Gene FOSB - ENSG00000125740 | NCBI Gene ID: 2354

Details for: FOSB

Gene ID: 2354

Symbol: FOSB

Ensembl ID: ENSG00000125740

Description: FosB proto-oncogene, AP-1 transcription factor subunit

Associated with

Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hormone stimulus
(GO:0032870)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Female pregnancy
(GO:0007565)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to camp
(GO:0051591)
Response to corticosterone
(GO:0051412)
Response to mechanical stimulus
(GO:0009612)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.27
Marker Score: 4906
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 4.59
Marker Score: 2874
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.9
Marker Score: 4170
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.52
Marker Score: 2487
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.51
Marker Score: 119517
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.34
Marker Score: 4347
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.34
Marker Score: 2842
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.22
Marker Score: 8901
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.15
Marker Score: 8829
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 3.12
Marker Score: 7665.5
Cell Name: memory T cell (CL0000813)
Fold Change: 3.02
Marker Score: 1299
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3
Marker Score: 6844
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.93
Marker Score: 1321
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.93
Marker Score: 18705
Cell Name: acinar cell (CL0000622)
Fold Change: 2.92
Marker Score: 2059
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.89
Marker Score: 2495
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.88
Marker Score: 1534.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.8
Marker Score: 4318.5
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.79
Marker Score: 6328
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.74
Marker Score: 3139
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.73
Marker Score: 30780
Cell Name: decidual cell (CL2000002)
Fold Change: 2.65
Marker Score: 11407
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.64
Marker Score: 147417
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.62
Marker Score: 2509
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.55
Marker Score: 3749
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.54
Marker Score: 1188.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.54
Marker Score: 13340
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.51
Marker Score: 4121
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.5
Marker Score: 944
Cell Name: basophil (CL0000767)
Fold Change: 2.48
Marker Score: 1179
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.47
Marker Score: 1793
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.47
Marker Score: 6460
Cell Name: supporting cell (CL0000630)
Fold Change: 2.44
Marker Score: 4589
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.44
Marker Score: 10470
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.41
Marker Score: 83324
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.37
Marker Score: 2021
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.36
Marker Score: 1214
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.36
Marker Score: 814
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.31
Marker Score: 2182
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.31
Marker Score: 4614
Cell Name: theca cell (CL0000503)
Fold Change: 2.3
Marker Score: 1650
Cell Name: leukocyte (CL0000738)
Fold Change: 2.29
Marker Score: 1315
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.26
Marker Score: 924
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.25
Marker Score: 3586
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.25
Marker Score: 1531
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.24
Marker Score: 556
Cell Name: naive T cell (CL0000898)
Fold Change: 2.23
Marker Score: 1438
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.22
Marker Score: 2420
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.22
Marker Score: 1487
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.21
Marker Score: 2330.5
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.21
Marker Score: 685
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.21
Marker Score: 1842.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.2
Marker Score: 14322
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.16
Marker Score: 1862
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.15
Marker Score: 7965
Cell Name: paneth cell (CL0000510)
Fold Change: 2.13
Marker Score: 1482
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.12
Marker Score: 1098
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.11
Marker Score: 785
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 2.1
Marker Score: 1185
Cell Name: fibroblast (CL0000057)
Fold Change: 2.1
Marker Score: 2026
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.1
Marker Score: 2097
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.09
Marker Score: 1043
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.09
Marker Score: 8046
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.08
Marker Score: 1024
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.07
Marker Score: 5061
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.06
Marker Score: 1512
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.04
Marker Score: 503
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.03
Marker Score: 688
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.02
Marker Score: 2792
Cell Name: basal cell (CL0000646)
Fold Change: 2.01
Marker Score: 2594
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.01
Marker Score: 835
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1989
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.99
Marker Score: 3365
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.99
Marker Score: 571
Cell Name: stromal cell (CL0000499)
Fold Change: 1.98
Marker Score: 2324
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.98
Marker Score: 5132
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.98
Marker Score: 455
Cell Name: granulocyte (CL0000094)
Fold Change: 1.97
Marker Score: 885
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.95
Marker Score: 820
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.92
Marker Score: 19430
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.91
Marker Score: 985
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.91
Marker Score: 12410
Cell Name: keratocyte (CL0002363)
Fold Change: 1.91
Marker Score: 439
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.89
Marker Score: 2620
Cell Name: peptic cell (CL0000155)
Fold Change: 1.89
Marker Score: 791
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.88
Marker Score: 3277
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.88
Marker Score: 1035
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.88
Marker Score: 7369
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.87
Marker Score: 705
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.87
Marker Score: 2707
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.87
Marker Score: 539
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.85
Marker Score: 843
Cell Name: neural cell (CL0002319)
Fold Change: 1.84
Marker Score: 889.5
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 1.84
Marker Score: 845
Cell Name: blood cell (CL0000081)
Fold Change: 1.83
Marker Score: 21254.5
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.81
Marker Score: 2182
Cell Name: enterocyte (CL0000584)
Fold Change: 1.8
Marker Score: 8662
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.8
Marker Score: 1187
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 1.8
Marker Score: 491
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.8
Marker Score: 2770

