Details for: GART

Gene ID: 2618

Symbol: GART

Ensembl ID: ENSG00000159131

Description: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.5175
    Cell Significance Index: -24.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.0080
    Cell Significance Index: -25.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.0165
    Cell Significance Index: -31.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.8112
    Cell Significance Index: -26.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 64.2557
    Cell Significance Index: -26.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6357
    Cell Significance Index: -26.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9992
    Cell Significance Index: -29.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6351
    Cell Significance Index: -28.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7343
    Cell Significance Index: -30.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6158
    Cell Significance Index: -20.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8981
    Cell Significance Index: -10.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3226
    Cell Significance Index: 1194.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0921
    Cell Significance Index: 30.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0686
    Cell Significance Index: 173.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0685
    Cell Significance Index: 28.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9297
    Cell Significance Index: 25.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9199
    Cell Significance Index: 26.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8004
    Cell Significance Index: 158.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6471
    Cell Significance Index: 129.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6208
    Cell Significance Index: 32.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6116
    Cell Significance Index: 42.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5623
    Cell Significance Index: 69.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5575
    Cell Significance Index: 15.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4948
    Cell Significance Index: 10.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4922
    Cell Significance Index: 88.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4276
    Cell Significance Index: 30.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4151
    Cell Significance Index: 26.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3837
    Cell Significance Index: 52.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3669
    Cell Significance Index: 16.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3559
    Cell Significance Index: 127.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3447
    Cell Significance Index: 16.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3405
    Cell Significance Index: 40.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3306
    Cell Significance Index: 146.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3293
    Cell Significance Index: 179.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3216
    Cell Significance Index: 8.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3042
    Cell Significance Index: 18.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2796
    Cell Significance Index: 3.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2678
    Cell Significance Index: 17.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2658
    Cell Significance Index: 34.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2657
    Cell Significance Index: 14.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2345
    Cell Significance Index: 18.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1683
    Cell Significance Index: 12.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1672
    Cell Significance Index: 3.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1105
    Cell Significance Index: 76.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1055
    Cell Significance Index: 4.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0851
    Cell Significance Index: 2.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0766
    Cell Significance Index: 1.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0723
    Cell Significance Index: 9.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0593
    Cell Significance Index: 1.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0568
    Cell Significance Index: 5.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0564
    Cell Significance Index: 1.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0500
    Cell Significance Index: 94.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0484
    Cell Significance Index: 0.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0477
    Cell Significance Index: 88.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0439
    Cell Significance Index: 8.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0222
    Cell Significance Index: 34.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0095
    Cell Significance Index: 0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0094
    Cell Significance Index: 5.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0056
    Cell Significance Index: 7.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0113
    Cell Significance Index: -0.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0147
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0202
    Cell Significance Index: -15.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0216
    Cell Significance Index: -9.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0247
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0369
    Cell Significance Index: -27.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0509
    Cell Significance Index: -2.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0525
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0532
    Cell Significance Index: -33.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0943
    Cell Significance Index: -2.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1055
    Cell Significance Index: -12.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1062
    Cell Significance Index: -4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1074
    Cell Significance Index: -30.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1208
    Cell Significance Index: -3.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1209
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1625
    Cell Significance Index: -34.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1838
    Cell Significance Index: -21.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1896
    Cell Significance Index: -3.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2141
    Cell Significance Index: -5.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2162
    Cell Significance Index: -4.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2284
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2522
    Cell Significance Index: -16.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2552
    Cell Significance Index: -26.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2601
    Cell Significance Index: -6.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3095
    Cell Significance Index: -3.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3102
    Cell Significance Index: -7.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3168
    Cell Significance Index: -16.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3214
    Cell Significance Index: -2.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3299
    Cell Significance Index: -3.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3312
    Cell Significance Index: -20.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3373
    Cell Significance Index: -26.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3554
    Cell Significance Index: -18.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3875
    Cell Significance Index: -12.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3983
    Cell Significance Index: -6.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4790
    Cell Significance Index: -7.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5021
    Cell Significance Index: -11.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5136
    Cell Significance Index: -3.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5720
    Cell Significance Index: -12.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional enzyme:** The GART protein is a multifunctional enzyme that catalyzes multiple reactions in the de novo purine biosynthetic pathway. 2. **Phosphoribosylglycinamide formyltransferase activity:** The GART protein exhibits phosphoribosylglycinamide formyltransferase activity, which is essential for the conversion of phosphoribosylglycinamide to phosphoribosylformylglycinamidine. 3. **Significant expression in various cell types:** The GART gene is significantly expressed in various cell types, including erythroid progenitor cells, choroid plexus epithelial cells, and skeletal muscle satellite stem cells. 4. **Implicated in purine nucleotide biosynthesis:** The GART gene is essential for the production of adenine, guanine, and other purine nucleotides, which are critical components of DNA and RNA. **Pathways and Functions:** 1. **De novo purine biosynthetic pathway:** The GART gene is involved in the de novo purine biosynthetic pathway, which is responsible for the production of adenine, guanine, and other purine nucleotides. 2. **Amp biosynthetic process:** The GART gene is also involved in the amp biosynthetic process, which is essential for the production of adenosine monophosphate (AMP). 3. **Implicated in brain development:** The GART gene is involved in brain development, particularly in the formation of the cerebral cortex, cerebellum, and brainstem. 4. **Involvement in nucleotide biosynthesis:** The GART gene is essential for the production of nucleotides, which are critical components of DNA and RNA. **Clinical Significance:** 1. **Implications for anemia:** Mutations in the GART gene have been associated with anemia, particularly in cases of severe anemia. 2. **Implications for cancer:** The GART gene is involved in the biosynthesis of purine nucleotides, which are critical components of DNA and RNA. Mutations in the GART gene may contribute to the development of cancer. 3. **Implications for neurological disorders:** The GART gene is involved in brain development, particularly in the formation of the cerebral cortex, cerebellum, and brainstem. Mutations in the GART gene may contribute to neurological disorders, such as cerebral palsy and autism. 4. **Potential therapeutic targets:** The GART gene is a potential therapeutic target for the treatment of anemia, cancer, and neurological disorders. In conclusion, the GART gene is a crucial gene involved in the biosynthesis of purine nucleotides. Its multifunctional enzyme activity and significant expression in various cell types make it an essential gene for human health. Mutations in the GART gene have been associated with anemia, cancer, and neurological disorders, highlighting its potential as a therapeutic target. Further research is needed to fully understand the implications of the GART gene for human health.

