Details for: GABPB1

Gene ID: 2553

Symbol: GABPB1

Ensembl ID: ENSG00000104064

Description: GA binding protein transcription factor subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.6449
    Cell Significance Index: -21.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.3276
    Cell Significance Index: -19.3600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 73.1404
    Cell Significance Index: -30.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.0266
    Cell Significance Index: -25.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.5685
    Cell Significance Index: -29.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.0224
    Cell Significance Index: -29.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.0125
    Cell Significance Index: -25.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.7874
    Cell Significance Index: -25.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4854
    Cell Significance Index: -25.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9283
    Cell Significance Index: -21.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7840
    Cell Significance Index: -26.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6847
    Cell Significance Index: -14.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6291
    Cell Significance Index: 56.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1093
    Cell Significance Index: 29.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0527
    Cell Significance Index: 208.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9711
    Cell Significance Index: 876.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8410
    Cell Significance Index: 17.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8188
    Cell Significance Index: 42.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6450
    Cell Significance Index: 129.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6319
    Cell Significance Index: 68.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6227
    Cell Significance Index: 101.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5646
    Cell Significance Index: 6.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5343
    Cell Significance Index: 3.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4972
    Cell Significance Index: 25.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4808
    Cell Significance Index: 26.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4747
    Cell Significance Index: 9.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4552
    Cell Significance Index: 27.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4217
    Cell Significance Index: 291.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4210
    Cell Significance Index: 229.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4152
    Cell Significance Index: 31.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3356
    Cell Significance Index: 9.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3294
    Cell Significance Index: 2.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3031
    Cell Significance Index: 8.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2963
    Cell Significance Index: 56.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2754
    Cell Significance Index: 4.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2744
    Cell Significance Index: 35.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2564
    Cell Significance Index: 6.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2531
    Cell Significance Index: 17.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2496
    Cell Significance Index: 89.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2158
    Cell Significance Index: 29.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2068
    Cell Significance Index: 4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1856
    Cell Significance Index: 4.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1657
    Cell Significance Index: 7.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1551
    Cell Significance Index: 10.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1476
    Cell Significance Index: 17.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1389
    Cell Significance Index: 17.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1020
    Cell Significance Index: 18.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0891
    Cell Significance Index: 4.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0879
    Cell Significance Index: 38.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0752
    Cell Significance Index: 2.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0591
    Cell Significance Index: 3.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0420
    Cell Significance Index: 1.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0317
    Cell Significance Index: 59.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0291
    Cell Significance Index: 0.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0248
    Cell Significance Index: 0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0146
    Cell Significance Index: 9.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0110
    Cell Significance Index: 14.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0101
    Cell Significance Index: 15.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0092
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 9.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0179
    Cell Significance Index: -2.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0274
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0293
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0298
    Cell Significance Index: -22.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0317
    Cell Significance Index: -23.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0367
    Cell Significance Index: -1.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0380
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0480
    Cell Significance Index: -27.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0501
    Cell Significance Index: -31.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0561
    Cell Significance Index: -5.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0620
    Cell Significance Index: -6.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0679
    Cell Significance Index: -0.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0836
    Cell Significance Index: -3.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0863
    Cell Significance Index: -24.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1050
    Cell Significance Index: -12.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1157
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1454
    Cell Significance Index: -30.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1511
    Cell Significance Index: -2.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1738
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1972
    Cell Significance Index: -22.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1996
    Cell Significance Index: -14.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2082
    Cell Significance Index: -3.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2183
    Cell Significance Index: -6.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2278
    Cell Significance Index: -23.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2434
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2513
    Cell Significance Index: -5.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2690
    Cell Significance Index: -3.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2693
    Cell Significance Index: -7.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2754
    Cell Significance Index: -12.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2854
    Cell Significance Index: -6.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2972
    Cell Significance Index: -9.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3012
    Cell Significance Index: -7.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3066
    Cell Significance Index: -5.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3312
    Cell Significance Index: -26.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3353
    Cell Significance Index: -4.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3396
    Cell Significance Index: -4.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GABPB1 is a subunit of the GA-binding protein (GABP), a transcription factor complex that plays a pivotal role in regulating gene expression. This gene is characterized by its ability to bind to specific DNA sequences, thereby modulating the transcriptional activity of target genes. The expression of GABPB1 is widespread, with significant levels detected in various cell types, including immune cells, neurons, and epithelial cells. The gene's involvement in mitochondrial biogenesis and organization highlights its potential role in energy metabolism and cellular homeostasis. **Pathways and Functions:** GABPB1 is involved in several key pathways, including: 1. **Positive regulation of transcription by RNA polymerase II**: GABPB1 acts as a co-activator, enhancing the transcriptional activity of RNA polymerase II, which is essential for the expression of many genes involved in cellular growth and differentiation. 2. **Transcriptional activation of mitochondrial biogenesis**: GABPB1 regulates the expression of genes involved in mitochondrial biogenesis, including those encoding mitochondrial DNA and proteins involved in energy metabolism. 3. **Mitochondrial organization and biogenesis**: GABPB1 plays a role in the organization and biogenesis of mitochondria, which is critical for maintaining cellular energy homeostasis. 4. **Cytoplasmic ribonucleoprotein granule formation**: GABPB1 is involved in the formation of cytoplasmic ribonucleoprotein granules, which are involved in RNA processing and storage. **Clinical Significance:** The functional significance of GABPB1 extends beyond its role in immune cell development and mitochondrial biogenesis. Its dysregulation has been implicated in various diseases, including: 1. **Mitochondrial disorders**: GABPB1 mutations have been associated with mitochondrial disorders, such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome). 2. **Immunodeficiency disorders**: GABPB1 is expressed in immune cells, and its dysregulation has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 3. **Neurological disorders**: GABPB1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, GABPB1 is a critical regulator of transcriptional processes, particularly in the context of mitochondrial biogenesis and immune cell development. Its dysregulation has significant implications for human health, highlighting the importance of further research into the functional significance of this gene.

Genular Protein ID: 285288057

Symbol: GABP1_HUMAN

Name: GA-binding protein subunit beta-1

UniProtKB Accession Codes:

Q06547 A8IE52 Q06545 Q12940 Q12941 Q12942 Q8IYD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441384

Title: cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.

PubMed ID: 8441384

DOI: 10.1128/mcb.13.3.1385-1391.1993

PubMed ID: 7799916

Title: Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.

PubMed ID: 7799916

DOI: 10.1128/mcb.15.1.102

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7918435

Title: Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

PubMed ID: 7918435

DOI: 10.1021/bi00206a017

PubMed ID: 8383622

Title: Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.

PubMed ID: 8383622

DOI: 10.1101/gad.7.3.380

PubMed ID: 8816484

Title: Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription.

PubMed ID: 8816484

DOI: 10.1128/mcb.16.10.5708

PubMed ID: 10675337

Title: The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.

PubMed ID: 10675337

DOI: 10.1093/emboj/19.4.683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 395
  • Mass: 42483
  • Checksum: 723D63962FB29BD9
  • Sequence:
    • MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA 
GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV 
ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT 
PQFIIGPGGV VNLTGLVSSE NSSKATDETG VSAVQFGNSS TSVLATLAAL AEASAPLSNS 
SETPVVATEE VVTAESVDGA IQQVVSSGGQ QVITIVTDGI QLGNLHSIPT SGIGQPIIVT 
MPDGQQVLTV PATDIAEETV ISEEPPAKRQ CIEIIENRVE SAEIEEREAL QKQLDEANRE 
AQKYRQQLLK KEQEAEAYRQ KLEAMTRLQT NKEAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.