Details for: RANBP6

Gene ID: 26953

Symbol: RANBP6

Ensembl ID: ENSG00000137040

Description: RAN binding protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.4490
    Cell Significance Index: -14.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.4572
    Cell Significance Index: -14.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.8516
    Cell Significance Index: -15.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5228
    Cell Significance Index: -15.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4874
    Cell Significance Index: -14.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9926
    Cell Significance Index: -15.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1861
    Cell Significance Index: 341.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0044
    Cell Significance Index: 63.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8050
    Cell Significance Index: 6.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7627
    Cell Significance Index: 21.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6975
    Cell Significance Index: 75.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6526
    Cell Significance Index: 106.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4915
    Cell Significance Index: 22.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4834
    Cell Significance Index: 96.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3763
    Cell Significance Index: 19.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3512
    Cell Significance Index: 24.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3443
    Cell Significance Index: 7.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2782
    Cell Significance Index: 17.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2734
    Cell Significance Index: 3.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2643
    Cell Significance Index: 116.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2461
    Cell Significance Index: 48.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2389
    Cell Significance Index: 85.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2010
    Cell Significance Index: 24.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1985
    Cell Significance Index: 35.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1972
    Cell Significance Index: 12.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1932
    Cell Significance Index: 174.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1909
    Cell Significance Index: 18.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1636
    Cell Significance Index: 4.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1630
    Cell Significance Index: 22.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1547
    Cell Significance Index: 29.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1486
    Cell Significance Index: 81.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1412
    Cell Significance Index: 4.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1291
    Cell Significance Index: 2.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1244
    Cell Significance Index: 8.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1090
    Cell Significance Index: 5.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1074
    Cell Significance Index: 1.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0733
    Cell Significance Index: 8.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0632
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0612
    Cell Significance Index: 7.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0593
    Cell Significance Index: 3.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0544
    Cell Significance Index: 1.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0356
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0305
    Cell Significance Index: 5.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0276
    Cell Significance Index: 2.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0246
    Cell Significance Index: 1.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0187
    Cell Significance Index: 0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0165
    Cell Significance Index: 0.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0121
    Cell Significance Index: 0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0068
    Cell Significance Index: 9.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0059
    Cell Significance Index: 0.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0034
    Cell Significance Index: 2.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0084
    Cell Significance Index: -15.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0248
    Cell Significance Index: -1.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0266
    Cell Significance Index: -0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0270
    Cell Significance Index: -2.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0293
    Cell Significance Index: -1.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0310
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0343
    Cell Significance Index: -7.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0419
    Cell Significance Index: -4.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0420
    Cell Significance Index: -6.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0489
    Cell Significance Index: -6.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0509
    Cell Significance Index: -5.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0569
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0666
    Cell Significance Index: -7.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0913
    Cell Significance Index: -2.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1064
    Cell Significance Index: -1.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1070
    Cell Significance Index: -2.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1388
    Cell Significance Index: -8.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1460
    Cell Significance Index: -11.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1472
    Cell Significance Index: -15.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1732
    Cell Significance Index: -7.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1817
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2015
    Cell Significance Index: -5.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2052
    Cell Significance Index: -7.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2170
    Cell Significance Index: -6.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2247
    Cell Significance Index: -4.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2362
    Cell Significance Index: -3.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2433
    Cell Significance Index: -1.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2572
    Cell Significance Index: -6.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2677
    Cell Significance Index: -7.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2708
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2811
    Cell Significance Index: -3.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2841
    Cell Significance Index: -9.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3007
    Cell Significance Index: -8.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3030
    Cell Significance Index: -9.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3297
    Cell Significance Index: -11.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3311
    Cell Significance Index: -7.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3350
    Cell Significance Index: -9.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3492
    Cell Significance Index: -7.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3869
    Cell Significance Index: -7.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3887
    Cell Significance Index: -14.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** RANBP6 is primarily localized to the cytoplasm and nucleus, where it interacts with various proteins to regulate nuclear import and export. 2. **Nuclear import:** RANBP6 binds to Ran GTPase, a key regulator of nuclear import, and facilitates the transport of proteins into the nucleus. 3. **Protein binding:** RANBP6 interacts with a range of proteins, including those involved in synaptic function, DNA replication, and transcriptional regulation. 4. **Expression patterns:** RANBP6 is expressed in various cell types, including cardiac muscle, endothelial cells, neurons, and intestinal epithelial cells. **Pathways and Functions:** 1. **Nuclear import signal receptor activity:** RANBP6 interacts with Ran GTPase to regulate nuclear import, facilitating the transport of proteins into the nucleus. 2. **Nuclear localization sequence binding:** RANBP6 binds to nuclear localization sequences (NLS) on proteins, ensuring their proper targeting to the nucleus. 3. **Protein import into nucleus:** RANBP6 plays a crucial role in importing proteins into the nucleus, where they can participate in various cellular processes. 4. **Synapse:** RANBP6 has been implicated in the regulation of synaptic activity, highlighting its importance in maintaining neuronal function and plasticity. **Clinical Significance:** 1. **Neurological disorders:** Alterations in RANBP6 expression or function may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cardiac function:** RANBP6 has been implicated in cardiac muscle development and function, highlighting its potential role in heart disease. 3. **Intestinal health:** RANBP6 expression in intestinal epithelial cells may influence gut health and function, particularly in the context of inflammatory bowel disease. 4. **Cancer:** RANBP6 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis and cancer progression. In conclusion, RANBP6 is a multifaceted gene involved in various cellular processes, including nuclear import, protein binding, and synaptic function. Its expression in multiple cell types and its role in regulating nuclear localization and synaptic activity highlight its importance in maintaining cellular homeostasis and neuronal function. Further studies are needed to fully elucidate the clinical significance of RANBP6 and its potential role in various diseases.

