Details for: GABPB1

Gene ID: 2553

Symbol: GABPB1

Ensembl ID: ENSG00000104064

Description: GA binding protein transcription factor subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.82
    Marker Score: 1967.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.79
    Marker Score: 7346
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.69
    Marker Score: 4927
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6
    Marker Score: 3256
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.56
    Marker Score: 2734
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.51
    Marker Score: 541
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.38
    Marker Score: 1477.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.25
    Marker Score: 4613
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.19
    Marker Score: 1403
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.14
    Marker Score: 657
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.13
    Marker Score: 1928
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.11
    Marker Score: 744
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.11
    Marker Score: 2709.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.1
    Marker Score: 617
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.09
    Marker Score: 3010
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.07
    Marker Score: 2896
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.06
    Marker Score: 1027
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.06
    Marker Score: 2111
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.05
    Marker Score: 10881
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.05
    Marker Score: 1715
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.04
    Marker Score: 4103
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.04
    Marker Score: 276
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.02
    Marker Score: 486
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.02
    Marker Score: 11512
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.02
    Marker Score: 10107
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.02
    Marker Score: 804
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.01
    Marker Score: 1435.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.01
    Marker Score: 1219
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1
    Marker Score: 4328
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71650
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47874
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.98
    Marker Score: 927
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30383
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.97
    Marker Score: 472
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.97
    Marker Score: 347
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.96
    Marker Score: 1811
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 652
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.94
    Marker Score: 501
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.93
    Marker Score: 31790
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.93
    Marker Score: 219
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.93
    Marker Score: 1953
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.92
    Marker Score: 657
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.92
    Marker Score: 797
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.91
    Marker Score: 571
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.91
    Marker Score: 808
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.91
    Marker Score: 1318
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.9
    Marker Score: 443
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.89
    Marker Score: 901
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.89
    Marker Score: 312
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.87
    Marker Score: 1128
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 572
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.87
    Marker Score: 1581
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.86
    Marker Score: 281
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.86
    Marker Score: 2466
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1392
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.86
    Marker Score: 3490
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 515
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.85
    Marker Score: 218
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13314
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.85
    Marker Score: 51998
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.84
    Marker Score: 1301
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.84
    Marker Score: 2969
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.83
    Marker Score: 900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.83
    Marker Score: 1761
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4758
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 438
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.83
    Marker Score: 1031
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.82
    Marker Score: 2131
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.82
    Marker Score: 7060
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.82
    Marker Score: 334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 328
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.81
    Marker Score: 551
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.81
    Marker Score: 1141
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 444
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8
    Marker Score: 259
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.8
    Marker Score: 791
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1540
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.79
    Marker Score: 909
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.79
    Marker Score: 7514
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.79
    Marker Score: 1051
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.79
    Marker Score: 1774
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1856
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.79
    Marker Score: 2062
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.79
    Marker Score: 329
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.78
    Marker Score: 248
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.78
    Marker Score: 187
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 698
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.78
    Marker Score: 179
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.78
    Marker Score: 17404
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 709
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.77
    Marker Score: 174
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.77
    Marker Score: 12345

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Other Information

**Key characteristics:** * The GABPB1 gene is located on chromosome 17q21.1. * It is a large gene with a size of approximately 2.2 million base pairs. * It contains 10 exons and 9 intronic regions. * The protein encoded by GABPB1 is a large protein of approximately 1200 amino acids. **Pathways and functions:** * The GABPB1 gene is a key regulator of mitochondrial biogenesis. * It is involved in the regulation of mitochondrial biogenesis in neurons and oligodendrocytes. * It is also involved in the regulation of mitochondrial respiration. * It is a key regulator of mitochondrial biogenesis in various cell types, including neurons, oligodendrocytes, and immune cells. * It is also involved in the regulation of mitochondrial function, including mitochondrial respiration, calcium signaling, and apoptosis. **Clinical significance:** * Mutations in the GABPB1 gene have been linked to a number of neurological disorders, including schizophrenia, autism, and epilepsy. * The GABPB1 gene is a potential therapeutic target for these disorders. **Additional information:** * The GABPB1 gene is a member of the GAB1 family of transcription factors. * It is regulated by a variety of factors, including growth factors, cytokines, and other transcription factors. * It is also regulated by post-translational modifications, including phosphorylation and acetylation.

Genular Protein ID: 285288057

Symbol: GABP1_HUMAN

Name: GA-binding protein subunit beta-1

UniProtKB Accession Codes:

Q06547 A8IE52 Q06545 Q12940 Q12941 Q12942 Q8IYD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441384

Title: cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.

PubMed ID: 8441384

DOI: 10.1128/mcb.13.3.1385-1391.1993

PubMed ID: 7799916

Title: Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.

PubMed ID: 7799916

DOI: 10.1128/mcb.15.1.102

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7918435

Title: Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

PubMed ID: 7918435

DOI: 10.1021/bi00206a017

PubMed ID: 8383622

Title: Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.

PubMed ID: 8383622

DOI: 10.1101/gad.7.3.380

PubMed ID: 8816484

Title: Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription.

PubMed ID: 8816484

DOI: 10.1128/mcb.16.10.5708

PubMed ID: 10675337

Title: The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.

PubMed ID: 10675337

DOI: 10.1093/emboj/19.4.683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 395
  • Mass: 42483
  • Checksum: 723D63962FB29BD9
  • Sequence:
    • MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA 
GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV 
ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT 
PQFIIGPGGV VNLTGLVSSE NSSKATDETG VSAVQFGNSS TSVLATLAAL AEASAPLSNS 
SETPVVATEE VVTAESVDGA IQQVVSSGGQ QVITIVTDGI QLGNLHSIPT SGIGQPIIVT 
MPDGQQVLTV PATDIAEETV ISEEPPAKRQ CIEIIENRVE SAEIEEREAL QKQLDEANRE 
AQKYRQQLLK KEQEAEAYRQ KLEAMTRLQT NKEAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.