Details for: ELP4

Gene ID: 26610

Symbol: ELP4

Ensembl ID: ENSG00000109911

Description: elongator acetyltransferase complex subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.6684
    Cell Significance Index: -43.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.1100
    Cell Significance Index: -42.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 119.5844
    Cell Significance Index: -49.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.3989
    Cell Significance Index: -45.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.1800
    Cell Significance Index: -36.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.3841
    Cell Significance Index: -44.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3349
    Cell Significance Index: -41.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3166
    Cell Significance Index: -37.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4444
    Cell Significance Index: -45.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0528
    Cell Significance Index: -24.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.1462
    Cell Significance Index: 122.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.3916
    Cell Significance Index: 302.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.3211
    Cell Significance Index: 53.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.7256
    Cell Significance Index: 58.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5622
    Cell Significance Index: 253.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0615
    Cell Significance Index: 739.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0433
    Cell Significance Index: 409.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0337
    Cell Significance Index: 1406.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8839
    Cell Significance Index: 71.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7942
    Cell Significance Index: 79.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7600
    Cell Significance Index: 3313.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.6340
    Cell Significance Index: 2515.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5459
    Cell Significance Index: 306.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4998
    Cell Significance Index: 115.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4046
    Cell Significance Index: 228.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3277
    Cell Significance Index: 2448.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2869
    Cell Significance Index: 1161.9400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.1964
    Cell Significance Index: 16.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0542
    Cell Significance Index: 29.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0245
    Cell Significance Index: 62.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9832
    Cell Significance Index: 23.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8342
    Cell Significance Index: 56.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8131
    Cell Significance Index: 15.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6441
    Cell Significance Index: 18.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6009
    Cell Significance Index: 381.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4872
    Cell Significance Index: 56.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3642
    Cell Significance Index: 16.5100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3082
    Cell Significance Index: 3.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2902
    Cell Significance Index: 30.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2597
    Cell Significance Index: 353.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2590
    Cell Significance Index: 17.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2556
    Cell Significance Index: 46.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2480
    Cell Significance Index: 3.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2044
    Cell Significance Index: 5.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2008
    Cell Significance Index: 4.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1938
    Cell Significance Index: 87.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1278
    Cell Significance Index: 15.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1127
    Cell Significance Index: 1.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0971
    Cell Significance Index: 42.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0692
    Cell Significance Index: 37.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0579
    Cell Significance Index: 3.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0062
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0099
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0272
    Cell Significance Index: -20.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0340
    Cell Significance Index: -24.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0381
    Cell Significance Index: -23.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0507
    Cell Significance Index: -28.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0605
    Cell Significance Index: -45.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0723
    Cell Significance Index: -9.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0953
    Cell Significance Index: -4.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1234
    Cell Significance Index: -23.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1250
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1335
    Cell Significance Index: -28.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1346
    Cell Significance Index: -38.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1579
    Cell Significance Index: -5.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1619
    Cell Significance Index: -20.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1913
    Cell Significance Index: -19.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2146
    Cell Significance Index: -27.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2174
    Cell Significance Index: -5.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2385
    Cell Significance Index: -3.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2457
    Cell Significance Index: -3.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2630
    Cell Significance Index: -13.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2794
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2827
    Cell Significance Index: -32.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3000
    Cell Significance Index: -19.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3010
    Cell Significance Index: -6.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3235
    Cell Significance Index: -22.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3365
    Cell Significance Index: -8.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3652
    Cell Significance Index: -5.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3683
    Cell Significance Index: -17.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4006
    Cell Significance Index: -29.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4029
    Cell Significance Index: -45.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4089
    Cell Significance Index: -19.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4098
    Cell Significance Index: -6.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4451
    Cell Significance Index: -11.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4533
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4621
    Cell Significance Index: -36.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5801
    Cell Significance Index: -10.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5929
    Cell Significance Index: -14.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5999
    Cell Significance Index: -36.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6177
    Cell Significance Index: -13.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6259
    Cell Significance Index: -32.6000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.6657
    Cell Significance Index: -4.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6857
    Cell Significance Index: -21.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6953
    Cell Significance Index: -13.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7181
    Cell Significance Index: -23.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7556
    Cell Significance Index: -14.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7639
    Cell Significance Index: -10.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the Elongator Complex:** ELP4 is a subunit of the elongator complex, a heteropentameric enzyme complex composed of ELP1, ELP2, ELP3, ELP4, and ELP5. 2. **Acetyltransferase Activity:** ELP4 possesses acetyltransferase activity, which is essential for the modification of histones and other proteins. 3. **RNA Polymerase II Regulation:** ELP4 modulates the activity of RNA polymerase II, a critical enzyme in the transcriptional process. 4. **Widespread Expression:** ELP4 is expressed in various cell types, including those of the nervous system, epithelial cells, and muscle cells. **Pathways and Functions:** 1. **Chromatin Modifying Enzymes:** ELP4 participates in chromatin modifying enzymes, which play a crucial role in regulating gene expression by modifying chromatin structure. 2. **Transcription Elongation:** ELP4 is involved in transcription elongation by RNA polymerase II, a process that is essential for the regulation of gene expression. 3. **Protein Binding:** ELP4 interacts with various proteins, including histones, transcription factors, and RNA polymerase II, to regulate gene expression. 4. **Regulation of Translation:** ELP4 may also modulate the translation of mRNAs, although the exact mechanisms are not yet fully understood. **Clinical Significance:** Dysregulation of ELP4 has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in ELP4 have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** ELP4 is often overexpressed in cancer cells, where it may contribute to tumorigenesis and cancer progression. 3. **Developmental Disorders:** ELP4 has been implicated in developmental disorders, such as Down syndrome and intellectual disability. In conclusion, ELP4 is a critical regulator of gene expression and cellular function, with implications for various diseases. Further research is needed to fully elucidate the mechanisms of ELP4 and its role in human health and disease.

