Details for: CKAP2

Gene ID: 26586

Symbol: CKAP2

Ensembl ID: ENSG00000136108

Description: cytoskeleton associated protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.4325
    Cell Significance Index: -11.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.9008
    Cell Significance Index: -16.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7232
    Cell Significance Index: -17.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.1682
    Cell Significance Index: -18.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9486
    Cell Significance Index: -15.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1033
    Cell Significance Index: -16.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4652
    Cell Significance Index: -17.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0974
    Cell Significance Index: -12.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9674
    Cell Significance Index: 14.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9510
    Cell Significance Index: -4.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5377
    Cell Significance Index: 250.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3524
    Cell Significance Index: 35.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3277
    Cell Significance Index: 131.3400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1998
    Cell Significance Index: 6.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1251
    Cell Significance Index: 1015.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0396
    Cell Significance Index: 113.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9896
    Cell Significance Index: 55.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9597
    Cell Significance Index: 113.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7027
    Cell Significance Index: 81.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7000
    Cell Significance Index: 138.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6421
    Cell Significance Index: 6.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6224
    Cell Significance Index: 37.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5652
    Cell Significance Index: 19.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4963
    Cell Significance Index: 13.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4807
    Cell Significance Index: 86.6600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.4611
    Cell Significance Index: 0.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4511
    Cell Significance Index: 29.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4066
    Cell Significance Index: 81.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4022
    Cell Significance Index: 27.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3936
    Cell Significance Index: 9.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3871
    Cell Significance Index: 8.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3355
    Cell Significance Index: 148.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3346
    Cell Significance Index: 120.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3188
    Cell Significance Index: 22.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3186
    Cell Significance Index: 16.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3042
    Cell Significance Index: 37.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2967
    Cell Significance Index: 162.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2872
    Cell Significance Index: 9.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2631
    Cell Significance Index: 3.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2537
    Cell Significance Index: 13.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2437
    Cell Significance Index: 5.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1984
    Cell Significance Index: 5.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1944
    Cell Significance Index: 5.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1698
    Cell Significance Index: 3.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1576
    Cell Significance Index: 9.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1497
    Cell Significance Index: 93.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1345
    Cell Significance Index: 6.1000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1175
    Cell Significance Index: 1.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0900
    Cell Significance Index: 12.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0884
    Cell Significance Index: 1.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0524
    Cell Significance Index: 1.4000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0441
    Cell Significance Index: 0.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0230
    Cell Significance Index: 0.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0060
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0048
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0004
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0097
    Cell Significance Index: -6.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0120
    Cell Significance Index: -2.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0172
    Cell Significance Index: -13.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0312
    Cell Significance Index: -4.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0332
    Cell Significance Index: -9.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0341
    Cell Significance Index: -15.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0342
    Cell Significance Index: -3.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0435
    Cell Significance Index: -0.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0466
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0524
    Cell Significance Index: -11.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0718
    Cell Significance Index: -2.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0770
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0875
    Cell Significance Index: -9.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0934
    Cell Significance Index: -12.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1018
    Cell Significance Index: -11.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1082
    Cell Significance Index: -8.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1128
    Cell Significance Index: -4.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1153
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1174
    Cell Significance Index: -3.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1237
    Cell Significance Index: -4.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1277
    Cell Significance Index: -6.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1284
    Cell Significance Index: -7.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1385
    Cell Significance Index: -2.9500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1386
    Cell Significance Index: -1.2600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1451
    Cell Significance Index: -1.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1558
    Cell Significance Index: -5.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1601
    Cell Significance Index: -3.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1642
    Cell Significance Index: -17.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1975
    Cell Significance Index: -14.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2124
    Cell Significance Index: -16.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2265
    Cell Significance Index: -2.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2459
    Cell Significance Index: -12.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2535
    Cell Significance Index: -3.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2758
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2845
    Cell Significance Index: -8.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CKAP2 is a cytoskeletal protein that belongs to the CKAP family of proteins. It is characterized by its ability to interact with microtubules and regulate their dynamics, thereby influencing the organization and function of the cytoskeleton. CKAP2 has been shown to be involved in various cellular processes, including cell migration, division, and survival. Its expression is widespread, with significant levels detected in neural progenitor cells, oogonial cells, and other cell types involved in development and tissue homeostasis. **Pathways and Functions:** CKAP2 is involved in several key pathways, including: 1. **Apoptotic process:** CKAP2 has been shown to regulate apoptosis by modulating the activity of pro-apoptotic proteins and promoting the formation of apoptotic bodies. 2. **Centrosome and microtubule organization:** CKAP2 interacts with microtubules and regulates their dynamics, influencing the organization and function of the centrosome. 3. **Microtubule cytoskeleton and mitotic cytokinesis:** CKAP2 plays a crucial role in regulating microtubule dynamics during mitosis, influencing the organization of the mitotic spindle and the completion of cytokinesis. 4. **Negative regulation of microtubule depolymerization:** CKAP2 has been shown to inhibit the depolymerization of microtubules, thereby maintaining their stability and function. 5. **Positive regulation of transcription by RNA polymerase II:** CKAP2 has been shown to regulate transcription by interacting with RNA polymerase II and promoting the expression of target genes. **Clinical Significance:** CKAP2 has significant clinical relevance, particularly in the context of various diseases and disorders. For example: 1. **Cancer:** CKAP2 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with tumor progression and metastasis. 2. **Neurodegenerative diseases:** CKAP2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its dysregulation is associated with the disruption of cytoskeletal dynamics and the progression of disease. 3. **Immune system disorders:** CKAP2 has been shown to play a role in the regulation of the immune response, particularly in the context of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In conclusion, CKAP2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell migration, division, and survival. Its significant expression in various cell types and its involvement in multiple pathways make it a key player in the regulation of cellular function and disease. Further research is needed to fully elucidate the mechanisms by which CKAP2 regulates cellular processes and to explore its clinical relevance in various diseases and disorders.

