Details for: GART

Gene ID: 2618

Symbol: GART

Ensembl ID: ENSG00000159131

Description: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.63
    Marker Score: 1104
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.5
    Marker Score: 1126
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167852
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.45
    Marker Score: 1516
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.36
    Marker Score: 1246
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.31
    Marker Score: 1398
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.22
    Marker Score: 1755
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.21
    Marker Score: 1521
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.15
    Marker Score: 39102
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1148
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.11
    Marker Score: 5464
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.11
    Marker Score: 1193
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.08
    Marker Score: 1194
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1579
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.06
    Marker Score: 4117
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 63695
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.03
    Marker Score: 587
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.02
    Marker Score: 2499
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.01
    Marker Score: 3966
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71681
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47904
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.99
    Marker Score: 8505
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.98
    Marker Score: 573
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.98
    Marker Score: 36107
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.97
    Marker Score: 1035
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.97
    Marker Score: 3978
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.97
    Marker Score: 1307
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1496
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9141
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1006
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.96
    Marker Score: 1352
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.93
    Marker Score: 453
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.92
    Marker Score: 1042
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5184
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.9
    Marker Score: 8460
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.9
    Marker Score: 448
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.9
    Marker Score: 432
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 937
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.88
    Marker Score: 2090
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.87
    Marker Score: 247
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.86
    Marker Score: 273
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.85
    Marker Score: 475
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.85
    Marker Score: 2310.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.85
    Marker Score: 1438
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.85
    Marker Score: 32127
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.85
    Marker Score: 1765
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.84
    Marker Score: 665
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1110
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.82
    Marker Score: 2245
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.82
    Marker Score: 600
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.82
    Marker Score: 288
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.82
    Marker Score: 1432
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.82
    Marker Score: 556
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.82
    Marker Score: 767
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1319
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 339
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.81
    Marker Score: 259
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 260
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.8
    Marker Score: 508
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1884
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.8
    Marker Score: 936
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.8
    Marker Score: 853
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.79
    Marker Score: 5114
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.78
    Marker Score: 11734
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.78
    Marker Score: 8814
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.78
    Marker Score: 485.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.77
    Marker Score: 383
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.77
    Marker Score: 757.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.77
    Marker Score: 2977
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.77
    Marker Score: 204
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5837
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.76
    Marker Score: 537
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 518
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.76
    Marker Score: 8787
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 569.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.74
    Marker Score: 2210
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.74
    Marker Score: 14812
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.74
    Marker Score: 3085
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3108.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 408
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 232
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5445
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.73
    Marker Score: 298
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.73
    Marker Score: 443
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.73
    Marker Score: 3133
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.72
    Marker Score: 402
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.72
    Marker Score: 177
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.71
    Marker Score: 1754
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 737
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.71
    Marker Score: 294

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Other Information

**Key characteristics** * The GART gene is located on chromosome 15q26.1. * It is a single-exon gene encoding a protein of 371 amino acids. * The protein is expressed in both humans and mice. * It is a member of the purine nucleotide biosynthetic pathway. * It is involved in the synthesis of phosphoribosylglycinamide, a precursor to various other metabolites involved in immune responses. **Pathways and functions** * The GART gene is involved in the 'de novo' imp biosynthetic process, which is a pathway that leads to the synthesis of complex molecules from simpler precursors. * It is also involved in the Atp binding pathway, the Glycine metabolic process, the Gmp biosynthetic process, the Metabolism, Metabolism of nucleotides, Metal ion binding, and Nucleotide biosynthesis pathways. * It plays a role in the purine nucleotide biosynthetic process, the Purine ribonucleoside monophosphate biosynthesis, and the Purine ribonucleoside monophosphate biosynthetic process. * It is also involved in the response to inorganic and organic substances. **Clinical significance** Mutations in the GART gene have been linked to several human diseases, including immune disorders and cancer. These mutations can lead to the accumulation of phosphoribosylglycinamide or its metabolites in the body, which can have toxic effects. Therefore, targeting the GART gene is a promising therapeutic strategy for these diseases.

Genular Protein ID: 3724614879

Symbol: PUR2_HUMAN

Name: Glycinamide ribonucleotide synthetase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2147474

Title: De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli.

PubMed ID: 2147474

DOI: 10.1093/nar/18.22.6665

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9224613

Title: Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene.

PubMed ID: 9224613

DOI: 10.1093/nar/25.15.3118

PubMed ID: 2183217

Title: Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

PubMed ID: 2183217

DOI: 10.1073/pnas.87.8.2916

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12450384

Title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

PubMed ID: 12450384

DOI: 10.1021/bi020522m

PubMed ID: 12755606

Title: Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

PubMed ID: 12755606

DOI: 10.1021/bi034219c

PubMed ID: 16026156

Title: The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.

PubMed ID: 16026156

DOI: 10.1021/bi050307g

PubMed ID: 20631005

Title: Structural studies of tri-functional human GART.

