Gene FLT3 - ENSG00000122025 | NCBI Gene ID: 2322

Details for: FLT3

Gene ID: 2322

Symbol: FLT3

Ensembl ID: ENSG00000122025

Description: fms related receptor tyrosine kinase 3

Associated with

Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Crenolanib-resistant flt3 mutants
(R-HSA-9702581)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Drug resistance of flt3 mutants
(R-HSA-9702506)
Flt3 mutants bind tkis
(R-HSA-9702509)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling by cbl mutants
(R-HSA-9706377)
Flt3 signaling in disease
(R-HSA-9682385)
Flt3 signaling through src family kinases
(R-HSA-9706374)
Gilteritinib-resistant flt3 mutants
(R-HSA-9702590)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Kw2449-resistant flt3 mutants
(R-HSA-9702569)
Lestaurtinib-resistant flt3 mutants
(R-HSA-9702596)
Linifanib-resistant flt3 mutants
(R-HSA-9702998)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Midostaurin-resistant flt3 mutants
(R-HSA-9702600)
Negative regulation of flt3
(R-HSA-9706369)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pexidartinib-resistant flt3 mutants
(R-HSA-9702605)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Ponatinib-resistant flt3 mutants
(R-HSA-9702614)
Quizartinib-resistant flt3 mutants
(R-HSA-9702620)
Raf/map kinase cascade
(R-HSA-5673001)
Semaxanib-resistant flt3 mutants
(R-HSA-9702577)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Sorafenib-resistant flt3 mutants
(R-HSA-9702624)
Stat5 activation
(R-HSA-9645135)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
Sunitinib-resistant flt3 mutants
(R-HSA-9702632)
Tamatinib-resistant flt3 mutants
(R-HSA-9703009)
Tandutinib-resistant flt3 mutants
(R-HSA-9702636)
Animal organ regeneration
(GO:0031100)
Atp binding
(GO:0005524)
B cell differentiation
(GO:0030183)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Common myeloid progenitor cell proliferation
(GO:0035726)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor activity
(GO:0004896)
Dendritic cell differentiation
(GO:0097028)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endosome membrane
(GO:0010008)
Growth factor binding
(GO:0019838)
Hemopoiesis
(GO:0030097)
Leukocyte homeostasis
(GO:0001776)
Lymphocyte proliferation
(GO:0046651)
Multicellular organism development
(GO:0007275)
Myeloid progenitor cell differentiation
(GO:0002318)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatidylinositol 3-kinase activator activity
(GO:0141038)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Pro-b cell differentiation
(GO:0002328)
Protein-containing complex binding
(GO:0044877)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein self-association
(GO:0043621)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of apoptotic process
(GO:0042981)
Response to organonitrogen compound
(GO:0010243)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vascular endothelial growth factor receptor activity
(GO:0005021)
Vascular endothelial growth factor signaling pathway
(GO:0038084)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 6.11
Marker Score: 17829
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.32
Marker Score: 4255
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 5.31
Marker Score: 15747
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 4.64
Marker Score: 4448.5
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.85
Marker Score: 32527
Cell Name: retinal cone cell (CL0000573)
Fold Change: 3.84
Marker Score: 11008
Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.42
Marker Score: 9754
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.41
Marker Score: 1082
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.06
Marker Score: 40994
Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.06
Marker Score: 516.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.99
Marker Score: 20163
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.95
Marker Score: 1332
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.49
Marker Score: 726.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169924
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.39
Marker Score: 51461
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.27
Marker Score: 763
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.16
Marker Score: 2395
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.14
Marker Score: 4773
Cell Name: myelocyte (CL0002193)
Fold Change: 1.09
Marker Score: 473
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.03
Marker Score: 747
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.98
Marker Score: 1989
Cell Name: neuron (CL0000540)
Fold Change: 0.96
Marker Score: 3916
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1794
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5338
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.87
Marker Score: 317
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.87
Marker Score: 1336
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.86
Marker Score: 278
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.85
Marker Score: 293
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.84
Marker Score: 7867
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.83
Marker Score: 572
Cell Name: interneuron (CL0000099)
Fold Change: 0.82
Marker Score: 375
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.79
Marker Score: 1868
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 602
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257
Cell Name: mature B cell (CL0000785)
Fold Change: 0.77
Marker Score: 567.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 705
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.76
Marker Score: 266
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.75
Marker Score: 513
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.67
Marker Score: 354
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.62
Marker Score: 636
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.62
Marker Score: 9751.5
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.62
Marker Score: 20919
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.59
Marker Score: 6122
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.59
Marker Score: 388
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.58
Marker Score: 369
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 445
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.51
Marker Score: 353
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.5
Marker Score: 2336
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.49
Marker Score: 2038
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.42
Marker Score: 1095
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.42
Marker Score: 5603
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.41
Marker Score: 109
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.41
Marker Score: 129
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.4
Marker Score: 642
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.38
Marker Score: 938
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.38
Marker Score: 378
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.37
Marker Score: 361.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.36
Marker Score: 240
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.36
Marker Score: 131
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.36
Marker Score: 20262
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.35
Marker Score: 173
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.35
Marker Score: 104
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.35
Marker Score: 167
Cell Name: leukocyte (CL0000738)
Fold Change: 0.33
Marker Score: 192
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.33
Marker Score: 344
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.33
Marker Score: 378
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.33
Marker Score: 159
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.33
Marker Score: 175
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.32
Marker Score: 1928
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.32
Marker Score: 1237
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.31
Marker Score: 157
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.31
Marker Score: 129
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3
Marker Score: 319
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.3
Marker Score: 172
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.29
Marker Score: 222
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.29
Marker Score: 75
Cell Name: monocyte (CL0000576)
Fold Change: 0.28
Marker Score: 365
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.28
Marker Score: 251
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.27
Marker Score: 85
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.27
Marker Score: 1121
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.27
Marker Score: 159
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.27
Marker Score: 83
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.26
Marker Score: 77
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.25
Marker Score: 634
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.25
Marker Score: 899
Cell Name: astrocyte (CL0000127)
Fold Change: 0.24
Marker Score: 212
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: 0.24
Marker Score: 82
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.24
Marker Score: 84
Cell Name: blood cell (CL0000081)
Fold Change: 0.23
Marker Score: 2692
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.23
Marker Score: 384
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.22
Marker Score: 277
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.22
Marker Score: 269.5