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**Key characteristics:** - The FOSB proto-oncogene is a member of the FOS family of transcription factors, which are known for their role in regulating cell growth, differentiation, and proliferation. - The FOSB proto-oncogene is a nuclear protein that is responsible for the transcription of a number of genes involved in female reproductive health. - The FOSB proto-oncogene is known to be a key regulator of oocyte development and differentiation. - In the ovary, FOSB is required for the expression of genes involved in the formation of the ovarian follicle. - In the uterus, FOSB is required for the maintenance of the epithelial lining of the uterus and for the development of uterine smooth muscle cells. **Pathways and functions:** - The FOSB proto-oncogene is a key regulator of female reproductive health. - In the ovary, FOSB is required for the expression of genes involved in the formation of the ovarian follicle. - In the uterus, FOSB is required for the maintenance of the epithelial lining of the uterus and for the development of uterine smooth muscle cells. - In addition, FOSB has been shown to play a role in the regulation of female fertility. **Clinical significance:** - Mutations in the FOSB proto-oncogene have been linked to a number of human diseases, including endometriosis, polycystic ovary syndrome (PCOS), and infertility. - Targeting the FOSB proto-oncogene has been explored as a therapeutic strategy for these diseases. - In clinical trials, inhibitors of the FOSB proto-oncogene have shown promise in improving fertility and reducing pain associated with endometriosis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

G0/G1 switch regulatory protein 3

Genular Protein ID: 1806381122

Symbol: FOSB_HUMAN

Name: G0/G1 switch regulatory protein 3

UniProtKB Accession Codes:

P53539 A8K9K5 A8VJE1 A8VJE6 A8VJF0 A8VJF3 A8VJF7 A8VJG1 A8VJG5 A8VJG9 E7EPR6 E9PHJ3 K7EKC1 K7EMJ6 Q49AD7

Database IDs:

Citations:

PubMed ID: 1301997

Title: Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.

PubMed ID: 1301997

DOI: 10.1038/ng0492-34

PubMed ID: 8985116

Title: Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).

PubMed ID: 8985116

DOI: 10.1089/dna.1996.15.1025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12618758

Title: An unexpected role for FosB in activation-induced cell death of T cells.

PubMed ID: 12618758

DOI: 10.1038/sj.onc.1206126

PubMed ID: 20473292

Title: DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.

PubMed ID: 20473292

DOI: 10.1038/nn.2551

PubMed ID: 28981703

Title: Activator Protein-1: redox switch controlling structure and DNA-binding.

PubMed ID: 28981703

DOI: 10.1093/nar/gkx795

PubMed ID: 32542236

Title: Self-assembly of the bZIP transcription factor FosB.

PubMed ID: 32542236

DOI: 10.1016/j.crstbi.2019.12.001

Sequence Information:

Length: 338
Mass: 35928
Checksum: DDFF827C5047850F
Sequence:

MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 
GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 
LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FOSB

Associated with

Cells (max top 100)

Other Information

Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. PubMed ID: 1301997

Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). PubMed ID: 8985116

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An unexpected role for FosB in activation-induced cell death of T cells. PubMed ID: 12618758

DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. PubMed ID: 20473292

Activator Protein-1: redox switch controlling structure and DNA-binding. PubMed ID: 28981703

Self-assembly of the bZIP transcription factor FosB. PubMed ID: 32542236