Details for: NPTN

Gene ID: 27020

Symbol: NPTN

Ensembl ID: ENSG00000156642

Description: neuroplastin

Associated with

  • Gaba receptor activation
    (R-HSA-977443)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Cell adhesion molecule binding
    (GO:0050839)
  • Cell surface
    (GO:0009986)
  • Excitatory synapse assembly
    (GO:1904861)
  • Homophilic cell adhesion via plasma membrane adhesion molecules
    (GO:0007156)
  • Immunological synapse
    (GO:0001772)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of fibroblast growth factor receptor signaling pathway
    (GO:0045743)
  • Positive regulation of long-term neuronal synaptic plasticity
    (GO:0048170)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Postsynaptic density
    (GO:0014069)
  • Presynaptic membrane
    (GO:0042734)
  • Protein binding
    (GO:0005515)
  • Regulation of receptor localization to synapse
    (GO:1902683)
  • Type 1 fibroblast growth factor receptor binding
    (GO:0005105)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 429.7464
    Cell Significance Index: -66.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 266.0822
    Cell Significance Index: -67.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 144.5387
    Cell Significance Index: -68.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 135.6530
    Cell Significance Index: -55.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 125.5965
    Cell Significance Index: -64.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 101.6807
    Cell Significance Index: -68.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.7642
    Cell Significance Index: -55.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.7505
    Cell Significance Index: -67.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7915
    Cell Significance Index: -63.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.2071
    Cell Significance Index: -67.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1872
    Cell Significance Index: -31.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7242
    Cell Significance Index: 103.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7097
    Cell Significance Index: 543.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6047
    Cell Significance Index: 115.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4027
    Cell Significance Index: 161.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1478
    Cell Significance Index: 47.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9244
    Cell Significance Index: 115.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8405
    Cell Significance Index: 660.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.7826
    Cell Significance Index: 50.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5797
    Cell Significance Index: 121.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2513
    Cell Significance Index: 683.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2105
    Cell Significance Index: 218.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0051
    Cell Significance Index: 123.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8574
    Cell Significance Index: 593.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7353
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7188
    Cell Significance Index: 20.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6989
    Cell Significance Index: 309.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6646
    Cell Significance Index: 131.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6532
    Cell Significance Index: 6.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6442
    Cell Significance Index: 30.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6180
    Cell Significance Index: 28.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5818
    Cell Significance Index: 94.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5606
    Cell Significance Index: 29.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4904
    Cell Significance Index: 67.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4660
    Cell Significance Index: 88.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4076
    Cell Significance Index: 8.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3434
    Cell Significance Index: 5.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3310
    Cell Significance Index: 36.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2976
    Cell Significance Index: 5.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2903
    Cell Significance Index: 16.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2751
    Cell Significance Index: 17.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2648
    Cell Significance Index: 7.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2548
    Cell Significance Index: 32.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2481
    Cell Significance Index: 224.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2404
    Cell Significance Index: 109.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1679
    Cell Significance Index: 316.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1545
    Cell Significance Index: 26.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1083
    Cell Significance Index: 3.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1036
    Cell Significance Index: 10.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0892
    Cell Significance Index: 6.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0352
    Cell Significance Index: 22.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0173
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0315
    Cell Significance Index: -42.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0585
    Cell Significance Index: -32.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0625
    Cell Significance Index: -47.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0906
    Cell Significance Index: -1.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1064
    Cell Significance Index: -0.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1222
    Cell Significance Index: -12.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1266
    Cell Significance Index: -5.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1285
    Cell Significance Index: -3.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1330
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1404
    Cell Significance Index: -29.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1853
    Cell Significance Index: -21.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2074
    Cell Significance Index: -59.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2433
    Cell Significance Index: -35.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2646
    Cell Significance Index: -3.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3225
    Cell Significance Index: -37.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3268
    Cell Significance Index: -34.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3431
    Cell Significance Index: -39.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3549
    Cell Significance Index: -5.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3731
    Cell Significance Index: -25.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4047
    Cell Significance Index: -3.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4265
    Cell Significance Index: -4.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4460
    Cell Significance Index: -57.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4704
    Cell Significance Index: -9.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5686
    Cell Significance Index: -36.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6102
    Cell Significance Index: -16.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7131
    Cell Significance Index: -53.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7306
    Cell Significance Index: -57.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7449
    Cell Significance Index: -38.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8649
    Cell Significance Index: -45.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9173
    Cell Significance Index: -29.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9306
    Cell Significance Index: -21.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9525
    Cell Significance Index: -58.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9897
    Cell Significance Index: -60.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9914
    Cell Significance Index: -5.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0069
    Cell Significance Index: -18.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0814
    Cell Significance Index: -34.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0874
    Cell Significance Index: -35.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0952
    Cell Significance Index: -29.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.1170
    Cell Significance Index: -14.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1171
    Cell Significance Index: -13.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2249
    Cell Significance Index: -30.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2712
    Cell Significance Index: -26.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** Neuroplastin is primarily expressed on the surface of neurons and glial cells, where it interacts with other proteins to regulate cell adhesion and signaling. 2. **Homophilic Cell Adhesion:** Neuroplastin mediates homophilic cell adhesion, which is essential for the formation and maintenance of synapses. 3. **Excitatory Synapse Assembly:** Neuroplastin is involved in the assembly of excitatory synapses, which are critical for learning and memory. 4. **Long-term Synaptic Potentiation:** Neuroplastin plays a key role in long-term synaptic potentiation, a process that underlies learning and memory. 5. **Regulation of Receptor Localization:** Neuroplastin regulates the localization of receptors to synapses, which is essential for synaptic function and plasticity. **Pathways and Functions:** 1. **Cell Adhesion Molecule Binding:** Neuroplastin binds to cell adhesion molecules, such as N-cadherin and L1CAM, to regulate cell adhesion and signaling. 2. **Excitatory Synapse Assembly:** Neuroplastin interacts with other proteins to assemble excitatory synapses, which are critical for learning and memory. 3. **Intracellular Calcium Ion Homeostasis:** Neuroplastin regulates intracellular calcium ion concentrations, which is essential for synaptic function and plasticity. 4. **Long-term Synaptic Potentiation:** Neuroplastin plays a key role in long-term synaptic potentiation, a process that underlies learning and memory. 5. **Neurotransmitter Receptors and Postsynaptic Signal Transmission:** Neuroplastin regulates the localization of neurotransmitter receptors to synapses, which is essential for postsynaptic signal transmission. **Clinical Significance:** 1. **Neurodegenerative Disorders:** Neuroplastin has been implicated in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Learning and Memory:** Neuroplastin plays a critical role in learning and memory, and its dysregulation has been linked to cognitive impairments. 3. **Synaptic Dysfunction:** Neuroplastin's involvement in synaptic function and plasticity makes it a potential target for the treatment of synaptic dysfunction-related disorders. 4. **Cancer:** Neuroplastin has been implicated in cancer, particularly in the development and progression of glioblastoma. 5. **Neurological Disorders:** Neuroplastin's involvement in neurological disorders, such as epilepsy and schizophrenia, highlights its potential as a therapeutic target. In conclusion, neuroplastin is a key player in neurological function and disease, and its dysregulation has been linked to various neurodegenerative disorders. Further research is needed to fully understand the role of neuroplastin in neurological function and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 2403089229