Hover over a box to see details here...

**Key characteristics:** * FLT3 is a transmembrane protein that is composed of 130 amino acids. * It is a member of the PI3K family of tyrosine kinases. * FLT3 is activated by a variety of growth factors and cytokines. * It is a key regulator of cell growth and survival. **Pathways and functions:** * FLT3 signaling is involved in a variety of cellular processes, including cell proliferation, migration, and differentiation. * It is essential for the growth and survival of epithelial cells in the gut. * It is also involved in the development of cancer. * FLT3 signaling is a target for cancer therapy. **Clinical significance:** * Mutations in the FLT3 gene have been linked to a number of human cancers. * FLT3 inhibitors are being tested as cancer drugs. * Inhibition of FLT3 has been shown to inhibit cancer cell growth and metastasis. **Additional information:** * FLT3 is a highly conserved protein that is found in organisms from yeast to humans. * It is a well-studied protein that has been extensively characterized. * FLT3 is a promising target for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Receptor-type tyrosine-protein kinase FLT3

Genular Protein ID: 944003877

Symbol: FLT3_HUMAN

Name: Receptor-type tyrosine-protein kinase FLT3

UniProtKB Accession Codes:

P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414

Database IDs:

Citations:

PubMed ID: 7507245

Title: STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

PubMed ID: 7507245

DOI: 10.1073/pnas.91.2.459

PubMed ID: 8394751

Title: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.

PubMed ID: 8394751

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2004790

Title: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene.

PubMed ID: 2004790

DOI: 10.1016/0888-7543(91)90270-o

PubMed ID: 8637232

Title: Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells.

PubMed ID: 8637232

PubMed ID: 8946930

Title: Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

PubMed ID: 8946930

PubMed ID: 9737679

Title: Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.

PubMed ID: 9737679

DOI: 10.1038/sj.leu.2401130

PubMed ID: 10080542

Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.

