Details for: FPGS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 119.0650
Cell Significance Index: -18.5200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 68.6003
Cell Significance Index: -17.4000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.6484
Cell Significance Index: -20.1700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 47.8901
Cell Significance Index: -22.6100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 43.7027
Cell Significance Index: -22.4800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.1994
Cell Significance Index: -20.2400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.0809
Cell Significance Index: -21.0600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.2736
Cell Significance Index: -19.4900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.5042
Cell Significance Index: -21.7200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5656
Cell Significance Index: 101.0100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.4548
Cell Significance Index: 100.6100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0195
Cell Significance Index: 13.9100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9755
Cell Significance Index: 880.7900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8153
Cell Significance Index: 88.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7063
Cell Significance Index: 114.8700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6095
Cell Significance Index: 71.8800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5693
Cell Significance Index: 16.7200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5129
Cell Significance Index: 13.9600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5043
Cell Significance Index: 14.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4727
Cell Significance Index: 24.5600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4699
Cell Significance Index: 93.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4628
Cell Significance Index: 63.5600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4272
Cell Significance Index: 11.9400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4014
Cell Significance Index: 80.5300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3959
Cell Significance Index: 71.3600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3764
Cell Significance Index: 10.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3196
Cell Significance Index: 60.8200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3138
Cell Significance Index: 24.0800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2933
Cell Significance Index: 36.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2862
Cell Significance Index: 6.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2579
Cell Significance Index: 140.8300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2400
Cell Significance Index: 10.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2241
Cell Significance Index: 80.3800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2208
Cell Significance Index: 2.4000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2153
Cell Significance Index: 21.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.2097
Cell Significance Index: 30.4900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1947
Cell Significance Index: 9.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1830
Cell Significance Index: 8.5300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1524
Cell Significance Index: 67.3900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1487
Cell Significance Index: 102.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1350
Cell Significance Index: 10.0600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1210
Cell Significance Index: 15.5100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0934
Cell Significance Index: 12.0700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0909
Cell Significance Index: 6.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0634
Cell Significance Index: 3.5600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0362
Cell Significance Index: 0.7700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0338
Cell Significance Index: 5.7700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0231
Cell Significance Index: 0.8100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0228
Cell Significance Index: 0.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0179
Cell Significance Index: 27.6200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0177
Cell Significance Index: 32.7100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0169
Cell Significance Index: 0.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0155
Cell Significance Index: 29.1200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0092
Cell Significance Index: 6.9500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0041
Cell Significance Index: 2.6100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0034
Cell Significance Index: 4.6900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0200
Cell Significance Index: -14.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0205
Cell Significance Index: -9.3000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0226
Cell Significance Index: -2.3100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0251
Cell Significance Index: -18.5900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0361
Cell Significance Index: -20.3800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0397
Cell Significance Index: -24.7800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0399
Cell Significance Index: -1.0200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0588
Cell Significance Index: -1.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0643
Cell Significance Index: -18.5000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0776
Cell Significance Index: -1.6100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0810
Cell Significance Index: -1.3600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0824
Cell Significance Index: -2.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0898
Cell Significance Index: -1.8800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1131
Cell Significance Index: -23.8200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1164
Cell Significance Index: -13.5700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1233
Cell Significance Index: -7.5800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1278
Cell Significance Index: -2.1900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1284
Cell Significance Index: -14.7100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1341
Cell Significance Index: -9.0200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1437
Cell Significance Index: -1.8400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1471
Cell Significance Index: -2.8700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1739
Cell Significance Index: -2.9300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1831
Cell Significance Index: -5.2500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1885
Cell Significance Index: -11.8800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1890
Cell Significance Index: -19.6800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1969
Cell Significance Index: -4.5500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2133
Cell Significance Index: -5.7100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2586
Cell Significance Index: -20.4800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2692
Cell Significance Index: -5.9000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2852
Cell Significance Index: -4.2100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2885
Cell Significance Index: -15.0300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3217
Cell Significance Index: -4.7500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3219
Cell Significance Index: -19.7400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3309
Cell Significance Index: -14.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3394
Cell Significance Index: -17.8200 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.3409
Cell Significance Index: -2.3100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3478
Cell Significance Index: -13.1700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3575
Cell Significance Index: -9.1900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3924
Cell Significance Index: -5.8800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4097
Cell Significance Index: -20.7000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4499
Cell Significance Index: -8.3200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4601
Cell Significance Index: -2.7800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4754
Cell Significance Index: -15.1400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4901
Cell Significance Index: -17.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1266369572
Symbol: FOLC_HUMAN
Name: Folylpolyglutamate synthase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8662720
Title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene.
PubMed ID: 8662720
PubMed ID: 7721888
Title: Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene.
PubMed ID: 7721888
PubMed ID: 1409616
Title: Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure.
PubMed ID: 1409616
PubMed ID: 8521387
Title: Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.
PubMed ID: 8521387
PubMed ID: 8408018
Title: Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.
PubMed ID: 8408018
PubMed ID: 8408019
Title: Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.
PubMed ID: 8408019
PubMed ID: 8408020
Title: Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-gamma-glutamate synthetase.
PubMed ID: 8408020
PubMed ID: 8408021
Title: Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity.
PubMed ID: 8408021
PubMed ID: 16169100
Title: Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells.
PubMed ID: 16169100
PubMed ID: 17875718
Title: Identification and characterization of genetic variation in the folylpolyglutamate synthase gene.
PubMed ID: 17875718
PubMed ID: 18672898
Title: Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.
PubMed ID: 18672898
DOI: 10.1021/bi800406w
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 587
- Mass: 64609
- Checksum: 5AF81409F5F77E5C
- Sequence:
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.