Details for: GJA4

Gene ID: 2701

Symbol: GJA4

Ensembl ID: ENSG00000187513

Description: gap junction protein alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.6
    Marker Score: 2033
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.96
    Marker Score: 1850.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.84
    Marker Score: 714.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.68
    Marker Score: 427
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.5
    Marker Score: 813
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.48
    Marker Score: 1054
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169459
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.42
    Marker Score: 1358
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.23
    Marker Score: 717
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.21
    Marker Score: 2278
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.1
    Marker Score: 321
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 676
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.03
    Marker Score: 225
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15267
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.96
    Marker Score: 271
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 455.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5316
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.89
    Marker Score: 7810
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.83
    Marker Score: 958
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5269
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1568
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.77
    Marker Score: 540
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.71
    Marker Score: 187
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.71
    Marker Score: 607
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.64
    Marker Score: 1637
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.63
    Marker Score: 159
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.62
    Marker Score: 171.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.53
    Marker Score: 150
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.52
    Marker Score: 874.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.51
    Marker Score: 337
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 299
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.5
    Marker Score: 246
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.47
    Marker Score: 421
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.46
    Marker Score: 497
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.46
    Marker Score: 107
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.43
    Marker Score: 178.5
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.4
    Marker Score: 109
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.4
    Marker Score: 182
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 104
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 222
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.35
    Marker Score: 136
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.33
    Marker Score: 658
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.32
    Marker Score: 277
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.32
    Marker Score: 558.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 597
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.3
    Marker Score: 85
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3
    Marker Score: 321
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.28
    Marker Score: 405.5
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.25
    Marker Score: 160
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 164
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.24
    Marker Score: 386
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.23
    Marker Score: 249
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 690
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.22
    Marker Score: 45
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.21
    Marker Score: 267
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 333
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.2
    Marker Score: 291
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2
    Marker Score: 198
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.19
    Marker Score: 73
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 173
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.18
    Marker Score: 160
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.17
    Marker Score: 127
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 294
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.15
    Marker Score: 201
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 177
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 876
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.15
    Marker Score: 500
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.13
    Marker Score: 28
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.13
    Marker Score: 1087
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.12
    Marker Score: 300

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Other Information

**Key characteristics:** - GJA4 is a type of gap junction protein, which are found in the heart, brain, and kidneys. - It is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is expressed in a variety of cell types, including endothelial cells, smooth muscle cells, and pericytes. **Pathways and functions:** - GJA4 is involved in a variety of cellular processes, including blood vessel development, calcium ion transport, cell-cell junction assembly, and cell-cell signaling. - It is essential for the formation of new blood vessels and the maintenance of existing blood vessels. - It also plays a role in regulating blood pressure and cardiac function. **Clinical significance:** - Mutations in GJA4 have been linked to a number of human diseases, including hypertension, heart failure, and stroke. - GJA4 is a potential therapeutic target for these diseases, as it is a key regulator of blood vessel function. **Additional notes:** - GJA4 is a highly conserved protein, with a similar sequence found in organisms from humans to flies. - It is a transmembrane protein that is expressed on the surface of endothelial cells. - It is a key component of the gap junction, a specialized channel that connects the cytoplasm of adjacent cells and allows the exchange of small molecules, ions, and signaling molecules.

Genular Protein ID: 3442182517

Symbol: CXA4_HUMAN

Name: Gap junction alpha-4 protein

UniProtKB Accession Codes:

P35212 A8K698 D3DPR4 Q9P106 Q9UBL1 Q9UNA9 Q9UNB0 Q9UNB1 Q9Y5N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7680674

Title: Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.

PubMed ID: 7680674

DOI: 10.1172/jci116321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8761439

Title: Human connexin 37 is polymorphic but not mutated in tumours.

PubMed ID: 8761439

DOI: 10.1093/carcin/17.8.1761

PubMed ID: 10447790

Title: A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development.

PubMed ID: 10447790

DOI: 10.1046/j.1365-2796.1999.00564.x

PubMed ID: 10728596

Title: Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene.

PubMed ID: 10728596

DOI: 10.1002/(sici)1097-0215(20000401)86:1<67::aid-ijc10>3.0.co;2-1

Sequence Information:

  • Length: 333
  • Mass: 37414
  • Checksum: 93AD224531E5EAD2
  • Sequence:
    • MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 
CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD 
PQVERALAAV ERQMAKISVA EDGRLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT 
MEPVFVCQRA PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELVH LLCRCLSRGM 
RARQGQDAPP TQGTSSDPYT DQVFFYLPVG QGPSSPPCPT YNGLSSSEQN WANLTTEERL 
ASSRPPLFLD PPPQNGQKPP SRPSSSASKK QYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.