Details for: NIPSNAP2

Gene ID: 2631

Symbol: NIPSNAP2

Ensembl ID: ENSG00000146729

Description: nipsnap homolog 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.3400
    Cell Significance Index: -63.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.0105
    Cell Significance Index: -65.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.9516
    Cell Significance Index: -53.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 117.8689
    Cell Significance Index: -60.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.9550
    Cell Significance Index: -65.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.8684
    Cell Significance Index: -53.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.5129
    Cell Significance Index: -57.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1850
    Cell Significance Index: -46.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8785
    Cell Significance Index: -21.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6456
    Cell Significance Index: 2388.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0579
    Cell Significance Index: 123.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6049
    Cell Significance Index: 123.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5545
    Cell Significance Index: 37.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5198
    Cell Significance Index: 70.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5062
    Cell Significance Index: 244.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4154
    Cell Significance Index: 283.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3268
    Cell Significance Index: 239.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1355
    Cell Significance Index: 620.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9904
    Cell Significance Index: 121.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9562
    Cell Significance Index: 342.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9383
    Cell Significance Index: 414.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9203
    Cell Significance Index: 65.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8592
    Cell Significance Index: 117.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8285
    Cell Significance Index: 164.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8253
    Cell Significance Index: 11.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7790
    Cell Significance Index: 35.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7744
    Cell Significance Index: 11.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7695
    Cell Significance Index: 57.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6863
    Cell Significance Index: 474.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6045
    Cell Significance Index: 33.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6010
    Cell Significance Index: 16.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4559
    Cell Significance Index: 13.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4504
    Cell Significance Index: 23.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3770
    Cell Significance Index: 10.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3739
    Cell Significance Index: 8.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3391
    Cell Significance Index: 43.4700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3297
    Cell Significance Index: 5.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3280
    Cell Significance Index: 8.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3043
    Cell Significance Index: 6.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2959
    Cell Significance Index: 29.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2923
    Cell Significance Index: 37.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2293
    Cell Significance Index: 11.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1902
    Cell Significance Index: 8.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1733
    Cell Significance Index: 9.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1410
    Cell Significance Index: 9.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1183
    Cell Significance Index: 222.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1019
    Cell Significance Index: 2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0959
    Cell Significance Index: 4.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0665
    Cell Significance Index: 122.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0622
    Cell Significance Index: 11.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0525
    Cell Significance Index: 80.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0521
    Cell Significance Index: 38.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0517
    Cell Significance Index: 23.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0355
    Cell Significance Index: 2.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0344
    Cell Significance Index: 21.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0227
    Cell Significance Index: 1.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0152
    Cell Significance Index: 20.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0039
    Cell Significance Index: -0.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0198
    Cell Significance Index: -2.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0671
    Cell Significance Index: -49.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0674
    Cell Significance Index: -6.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0716
    Cell Significance Index: -2.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0717
    Cell Significance Index: -2.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0987
    Cell Significance Index: -55.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1015
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1128
    Cell Significance Index: -70.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1267
    Cell Significance Index: -14.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1281
    Cell Significance Index: -2.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1548
    Cell Significance Index: -22.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1571
    Cell Significance Index: -2.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1885
    Cell Significance Index: -54.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2223
    Cell Significance Index: -7.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2743
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3262
    Cell Significance Index: -68.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3324
    Cell Significance Index: -38.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3715
    Cell Significance Index: -9.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3729
    Cell Significance Index: -3.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4439
    Cell Significance Index: -35.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4921
    Cell Significance Index: -51.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5553
    Cell Significance Index: -17.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6881
    Cell Significance Index: -13.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7783
    Cell Significance Index: -16.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7895
    Cell Significance Index: -20.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8003
    Cell Significance Index: -7.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8278
    Cell Significance Index: -50.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9609
    Cell Significance Index: -11.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0434
    Cell Significance Index: -27.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0704
    Cell Significance Index: -25.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1553
    Cell Significance Index: -33.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1680
    Cell Significance Index: -24.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1952
    Cell Significance Index: -22.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2845
    Cell Significance Index: -52.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2886
    Cell Significance Index: -41.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.2926
    Cell Significance Index: -22.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3187
    Cell Significance Index: -46.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3424
    Cell Significance Index: -49.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3777
    Cell Significance Index: -40.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.3852
    Cell Significance Index: -11.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3902
    Cell Significance Index: -30.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NIPSNAP2 is a mitochondrial protein that exhibits a unique structure, consisting of two tandem repeats of the NipSnap domain. This domain is essential for binding to and regulating the activity of Rho GTPases, which are crucial for maintaining mitochondrial function and integrity. NIPSNAP2 has been shown to interact with other mitochondrial proteins, including Miro and Rhobtb3, to regulate mitochondrial dynamics and oxidative phosphorylation. **Pathways and Functions:** NIPSNAP2 is involved in several critical signaling pathways, including: 1. **Mitochondrial outer membrane permeabilization (MOMP):** NIPSNAP2 regulates the opening of the mitochondrial outer membrane, which is essential for apoptosis and cell death. Dysregulation of NIPSNAP2 has been linked to various diseases, including cancer and neurodegenerative disorders. 2. **Oxidative phosphorylation:** NIPSNAP2 is involved in regulating the activity of Complex I and Complex III of the mitochondrial electron transport chain, which is essential for energy production in cells. 3. **Calcium signaling:** NIPSNAP2 regulates the activity of high-voltage-gated calcium channels, which are essential for calcium signaling in cardiac muscle cells. 4. **Rho GTPase cycle:** NIPSNAP2 regulates the activity of Rho GTPases, which are involved in regulating mitochondrial dynamics, oxidative phosphorylation, and cell survival. **Clinical Significance:** Dysregulation of NIPSNAP2 has been implicated in various diseases, including: 1. **Cardiovascular disease:** NIPSNAP2 has been linked to cardiac arrhythmias, cardiac failure, and myocardial infarction. 2. **Neurodegenerative disorders:** NIPSNAP2 has been implicated in Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Cancer:** NIPSNAP2 has been linked to cancer progression, metastasis, and chemotherapy resistance. 4. **Inflammatory disorders:** NIPSNAP2 has been implicated in inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. In conclusion, NIPSNAP2 is a critical regulator of mitochondrial function and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of NIPSNAP2 in maintaining cellular homeostasis. Further research is necessary to elucidate the full extent of NIPSNAP2's role in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 2567577043

