Details for: FOXO1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 277.4113
Cell Significance Index: -43.1500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 170.3179
Cell Significance Index: -43.2000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 85.3062
Cell Significance Index: -40.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 82.1155
Cell Significance Index: -33.3600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 76.2269
Cell Significance Index: -39.2100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.4650
Cell Significance Index: -33.8600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.1513
Cell Significance Index: -43.3400 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 27.8647
Cell Significance Index: 121.3000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.1911
Cell Significance Index: -44.1900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.5808
Cell Significance Index: -39.0600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.4078
Cell Significance Index: -38.1100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.0668
Cell Significance Index: -43.6700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 10.2619
Cell Significance Index: 69.5300 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 9.9442
Cell Significance Index: 125.2200 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 8.9881
Cell Significance Index: 145.0300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 8.1855
Cell Significance Index: 199.7200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 7.8246
Cell Significance Index: 131.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 6.7993
Cell Significance Index: 182.1900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 5.2041
Cell Significance Index: 101.5700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 4.8276
Cell Significance Index: 69.3300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 4.5245
Cell Significance Index: 116.3000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.2755
Cell Significance Index: 47.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.1666
Cell Significance Index: 119.9100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1070
Cell Significance Index: 137.4300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.1012
Cell Significance Index: 43.3700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.8015
Cell Significance Index: 555.9600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.5849
Cell Significance Index: 145.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.9632
Cell Significance Index: 150.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8736
Cell Significance Index: 257.3000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.8161
Cell Significance Index: 38.8200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.7157
Cell Significance Index: 15.2300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1.6005
Cell Significance Index: 9.6700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2891
Cell Significance Index: 86.6800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.2330
Cell Significance Index: 18.5800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9814
Cell Significance Index: 352.0200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9739
Cell Significance Index: 879.3300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.7589
Cell Significance Index: 21.2100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7480
Cell Significance Index: 38.9600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5979
Cell Significance Index: 17.1400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5702
Cell Significance Index: 92.7400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5492
Cell Significance Index: 59.7400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5285
Cell Significance Index: 13.2100 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.5175
Cell Significance Index: 5.3600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4767
Cell Significance Index: 28.6200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4374
Cell Significance Index: 83.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4296
Cell Significance Index: 9.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4068
Cell Significance Index: 222.1400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3792
Cell Significance Index: 46.6200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3029
Cell Significance Index: 54.6100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2950
Cell Significance Index: 130.4400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2698
Cell Significance Index: 7.1000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2656
Cell Significance Index: 3.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2515
Cell Significance Index: 17.4000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2061
Cell Significance Index: 24.3000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1774
Cell Significance Index: 2.4200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1621
Cell Significance Index: 16.0400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1418
Cell Significance Index: 16.1900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1334
Cell Significance Index: 26.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1271
Cell Significance Index: 8.9900 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.0967
Cell Significance Index: 1.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0964
Cell Significance Index: 4.5300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0823
Cell Significance Index: 14.0500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0587
Cell Significance Index: 108.3400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0580
Cell Significance Index: 2.6300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0421
Cell Significance Index: 64.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0359
Cell Significance Index: 22.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0240
Cell Significance Index: 10.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0097
Cell Significance Index: 18.2600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0076
Cell Significance Index: -0.2200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0111
Cell Significance Index: -0.3900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0125
Cell Significance Index: -0.2700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0210
Cell Significance Index: -15.5700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0216
Cell Significance Index: -29.3600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0237
Cell Significance Index: -14.7800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0267
Cell Significance Index: -19.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0365
Cell Significance Index: -5.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0416
Cell Significance Index: -23.4700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0528
Cell Significance Index: -39.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0711
Cell Significance Index: -9.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0814
Cell Significance Index: -17.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1162
Cell Significance Index: -13.3100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1258
Cell Significance Index: -36.2000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1267
Cell Significance Index: -14.7700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1307
Cell Significance Index: -1.9300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1380
Cell Significance Index: -14.1000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1922
Cell Significance Index: -12.4000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2018
Cell Significance Index: -3.4900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2226
Cell Significance Index: -6.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2441
Cell Significance Index: -11.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2534
Cell Significance Index: -32.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2789
Cell Significance Index: -17.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3733
Cell Significance Index: -38.8700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4106
Cell Significance Index: -25.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4114
Cell Significance Index: -30.6700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4226
Cell Significance Index: -33.4700 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.4383
Cell Significance Index: -3.4600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4421
Cell Significance Index: -10.2200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4597
Cell Significance Index: -23.8800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4802
Cell Significance Index: -15.3800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2634259510
Symbol: FOXO1_HUMAN
Name: Forkhead box protein O1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8275086
Title: Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
PubMed ID: 8275086
DOI: 10.1038/ng1193-230
PubMed ID: 9479491
Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
PubMed ID: 9479491
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8187070
Title: Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.
PubMed ID: 8187070
PubMed ID: 10358075
Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
PubMed ID: 10358075
PubMed ID: 10358076
Title: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.
PubMed ID: 10358076
PubMed ID: 11311120
Title: The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
PubMed ID: 11311120
DOI: 10.1042/bj3550597
PubMed ID: 11237865
Title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
PubMed ID: 11237865
PubMed ID: 11980723
Title: Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
PubMed ID: 11980723
PubMed ID: 12228231
Title: Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
PubMed ID: 12228231
PubMed ID: 15220471
Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
PubMed ID: 15220471
PubMed ID: 15890677
Title: The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
PubMed ID: 15890677
DOI: 10.1210/me.2004-0292
PubMed ID: 15668399
Title: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
PubMed ID: 15668399
PubMed ID: 17024043
Title: Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.
PubMed ID: 17024043
DOI: 10.1038/nature05288
PubMed ID: 18951090
Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
PubMed ID: 18951090
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18356527
Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
PubMed ID: 18356527
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19483080
Title: C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.
PubMed ID: 19483080
PubMed ID: 19221179
Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.
PubMed ID: 19221179
PubMed ID: 20543840
Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
PubMed ID: 20543840
DOI: 10.1038/ncb2069
PubMed ID: 20668652
Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
PubMed ID: 20668652
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21245099
Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
PubMed ID: 21245099
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25009184
Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
PubMed ID: 25009184
PubMed ID: 31063815
Title: Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.
PubMed ID: 31063815
PubMed ID: 18786403
Title: Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.
PubMed ID: 18786403
Sequence Information:
- Length: 655
- Mass: 69662
- Checksum: 6DEF6C994BDFDBAB
- Sequence:
MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.