Genular Protein ID: 3724614879

Symbol: PUR2_HUMAN

Name: Glycinamide ribonucleotide synthetase

UniProtKB Accession Codes:

P22102 A8K945 A8KA32 D3DSF3 D3DSF4 O14659 Q52M77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 12 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 3 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 3 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 6 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2147474

Title: De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli.

PubMed ID: 2147474

DOI: 10.1093/nar/18.22.6665

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9224613

Title: Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene.

PubMed ID: 9224613

DOI: 10.1093/nar/25.15.3118

PubMed ID: 2183217

Title: Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

PubMed ID: 2183217

DOI: 10.1073/pnas.87.8.2916

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12450384

Title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

PubMed ID: 12450384

DOI: 10.1021/bi020522m

PubMed ID: 12755606

Title: Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

PubMed ID: 12755606

DOI: 10.1021/bi034219c

PubMed ID: 16026156

Title: The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.

PubMed ID: 16026156

DOI: 10.1021/bi050307g

PubMed ID: 20631005

Title: Structural studies of tri-functional human GART.

PubMed ID: 20631005

DOI: 10.1093/nar/gkq595

Sequence Information:

  • Length: 1010
  • Mass: 107767
  • Checksum: 9A4213F746EB17A2
  • Sequence:
    • MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI SISDHTALAQ 
FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA AQLESSKRFA KEFMDRHGIP 
TAQWKAFTKP EEACSFILSA DFPALVVKAS GLAAGKGVIV AKSKEEACKA VQEIMQEKAF 
GAAGETIVIE ELLDGEEVSC LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP 
QVSNDLLLKI KDTVLQRTVD GMQQEGTPYT GILYAGIMLT KNGPKVLEFN CRFGDPECQV 
ILPLLKSDLY EVIQSTLDGL LCTSLPVWLE NHTALTVVMA SKGYPGDYTK GVEITGFPEA 
QALGLEVFHA GTALKNGKVV THGGRVLAVT AIRENLISAL EEAKKGLAAI KFEGAIYRKD 
VGFRAIAFLQ QPRSLTYKES GVDIAAGNML VKKIQPLAKA TSRSGCKVDL GGFAGLFDLK 
AAGFKDPLLA SGTDGVGTKL KIAQLCNKHD TIGQDLVAMC VNDILAQGAE PLFFLDYFSC 