Genular Protein ID: 3829689071

Symbol: RNBP6_HUMAN

Name: Ran-binding protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 1105
  • Mass: 124714
  • Checksum: 9434C69D548DF150
  • Sequence:
  • MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGLCKT TFLLDAVRNR 
    RAGYEVRQMA AALLRRLLSS GFEEVYPNLP ADVQRDVKIE LILAVKLETH ASMRKKLCDI 
    FAVLARNLID EDGTNHWPEG LKFLIDSIYS KNVVLWEVAL HVFWHFPGIF GTQERHDLDI 
    IKRLLDQCIQ DQEHPAIRTL SARAAAAFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD 
    DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP 
    MLKKHTNIIA QAVPHILAMM VDLQDDEDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG 
    KVVLPMTKEH IMQMLQSPDW KYRHAGLMAL SAIGEGCHQQ MESILDETVN SVLLFLQDPH 
    PRVRAAACTT LGQMATDFAP NFQKKFHETV IAALLRTMEN QGNQRVQSHA ASALIIFIED 
    CPKSLLVLYV DSMVKNLHSV LVIKLQELIR NGTKLALEQL VTTIASVADT IEEKFVPYYD 
    IFMPSLKHIV ELAVQKELKL LRGKTIECIS HIGLAVGKEK FMQDASNVMQ LLLKTQSDLN 
    NMEDDDPQTS YMVSAWARMC KILGKDFQQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS 
    DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKLMVPLLK 
    FYFHDNVRVA AAESMPFLLE CARIRGPEYL AQMWQFICDP LIKAIGTEPD TDVLSEIMNS 
    FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED 
    ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII 
    EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV 
    KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT 
    LSFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIN YEDPCAKRLA NVVRQVQTSE 
    DLWLECVSQL DDEQQEALQE LLNFA

Genular Protein ID: 2495361489

Symbol: B4DTX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 693
  • Mass: 78557
  • Checksum: FD0614713779ED53
  • Sequence:
  • MKISQDPHPR VRAAACTTLG QMATDFAPNF QKKFHETVIA ALLRTMENQG NQRVQSHAAS 
    ALIIFIEDCP KSLLVLYVDS MVKNLHSVLV IKLQELIRNG TKLALEQLVT TIASVADTIE 
    EKFVPYYDIF MPSLKHIVEL AVQKELKLLR GKTIECISHI GLAVGKEKFM QDASNVMQLL 
    LKTQSDLNNM EDDDPQTSYM VSAWARMCKI LGKDFQQYLP LVIEPLIKTA SAKPDVALLD 
    TQDVENMSDD DGWQFVNLGD QQSFGIKTSG LEAKATACQM LVYYAKELRE GFVECTEQVV 
    KLMVPLLKFY FHDNVRVAAA ESMPFLLECA RIRGPEYLAQ MWQFICDPLI KAIGTEPDTD 
    VLSEIMNSFA KSIEVMGDGC LNDEHLEELG GILKAKLEGH FKNQELRQVK RQEENYDQQV 
    EMSLQDEDEC DVYILTKVSD ILHSLFSTYK EKILPWFEQL LPLIVNLICS SRPWPDRQWG 
    LCIFDDIIEH CSPTSFKYVE YFRWPMLLNM RDNNPEVRQA AAYGLGVMAQ FGGDDYRSLC 
    SEAVPLLVKV IKCANSKTKK NVIATENCIS AIGKILKFKP NCVNVDEVLP HWLSWLPLHE 
    DKEEAIQTLS FLCDLIESNH PVVIGPNNSN LPKIISIIAE GKINETINYE DPCAKRLANV 
    VRQVQTSEDL WLECVSQLDD EQQEALQELL NFA

Genular Protein ID: 1911897946

Symbol: A0A096LNS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 68
  • Mass: 7564
  • Checksum: 7D62856D1608BEB9
  • Sequence:
  • MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGSSSK GEGCSLYYTW 
    TDGYRFCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.