Genular Protein ID: 4031155912

Symbol: CKAP2_HUMAN

Name: Cytoskeleton-associated protein 2

UniProtKB Accession Codes:

Q8WWK9 A2BDE0 A5YM58 B4DR35 E9PD90 Q3KRA5 Q5VXB4 Q8IWV5 Q8IWV6 Q96FH9 Q9H012 Q9H0D0 Q9H988 Q9HC49 Q9NVG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9771967

Title: Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas.

PubMed ID: 9771967

DOI: 10.1038/sj.onc.1202048

PubMed ID: 11234418

Title: Evolutionarily-conserved gene CKAP2, located in region 13q14.3 of the human genome, is frequently rearranged in various tumors.

PubMed ID: 11234418

PubMed ID: 12942315

Title: Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas.

PubMed ID: 12942315

DOI: 10.1007/s00432-003-0484-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11149944

Title: Serological detection of cutaneous T-cell lymphoma-associated antigens.

PubMed ID: 11149944

DOI: 10.1073/pnas.98.2.629

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17376772

Title: CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit.

PubMed ID: 17376772

DOI: 10.1074/jbc.m701688200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 683
  • Mass: 76987
  • Checksum: 15287A7D860A4B23
  • Sequence:
    • MSTPAVPQDL QLPPSQRAQS AFKEQRRQKL KEHLLRRKTL FAYKQENEML SSSRDQRVVT 
SEDQVQEGTK VLKLKTKMAD KENMKRPAES KNNTVVGKHC IPLKPSNELT NSTVVIDTHK 
PKDSNQTPHL LLTEDDPQSQ HMTLSQAFHL KNNSKKKQMT TEKQKQDANM PKKPVLGSYR 
GQIVQSKINS FRKPLQVKDE SSAATKKLSA TIPKATKPQP VNTSSVTVKS NRSSNMTATT 
KFVSTTSQNT QLVRPPIRSH HSNTRDTVKQ GISRTSANVT IRKGPHEKEL LQSKTALSSV 
KTSSSQGIIR NKTLSRSIAS EVIARPASLS NDKLMEKSEP VDQRRHTAGK AIVDSRSAQP 
KETSEERKAR LSEWKAGKGR VLKRPPNSVV TQHEPAGQNE KPVGSFWTTM AEEDEQRLFT 
EKVNNTFSEC LNLINEGCPK EDILVTLNDL IKNIPDAKKL VKYWICLALI EPITSPIENI 
IAIYEKAILA GAQPIEEMRH TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV 
DVDPEKLEME SKLHRNLLFQ DCEKEQDNKT KDPTHDVKTP NTETRTSCLI KYNVSTTPYL 
QSVKKKVQFD GTNSAFKELK FLTPVRRSRR LQEKTSKLPD MLKDHYPCVS SLEQLTELGR 
ETDAFVCRPN AALCRVYYEA DTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.