GKLDLSVTEA VVAGIAKACG KAGCALLGGE TAEMPDMYPP GEYDLAGFAV GAMERDQKLP 
HLERITEGDV VVGIASSGLH SNGFSLVRKI VAKSSLQYSS PAPDGCGDQT LGDLLLTPTR 
IYSHSLLPVL RSGHVKAFAH ITGGGLLENI PRVLPEKLGV DLDAQTWRIP RVFSWLQQEG 
HLSEEEMART FNCGVGAVLV VSKEQTEQIL RDIQQHKEEA WVIGSVVARA EGSPRVKVKN 
LIESMQINGS VLKNGSLTNH FSFEKKKARV AVLISGTGSN LQALIDSTRE PNSSAQIDIV 
ISNKAAVAGL DKAERAGIPT RVINHKLYKN RVEFDSAIDL VLEEFSIDIV CLAGFMRILS 
GPFVQKWNGK MLNIHPSLLP SFKGSNAHEQ ALETGVTVTG CTVHFVAEDV DAGQIILQEA 
VPVKRGDTVA TLSERVKLAE HKIFPAALQL VASGTVQLGE NGKICWVKEE

Genular Protein ID: 1126974559

Symbol: Q59HH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HH3

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 18 DNASU 1 DisGeNET 1 EC 3 EMBL 2 GO 9 Gene3D 7 HAMAP 3 IntAct 1 InterPro 19 NCBI Taxonomy 1 NCBIfam 3 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 2 SUPFAM 6 UniPathway 1

Sequence Information:

  • Length: 1046
  • Mass: 112138
  • Checksum: DF03CB4B83AE9EEA
  • Sequence:
    • RRRGRRARRA TRCLTHGFQA LSGFIFLWNF CFTDRTMAAR VLIIGSGGRE HTLAWKLAQS 
HHVKQVLVAP GNAGTACSEK ISNTAISISD HTALAQFCKE KKIEFVVVGP EAPLAAGIVG 
NLRSAGVQCF GPTAEAAQLE SSKRFAKEFM DRHGIPTAQW KAFTKPEEAC SFILSADFPA 
LVVKASGLAA GKGVIVAKSK EEACKAVQEI MQEKAFGAAG ETIVIEELLD GEEVSCLCFT 
DGKTVAPMPP AQDHKRLLEG DGGPNTGGMG AYCPAPQVSN DLLLKIKDTV LQRTVDGMQQ 
EGTPYTGILY AGIMLTKNGP KVLEFNCRFG DPECQVILPL LKSDLYEVIQ STLDGLLCTS 
LPVWLENHTA LTVVMASKGY PGDYTKGVEI TGFPEAQALG LEVFHAGTAL KNGKVVTHGG 
RVLAVTAIRE NLISALEEAK KGLAAIKFEG AIYRKDIGFR AIAFLQQPRS LTYKESGVDI 
AAGNMLVKKI QPLAKATSRS GCKVDLGGFA GLFDLKAAGF KDPLLASGTD GVGTKLKIAQ 
LCNKHDTIGQ DLVAMCVNDI LAQGAEPLFF LDYFSCGKLD LSVTEAVVAG IAKACGKAGC 
ALLGGETAEM PDMYPPGEYD LAGFAVGAME RDQKLPHLER ITEGDVVVGI ASSGLHSNGF 
SLVRKIVAKS SLQYSSPAPD GCGDQTLGDL LLTPTRIYSH SLLPVLRSGH VKAFAHITGG 
GLLENIPRVL PEKLGVDLDA QTWRIPRVFS WLQQEGHLSE EEMARTFNCG VGAVLVVSKE 
QTEQILRDIQ QHKEEAWVIG SVVARAEGSP RVKVKNLIES MQINGSVLKN GSLTNHFSFE 
KKKARVAVLI SGTGSNLQAL IDSTREPNSS AQIDIVISNK AAVAGLDKAE RAGIPTRVIN 
HKLYKNRVEF DSAIDLVLEE FSIDIVCLAG FMRILSGPFV QKWNGKMLNI HPSLLPSFKG 
SNAHEQALET GVTVTGCTVH FVAEDVDAGQ IILQEAVPVK RGDTVATLSE RVKLAEHKIF 
PAALQLVASG TVQLGENGKI CWVKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.