Details for: TRMT2A

Gene ID: 27037

Symbol: TRMT2A

Ensembl ID: ENSG00000099899

Description: tRNA methyltransferase 2 homolog A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.7056
    Cell Significance Index: -13.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.4288
    Cell Significance Index: -12.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.0671
    Cell Significance Index: -13.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6532
    Cell Significance Index: -13.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3200
    Cell Significance Index: -15.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2294
    Cell Significance Index: -11.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9863
    Cell Significance Index: -15.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6693
    Cell Significance Index: -11.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2846
    Cell Significance Index: -5.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9560
    Cell Significance Index: 863.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8165
    Cell Significance Index: 88.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7370
    Cell Significance Index: 119.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5318
    Cell Significance Index: 61.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4436
    Cell Significance Index: 9.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4052
    Cell Significance Index: 28.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3753
    Cell Significance Index: 10.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3687
    Cell Significance Index: 16.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3279
    Cell Significance Index: 15.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3008
    Cell Significance Index: 15.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2834
    Cell Significance Index: 7.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2707
    Cell Significance Index: 17.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2699
    Cell Significance Index: 7.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2604
    Cell Significance Index: 35.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2554
    Cell Significance Index: 30.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2493
    Cell Significance Index: 24.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2452
    Cell Significance Index: 1.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2268
    Cell Significance Index: 29.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2171
    Cell Significance Index: 118.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2133
    Cell Significance Index: 38.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2054
    Cell Significance Index: 10.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1945
    Cell Significance Index: 9.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1846
    Cell Significance Index: 37.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1713
    Cell Significance Index: 34.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1656
    Cell Significance Index: 20.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1470
    Cell Significance Index: 2.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1406
    Cell Significance Index: 62.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1327
    Cell Significance Index: 4.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1247
    Cell Significance Index: 3.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1164
    Cell Significance Index: 1.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1126
    Cell Significance Index: 14.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1090
    Cell Significance Index: 39.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0925
    Cell Significance Index: 63.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0783
    Cell Significance Index: 2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0669
    Cell Significance Index: 2.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0608
    Cell Significance Index: 4.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0550
    Cell Significance Index: 10.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0519
    Cell Significance Index: 3.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0493
    Cell Significance Index: 3.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0362
    Cell Significance Index: 0.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0354
    Cell Significance Index: 1.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0164
    Cell Significance Index: 2.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0077
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0082
    Cell Significance Index: -12.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -15.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0160
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0227
    Cell Significance Index: -10.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0263
    Cell Significance Index: -14.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0292
    Cell Significance Index: -18.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0360
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0397
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0404
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0438
    Cell Significance Index: -12.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0551
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0593
    Cell Significance Index: -1.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0695
    Cell Significance Index: -5.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0777
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0859
    Cell Significance Index: -18.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0985
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1288
    Cell Significance Index: -8.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1339
    Cell Significance Index: -8.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1355
    Cell Significance Index: -4.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1452
    Cell Significance Index: -15.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1637
    Cell Significance Index: -1.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1687
    Cell Significance Index: -13.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1714
    Cell Significance Index: -9.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1750
    Cell Significance Index: -10.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1776
    Cell Significance Index: -4.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1981
    Cell Significance Index: -1.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2259
    Cell Significance Index: -4.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2526
    Cell Significance Index: -7.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2665
    Cell Significance Index: -11.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2714
    Cell Significance Index: -7.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2913
    Cell Significance Index: -6.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3153
    Cell Significance Index: -11.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3364
    Cell Significance Index: -9.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3503
    Cell Significance Index: -9.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3529
    Cell Significance Index: -11.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3550
    Cell Significance Index: -12.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3644
    Cell Significance Index: -4.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3647
    Cell Significance Index: -11.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3686
    Cell Significance Index: -13.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3731
    Cell Significance Index: -9.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3740
    Cell Significance Index: -6.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRMT2A is a s-adenosyl methionine-dependent enzyme, meaning it requires the cofactor s-adenosyl methionine (SAM) to catalyze the methylation reaction. The enzyme exhibits high specificity for the tRNA molecule, with a substrate specificity profile that highlights its unique role in tRNA modification. TRMT2A is predominantly expressed in various cell types, including germ cells, pulmonary interstitial fibroblasts, cerebral cortex GABAergic interneurons, and intestinal epithelial cells, suggesting its widespread involvement in cellular regulation. **Pathways and Functions:** TRMT2A is involved in several key cellular pathways, including: 1. **Cytosol:** TRMT2A is localized to the cytosol, where it regulates tRNA processing and modification. 2. **Methylation:** TRMT2A catalyzes the methylation of uracil at position 54 of tRNA, a process essential for tRNA folding and function. 3. **RNA binding:** TRMT2A interacts with tRNA molecules, facilitating their processing and modification. 4. **Protein binding:** TRMT2A interacts with various proteins, including RNA-binding proteins and transcription factors, to regulate cellular processes. 5. **mRNA processing:** TRMT2A regulates the processing of mRNA molecules, affecting the translation of proteins. 6. **C-methyltransferase activity:** TRMT2A exhibits C-methyltransferase activity, catalyzing the methylation of nucleotides in RNA molecules. **Clinical Significance:** Dysregulation of TRMT2A has been implicated in various diseases, including: 1. **Neurological disorders:** Mutations in TRMT2A have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** TRMT2A expression is altered in various types of cancer, including colorectal cancer and lung cancer. 3. **Immune system disorders:** TRMT2A is involved in the regulation of immune responses, and alterations in its expression have been linked to autoimmune disorders. 4. **Neurodegenerative diseases:** TRMT2A has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRMT2A is a critical enzyme involved in the regulation of tRNA modification and cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms of TRMT2A.

