Details for: FLII
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 177.4404
Cell Significance Index: -27.6000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 104.8717
Cell Significance Index: -26.6000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 73.6198
Cell Significance Index: -30.3300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 68.1391
Cell Significance Index: -32.1700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 65.4881
Cell Significance Index: -26.6100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 60.9660
Cell Significance Index: -31.3600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 47.9716
Cell Significance Index: -32.1900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 28.6988
Cell Significance Index: -27.4000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.5937
Cell Significance Index: -29.0900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.2992
Cell Significance Index: -27.5900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.4834
Cell Significance Index: -29.5300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.3516
Cell Significance Index: -22.5800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.8302
Cell Significance Index: -12.7600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.0851
Cell Significance Index: 213.3500 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.5241
Cell Significance Index: 40.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.8570
Cell Significance Index: 1676.7300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5957
Cell Significance Index: 173.5600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.1132
Cell Significance Index: 20.5800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9552
Cell Significance Index: 117.4500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9109
Cell Significance Index: 47.4500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8628
Cell Significance Index: 155.5400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7977
Cell Significance Index: 41.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6720
Cell Significance Index: 18.2900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6577
Cell Significance Index: 30.9100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6525
Cell Significance Index: 356.3700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6298
Cell Significance Index: 18.1500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6294
Cell Significance Index: 28.5300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6139
Cell Significance Index: 99.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5585
Cell Significance Index: 12.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5141
Cell Significance Index: 23.9700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4125
Cell Significance Index: 48.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3765
Cell Significance Index: 51.7100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3455
Cell Significance Index: 22.2900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3241
Cell Significance Index: 8.6900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2985
Cell Significance Index: 22.2500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2906
Cell Significance Index: 58.3000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2815
Cell Significance Index: 124.4600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2696
Cell Significance Index: 46.0400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2493
Cell Significance Index: 47.4400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2362
Cell Significance Index: 46.8700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1970
Cell Significance Index: 25.4500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1795
Cell Significance Index: 2.6900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1787
Cell Significance Index: 9.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1505
Cell Significance Index: 5.2900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1500
Cell Significance Index: 103.7200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1334
Cell Significance Index: 1.5200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1267
Cell Significance Index: 12.5300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1246
Cell Significance Index: 44.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0840
Cell Significance Index: 10.7700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0766
Cell Significance Index: 0.7100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0739
Cell Significance Index: 2.1700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0424
Cell Significance Index: 3.0000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0423
Cell Significance Index: 3.2500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0272
Cell Significance Index: 0.7600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0069
Cell Significance Index: 13.0600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0068
Cell Significance Index: 0.1700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0067
Cell Significance Index: 0.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0060
Cell Significance Index: 11.1200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0057
Cell Significance Index: 8.8000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0062
Cell Significance Index: -8.3900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0113
Cell Significance Index: -7.0800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0140
Cell Significance Index: -10.3000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0168
Cell Significance Index: -1.7200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0183
Cell Significance Index: -13.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0199
Cell Significance Index: -12.6600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0374
Cell Significance Index: -21.1000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0458
Cell Significance Index: -20.7800 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0606
Cell Significance Index: -0.4000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0656
Cell Significance Index: -0.5400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0697
Cell Significance Index: -1.4900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0739
Cell Significance Index: -8.4700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0754
Cell Significance Index: -15.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0824
Cell Significance Index: -23.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0946
Cell Significance Index: -11.0300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1186
Cell Significance Index: -3.8000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1263
Cell Significance Index: -3.3200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1275
Cell Significance Index: -3.1100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1315
Cell Significance Index: -19.1100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1450
Cell Significance Index: -16.5600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1790
Cell Significance Index: -3.0000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1957
Cell Significance Index: -2.6700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2434
Cell Significance Index: -15.3400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2630
Cell Significance Index: -7.5400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2702
Cell Significance Index: -28.1300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2872
Cell Significance Index: -9.9800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3409
Cell Significance Index: -27.0000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3460
Cell Significance Index: -8.8400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3500
Cell Significance Index: -19.6400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3667
Cell Significance Index: -15.0300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3670
Cell Significance Index: -19.2700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3826
Cell Significance Index: -8.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3880
Cell Significance Index: -23.7900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.4087
Cell Significance Index: -2.5200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4295
Cell Significance Index: -8.9900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4314
Cell Significance Index: -11.0900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5464
Cell Significance Index: -24.1700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.5589
Cell Significance Index: -7.8400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5685
Cell Significance Index: -20.8700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5806
Cell Significance Index: -17.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4252868451
Symbol: FLII_HUMAN
Name: Protein flightless-1 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9177775
Title: Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.
PubMed ID: 9177775
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 8248259
Title: The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.
PubMed ID: 8248259
PubMed ID: 9525888
Title: Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies.
PubMed ID: 9525888
PubMed ID: 9671805
Title: TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.
PubMed ID: 9671805
PubMed ID: 10366446
Title: Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system.
PubMed ID: 10366446
PubMed ID: 14966289
Title: Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.
PubMed ID: 14966289
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19293151
Title: Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.
PubMed ID: 19293151
PubMed ID: 19265123
Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
PubMed ID: 19265123
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 37126682
Title: A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy.
PubMed ID: 37126682
PubMed ID: 32870709
Title: Categorized genetic analysis in childhood-onset cardiomyopathy.
PubMed ID: 32870709
PubMed ID: 37561591
Title: Biallelic variants in FLII cause pediatric cardiomyopathy by disrupting cardiomyocyte cell adhesion and myofibril organization.
PubMed ID: 37561591
Sequence Information:
- Length: 1269
- Mass: 144751
- Checksum: 29AC7C07738B7B47
- Sequence:
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA WSAFCKALA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.