Details for: UTP25

Gene ID: 27042

Symbol: UTP25

Ensembl ID: ENSG00000117597

Description: UTP25 small subunit processome component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 41.6315
    Cell Significance Index: -17.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.9742
    Cell Significance Index: -16.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.9656
    Cell Significance Index: -12.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.9485
    Cell Significance Index: -16.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2811
    Cell Significance Index: -12.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1626
    Cell Significance Index: -13.8300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.4474
    Cell Significance Index: 40.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5629
    Cell Significance Index: 154.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3332
    Cell Significance Index: 18.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1100
    Cell Significance Index: 1002.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9963
    Cell Significance Index: 108.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8204
    Cell Significance Index: 133.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4937
    Cell Significance Index: 34.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4890
    Cell Significance Index: 97.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4661
    Cell Significance Index: 24.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4401
    Cell Significance Index: 11.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4189
    Cell Significance Index: 84.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3341
    Cell Significance Index: 38.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3323
    Cell Significance Index: 59.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2857
    Cell Significance Index: 35.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2405
    Cell Significance Index: 6.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2169
    Cell Significance Index: 41.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2084
    Cell Significance Index: 92.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1868
    Cell Significance Index: 25.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1825
    Cell Significance Index: 11.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1822
    Cell Significance Index: 65.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1599
    Cell Significance Index: 4.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1560
    Cell Significance Index: 7.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1474
    Cell Significance Index: 101.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1449
    Cell Significance Index: 3.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1357
    Cell Significance Index: 9.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1329
    Cell Significance Index: 72.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1033
    Cell Significance Index: 4.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0826
    Cell Significance Index: 5.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0701
    Cell Significance Index: 3.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0592
    Cell Significance Index: 2.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0579
    Cell Significance Index: 2.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0552
    Cell Significance Index: 7.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0512
    Cell Significance Index: 1.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0483
    Cell Significance Index: 6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0444
    Cell Significance Index: 1.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0092
    Cell Significance Index: 0.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0079
    Cell Significance Index: -0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0132
    Cell Significance Index: -2.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0176
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0269
    Cell Significance Index: -15.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0289
    Cell Significance Index: -13.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0304
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0313
    Cell Significance Index: -19.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0407
    Cell Significance Index: -4.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0411
    Cell Significance Index: -11.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0423
    Cell Significance Index: -0.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0456
    Cell Significance Index: -0.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0506
    Cell Significance Index: -7.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0522
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0536
    Cell Significance Index: -6.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0818
    Cell Significance Index: -6.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0830
    Cell Significance Index: -17.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1391
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1430
    Cell Significance Index: -14.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1452
    Cell Significance Index: -3.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1669
    Cell Significance Index: -13.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1848
    Cell Significance Index: -4.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1870
    Cell Significance Index: -9.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1961
    Cell Significance Index: -5.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1972
    Cell Significance Index: -3.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2029
    Cell Significance Index: -5.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2037
    Cell Significance Index: -4.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2071
    Cell Significance Index: -12.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2136
    Cell Significance Index: -3.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2201
    Cell Significance Index: -7.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2230
    Cell Significance Index: -9.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2387
    Cell Significance Index: -3.4200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2561
    Cell Significance Index: -3.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2638
    Cell Significance Index: -8.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2889
    Cell Significance Index: -7.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2940
    Cell Significance Index: -4.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3002
    Cell Significance Index: -5.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3021
    Cell Significance Index: -9.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3058
    Cell Significance Index: -9.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3123
    Cell Significance Index: -10.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3339
    Cell Significance Index: -3.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3348
    Cell Significance Index: -9.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3388
    Cell Significance Index: -7.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3597
    Cell Significance Index: -13.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3776
    Cell Significance Index: -5.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3791
    Cell Significance Index: -11.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3815
    Cell Significance Index: -7.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small subunit processome component:** UTP25 is a protein component of the small subunit processome, a complex involved in the maturation of ssu-rRNA. 2. **RNA processing:** UTP25 plays a crucial role in the processing of ssu-rRNA, a critical step in ribosome biogenesis. 3. **Embryonic development:** The UTP25 gene is significantly expressed during embryonic development, suggesting its importance in early cell fate determination and tissue patterning. 4. **Cellular localization:** UTP25 is primarily localized to the nucleolus and cytosol, where it interacts with other components of the ribosome biogenesis machinery. **Pathways and Functions:** 1. **RNA processing pathways:** UTP25 is involved in the maturation of ssu-rRNA from the tricistronic rRNA transcript, a process that requires the coordinated action of multiple enzymes and factors. 2. **Ribosome biogenesis:** UTP25 plays a critical role in the biogenesis of ribosomes, which are essential for protein synthesis and cellular growth. 3. **RNA modification:** UTP25 is involved in the modification of ssu-rRNA, a process that involves the addition of nucleotides and the removal of internal nucleotides. 4. **Protein binding:** UTP25 interacts with other proteins involved in ribosome biogenesis, including RNA-binding proteins and enzymes. **Clinical Significance:** 1. **Diseases associated with UTP25:** Abnormal expression of UTP25 has been linked to several diseases, including cancer, neurological disorders, and metabolic disorders. 2. **Ribosome biogenesis defects:** Mutations in the UTP25 gene or other components of the ribosome biogenesis machinery can lead to ribosome biogenesis defects, which can result in impaired protein synthesis and cellular dysfunction. 3. **Therapeutic targets:** Understanding the role of UTP25 in ribosome biogenesis and RNA processing may lead to the identification of therapeutic targets for diseases associated with ribosome biogenesis defects. 4. **Cancer therapy:** UTP25 may play a role in cancer development and progression, and targeting UTP25 or other components of the ribosome biogenesis machinery may provide a new avenue for cancer therapy. In conclusion, the UTP25 gene plays a crucial role in the biogenesis of ribosomes and the maturation of ssu-rRNA. Its dysregulation has been linked to several diseases, highlighting its importance in maintaining cellular function and tissue homeostasis. Further research on the role of UTP25 in ribosome biogenesis and RNA processing may lead to the identification of new therapeutic targets for diseases associated with ribosome biogenesis defects.

