Details for: FLT3

Gene ID: 2322

Symbol: FLT3

Ensembl ID: ENSG00000122025

Description: fms related receptor tyrosine kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 94.6349
    Cell Significance Index: -14.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.9279
    Cell Significance Index: -4.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8577
    Cell Significance Index: -14.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6968
    Cell Significance Index: 173.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4059
    Cell Significance Index: 52.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9869
    Cell Significance Index: -2.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.9841
    Cell Significance Index: 24.5400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.9148
    Cell Significance Index: 5.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7343
    Cell Significance Index: 11.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5609
    Cell Significance Index: 387.9700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2819
    Cell Significance Index: 1.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2517
    Cell Significance Index: 49.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1558
    Cell Significance Index: 2.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1275
    Cell Significance Index: 45.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0837
    Cell Significance Index: 16.7900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0368
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0144
    Cell Significance Index: -2.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0158
    Cell Significance Index: -29.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0191
    Cell Significance Index: -29.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0229
    Cell Significance Index: -17.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0233
    Cell Significance Index: -12.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0239
    Cell Significance Index: -32.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0276
    Cell Significance Index: -17.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0313
    Cell Significance Index: -14.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0344
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0344
    Cell Significance Index: -0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0373
    Cell Significance Index: -10.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0381
    Cell Significance Index: -0.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0386
    Cell Significance Index: -1.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0457
    Cell Significance Index: -0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0481
    Cell Significance Index: -8.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0587
    Cell Significance Index: -6.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0756
    Cell Significance Index: -9.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0791
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0814
    Cell Significance Index: -17.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0845
    Cell Significance Index: -1.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1055
    Cell Significance Index: -10.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1078
    Cell Significance Index: -13.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1156
    Cell Significance Index: -13.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1169
    Cell Significance Index: -16.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1228
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1237
    Cell Significance Index: -3.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1400
    Cell Significance Index: -11.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1403
    Cell Significance Index: -16.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1412
    Cell Significance Index: -14.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1428
    Cell Significance Index: -3.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1453
    Cell Significance Index: -9.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1501
    Cell Significance Index: -11.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1526
    Cell Significance Index: -9.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1922
    Cell Significance Index: -14.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2189
    Cell Significance Index: -11.4000
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2246
    Cell Significance Index: -2.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2284
    Cell Significance Index: -8.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2470
    Cell Significance Index: -13.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2494
    Cell Significance Index: -5.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2500
    Cell Significance Index: -11.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2596
    Cell Significance Index: -6.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2655
    Cell Significance Index: -12.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2694
    Cell Significance Index: -12.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3028
    Cell Significance Index: -2.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3035
    Cell Significance Index: -7.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3037
    Cell Significance Index: -11.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3052
    Cell Significance Index: -7.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3222
    Cell Significance Index: -8.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3239
    Cell Significance Index: -14.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3272
    Cell Significance Index: -11.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3280
    Cell Significance Index: -17.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3327
    Cell Significance Index: -6.1500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3550
    Cell Significance Index: -5.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3618
    Cell Significance Index: -4.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3843
    Cell Significance Index: -12.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3882
    Cell Significance Index: -11.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3921
    Cell Significance Index: -6.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3981
    Cell Significance Index: -16.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4049
    Cell Significance Index: -6.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4280
    Cell Significance Index: -2.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4285
    Cell Significance Index: -14.0300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4658
    Cell Significance Index: -5.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4669
    Cell Significance Index: -9.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4713
    Cell Significance Index: -17.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4779
    Cell Significance Index: -11.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4783
    Cell Significance Index: -5.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4808
    Cell Significance Index: -14.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4863
    Cell Significance Index: -13.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5040
    Cell Significance Index: -5.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5146
    Cell Significance Index: -10.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5212
    Cell Significance Index: -11.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5217
    Cell Significance Index: -13.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5220
    Cell Significance Index: -10.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5283
    Cell Significance Index: -13.4600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.5295
    Cell Significance Index: -7.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5351
    Cell Significance Index: -7.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5367
    Cell Significance Index: -18.8600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.5409
    Cell Significance Index: -5.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5421
    Cell Significance Index: -27.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * **Structure**: FLT3 is a receptor-type tyrosine-protein kinase with an extracellular domain, a transmembrane domain, and an intracellular domain containing tyrosine kinase activity. * **Function**: FLT3 is involved in the development and function of hematopoietic cells, including stem cells, progenitor cells, and mature cells of the myeloid lineage. * **Ligand**: FLT3 binds to its ligand, stem cell factor (SCF), which is produced by various cell types, including stromal cells and epithelial cells. * **Expression**: FLT3 is expressed in hematopoietic cells, including stem cells, progenitor cells, and mature cells of the myeloid lineage, as well as in non-hematopoietic cells, such as epithelial cells and neurons. **Pathways and Functions** * **Signaling pathways**: FLT3 activates downstream signaling pathways involved in cell proliferation, differentiation, and survival, including the PI3K/AKT, MAPK/ERK, and STAT5 pathways. * **Cellular processes**: FLT3 is involved in various cellular processes, including cell proliferation, differentiation, survival, and migration. * **Hematopoiesis**: FLT3 plays a crucial role in the development and function of hematopoietic cells, including stem cells, progenitor cells, and mature cells of the myeloid lineage. * **Cancer**: Mutations in the FLT3 gene have been implicated in various hematological malignancies, including AML and CML. **Clinical Significance** * **Acute myeloid leukemia (AML)**: Mutations in the FLT3 gene are associated with poor prognosis and resistance to chemotherapy in AML patients. * **Chronic myeloid leukemia (CML)**: Mutations in the FLT3 gene are associated with resistance to tyrosine kinase inhibitors (TKIs) in CML patients. * **Therapeutic targets**: FLT3 is a promising therapeutic target for the treatment of AML and CML, with several TKIs, including sunitinib, midostaurin, and ponatinib, approved for use in these diseases. * **Prognostic markers**: FLT3 mutations can serve as prognostic markers for AML and CML patients, with patients harboring these mutations generally having a poorer prognosis. In conclusion, the FLT3 gene plays a critical role in the development and function of hematopoietic cells, and its dysregulation is implicated in various hematological malignancies. Understanding the molecular mechanisms underlying FLT3 signaling and its role in cancer will be essential for the development of effective therapeutic strategies for the treatment of AML and CML.

