMed ID: 20543840

DOI: 10.1038/ncb2069

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21245099

Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

PubMed ID: 21245099

DOI: 10.1158/0008-5472.can-10-2203

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25009184

Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

PubMed ID: 25009184

DOI: 10.1073/pnas.1411026111

PubMed ID: 31063815

Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.

PubMed ID: 31063815

DOI: 10.1016/j.cellsig.2019.04.014

PubMed ID: 18786403

Title: Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.

PubMed ID: 18786403

DOI: 10.1016/j.str.2008.06.013

Sequence Information:

Length: 655
Mass: 69662
Checksum: 6DEF6C994BDFDBAB
Sequence:

MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS 
ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP 
APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR 
LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN 
PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG 
SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP 
SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN 
YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV 
DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP 
HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS 
DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOXO1

Associated with

Cells (max top 100)

Other Information

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. PubMed ID: 8275086

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. PubMed ID: 9479491

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. PubMed ID: 8187070

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. PubMed ID: 10358075

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. PubMed ID: 10358076

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. PubMed ID: 11311120

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. PubMed ID: 11237865

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. PubMed ID: 11980723

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. PubMed ID: 12228231

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. PubMed ID: 15220471

The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. PubMed ID: 15890677

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. PubMed ID: 15668399

Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection. PubMed ID: 17024043

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. PubMed ID: 18951090

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. PubMed ID: 18356527

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. PubMed ID: 19483080

Regulation of neuronal cell death by MST1-FOXO1 signaling. PubMed ID: 19221179

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. PubMed ID: 20543840

KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PubMed ID: 20668652

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner. PubMed ID: 21245099

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. PubMed ID: 25009184

Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis. PubMed ID: 31063815

Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. PubMed ID: 18786403