Genular Protein ID: 3056176175

Symbol: TRM2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IZ69 D3DX25 Q32P57 Q96ME6 Q9H732

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 13 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 8 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 31361898

Title: FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.

PubMed ID: 31361898

DOI: 10.1093/nar/gkz658

PubMed ID: 34123281

Title: Chemical tagging for sensitive determination of uridine modifications in RNA.

PubMed ID: 34123281

DOI: 10.1039/c9sc05094a

PubMed ID: 33799331

Title: m5U54 tRNA hypomodification by lack of TRMT2A drives the generation of tRNA-derived small RNAs.

PubMed ID: 33799331

DOI: 10.3390/ijms22062941

PubMed ID: 34556860

Title: Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation.

PubMed ID: 34556860

DOI: 10.1038/s41589-021-00874-8

Sequence Information:

  • Length: 625
  • Mass: 68726
  • Checksum: 2D310E521D846E06
  • Sequence:
    • MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY 
SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA 
ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE SEPPVTRVAD VVTPLWTVPY 
AEQLERKQLE CEQVLQKLAK EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR 
NKCEFLVGVG VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP 
YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA QHFTAGPGRA 
SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL TFRISPHAFF QVNTPAAEVL 
YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL ARKVKRVIGV ELCPEAVEDA RVNAQDNELS 
NVEFHCGRAE DLVPTLVSRL ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP 
RAAMGNFVDL CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP 
HSPPAQPTPG PPDNTLQETG TFPSS

Genular Protein ID: 3740945958

Symbol: F2Z2W7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F2Z2W7

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 4 SAM 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18477386

Title: Finishing the finished human chromosome 22 sequence.

PubMed ID: 18477386

DOI: 10.1186/gb-2008-9-5-r78

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 643
  • Mass: 70835
  • Checksum: 2004611A69FEC4D4
  • Sequence:
    • MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY 
SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA 
ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE SEPPVTRVAD VVTPLWTVPY 
AEQLERKQLE CEQVLQKLAK EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR 
NKCEFLVGVG VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP 
YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA QHFTAGPGRA 
SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL TFRISPHAFF QVNTPAAEVL 
YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL ARGPMYSPPW VGRHHAFLFQ KVKRVIGVEL 
CPEAVEDARV NAQDNELSNV EFHCGRAEDL VPTLVSRLAS QHLVAILDPP RAGLHSKVIL 
AIRRAKNLRR LLYVSCNPRA AMGNFVDLCR APSNRVKGIP FRPVKAVAVD LFPQTPHCEM 
LILFERVEHP NGTGVLGPHS PPAQPTPGPP DNTLQETGTF PSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.