Genular Protein ID: 944003877

Symbol: FLT3_HUMAN

Name: Receptor-type tyrosine-protein kinase FLT3

UniProtKB Accession Codes:

P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 4 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 2 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 9 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 2 PIRSF 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 27 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7507245

Title: STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

PubMed ID: 7507245

DOI: 10.1073/pnas.91.2.459

PubMed ID: 8394751

Title: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.

PubMed ID: 8394751

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2004790

Title: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene.

PubMed ID: 2004790

DOI: 10.1016/0888-7543(91)90270-o

PubMed ID: 8637232

Title: Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells.

PubMed ID: 8637232

PubMed ID: 8946930

Title: Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

PubMed ID: 8946930

PubMed ID: 9737679

Title: Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.

PubMed ID: 9737679

DOI: 10.1038/sj.leu.2401130

PubMed ID: 10080542

Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.

PubMed ID: 10080542

DOI: 10.1002/jlb.65.3.372

PubMed ID: 11090077

Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

PubMed ID: 11090077

PubMed ID: 16266983

Title: Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

PubMed ID: 16266983

DOI: 10.1158/0008-5472.can-05-0422

PubMed ID: 15831474

Title: Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

PubMed ID: 15831474

DOI: 10.1128/mcb.25.9.3690-3703.2005

PubMed ID: 16627759

Title: Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

PubMed ID: 16627759

DOI: 10.1182/blood-2005-11-011429

PubMed ID: 16684964

Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.

PubMed ID: 16684964

DOI: 10.1182/blood-2005-07-008896

PubMed ID: 18305215

Title: Structural and numerical variation of FLT3/ITD in pediatric AML.

PubMed ID: 18305215

DOI: 10.1182/blood-2008-01-117770

PubMed ID: 18490735

Title: Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.

PubMed ID: 18490735

DOI: 10.4049/jimmunol.180.11.7358

PubMed ID: 19477218

Title: Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation.

PubMed ID: 19477218

DOI: 10.1016/j.exphem.2009.05.008

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20111072

Title: FES kinases are required for oncogenic FLT3 signaling.

PubMed ID: 20111072

DOI: 10.1038/leu.2009.301

PubMed ID: 20508617

Title: Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.

PubMed ID: 20508617

DOI: 10.1038/leu.2010.114

PubMed ID: 21067588

Title: mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells.

PubMed ID: 21067588

DOI: 10.1186/1476-4598-9-292

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

PubMed ID: 21516120

Title: Further activation of FLT3 mutants by FLT3 ligand.

PubMed ID: 21516120

DOI: 10.1038/onc.2011.110

PubMed ID: 12951584

Title: The role of FLT3 in haematopoietic malignancies.

PubMed ID: 12951584

DOI: 10.1038/nrc1169

PubMed ID: 19549778

Title: Structural and functional alterations of FLT3 in acute myeloid leukemia.

PubMed ID: 19549778

DOI: 10.1158/1078-0432.ccr-08-1123

PubMed ID: 29691342

Title: Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation.

PubMed ID: 29691342

DOI: 10.1128/mbio.00682-18

PubMed ID: 14759363

Title: The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.

PubMed ID: 14759363

DOI: 10.1016/s1097-2765(03)00505-7

PubMed ID: 21389326

Title: Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.

PubMed ID: 21389326

DOI: 10.1182/blood-2011-01-329532

PubMed ID: 11442493

Title: Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia.

PubMed ID: 11442493

DOI: 10.1046/j.1365-2141.2001.02850.x

PubMed ID: 11290608

Title: Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

PubMed ID: 11290608

DOI: 10.1182/blood.v97.8.2434

PubMed ID: 14504097

Title: FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

PubMed ID: 14504097

DOI: 10.1182/blood-2003-02-0418

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 993
  • Mass: 112903
  • Checksum: 6C1995718F352ECE
  • Sequence:
    • MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 
EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL 
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 
ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 
CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 
IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA 
ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE 
GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 
NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 
ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 
HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL 
NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG 
RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.