Details for: AMPD2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 98.4280
Cell Significance Index: -15.3100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 48.0990
Cell Significance Index: -12.2000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 35.4701
Cell Significance Index: -14.4100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 31.8438
Cell Significance Index: -16.3800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.2083
Cell Significance Index: -14.5200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.6931
Cell Significance Index: -15.6500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.7095
Cell Significance Index: -15.3000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.3823
Cell Significance Index: -13.4600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.0522
Cell Significance Index: -15.9900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.3072
Cell Significance Index: 38.0200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0607
Cell Significance Index: -4.5100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6461
Cell Significance Index: 162.8400 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.5218
Cell Significance Index: 11.7300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2357
Cell Significance Index: 1115.7500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0496
Cell Significance Index: 55.1100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9426
Cell Significance Index: 102.5300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8826
Cell Significance Index: 143.5500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8516
Cell Significance Index: 51.1200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5164
Cell Significance Index: 103.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4932
Cell Significance Index: 14.2100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4835
Cell Significance Index: 56.3500 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4684
Cell Significance Index: 5.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4620
Cell Significance Index: 12.3800 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.4412
Cell Significance Index: 11.2700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4314
Cell Significance Index: 11.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4159
Cell Significance Index: 82.5400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4030
Cell Significance Index: 144.5600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4028
Cell Significance Index: 25.9900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3963
Cell Significance Index: 11.3600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3854
Cell Significance Index: 73.3400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3213
Cell Significance Index: 8.9800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2783
Cell Significance Index: 6.0300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2500
Cell Significance Index: 4.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2290
Cell Significance Index: 10.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2227
Cell Significance Index: 28.5500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1883
Cell Significance Index: 130.2400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1532
Cell Significance Index: 5.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1520
Cell Significance Index: 10.2200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1444
Cell Significance Index: 19.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1080
Cell Significance Index: 2.3000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0908
Cell Significance Index: 49.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0730
Cell Significance Index: 3.3100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0526
Cell Significance Index: 23.2500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0485
Cell Significance Index: 2.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0435
Cell Significance Index: 7.4300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0371
Cell Significance Index: 1.7300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0369
Cell Significance Index: 23.4500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0335
Cell Significance Index: 6.0500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0328
Cell Significance Index: 0.6800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0199
Cell Significance Index: 37.4200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0148
Cell Significance Index: 0.5200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0004
Cell Significance Index: 0.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0017
Cell Significance Index: -1.2800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0028
Cell Significance Index: -5.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0042
Cell Significance Index: -6.4800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0099
Cell Significance Index: -6.2100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0113
Cell Significance Index: -0.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0115
Cell Significance Index: -15.6200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0128
Cell Significance Index: -9.4200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0134
Cell Significance Index: -10.1700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0166
Cell Significance Index: -7.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0193
Cell Significance Index: -0.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0196
Cell Significance Index: -11.0600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0210
Cell Significance Index: -3.0500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0218
Cell Significance Index: -0.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0221
Cell Significance Index: -2.8500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0294
Cell Significance Index: -0.8400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0342
Cell Significance Index: -3.4900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0360
Cell Significance Index: -4.2400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0382
Cell Significance Index: -8.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0470
Cell Significance Index: -13.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0695
Cell Significance Index: -5.3300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0737
Cell Significance Index: -8.4400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0750
Cell Significance Index: -8.5700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0757
Cell Significance Index: -1.9900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0785
Cell Significance Index: -5.5500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0790
Cell Significance Index: -2.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0899
Cell Significance Index: -2.8800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0997
Cell Significance Index: -5.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1217
Cell Significance Index: -9.0700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1279
Cell Significance Index: -3.4800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1309
Cell Significance Index: -2.7400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1318
Cell Significance Index: -3.1600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1450
Cell Significance Index: -15.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1517
Cell Significance Index: -9.3000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1524
Cell Significance Index: -7.9400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1684
Cell Significance Index: -3.3800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1684
Cell Significance Index: -4.2100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1726
Cell Significance Index: -5.0700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1798
Cell Significance Index: -14.2400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2222
Cell Significance Index: -2.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2359
Cell Significance Index: -13.2400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2367
Cell Significance Index: -8.2300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2378
Cell Significance Index: -14.9900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2469
Cell Significance Index: -5.2400 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.2736
Cell Significance Index: -2.4100 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.2854
Cell Significance Index: -4.0000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2897
Cell Significance Index: -6.2600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2914
Cell Significance Index: -9.2800 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.3211
Cell Significance Index: -2.0100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 610447293
Symbol: AMPD2_HUMAN
Name: AMP deaminase isoform L
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1429593
Title: Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.
PubMed ID: 1429593
PubMed ID: 8526848
Title: Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L.
PubMed ID: 8526848
DOI: 10.1042/bj3120401
PubMed ID: 8764830
Title: Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters.
PubMed ID: 8764830
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23911318
Title: AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.
PubMed ID: 23911318
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24482476
Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
PubMed ID: 24482476
Sequence Information:
- Length: 825
- Mass: 94890
- Checksum: F79EAD41CBA771AC
- Sequence:
MASYPSGSGK PKAKYPFKKR ASLQASTAAP EARGGLGAPP LQSARSLPGP APCLKHFPLD LRTSMDGKCK EIAEELFTRS LAESELRSAP YEFPEESPIE QLEERRQRLE RQISQDVKLE PDILLRAKQD FLKTDSDSDL QLYKEQGEGQ GDRSLRERDV LEREFQRVTI SGEEKCGVPF TDLLDAAKSV VRALFIREKY MALSLQSFCP TTRRYLQQLA EKPLETRTYE QGPDTPVSAD APVHPPALEQ HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RREPDEHCSE VELPYPDLQE FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV PHRDFYNIRK VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ TLREVFESMN LTAYDLSVDT LDVHADRNTF HRFDKFNAKY NPIGESVLRE IFIKTDNRVS GKYFAHIIKE VMSDLEESKY QNAELRLSIY GRSRDEWDKL ARWAVMHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML ENIFLPLFEA TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA ENISHGLLLR KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS RGLMVSLSTD DPLQFHFTKE PLMEEYSIAT QVWKLSSCDM CELARNSVLM SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN VPDIRVGYRY ETLCQELALI TQAVQSEMLE TIPEEAGITM SPGPQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.