Details for: FPGS

Gene ID: 2356

Symbol: FPGS

Ensembl ID: ENSG00000136877

Description: folylpolyglutamate synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5
    Marker Score: 15191
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.25
    Marker Score: 1261
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.23
    Marker Score: 3335
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2
    Marker Score: 2094
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.19
    Marker Score: 860
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.18
    Marker Score: 379
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.07
    Marker Score: 1257
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16503
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.02
    Marker Score: 358
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.02
    Marker Score: 1079
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71683
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47907
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.98
    Marker Score: 5973
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.98
    Marker Score: 2656
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 697
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.96
    Marker Score: 1148
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7106
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.95
    Marker Score: 2824
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.93
    Marker Score: 3820
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.93
    Marker Score: 453
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 991
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.91
    Marker Score: 1930
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9
    Marker Score: 5781
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.89
    Marker Score: 228
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.88
    Marker Score: 8872
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.88
    Marker Score: 483
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.87
    Marker Score: 428
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.87
    Marker Score: 652
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.87
    Marker Score: 206
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.86
    Marker Score: 1217
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.85
    Marker Score: 2357
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4728
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.83
    Marker Score: 412
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.81
    Marker Score: 281
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.81
    Marker Score: 425
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 543
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.8
    Marker Score: 506
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1876
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.79
    Marker Score: 762.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1159
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.78
    Marker Score: 10467
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.78
    Marker Score: 3361
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.78
    Marker Score: 4987
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47580
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.76
    Marker Score: 3296
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.76
    Marker Score: 623.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.75
    Marker Score: 4894
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.75
    Marker Score: 19227
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.75
    Marker Score: 366
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 509
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1140
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.74
    Marker Score: 6997
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.73
    Marker Score: 1313
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.73
    Marker Score: 192
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.72
    Marker Score: 2284
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.72
    Marker Score: 1183
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.72
    Marker Score: 4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.72
    Marker Score: 6170
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.71
    Marker Score: 394
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 422
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4218
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.69
    Marker Score: 342
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.69
    Marker Score: 171
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.69
    Marker Score: 1688
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.69
    Marker Score: 6481
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.69
    Marker Score: 724
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.68
    Marker Score: 279
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.68
    Marker Score: 539
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.68
    Marker Score: 1680
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2862.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.68
    Marker Score: 1083
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 617
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.67
    Marker Score: 190
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 232
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.66
    Marker Score: 6844
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 327
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.66
    Marker Score: 3557
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.66
    Marker Score: 1378
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 436
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.66
    Marker Score: 515
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.65
    Marker Score: 435
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.65
    Marker Score: 2656
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.65
    Marker Score: 155

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Other Information

**Key characteristics:** * The FPGS gene is located on chromosome 17q21.1. * It is a highly expressed gene in early pro-B cells, which are responsible for generating plasma cells. * The protein encoded by FPGS is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a bifunctional enzyme that can be divided into two subunits, FPG1 and FPG2. * FPG1 is responsible for the initial synthesis of FPG, while FPG2 is involved in the maintenance of FPG levels. **Pathways and functions:** * FPGS is a key enzyme in the folate metabolic pathway. * It participates in the synthesis of DNA and RNA molecules, as well as the synthesis of proteins. * It is also involved in the metabolism of vitamins and cofactors, including folate, vitamin B12, and coenzyme A. * It plays a role in liver development and the maintenance of normal homocysteine levels. * It has been linked to the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the FPGS gene have been linked to several human diseases, including megaloblastic anemia, which is characterized by low levels of red blood cells and folate-dependent disorders. * FPGS inhibitors are being investigated as potential therapeutic agents for these disorders. * Understanding the function of FPGS and its role in human health is important for the development of new treatments for folate-related diseases.

Genular Protein ID: 1266369572

Symbol: FOLC_HUMAN

Name: Folylpolyglutamate synthase, mitochondrial

UniProtKB Accession Codes:

Q05932 B3KPW4 B7Z2Z3 F5H0K6 Q5JU19 Q5JU22 Q6P2P6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8662720

Title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene.

PubMed ID: 8662720

DOI: 10.1074/jbc.271.22.13077

PubMed ID: 7721888

Title: Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene.

PubMed ID: 7721888

DOI: 10.1074/jbc.270.16.9579

PubMed ID: 1409616

Title: Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure.

PubMed ID: 1409616

DOI: 10.1073/pnas.89.19.9151

PubMed ID: 8521387

Title: Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.

PubMed ID: 8521387

PubMed ID: 8408018

Title: Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.

PubMed ID: 8408018

DOI: 10.1016/s0021-9258(20)80592-4

PubMed ID: 8408019

Title: Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.

PubMed ID: 8408019

DOI: 10.1016/s0021-9258(20)80593-6

PubMed ID: 8408020

Title: Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-gamma-glutamate synthetase.

PubMed ID: 8408020

DOI: 10.1016/s0021-9258(20)80594-8

PubMed ID: 8408021

Title: Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity.

PubMed ID: 8408021

DOI: 10.1016/s0021-9258(20)80595-x

PubMed ID: 16169100

Title: Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells.

PubMed ID: 16169100

DOI: 10.1016/j.bbamcr.2005.08.004

PubMed ID: 17875718

Title: Identification and characterization of genetic variation in the folylpolyglutamate synthase gene.

PubMed ID: 17875718

DOI: 10.1158/0008-5472.can-07-0156

PubMed ID: 18672898

Title: Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.

PubMed ID: 18672898

DOI: 10.1021/bi800406w

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 587
  • Mass: 64609
  • Checksum: 5AF81409F5F77E5C
  • Sequence:
    • MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG 
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.