Details for: FLII

Gene ID: 2314

Symbol: FLII

Ensembl ID: ENSG00000177731

Description: FLII actin remodeling protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.79
    Marker Score: 2156
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.72
    Marker Score: 1150
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.61
    Marker Score: 1097
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.53
    Marker Score: 85440
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.45
    Marker Score: 2816
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.33
    Marker Score: 9878.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1954
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.33
    Marker Score: 8056
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.32
    Marker Score: 3280.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.31
    Marker Score: 15285.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.29
    Marker Score: 604
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.28
    Marker Score: 6307
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.22
    Marker Score: 4192
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2717
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.12
    Marker Score: 28686
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.12
    Marker Score: 1982
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.1
    Marker Score: 831
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 38118
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.09
    Marker Score: 389
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.03
    Marker Score: 9055.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.02
    Marker Score: 745
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.02
    Marker Score: 3205
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.02
    Marker Score: 8758
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71621.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.99
    Marker Score: 287
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47846
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.99
    Marker Score: 495
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 824
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.98
    Marker Score: 485
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30374
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.97
    Marker Score: 1016.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.96
    Marker Score: 1103
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.95
    Marker Score: 398
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 983
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.94
    Marker Score: 624
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2206
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2379
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.93
    Marker Score: 440.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.93
    Marker Score: 294
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.91
    Marker Score: 219
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.91
    Marker Score: 317
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 429
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.91
    Marker Score: 1170
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 969
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.9
    Marker Score: 915
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9
    Marker Score: 214
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5105
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2672
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.89
    Marker Score: 7749
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.89
    Marker Score: 308
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.89
    Marker Score: 1041
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.88
    Marker Score: 606
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.88
    Marker Score: 935
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.87
    Marker Score: 870
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.87
    Marker Score: 963
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.87
    Marker Score: 1978
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.87
    Marker Score: 8755
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.87
    Marker Score: 881
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.86
    Marker Score: 545
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.86
    Marker Score: 858.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.86
    Marker Score: 472
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5192
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.86
    Marker Score: 2292
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.85
    Marker Score: 211
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.85
    Marker Score: 4083
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.85
    Marker Score: 2307
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.85
    Marker Score: 1126
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.84
    Marker Score: 223
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.83
    Marker Score: 186
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.83
    Marker Score: 2467.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.82
    Marker Score: 896
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.82
    Marker Score: 283
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.82
    Marker Score: 1156.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.82
    Marker Score: 398.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.81
    Marker Score: 1720
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.81
    Marker Score: 815
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.81
    Marker Score: 1955
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.81
    Marker Score: 245
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.8
    Marker Score: 347
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.8
    Marker Score: 5107
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.8
    Marker Score: 722
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.8
    Marker Score: 1392
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.8
    Marker Score: 210
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.79
    Marker Score: 8187
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.79
    Marker Score: 745.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.79
    Marker Score: 1996
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.79
    Marker Score: 3043
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.79
    Marker Score: 223
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.77
    Marker Score: 6049
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.77
    Marker Score: 356
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.77
    Marker Score: 169.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.77
    Marker Score: 2005
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.77
    Marker Score: 4940
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.77
    Marker Score: 216
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.76
    Marker Score: 198

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Other Information

**Key characteristics:** * FLII is a cytoskeletal protein that is highly expressed in myeloid leukocytes, nasal mucosa goblet cells, squamous epithelial cells, and blood cells. * It is also expressed in epithelial cells of the trachea, bladder urothelial cells, and elicited macrophages. * FLII is a key regulator of cell adhesion, migration, and signaling. * It is involved in the assembly and disassembly of actin filaments, and it is a key component of the network of cytoskeletal filaments that extends cell surface, providing structural support and allowing cells to move. **Pathways and functions:** * FLII is involved in cell adhesion by binding to other cytoskeletal proteins, such as actin and microtubules. * It is also involved in cell migration by regulating the formation and disassembly of cell adhesion complexes. * FLII is a key regulator of cell signaling by binding to phosphatidylinositol 4,5-bisphosphate (PIP2), a signaling molecule that is involved in cell adhesion and migration. * It is involved in the regulation of cell cycle progression by controlling the G1/S transition. * FLII is also involved in the regulation of inflammation by binding to inflammatory cytokines and signaling pathways. **Clinical significance:** * Mutations in the FLII gene have been linked to several human diseases, including cancer and cardiovascular disease. * FLII inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 4252868451

Symbol: FLII_HUMAN

Name: Protein flightless-1 homolog

UniProtKB Accession Codes:

Q13045 B4DIL0 F5H407 J3QLG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177775

Title: Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.

PubMed ID: 9177775

DOI: 10.1006/geno.1997.4709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8248259

Title: The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.

PubMed ID: 8248259

DOI: 10.1073/pnas.90.23.11386

PubMed ID: 9525888

Title: Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies.

PubMed ID: 9525888

DOI: 10.1074/jbc.273.14.7920

PubMed ID: 9671805

Title: TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.

PubMed ID: 9671805

DOI: 10.1093/nar/26.15.3460

PubMed ID: 10366446

Title: Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system.

PubMed ID: 10366446

DOI: 10.1006/geno.1999.5817

PubMed ID: 14966289

Title: Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.

PubMed ID: 14966289

DOI: 10.1128/mcb.24.5.2103-2117.2004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19293151

Title: Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.

PubMed ID: 19293151

DOI: 10.1074/jbc.m807770200

PubMed ID: 19265123

Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.

PubMed ID: 19265123

DOI: 10.4049/jimmunol.0802260

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1269
  • Mass: 144751
  • Checksum: 29AC7C07738B7B47
  • Sequence:
    • MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH 
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP 
RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV 
LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE 
CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN 
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH 
FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP 
KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL 
EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS 
LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY 
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR 
GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED 
FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC 
WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD 
VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW 
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE 
GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR 
MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL 
NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP 
ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN 
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA 
WSAFCKALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.