Details for: LAMP3

Gene ID: 27074

Symbol: LAMP3

Ensembl ID: ENSG00000078081

Description: lysosomal associated membrane protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.8942
    Cell Significance Index: -3.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.8527
    Cell Significance Index: -3.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.5660
    Cell Significance Index: -3.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.6345
    Cell Significance Index: -3.4700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 3.1723
    Cell Significance Index: 54.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.6441
    Cell Significance Index: -3.2600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.7943
    Cell Significance Index: 6.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5979
    Cell Significance Index: 452.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4478
    Cell Significance Index: 6.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4153
    Cell Significance Index: 79.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3918
    Cell Significance Index: 23.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3648
    Cell Significance Index: 36.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3058
    Cell Significance Index: 33.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2197
    Cell Significance Index: 35.7300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1759
    Cell Significance Index: 2.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1463
    Cell Significance Index: 7.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1444
    Cell Significance Index: 1.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1230
    Cell Significance Index: 8.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1079
    Cell Significance Index: 13.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1017
    Cell Significance Index: 91.8100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0931
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0836
    Cell Significance Index: 1.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0788
    Cell Significance Index: 9.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0769
    Cell Significance Index: 34.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0655
    Cell Significance Index: 3.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0411
    Cell Significance Index: 2.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0391
    Cell Significance Index: 7.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0378
    Cell Significance Index: 1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0316
    Cell Significance Index: 5.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0303
    Cell Significance Index: 5.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0245
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0242
    Cell Significance Index: 8.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0166
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0147
    Cell Significance Index: 2.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0134
    Cell Significance Index: 0.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0106
    Cell Significance Index: 0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0089
    Cell Significance Index: 4.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0081
    Cell Significance Index: 0.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0047
    Cell Significance Index: 0.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0028
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0064
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0085
    Cell Significance Index: -0.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0116
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0123
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0170
    Cell Significance Index: -3.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0247
    Cell Significance Index: -2.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0263
    Cell Significance Index: -3.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0297
    Cell Significance Index: -3.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0302
    Cell Significance Index: -0.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0312
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0351
    Cell Significance Index: -2.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0394
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0419
    Cell Significance Index: -1.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0436
    Cell Significance Index: -1.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0439
    Cell Significance Index: -3.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0490
    Cell Significance Index: -3.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0500
    Cell Significance Index: -0.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0508
    Cell Significance Index: -3.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0521
    Cell Significance Index: -3.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0567
    Cell Significance Index: -3.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0568
    Cell Significance Index: -3.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0572
    Cell Significance Index: -1.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0590
    Cell Significance Index: -1.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0621
    Cell Significance Index: -2.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0626
    Cell Significance Index: -2.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0638
    Cell Significance Index: -1.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0649
    Cell Significance Index: -2.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0724
    Cell Significance Index: -2.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0726
    Cell Significance Index: -1.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0767
    Cell Significance Index: -3.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0817
    Cell Significance Index: -3.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0826
    Cell Significance Index: -2.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0831
    Cell Significance Index: -3.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0878
    Cell Significance Index: -3.0500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0929
    Cell Significance Index: -0.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0934
    Cell Significance Index: -2.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0954
    Cell Significance Index: -0.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0964
    Cell Significance Index: -3.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0994
    Cell Significance Index: -2.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1018
    Cell Significance Index: -2.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1032
    Cell Significance Index: -2.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAMP3 is a transmembrane glycoprotein that is primarily expressed on the surface of lysosomes, late endosomes, and perinuclear regions of cells. It is also found in the plasma membrane and has been implicated in the regulation of autophagy, a vital process for maintaining cellular homeostasis. LAMP3 is known to interact with various proteins, including cysteine-type endopeptidases, and modulate their activity, thereby influencing apoptosis and proteasomal protein catabolism. **Pathways and Functions:** LAMP3 is involved in several key pathways, including: 1. **Adaptive Immune Response**: LAMP3 plays a crucial role in regulating the immune response by modulating the activity of cysteine-type endopeptidases, which are essential for the processing and presentation of antigens to T-cells. 2. **Autophagy**: LAMP3 is a key regulator of autophagy, a process that involves the degradation and recycling of cellular components. LAMP3 interacts with autophagic proteins and modulates the activity of autophagy-related genes. 3. **Viral Life Cycle**: LAMP3 has been shown to regulate the entry of viruses into host cells, suggesting its importance in viral infection and immune response. 4. **Regulation of Gene Expression**: LAMP3 has been implicated in the regulation of gene expression, particularly in the context of immune response and cellular homeostasis. **Clinical Significance:** LAMP3 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: LAMP3 has been shown to play a role in autoimmune disorders, such as rheumatoid arthritis and lupus, where dysregulation of autophagy and immune response can contribute to disease pathogenesis. 2. **Infectious Diseases**: LAMP3 has been implicated in the regulation of viral entry and immune response, suggesting its importance in infectious diseases such as HIV and influenza. 3. **Cancer**: LAMP3 has been shown to regulate the autophagy and immune response in cancer cells, suggesting its potential as a therapeutic target in cancer treatment. In conclusion, LAMP3 is a multifaceted gene that plays a crucial role in maintaining cellular homeostasis and responding to various stimuli. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 56248284

Symbol: LAMP3_HUMAN

Name: Lysosome-associated membrane glycoprotein 3

UniProtKB Accession Codes:

Q9UQV4 D3DNS4 O94781 Q8NEC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9721848

Title: Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues.

PubMed ID: 9721848

PubMed ID: 9768752

Title: A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.

PubMed ID: 9768752

DOI: 10.1016/s1074-7613(00)80615-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21930964

Title: Reciprocal polarization of T and B cells at the immunological synapse.

PubMed ID: 21930964

DOI: 10.4049/jimmunol.1100600

PubMed ID: 21810281

Title: Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells.

PubMed ID: 21810281

DOI: 10.1186/1743-422x-8-384

PubMed ID: 24434718

Title: LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy.

PubMed ID: 24434718

DOI: 10.1530/erc-13-0183

PubMed ID: 25681212

Title: Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition.

PubMed ID: 25681212

DOI: 10.1016/j.ejcb.2015.01.003

PubMed ID: 27329040

Title: LAMP-3 (Lysosome-Associated Membrane Protein 3) Promotes the Intracellular Proliferation of Salmonella typhimurium.

PubMed ID: 27329040

DOI: 10.14348/molcells.2016.0112

PubMed ID: 29056532

Title: LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway.

PubMed ID: 29056532

DOI: 10.1016/j.mce.2017.10.010

PubMed ID: 32295904

Title: Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

PubMed ID: 32295904

DOI: 10.1128/jvi.00050-20

PubMed ID: 22809326

Title: Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.

PubMed ID: 22809326

DOI: 10.1186/1741-7007-10-62

Sequence Information:

  • Length: 416
  • Mass: 44346
  • Checksum: D615895D382B8F88
  • Sequence:
    • MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 
HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 
TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 
TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 
EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 
QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.