Symbol: NPTN_HUMAN

Name: Neuroplastin

UniProtKB Accession Codes:

Q9Y639 B2RAL7 B7Z4D3 B7ZLL2 Q17R52 Q59EJ9 Q6NVX7 Q9Y640

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17196182

Title: The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.

PubMed ID: 17196182

DOI: 10.1016/j.brainres.2006.11.090

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27503893

Title: Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

PubMed ID: 27503893

DOI: 10.1073/pnas.1610403113

PubMed ID: 30190470

Title: Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

PubMed ID: 30190470

DOI: 10.1038/s41467-018-06075-7

Sequence Information:

  • Length: 398
  • Mass: 44387
  • Checksum: 5109E3C03B4967EA
  • Sequence:
    • MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL YCDVVGSPTP 
EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV LRITRLTLED SGTYECRASN 
DPKRNDLRQN PSITWIRAQA TISVLQKPRI VTSEEVIIRD SPVLPVTLQC NLTSSSHTLT 
YSYWTKNGVE LSATRKNASN MEYRINKPRA EDSGEYHCVY HFVSAPKANA TIEVKAAPDI 
TGHKRSENKN EGQDATMYCK SVGYPHPDWI WRKKENGMPM DIVNTSGRFF IINKENYTEL 
NIVNLQITED PGEYECNATN AIGSASVVTV LRVRSHLAPL WPFLGILAEI IILVVIIVVY 
EKRKRPDEVP DDDEPAGPMK TNSTNNHKDK NLRQRNTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.