Details for: GIPR

Gene ID: 2696

Symbol: GIPR

Ensembl ID: ENSG00000010310

Description: gastric inhibitory polypeptide receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169705
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.34
    Marker Score: 692
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.32
    Marker Score: 4527
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.1
    Marker Score: 524
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.1
    Marker Score: 9556
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1889
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.96
    Marker Score: 1983
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5249
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14257
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.88
    Marker Score: 3136
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.84
    Marker Score: 1591
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 660
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1311
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 381
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.63
    Marker Score: 318
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.59
    Marker Score: 3778
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.52
    Marker Score: 178
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.49
    Marker Score: 4173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 324
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.48
    Marker Score: 219
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.44
    Marker Score: 472
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 206
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.41
    Marker Score: 4274
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.41
    Marker Score: 549
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.39
    Marker Score: 265
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 119
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.36
    Marker Score: 187
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 346.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.34
    Marker Score: 167
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.33
    Marker Score: 7426
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.33
    Marker Score: 123
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.31
    Marker Score: 134
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3
    Marker Score: 205
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.28
    Marker Score: 249
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 277
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.23
    Marker Score: 308
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.23
    Marker Score: 243
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.23
    Marker Score: 207
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.22
    Marker Score: 358
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.21
    Marker Score: 215
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2
    Marker Score: 54
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 473
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.19
    Marker Score: 423
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.19
    Marker Score: 437
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.18
    Marker Score: 464
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.17
    Marker Score: 451
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 390
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 227
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.15
    Marker Score: 168
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.15
    Marker Score: 427
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.15
    Marker Score: 218
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 184

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Other Information

**Key characteristics:** * The GIPR is a single-pass transmembrane protein with seven extracellular domains. * It is expressed in high levels in the stomach, small intestine, and lung. * It is a ligand for gastrin, a peptide hormone that is produced in the stomach. **Pathways and functions:** * The GIPR is a key regulator of gastric acid secretion. It binds to gastrin and activates the G protein-coupled receptor pathway, which leads to the inhibition of gastric acid secretion. * It also binds to other peptides, including glucagon and secretin, which are also involved in gastric acid secretion. * The GIPR is a potential therapeutic target for gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus. **Clinical significance:** * The GIPR is a potential therapeutic target for gastroesophageal reflux disease (GERD). * It is a simple and cost-effective therapy that can be used to treat GERD. * It is well-tolerated, with few side effects. **Additional points:** * The GIPR is a member of the GPCR superfamily, which is a large family of cell surface receptors that are activated by the binding of small peptides. * The GIPR is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. * It is a key regulator of gastric acid secretion. * It is a potential therapeutic target for gastroesophageal reflux disease (GERD).

Genular Protein ID: 3795541991

Symbol: GIPR_HUMAN

Name: Gastric inhibitory polypeptide receptor

UniProtKB Accession Codes:

P48546 B7WP14 B7ZKQ0 Q14401 Q16400 Q52M04 Q9UPI1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 3 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7589426

Title: Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.

PubMed ID: 7589426

DOI: 10.1016/0014-5793(95)01006-z

PubMed ID: 7556958

Title: Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.

PubMed ID: 7556958

DOI: 10.2337/diab.44.10.1202

PubMed ID: 8575774

Title: Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.

PubMed ID: 8575774

DOI: 10.1006/geno.1995.9937

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22412906

Title: Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

PubMed ID: 22412906

DOI: 10.1371/journal.pone.0032675

PubMed ID: 17715056

Title: Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

PubMed ID: 17715056

DOI: 10.1073/pnas.0706404104

Sequence Information:

  • Length: 466
  • Mass: 53157
  • Checksum: CA5CF86BA0E32383
  • Sequence:
    • MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA 
CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN 
PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF 
MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY 
LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR 
TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV 
TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC RLRRSLGEEQ 
RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.