PubMed ID: 20631005

DOI: 10.1093/nar/gkq595

Sequence Information:

  • Length: 1010
  • Mass: 107767
  • Checksum: 9A4213F746EB17A2
  • Sequence:
  • MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI SISDHTALAQ 
    FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA AQLESSKRFA KEFMDRHGIP 
    TAQWKAFTKP EEACSFILSA DFPALVVKAS GLAAGKGVIV AKSKEEACKA VQEIMQEKAF 
    GAAGETIVIE ELLDGEEVSC LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP 
    QVSNDLLLKI KDTVLQRTVD GMQQEGTPYT GILYAGIMLT KNGPKVLEFN CRFGDPECQV 
    ILPLLKSDLY EVIQSTLDGL LCTSLPVWLE NHTALTVVMA SKGYPGDYTK GVEITGFPEA 
    QALGLEVFHA GTALKNGKVV THGGRVLAVT AIRENLISAL EEAKKGLAAI KFEGAIYRKD 
    VGFRAIAFLQ QPRSLTYKES GVDIAAGNML VKKIQPLAKA TSRSGCKVDL GGFAGLFDLK 
    AAGFKDPLLA SGTDGVGTKL KIAQLCNKHD TIGQDLVAMC VNDILAQGAE PLFFLDYFSC 
    GKLDLSVTEA VVAGIAKACG KAGCALLGGE TAEMPDMYPP GEYDLAGFAV GAMERDQKLP 
    HLERITEGDV VVGIASSGLH SNGFSLVRKI VAKSSLQYSS PAPDGCGDQT LGDLLLTPTR 
    IYSHSLLPVL RSGHVKAFAH ITGGGLLENI PRVLPEKLGV DLDAQTWRIP RVFSWLQQEG 
    HLSEEEMART FNCGVGAVLV VSKEQTEQIL RDIQQHKEEA WVIGSVVARA EGSPRVKVKN 
    LIESMQINGS VLKNGSLTNH FSFEKKKARV AVLISGTGSN LQALIDSTRE PNSSAQIDIV 
    ISNKAAVAGL DKAERAGIPT RVINHKLYKN RVEFDSAIDL VLEEFSIDIV CLAGFMRILS 
    GPFVQKWNGK MLNIHPSLLP SFKGSNAHEQ ALETGVTVTG CTVHFVAEDV DAGQIILQEA 
    VPVKRGDTVA TLSERVKLAE HKIFPAALQL VASGTVQLGE NGKICWVKEE

Genular Protein ID: 1126974559

Symbol: Q59HH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1046
  • Mass: 112138
  • Checksum: DF03CB4B83AE9EEA
  • Sequence:
  • RRRGRRARRA TRCLTHGFQA LSGFIFLWNF CFTDRTMAAR VLIIGSGGRE HTLAWKLAQS 
    HHVKQVLVAP GNAGTACSEK ISNTAISISD HTALAQFCKE KKIEFVVVGP EAPLAAGIVG 
    NLRSAGVQCF GPTAEAAQLE SSKRFAKEFM DRHGIPTAQW KAFTKPEEAC SFILSADFPA 
    LVVKASGLAA GKGVIVAKSK EEACKAVQEI MQEKAFGAAG ETIVIEELLD GEEVSCLCFT 
    DGKTVAPMPP AQDHKRLLEG DGGPNTGGMG AYCPAPQVSN DLLLKIKDTV LQRTVDGMQQ 
    EGTPYTGILY AGIMLTKNGP KVLEFNCRFG DPECQVILPL LKSDLYEVIQ STLDGLLCTS 
    LPVWLENHTA LTVVMASKGY PGDYTKGVEI TGFPEAQALG LEVFHAGTAL KNGKVVTHGG 
    RVLAVTAIRE NLISALEEAK KGLAAIKFEG AIYRKDIGFR AIAFLQQPRS LTYKESGVDI 
    AAGNMLVKKI QPLAKATSRS GCKVDLGGFA GLFDLKAAGF KDPLLASGTD GVGTKLKIAQ 
    LCNKHDTIGQ DLVAMCVNDI LAQGAEPLFF LDYFSCGKLD LSVTEAVVAG IAKACGKAGC 
    ALLGGETAEM PDMYPPGEYD LAGFAVGAME RDQKLPHLER ITEGDVVVGI ASSGLHSNGF 
    SLVRKIVAKS SLQYSSPAPD GCGDQTLGDL LLTPTRIYSH SLLPVLRSGH VKAFAHITGG 
    GLLENIPRVL PEKLGVDLDA QTWRIPRVFS WLQQEGHLSE EEMARTFNCG VGAVLVVSKE 
    QTEQILRDIQ QHKEEAWVIG SVVARAEGSP RVKVKNLIES MQINGSVLKN GSLTNHFSFE 
    KKKARVAVLI SGTGSNLQAL IDSTREPNSS AQIDIVISNK AAVAGLDKAE RAGIPTRVIN 
    HKLYKNRVEF DSAIDLVLEE FSIDIVCLAG FMRILSGPFV QKWNGKMLNI HPSLLPSFKG 
    SNAHEQALET GVTVTGCTVH FVAEDVDAGQ IILQEAVPVK RGDTVATLSE RVKLAEHKIF 
    PAALQLVASG TVQLGENGKI CWVKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.