Details for: FOSB

Gene ID: 2354

Symbol: FOSB

Ensembl ID: ENSG00000125740

Description: FosB proto-oncogene, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 512.4876
    Cell Significance Index: -79.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 257.6058
    Cell Significance Index: -65.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 217.2364
    Cell Significance Index: -89.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 196.2796
    Cell Significance Index: -79.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 187.8431
    Cell Significance Index: -88.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 176.0937
    Cell Significance Index: -90.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 131.6574
    Cell Significance Index: -88.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.8499
    Cell Significance Index: -81.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.7067
    Cell Significance Index: -85.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.6755
    Cell Significance Index: -71.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.3936
    Cell Significance Index: -84.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.8451
    Cell Significance Index: 877.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6539
    Cell Significance Index: 190.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.9567
    Cell Significance Index: 137.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.4116
    Cell Significance Index: 147.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.3833
    Cell Significance Index: 33.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.3785
    Cell Significance Index: 250.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.5221
    Cell Significance Index: 433.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.5099
    Cell Significance Index: 64.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4935
    Cell Significance Index: 61.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.3158
    Cell Significance Index: 1465.9800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.2800
    Cell Significance Index: 19.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0633
    Cell Significance Index: 552.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7451
    Cell Significance Index: 142.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5066
    Cell Significance Index: 117.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4844
    Cell Significance Index: 175.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4837
    Cell Significance Index: 1356.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.3993
    Cell Significance Index: 50.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1212
    Cell Significance Index: 158.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9921
    Cell Significance Index: 128.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9788
    Cell Significance Index: 271.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6694
    Cell Significance Index: 48.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6495
    Cell Significance Index: 213.1000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.0097
    Cell Significance Index: 5.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9949
    Cell Significance Index: 45.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8221
    Cell Significance Index: 21.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7731
    Cell Significance Index: 16.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7006
    Cell Significance Index: 133.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5364
    Cell Significance Index: 4.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4501
    Cell Significance Index: 406.4500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4138
    Cell Significance Index: 4.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2504
    Cell Significance Index: 24.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2124
    Cell Significance Index: 2.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1776
    Cell Significance Index: 4.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1109
    Cell Significance Index: 1.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0521
    Cell Significance Index: 1.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0361
    Cell Significance Index: 3.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0305
    Cell Significance Index: 0.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0172
    Cell Significance Index: 2.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0300
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0350
    Cell Significance Index: -21.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0430
    Cell Significance Index: -80.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0529
    Cell Significance Index: -39.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0566
    Cell Significance Index: -104.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0579
    Cell Significance Index: -42.4800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0648
    Cell Significance Index: -0.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0667
    Cell Significance Index: -102.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0716
    Cell Significance Index: -3.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0769
    Cell Significance Index: -104.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0963
    Cell Significance Index: -3.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1088
    Cell Significance Index: -61.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1121
    Cell Significance Index: -71.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1682
    Cell Significance Index: -76.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2094
    Cell Significance Index: -44.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2415
    Cell Significance Index: -26.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2416
    Cell Significance Index: -8.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2479
    Cell Significance Index: -88.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2524
    Cell Significance Index: -50.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2902
    Cell Significance Index: -83.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3375
    Cell Significance Index: -66.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3792
    Cell Significance Index: -5.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3855
    Cell Significance Index: -20.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4275
    Cell Significance Index: -49.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4317
    Cell Significance Index: -49.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4353
    Cell Significance Index: -63.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4683
    Cell Significance Index: -6.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4717
    Cell Significance Index: -55.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5354
    Cell Significance Index: -18.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5664
    Cell Significance Index: -39.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5726
    Cell Significance Index: -65.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5918
    Cell Significance Index: -35.5300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.6320
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8169
    Cell Significance Index: -26.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8305
    Cell Significance Index: -86.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8920
    Cell Significance Index: -17.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9729
    Cell Significance Index: -24.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0824
    Cell Significance Index: -85.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0972
    Cell Significance Index: -28.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2250
    Cell Significance Index: -94.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2365
    Cell Significance Index: -75.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2389
    Cell Significance Index: -69.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2512
    Cell Significance Index: -78.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3241
    Cell Significance Index: -89.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3563
    Cell Significance Index: -28.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3859
    Cell Significance Index: -72.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4764
    Cell Significance Index: -90.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.5394
    Cell Significance Index: -43.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.6621
    Cell Significance Index: -23.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6876
    Cell Significance Index: -43.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOSB is a transcription factor that belongs to the Jun/Fos family of proto-oncogenes. It is a subunit of the AP-1 transcription factor complex, which is composed of multiple proteins, including c-Fos, c-Jun, and ATF. FOSB is characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes involved in cell growth, differentiation, and survival. It exhibits a high degree of sequence similarity to other Fos family members, such as FOS and JUN. **Pathways and Functions** FOSB is involved in various signaling pathways, including: 1. **Cellular response to calcium ion**: FOSB is activated by calcium ion signaling, which is essential for cell proliferation and differentiation. 2. **Cellular response to hormone stimulus**: FOSB is also activated by hormone signaling, such as estrogen and progesterone, which regulate cell growth and differentiation in certain tissues. 3. **Chromatin remodeling**: FOSB is involved in chromatin remodeling, which is essential for gene regulation and transcriptional activation. 4. **RNA polymerase II-specific transcription**: FOSB regulates the expression of target genes by interacting with RNA polymerase II, a key enzyme involved in transcriptional activation. 5. **Signaling by NTRK1 and NTRK3**: FOSB is also involved in signaling pathways mediated by NTRK1 (trka) and NTRK3, which are receptor tyrosine kinases that regulate cell growth and differentiation. FOSB's functions can be summarized as follows: * Regulates cell proliferation and differentiation * Involved in chromatin remodeling and gene regulation * Regulates transcriptional activation by interacting with RNA polymerase II * Involved in signaling pathways mediated by NTRK1 and NTRK3 **Clinical Significance** FOSB's dysregulation has been implicated in various diseases, including: 1. **Addiction**: FOSB is overexpressed in the brains of individuals with substance use disorders, suggesting its role in the development of addiction. 2. **Cancer**: FOSB is overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its role in tumor growth and progression. 3. **Neurological disorders**: FOSB is involved in the pathophysiology of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory diseases**: FOSB is overexpressed in certain inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. Overall, FOSB is a key regulator of cellular processes, and its dysregulation has significant implications for human health and disease. Further research is needed to fully understand its role in various diseases and to develop therapeutic strategies targeting FOSB.

