Details for: GJA4

Gene ID: 2701

Symbol: GJA4

Ensembl ID: ENSG00000187513

Description: gap junction protein alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.5401
    Cell Significance Index: -10.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.1207
    Cell Significance Index: -10.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.1689
    Cell Significance Index: -8.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 10.2443
    Cell Significance Index: 86.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4107
    Cell Significance Index: -10.3700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 6.9833
    Cell Significance Index: 41.2300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.5101
    Cell Significance Index: 9.3600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4807
    Cell Significance Index: 24.4000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.3081
    Cell Significance Index: 6.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2663
    Cell Significance Index: 65.9600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1114
    Cell Significance Index: 19.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3437
    Cell Significance Index: 7.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1625
    Cell Significance Index: 4.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0433
    Cell Significance Index: 0.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0304
    Cell Significance Index: 16.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0290
    Cell Significance Index: 5.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0083
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0150
    Cell Significance Index: -9.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0222
    Cell Significance Index: -2.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0324
    Cell Significance Index: -9.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0335
    Cell Significance Index: -4.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0338
    Cell Significance Index: -6.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0466
    Cell Significance Index: -5.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0500
    Cell Significance Index: -7.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0552
    Cell Significance Index: -11.0700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0567
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0575
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0635
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0665
    Cell Significance Index: -11.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0693
    Cell Significance Index: -2.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0745
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0831
    Cell Significance Index: -9.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0846
    Cell Significance Index: -9.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0998
    Cell Significance Index: -10.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1164
    Cell Significance Index: -2.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1215
    Cell Significance Index: -9.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1241
    Cell Significance Index: -9.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1261
    Cell Significance Index: -9.4000
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.1469
    Cell Significance Index: -1.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1545
    Cell Significance Index: -9.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1563
    Cell Significance Index: -10.5100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1693
    Cell Significance Index: -1.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1721
    Cell Significance Index: -10.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1863
    Cell Significance Index: -5.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1983
    Cell Significance Index: -9.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2106
    Cell Significance Index: -3.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2118
    Cell Significance Index: -9.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2137
    Cell Significance Index: -11.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2276
    Cell Significance Index: -12.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2315
    Cell Significance Index: -2.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2330
    Cell Significance Index: -6.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2337
    Cell Significance Index: -12.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2408
    Cell Significance Index: -6.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2477
    Cell Significance Index: -11.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2521
    Cell Significance Index: -6.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2562
    Cell Significance Index: -3.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2810
    Cell Significance Index: -9.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2837
    Cell Significance Index: -12.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2887
    Cell Significance Index: -7.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3005
    Cell Significance Index: -9.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3021
    Cell Significance Index: -8.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3126
    Cell Significance Index: -10.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3130
    Cell Significance Index: -9.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3157
    Cell Significance Index: -11.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3317
    Cell Significance Index: -12.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3381
    Cell Significance Index: -11.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3438
    Cell Significance Index: -10.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3489
    Cell Significance Index: -8.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3534
    Cell Significance Index: -9.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3764
    Cell Significance Index: -10.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3875
    Cell Significance Index: -8.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3883
    Cell Significance Index: -12.2800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3919
    Cell Significance Index: -5.6900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3965
    Cell Significance Index: -3.1300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4042
    Cell Significance Index: -4.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4072
    Cell Significance Index: -10.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4133
    Cell Significance Index: -10.5300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4186
    Cell Significance Index: -5.0200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4190
    Cell Significance Index: -5.1500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4213
    Cell Significance Index: -5.3400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.4265
    Cell Significance Index: -1.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4444
    Cell Significance Index: -9.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4450
    Cell Significance Index: -11.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4489
    Cell Significance Index: -9.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4626
    Cell Significance Index: -10.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4641
    Cell Significance Index: -11.1300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4858
    Cell Significance Index: -6.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** GJA4 is a transmembrane protein that forms gap junction channels, allowing for the exchange of ions, metabolites, and signaling molecules between adjacent cells. 2. **Expression Patterns:** GJA4 is significantly expressed in endocardial cells, enteroendocrine cells, neuroendocrine cells, smooth muscle cells, kidney interstitial cells, mural cells, and pericytes. 3. **Cellular Localization:** GJA4 is primarily localized to the plasma membrane, where it forms gap junction channels. **Pathways and Functions:** 1. **Cell-Cell Signaling:** GJA4 mediates intercellular communication through gap junction channels, facilitating the exchange of signaling molecules and ions between adjacent cells. 2. **Calcium Ion Transport:** GJA4 plays a crucial role in calcium ion homeostasis, regulating the influx and efflux of calcium ions into and out of cells. 3. **Cell-Cell Junction Assembly:** GJA4 is involved in the assembly and regulation of gap junction channels, ensuring proper cell-cell communication and tissue function. 4. **Membrane Trafficking:** GJA4 is involved in the trafficking and regulation of gap junction channels, ensuring their proper localization and function. **Clinical Significance:** 1. **Cardiovascular Diseases:** Dysregulation of GJA4 has been linked to various cardiovascular diseases, including arrhythmias, hypertension, and atherosclerosis. 2. **Neurological Disorders:** GJA4 has been implicated in neurological disorders, such as epilepsy, migraines, and multiple sclerosis, where gap junction dysfunction contributes to disease pathology. 3. **Kidney Disease:** GJA4 dysregulation has been linked to kidney disease, including diabetic nephropathy and hypertension. 4. **Cancer:** GJA4 has been implicated in cancer development and progression, where gap junction dysfunction can contribute to tumor growth and metastasis. In conclusion, GJA4 plays a crucial role in maintaining cellular homeostasis and tissue function through its involvement in cell-cell signaling, calcium ion transport, and gap junction assembly. Dysregulation of this gene has been linked to various diseases, emphasizing the importance of further research into its role in human disease.

Genular Protein ID: 3442182517

Symbol: CXA4_HUMAN

Name: Gap junction alpha-4 protein

UniProtKB Accession Codes:

P35212 A8K698 D3DPR4 Q9P106 Q9UBL1 Q9UNA9 Q9UNB0 Q9UNB1 Q9Y5N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7680674

Title: Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.

PubMed ID: 7680674

DOI: 10.1172/jci116321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8761439

Title: Human connexin 37 is polymorphic but not mutated in tumours.

PubMed ID: 8761439

DOI: 10.1093/carcin/17.8.1761

PubMed ID: 10447790

Title: A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development.

PubMed ID: 10447790

DOI: 10.1046/j.1365-2796.1999.00564.x

PubMed ID: 10728596

Title: Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene.

PubMed ID: 10728596

DOI: 10.1002/(sici)1097-0215(20000401)86:1<67::aid-ijc10>3.0.co;2-1

Sequence Information:

  • Length: 333
  • Mass: 37414
  • Checksum: 93AD224531E5EAD2
  • Sequence:
    • MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 
CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD 
PQVERALAAV ERQMAKISVA EDGRLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT 
MEPVFVCQRA PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELVH LLCRCLSRGM 
RARQGQDAPP TQGTSSDPYT DQVFFYLPVG QGPSSPPCPT YNGLSSSEQN WANLTTEERL 
ASSRPPLFLD PPPQNGQKPP SRPSSSASKK QYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.