Details for: GIPR

Gene ID: 2696

Symbol: GIPR

Ensembl ID: ENSG00000010310

Description: gastric inhibitory polypeptide receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.8380
    Cell Significance Index: -6.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0529
    Cell Significance Index: -6.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.9333
    Cell Significance Index: -4.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3241
    Cell Significance Index: 60.0200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.1884
    Cell Significance Index: 12.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1022
    Cell Significance Index: 16.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0874
    Cell Significance Index: -3.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9470
    Cell Significance Index: 12.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7175
    Cell Significance Index: 15.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5811
    Cell Significance Index: 524.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5272
    Cell Significance Index: 33.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4081
    Cell Significance Index: 40.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3444
    Cell Significance Index: 4.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3439
    Cell Significance Index: 55.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3372
    Cell Significance Index: 11.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3159
    Cell Significance Index: 34.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3155
    Cell Significance Index: 16.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2883
    Cell Significance Index: 22.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2694
    Cell Significance Index: 51.2600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.2240
    Cell Significance Index: 3.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1810
    Cell Significance Index: 10.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1756
    Cell Significance Index: 12.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1683
    Cell Significance Index: 19.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1488
    Cell Significance Index: 0.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1010
    Cell Significance Index: 2.9100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0913
    Cell Significance Index: 0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0904
    Cell Significance Index: 16.2900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0767
    Cell Significance Index: 0.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0481
    Cell Significance Index: 1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0414
    Cell Significance Index: 22.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0365
    Cell Significance Index: 1.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0325
    Cell Significance Index: 0.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0224
    Cell Significance Index: 41.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0196
    Cell Significance Index: 0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0193
    Cell Significance Index: 2.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0178
    Cell Significance Index: 0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0148
    Cell Significance Index: 0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0143
    Cell Significance Index: 2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0092
    Cell Significance Index: 0.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0091
    Cell Significance Index: 0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0049
    Cell Significance Index: 0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0018
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0016
    Cell Significance Index: 1.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0010
    Cell Significance Index: 0.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0052
    Cell Significance Index: -2.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0070
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0075
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0093
    Cell Significance Index: -1.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0161
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0176
    Cell Significance Index: -3.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0294
    Cell Significance Index: -1.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0300
    Cell Significance Index: -0.9600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0309
    Cell Significance Index: -0.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0329
    Cell Significance Index: -0.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0371
    Cell Significance Index: -4.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0379
    Cell Significance Index: -2.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0382
    Cell Significance Index: -2.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0471
    Cell Significance Index: -5.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0479
    Cell Significance Index: -6.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0560
    Cell Significance Index: -3.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0577
    Cell Significance Index: -2.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0596
    Cell Significance Index: -6.2100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0631
    Cell Significance Index: -0.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0667
    Cell Significance Index: -3.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0788
    Cell Significance Index: -5.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0806
    Cell Significance Index: -5.2000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0843
    Cell Significance Index: -0.1900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0887
    Cell Significance Index: -1.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0918
    Cell Significance Index: -4.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0936
    Cell Significance Index: -4.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0940
    Cell Significance Index: -4.7500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0980
    Cell Significance Index: -1.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1008
    Cell Significance Index: -5.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1078
    Cell Significance Index: -6.0500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1103
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1151
    Cell Significance Index: -0.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1194
    Cell Significance Index: -3.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1215
    Cell Significance Index: -4.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1220
    Cell Significance Index: -2.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1251
    Cell Significance Index: -3.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1262
    Cell Significance Index: -3.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1267
    Cell Significance Index: -1.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1315
    Cell Significance Index: -4.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1348
    Cell Significance Index: -3.9700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1365
    Cell Significance Index: -1.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1523
    Cell Significance Index: -5.5900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1535
    Cell Significance Index: -1.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1547
    Cell Significance Index: -5.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GIPR is a transmembrane receptor with a single transmembrane domain, and its ligand is gastric inhibitory polypeptide (GIP). It belongs to the secretin family of GPCRs, which are characterized by their ability to activate adenylate cyclase activity and modulate intracellular signaling pathways. GIPR is highly expressed in various tissues, including the pancreas, small intestine, and lung, and is also found in immune cells such as granulocytes and T lymphocytes. **Pathways and Functions:** GIPR is involved in several signaling pathways, including the adenylate cyclase-activating g protein-coupled receptor signaling pathway, adenylate cyclase-modulating g protein-coupled receptor signaling pathway, and cell surface receptor signaling pathway. Upon binding to GIP, GIPR activates the Gαs protein, leading to an increase in intracellular cAMP levels, which in turn stimulates insulin secretion from pancreatic beta cells. Additionally, GIPR has been shown to modulate other signaling pathways, including the generation of precursor metabolites and energy, cell surface receptor signaling pathway, and signal transduction. **Clinical Significance:** Dysregulation of GIPR has been implicated in various diseases, including type 2 diabetes, obesity, and metabolic syndrome. GIPR is also involved in the regulation of insulin secretion, and its dysfunction can lead to impaired glucose homeostasis. Furthermore, GIPR has been shown to play a role in the pathogenesis of other diseases, including cancer, cardiovascular disease, and inflammatory disorders. Understanding the function and significance of GIPR can provide valuable insights into the development of novel therapeutic strategies for these diseases. **Significantly Expressed Cells:** GIPR is highly expressed in various cell types, including: * Mural cell * Granulocyte monocyte progenitor cell * Endocrine cell * Ciliated cell * Intestinal crypt stem cell of small intestine * Lung ciliated cell * Ciliated columnar cell of tracheobronchial tree * Early T lineage precursor * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell **Proteins:** GIPR_HUMAN is the protein encoded by the GIPR gene. In conclusion, GIPR is a critical GPCR that plays a significant role in various physiological processes, including glucose homeostasis and insulin secretion. Its dysregulation has been implicated in various diseases, and understanding its function and significance can provide valuable insights into the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of GIPR and its role in human disease.

Genular Protein ID: 3795541991

Symbol: GIPR_HUMAN

Name: Gastric inhibitory polypeptide receptor

UniProtKB Accession Codes:

P48546 B7WP14 B7ZKQ0 Q14401 Q16400 Q52M04 Q9UPI1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 EMDB 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 3 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7589426

Title: Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.

PubMed ID: 7589426

DOI: 10.1016/0014-5793(95)01006-z

PubMed ID: 7556958

Title: Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.

PubMed ID: 7556958

DOI: 10.2337/diab.44.10.1202

PubMed ID: 8575774

Title: Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.

PubMed ID: 8575774

DOI: 10.1006/geno.1995.9937

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22412906

Title: Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

PubMed ID: 22412906

DOI: 10.1371/journal.pone.0032675

PubMed ID: 17715056

Title: Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

PubMed ID: 17715056

DOI: 10.1073/pnas.0706404104

Sequence Information:

  • Length: 466
  • Mass: 53157
  • Checksum: CA5CF86BA0E32383
  • Sequence:
    • MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA 
CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN 
PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF 
MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY 
LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR 
TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV 
TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC RLRRSLGEEQ 
RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.