Details for: AP3M1

Gene ID: 26985

Symbol: AP3M1

Ensembl ID: ENSG00000185009

Description: adaptor related protein complex 3 subunit mu 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.7664
    Cell Significance Index: -21.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.7540
    Cell Significance Index: -20.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.0650
    Cell Significance Index: -21.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.6269
    Cell Significance Index: -23.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.8115
    Cell Significance Index: -19.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.0331
    Cell Significance Index: -22.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.9169
    Cell Significance Index: -23.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0109
    Cell Significance Index: -20.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6138
    Cell Significance Index: -22.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7384
    Cell Significance Index: -20.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8692
    Cell Significance Index: -23.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1376
    Cell Significance Index: -15.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0803
    Cell Significance Index: -8.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4637
    Cell Significance Index: 19.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2237
    Cell Significance Index: 1104.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9994
    Cell Significance Index: 60.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9841
    Cell Significance Index: 107.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8402
    Cell Significance Index: 136.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7430
    Cell Significance Index: 11.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7318
    Cell Significance Index: 19.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6479
    Cell Significance Index: 128.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6251
    Cell Significance Index: 16.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6015
    Cell Significance Index: 120.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4972
    Cell Significance Index: 34.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4278
    Cell Significance Index: 22.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4016
    Cell Significance Index: 8.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3643
    Cell Significance Index: 12.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3629
    Cell Significance Index: 65.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3297
    Cell Significance Index: 9.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3234
    Cell Significance Index: 14.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3111
    Cell Significance Index: 38.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3100
    Cell Significance Index: 7.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2983
    Cell Significance Index: 106.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2742
    Cell Significance Index: 21.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2701
    Cell Significance Index: 17.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2672
    Cell Significance Index: 31.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2656
    Cell Significance Index: 12.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2240
    Cell Significance Index: 12.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2182
    Cell Significance Index: 119.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2175
    Cell Significance Index: 21.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2131
    Cell Significance Index: 11.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2091
    Cell Significance Index: 13.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2048
    Cell Significance Index: 90.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1704
    Cell Significance Index: 23.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1521
    Cell Significance Index: 4.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1114
    Cell Significance Index: 77.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1035
    Cell Significance Index: 19.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0974
    Cell Significance Index: 12.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0885
    Cell Significance Index: 2.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0674
    Cell Significance Index: 1.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0568
    Cell Significance Index: 1.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0415
    Cell Significance Index: 1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0159
    Cell Significance Index: 0.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0099
    Cell Significance Index: 0.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0123
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0140
    Cell Significance Index: -8.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0172
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0339
    Cell Significance Index: -4.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0369
    Cell Significance Index: -2.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0393
    Cell Significance Index: -22.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0432
    Cell Significance Index: -27.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0436
    Cell Significance Index: -2.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0454
    Cell Significance Index: -6.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0554
    Cell Significance Index: -5.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0633
    Cell Significance Index: -1.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0636
    Cell Significance Index: -18.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0744
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0755
    Cell Significance Index: -8.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0869
    Cell Significance Index: -1.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0902
    Cell Significance Index: -1.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0993
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1167
    Cell Significance Index: -13.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1262
    Cell Significance Index: -26.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1299
    Cell Significance Index: -4.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1612
    Cell Significance Index: -7.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1870
    Cell Significance Index: -4.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1899
    Cell Significance Index: -1.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2015
    Cell Significance Index: -10.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2116
    Cell Significance Index: -22.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2229
    Cell Significance Index: -8.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2417
    Cell Significance Index: -19.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2631
    Cell Significance Index: -2.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2756
    Cell Significance Index: -1.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2886
    Cell Significance Index: -6.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2987
    Cell Significance Index: -4.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3045
    Cell Significance Index: -3.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3328
    Cell Significance Index: -3.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3760
    Cell Significance Index: -11.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3768
    Cell Significance Index: -23.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3848
    Cell Significance Index: -7.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AP3M1 is a member of the AP-3 complex, which is composed of three subunits: mu 1, mu 2, and sigma 1. AP3M1 is a small, acidic protein that interacts with various proteins, including clathrin, B4DRN6, and small GTPases, to regulate protein sorting and trafficking. AP3M1 is highly expressed in various cell types, including pulmonary interstitial fibroblasts, mural cells, cerebral cortex GABAergic interneurons, and cardiac muscle myoblasts. **Pathways and Functions:** AP3M1 is involved in several cellular pathways, including: 1. **Anterograde axonal transport**: AP3M1 plays a crucial role in regulating the transport of proteins and lipids from the cell body to the axon terminals. 2. **Anterograde synaptic vesicle transport**: AP3M1 is involved in the regulation of synaptic vesicle transport, which is essential for neurotransmitter release and synaptic plasticity. 3. **Ap-3 adaptor complex**: AP3M1 is a key subunit of the AP-3 complex, which regulates protein sorting and targeting to specific compartments within the cell. 4. **Association of tric/cct with target proteins during biosynthesis**: AP3M1 interacts with tric/cct, a chaperone complex, to regulate protein folding and targeting to specific compartments. 5. **Protein binding**: AP3M1 binds to various proteins, including clathrin and small GTPases, to regulate protein sorting and trafficking. **Clinical Significance:** Dysregulation of AP3M1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: AP3M1 has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: AP3M1 has been implicated in cancer development and progression, particularly in the regulation of cell growth, survival, and migration. 3. **Neurodevelopmental disorders**: AP3M1 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cardiovascular disease**: AP3M1 has been implicated in cardiovascular disease, particularly in the regulation of cardiac cell growth and survival. In conclusion, AP3M1 is a critical component of the AP-3 complex, which plays a vital role in regulating protein sorting, trafficking, and signaling pathways. Dysregulation of AP3M1 has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis and regulating cellular processes. Further research is needed to fully elucidate the role of AP3M1 in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 2947591085