Genular Protein ID: 3624983799

Symbol: ELP4_HUMAN

Name: Elongator complex protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11889558

Title: Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance.

PubMed ID: 11889558

DOI: 10.1007/s00335-001-3058-y

PubMed ID: 11714725

Title: Purification and characterization of the human elongator complex.

PubMed ID: 11714725

DOI: 10.1074/jbc.m110445200

PubMed ID: 11818576

Title: Human Elongator facilitates RNA polymerase II transcription through chromatin.

PubMed ID: 11818576

DOI: 10.1073/pnas.251672198

PubMed ID: 16713582

Title: Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia.

PubMed ID: 16713582

DOI: 10.1016/j.molcel.2006.04.017

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22854966

Title: DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.

PubMed ID: 22854966

DOI: 10.1074/jbc.m112.402727

PubMed ID: 24290376

Title: Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.

PubMed ID: 24290376

DOI: 10.1016/j.ajhg.2013.10.028

PubMed ID: 29332244

Title: Structural insights into the function of Elongator.

PubMed ID: 29332244

DOI: 10.1007/s00018-018-2747-6

Sequence Information:

  • Length: 424
  • Mass: 46588
  • Checksum: A044C964F7C91E73
  • Sequence:
  • MAAVATCGSV AASTGSAVAT ASKSNVTSFQ RRGPRASVTN DSGPRLVSIA GTRPSVRNGQ 
    LLVSTGLPAL DQLLGGGLAV GTVLLIEEDK YNIYSPLLFK YFLAEGIVNG HTLLVASAKE 
    DPANILQELP APLLDDKCKK EFDEDVYNHK TPESNIKMKI AWRYQLLPKM EIGPVSSSRF 
    GHYYDASKRM PQELIEASNW HGFFLPEKIS STLKVEPCSL TPGYTKLLQF IQNIIYEEGF 
    DGSNPQKKQR NILRIGIQNL GSPLWGDDIC CAENGGNSHS LTKFLYVLRG LLRTSLSACI 
    ITMPTHLIQN KAIIARVTTL SDVVVGLESF IGSERETNPL YKDYHGLIHI RQIPRLNNLI 
    CDESDVKDLA FKLKRKLFTI ERLHLPPDLS DTVSRSSKMD LAESAKRLGP GCGMMAGGKK 
    HLDF

Genular Protein ID: 3018237540

Symbol: G5E9D4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 535
  • Mass: 58833
  • Checksum: 892DAD8B52F5E526
  • Sequence:
  • MAAVATCGSV AASTGSAVAT ASKSNVTSFQ RRGPRASVTN DSGPRLVSIA GTRPSVRNGQ 
    LLVSTGLPAL DQLLGGGLAV GTVLLIEEDK YNIYSPLLFK YFLAEGIVNG HTLLVASAKE 
    DPANILQELP APLLDDKCKK EFDEDVYNHK TPESNIKMKI AWRYQLLPKM EIGPVSSSRF 
    GHYYDASKRM PQELIEASNW HGFFLPEKIS STLKVEPCSL TPGYTKLLQF IQNIIYEEGF 
    DGSNPQKKQR NILRIGIQNL GSPLWGDDIC CAENGGNSHS LTKFLYVLRG LLRTSLSACI 
    ITMPTHLIQN KAIIARVTTL SDVVVGLESF IGSERETNPL YKDYHGLIHI RQIPRLNNLI 
    CDESDVKDLA FKLKRKLFTI EAGVQWHDLG SRQPRLLGSS NSPASASLVA GITGAHHHTQ 
    LIFVFLVEMG FHHVGQAGLE LLTSGDSSAS ASQSAGITGM SYRARPRALY FKENKSKVGA 
    RQLLETREEH LSSRLLILTQ AERLCMGRRF FTAFHIFNEL PCKGDCICLQ TCQTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.