Details for: OSTF1

Gene ID: 26578

Symbol: OSTF1

Ensembl ID: ENSG00000134996

Description: osteoclast stimulating factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 262.7532
    Cell Significance Index: -40.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.5353
    Cell Significance Index: -37.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.7212
    Cell Significance Index: -42.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.3142
    Cell Significance Index: -45.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.1647
    Cell Significance Index: -45.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.1513
    Cell Significance Index: -45.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.2687
    Cell Significance Index: -43.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.8674
    Cell Significance Index: -42.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7336
    Cell Significance Index: -25.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.4766
    Cell Significance Index: -35.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0845
    Cell Significance Index: -43.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.7493
    Cell Significance Index: 168.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.4628
    Cell Significance Index: 52.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3265
    Cell Significance Index: 43.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2130
    Cell Significance Index: 59.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1496
    Cell Significance Index: 349.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5424
    Cell Significance Index: 99.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4937
    Cell Significance Index: 162.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.3476
    Cell Significance Index: -3.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2268
    Cell Significance Index: 221.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1940
    Cell Significance Index: 239.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0767
    Cell Significance Index: 126.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0517
    Cell Significance Index: 129.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8582
    Cell Significance Index: 44.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7365
    Cell Significance Index: 34.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6792
    Cell Significance Index: 4.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5797
    Cell Significance Index: 316.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4492
    Cell Significance Index: 21.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4368
    Cell Significance Index: 193.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4215
    Cell Significance Index: 29.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3706
    Cell Significance Index: 50.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3469
    Cell Significance Index: 44.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3406
    Cell Significance Index: 9.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2688
    Cell Significance Index: 53.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2645
    Cell Significance Index: 7.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1687
    Cell Significance Index: 16.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1529
    Cell Significance Index: 29.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1176
    Cell Significance Index: 17.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1027
    Cell Significance Index: 2.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0895
    Cell Significance Index: 1.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0771
    Cell Significance Index: 0.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0476
    Cell Significance Index: 32.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0411
    Cell Significance Index: 55.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0031
    Cell Significance Index: 5.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0051
    Cell Significance Index: -0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0092
    Cell Significance Index: -3.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0285
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0354
    Cell Significance Index: -2.6400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0372
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0417
    Cell Significance Index: -30.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0427
    Cell Significance Index: -27.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0456
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0577
    Cell Significance Index: -42.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0587
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0731
    Cell Significance Index: -33.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0755
    Cell Significance Index: -42.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0780
    Cell Significance Index: -48.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1071
    Cell Significance Index: -5.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1241
    Cell Significance Index: -35.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1324
    Cell Significance Index: -15.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1389
    Cell Significance Index: -23.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1692
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2159
    Cell Significance Index: -24.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2334
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2338
    Cell Significance Index: -49.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2655
    Cell Significance Index: -9.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2661
    Cell Significance Index: -3.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2903
    Cell Significance Index: -4.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3240
    Cell Significance Index: -24.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3280
    Cell Significance Index: -8.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3514
    Cell Significance Index: -22.1500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.3584
    Cell Significance Index: -0.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3733
    Cell Significance Index: -16.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3825
    Cell Significance Index: -12.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4109
    Cell Significance Index: -42.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5003
    Cell Significance Index: -12.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5232
    Cell Significance Index: -41.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5379
    Cell Significance Index: -20.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5417
    Cell Significance Index: -28.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5502
    Cell Significance Index: -11.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5534
    Cell Significance Index: -37.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5759
    Cell Significance Index: -35.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5821
    Cell Significance Index: -30.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7325
    Cell Significance Index: -44.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7330
    Cell Significance Index: -41.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7926
    Cell Significance Index: -22.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8066
    Cell Significance Index: -36.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8457
    Cell Significance Index: -14.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9471
    Cell Significance Index: -15.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9545
    Cell Significance Index: -18.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9567
    Cell Significance Index: -14.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9671
    Cell Significance Index: -39.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9691
    Cell Significance Index: -42.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0031
    Cell Significance Index: -35.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0131
    Cell Significance Index: -8.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0418
    Cell Significance Index: -17.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immune Cell Expression:** OSTF1 is expressed in a wide range of immune cells, including decidual natural killer cells, T cells, and monocytes, indicating its importance in immune regulation. 2. **Signal Transduction Pathways:** OSTF1 is involved in various signal transduction pathways, including those related to immune response, osteoclast formation, and neutrophil degranulation. 3. **Protein Binding:** The OSTF1 protein interacts with multiple proteins, including those with Sh3 domain-binding capabilities, suggesting its role in protein-protein interactions and signaling. 4. **Innate and Adaptive Immunity:** OSTF1 is involved in both innate and adaptive immune responses, highlighting its broad role in immune regulation. **Pathways and Functions:** 1. **Immune System:** OSTF1 is involved in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 2. **Osteoclast Formation:** OSTF1 is essential for the formation and activation of osteoclasts, which are responsible for bone resorption. 3. **Neutrophil Degranulation:** OSTF1 is involved in the regulation of neutrophil degranulation, a process that leads to the release of inflammatory mediators. 4. **Signal Transduction:** OSTF1 interacts with various signaling molecules to modulate immune cell function and bone metabolism. **Clinical Significance:** 1. **Bone Disorders:** Alterations in OSTF1 expression or function may contribute to bone disorders, such as osteoporosis, osteoarthritis, and Paget's disease. 2. **Immune-Related Disorders:** OSTF1 may play a role in the development of immune-related disorders, including autoimmune diseases and cancer. 3. **Inflammation:** OSTF1's involvement in neutrophil degranulation and immune response regulation makes it a potential target for the treatment of inflammatory diseases. 4. **Cancer:** OSTF1's role in immune regulation and bone metabolism may also make it a potential target for cancer therapy. In conclusion, OSTF1 is a multifaceted gene that plays a crucial role in regulating the immune system and bone metabolism. Its involvement in various signal transduction pathways and its expression in a wide range of immune cells highlight its importance in immune regulation and bone health. Further research is needed to fully understand the clinical significance of OSTF1 and its potential applications in the treatment of bone and immune-related disorders.

Genular Protein ID: 2908295926

Symbol: OSTF1_HUMAN

Name: Osteoclast-stimulating factor 1

UniProtKB Accession Codes:

Q92882 Q5W126 Q96IJ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10092216

Title: Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption.

PubMed ID: 10092216

DOI: 10.1002/(sici)1097-4652(199812)177:4<636::aid-jcp14>3.0.co;2-h

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551898

Title: Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation.

PubMed ID: 11551898

DOI: 10.1074/jbc.m100233200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 214
  • Mass: 23787
  • Checksum: 6C37F3D2B68578C3
  • Sequence:
    • MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW KGTSKGRTGL 
IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHKD 
IVEMLFTQPN IELNQQNKLG DTALHAAAWK GYADIVQLLL AKGARTDLRN IEKKLAFDMA 
TNAACASLLK KKQGTDAVRT LSNAEDYLDD EDSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.