Symbol: NIPS2_HUMAN

Name: Protein NipSnap homolog 2

UniProtKB Accession Codes:

O75323 C9IYJ3 O43801 Q53X96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9615231

Title: GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR.

PubMed ID: 9615231

DOI: 10.1006/geno.1998.5239

PubMed ID: 9661659

Title: Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.

PubMed ID: 9661659

DOI: 10.1016/s0378-1119(98)00098-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26387735

Title: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.

PubMed ID: 26387735

DOI: 10.1016/j.molcel.2015.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30982665

Title: NIPSNAP1 and NIPSNAP2 act as 'eat me' signals for mitophagy.

PubMed ID: 30982665

DOI: 10.1016/j.devcel.2019.03.013

Sequence Information:

  • Length: 286
  • Mass: 33743
  • Checksum: 7ED85297E4DC9D08
  • Sequence:
    • MAARVLRARG AAWAGGLLQR AAPCSLLPRL RTWTSSSNRS REDSWLKSLF VRKVDPRKDA 
HSNLLAKKET SNLYKLQFHN VKPECLEAYN KICQEVLPKI HEDKHYPCTL VGTWNTWYGE 
QDQAVHLWRY EGGYPALTEV MNKLRENKEF LEFRKARSDM LLSRKNQLLL EFSFWNEPVP 
RSGPNIYELR SYQLRPGTMI EWGNYWARAI RFRQDGNEAV GGFFSQIGQL YMVHHLWAYR 
DLQTREDIRN AAWHKHGWEE LVYYTVPLIQ EMESRIMIPL KTSPLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.