Symbol: AP3M1_HUMAN

Name: AP-3 complex subunit mu-1

UniProtKB Accession Codes:

Q9Y2T2 Q5JQ12 Q9H5L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10024875

Title: Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.

PubMed ID: 10024875

DOI: 10.1016/s1097-2765(00)80170-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29028839

Title: Interaction of the Human Respiratory Syncytial Virus matrix protein with cellular adaptor protein complex 3 plays a critical role in trafficking.

PubMed ID: 29028839

DOI: 10.1371/journal.pone.0184629

Sequence Information:

  • Length: 418
  • Mass: 46939
  • Checksum: 533E189C320C4C48
  • Sequence:
    • MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS TPHHYLISIY 
RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA AIKDNVVIVY ELLEEMLDNG 
FPLATESNIL KELIKPPTIL RSVVNSITGS SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY 
FDVVEEIDAI IDKSGSTVFA EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK 
RWESERVLSF IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN 
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK LPSLKGLVNL 
QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK PFKGVKYVTK AGKFQVRT

Genular Protein ID: 1477179841

Symbol: B4DRN6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRN6

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 4 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 2

Sequence Information:

  • Length: 364
  • Mass: 41026
  • Checksum: 50A57464B94F4889
  • Sequence:
    • MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS TPHHYLISIY 
RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGSSNVG DTLPTGQLSN IPWRRAGVKY 
TNNEAYFDVV EEIDAIIDKS GSTVFAEIQG VIDACIKLSG MPDLSLSFMN PRLLDDVSFH 
PCIRFKRWES ERVLSFIPPD GNFRLISYRV SSQNLVAIPV YVKHSISFKE NSSCGRFDIT 
IGPKQNMGKT IEGITVTVHM PKVVLNMNLT PTQGSYTFDP VTKVLTWDVG KITPQKLPSL 
KGLVNLQSGA PKPEENPSLN IQFKIQQLAI SGLKVNRLDM YGEKYKPFKG VKYVTKAGKF 
QVRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.