PubMed ID: 10080542

DOI: 10.1002/jlb.65.3.372

PubMed ID: 11090077

Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

PubMed ID: 11090077

PubMed ID: 16266983

Title: Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

PubMed ID: 16266983

DOI: 10.1158/0008-5472.can-05-0422

PubMed ID: 15831474

Title: Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

PubMed ID: 15831474

DOI: 10.1128/mcb.25.9.3690-3703.2005

PubMed ID: 16627759

Title: Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

PubMed ID: 16627759

DOI: 10.1182/blood-2005-11-011429

PubMed ID: 16684964

Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.

PubMed ID: 16684964

DOI: 10.1182/blood-2005-07-008896

PubMed ID: 18305215

Title: Structural and numerical variation of FLT3/ITD in pediatric AML.

PubMed ID: 18305215

DOI: 10.1182/blood-2008-01-117770

PubMed ID: 18490735

Title: Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.

PubMed ID: 18490735

DOI: 10.4049/jimmunol.180.11.7358

PubMed ID: 19477218

Title: Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation.

PubMed ID: 19477218

DOI: 10.1016/j.exphem.2009.05.008

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20111072

Title: FES kinases are required for oncogenic FLT3 signaling.

PubMed ID: 20111072

DOI: 10.1038/leu.2009.301

PubMed ID: 20508617

Title: Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.

PubMed ID: 20508617

DOI: 10.1038/leu.2010.114

PubMed ID: 21067588

Title: mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells.

PubMed ID: 21067588

DOI: 10.1186/1476-4598-9-292

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

PubMed ID: 21516120

Title: Further activation of FLT3 mutants by FLT3 ligand.

PubMed ID: 21516120

DOI: 10.1038/onc.2011.110

PubMed ID: 12951584

Title: The role of FLT3 in haematopoietic malignancies.

PubMed ID: 12951584

DOI: 10.1038/nrc1169

PubMed ID: 19549778

Title: Structural and functional alterations of FLT3 in acute myeloid leukemia.

PubMed ID: 19549778

DOI: 10.1158/1078-0432.ccr-08-1123

PubMed ID: 29691342

Title: Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation.

PubMed ID: 29691342

DOI: 10.1128/mbio.00682-18

PubMed ID: 14759363

Title: The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.

PubMed ID: 14759363

DOI: 10.1016/s1097-2765(03)00505-7

PubMed ID: 21389326

Title: Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.

PubMed ID: 21389326

DOI: 10.1182/blood-2011-01-329532

PubMed ID: 11442493

Title: Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia.

PubMed ID: 11442493

DOI: 10.1046/j.1365-2141.2001.02850.x

PubMed ID: 11290608

Title: Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

PubMed ID: 11290608

DOI: 10.1182/blood.v97.8.2434

PubMed ID: 14504097

Title: FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

PubMed ID: 14504097

DOI: 10.1182/blood-2003-02-0418

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

Length: 993
Mass: 112903
Checksum: 6C1995718F352ECE
Sequence:

MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 
EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL 
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 
ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 
CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 
IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA 
ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE 
GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 
NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 
ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 
HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL 
NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG 
RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FLT3

Associated with

Cells (max top 100)

Other Information

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. PubMed ID: 7507245

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. PubMed ID: 8394751

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. PubMed ID: 2004790

Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. PubMed ID: 8637232

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. PubMed ID: 8946930

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. PubMed ID: 9737679

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. PubMed ID: 10080542

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. PubMed ID: 11090077

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. PubMed ID: 16266983

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. PubMed ID: 15831474

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. PubMed ID: 16627759

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. PubMed ID: 16684964

Structural and numerical variation of FLT3/ITD in pediatric AML. PubMed ID: 18305215

Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. PubMed ID: 18490735

Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. PubMed ID: 19477218

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

FES kinases are required for oncogenic FLT3 signaling. PubMed ID: 20111072

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. PubMed ID: 20508617

mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells. PubMed ID: 21067588

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. PubMed ID: 21262971

Further activation of FLT3 mutants by FLT3 ligand. PubMed ID: 21516120

The role of FLT3 in haematopoietic malignancies. PubMed ID: 12951584

Structural and functional alterations of FLT3 in acute myeloid leukemia. PubMed ID: 19549778

Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation. PubMed ID: 29691342

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. PubMed ID: 14759363

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex. PubMed ID: 21389326

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. PubMed ID: 11442493

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. PubMed ID: 11290608

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. PubMed ID: 14504097

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. PubMed ID: 18987736