Genular Protein ID: 132093296

Symbol: UTP25_HUMAN

Name: Digestive organ expansion factor homolog

UniProtKB Accession Codes:

Q68CQ4 O75992 Q4VY00 Q63HL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25007945

Title: MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.

PubMed ID: 25007945

DOI: 10.1186/1471-230x-14-123

PubMed ID: 27657329

Title: Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.

PubMed ID: 27657329

DOI: 10.1371/journal.pbio.1002555

PubMed ID: 23357851

Title: Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.

PubMed ID: 23357851

DOI: 10.1038/cr.2013.16

Sequence Information:

  • Length: 756
  • Mass: 87055
  • Checksum: A8821B0AC4BF4067
  • Sequence:
    • MGKRGSRSQS QLLNTLTKKQ KKHLRDFGEE HPFYDRVSRK EAKPQICQLS ESSDSSDSES 
DSESEPQQVS GYHRLLATLK NVSEEEEEDE EEEEEEDSIV DDAEMNDEDG GSDVSVEEEM 
AAESTESPEN VALSADPEGK EDGEEPPGTS QTSPEEFTDA KHESLFSLET NFLEEESGDN 
SSLKASQDPF LQHVNKELKE KAIQAVATNP KTTHELKWPI LGQLFFSSKF QKLETFKPPK 
DIDLKSLHLQ KPLESTWTKT NSQFLSGPQK SSSPFTPLQK ELFLIMNSYR DLFYPERTAL 
KNGEEIRHVY CLHVINHILK ANAQVLGNNS RRRSQKFGVG DDDDFRDQGL TRPKVLIVVP 
FREAALRVVQ LFISLLEGDS KKKIIVSNKK RFQGEYGSDP EERPPNLKRP EDYEAVFVGN 
IDDHFRIGVA ILQRSIRLYA PFYSSDILIA SPLGLRTIIG GEGEKKRDFD FLSSIELLII 
DQADIYLMQN WEHVLHLMNH MNLLPLDSHG VDFSRVRMWS LNNWSKYYRQ TLLFGALQDA 
QINSVFNKYC VNMQGQVAVR NVPMTGSISH VLVQLPHVFQ RMEAENLASV IDARFNFFVN 
KILPQYRDAV MSHTLIYIPS YFDFVRLRNY FKKEELNFTH ICEYTQKSGV SRARHFFLQG 
EKQFLLFTER FHFYKRYTIK GIRNLIFYEL PTYPHFYSEI CNMLRATNRG EEATWTCTVL 
YSKYDAQRLA AVVGVERAAQ MLQSNKNVHL FITGEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.