Genular Protein ID: 1806381122

Symbol: FOSB_HUMAN

Name: G0/G1 switch regulatory protein 3

UniProtKB Accession Codes:

P53539 A8K9K5 A8VJE1 A8VJE6 A8VJF0 A8VJF3 A8VJF7 A8VJG1 A8VJG5 A8VJG9 E7EPR6 E9PHJ3 K7EKC1 K7EMJ6 Q49AD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 7 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1301997

Title: Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.

PubMed ID: 1301997

DOI: 10.1038/ng0492-34

PubMed ID: 8985116

Title: Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).

PubMed ID: 8985116

DOI: 10.1089/dna.1996.15.1025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12618758

Title: An unexpected role for FosB in activation-induced cell death of T cells.

PubMed ID: 12618758

DOI: 10.1038/sj.onc.1206126

PubMed ID: 20473292

Title: DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.

PubMed ID: 20473292

DOI: 10.1038/nn.2551

PubMed ID: 28981703

Title: Activator Protein-1: redox switch controlling structure and DNA-binding.

PubMed ID: 28981703

DOI: 10.1093/nar/gkx795

PubMed ID: 32542236

Title: Self-assembly of the bZIP transcription factor FosB.

PubMed ID: 32542236

DOI: 10.1016/j.crstbi.2019.12.001

Sequence Information:

  • Length: 338
  • Mass: 35928
  • Checksum: DDFF827C5047850F
  • Sequence:
    • MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 
GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 
LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.