Details for: GK

Gene ID: 2710

Symbol: GK

Ensembl ID: ENSG00000198814

Description: glycerol kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5486
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.52
    Marker Score: 38944
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.49
    Marker Score: 9070
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167940
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.39
    Marker Score: 2424
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.36
    Marker Score: 1552
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.32
    Marker Score: 3421
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.29
    Marker Score: 22953
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.29
    Marker Score: 79323
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1869
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.15
    Marker Score: 417
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.15
    Marker Score: 25714.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.13
    Marker Score: 63169
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.13
    Marker Score: 41633
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.13
    Marker Score: 1739
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.11
    Marker Score: 464
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.11
    Marker Score: 7133
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.1
    Marker Score: 2228.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.08
    Marker Score: 9318.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11190
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.07
    Marker Score: 801
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.05
    Marker Score: 960.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.04
    Marker Score: 9817
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.04
    Marker Score: 9066
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251718
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.03
    Marker Score: 4442
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.02
    Marker Score: 505
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.01
    Marker Score: 9568.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71737
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.99
    Marker Score: 4116
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.99
    Marker Score: 4764
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.97
    Marker Score: 3736
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15114
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.97
    Marker Score: 4039
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.93
    Marker Score: 13838.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2177
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1468
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.9
    Marker Score: 2181
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.89
    Marker Score: 4806
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.89
    Marker Score: 1731
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.89
    Marker Score: 1307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3571
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.88
    Marker Score: 330
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.87
    Marker Score: 1660
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.85
    Marker Score: 3032.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.85
    Marker Score: 2673
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 887
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.83
    Marker Score: 186
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.82
    Marker Score: 16390
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.8
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.79
    Marker Score: 3290
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3318
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.79
    Marker Score: 2718
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 251.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.78
    Marker Score: 5978
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.77
    Marker Score: 1105
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.76
    Marker Score: 846
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.75
    Marker Score: 501
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.74
    Marker Score: 28007
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.73
    Marker Score: 2392
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.73
    Marker Score: 11673
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7
    Marker Score: 4506
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.7
    Marker Score: 4560
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 201.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 626
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.68
    Marker Score: 695
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.68
    Marker Score: 1093
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 254
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.68
    Marker Score: 196
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 461
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.67
    Marker Score: 194
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.67
    Marker Score: 228
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.66
    Marker Score: 365
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 398
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.66
    Marker Score: 13980.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.65
    Marker Score: 240
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.65
    Marker Score: 839
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.64
    Marker Score: 744
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.63
    Marker Score: 1149
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.63
    Marker Score: 1010
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.63
    Marker Score: 432
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.62
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.62
    Marker Score: 380
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.62
    Marker Score: 169
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.61
    Marker Score: 421

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Other Information

**Key characteristics:** - It is an enzyme of the glycerol phosphate family. - It is highly expressed in epithelial cells of the proximal tubule, alveolar macrophage, elicited macrophage, mural cell, germ cell, and CD1c-positive myeloid dendritic cell. - It is also expressed in L2/3-6 intratelencephalic projecting glutamatergic neuron, L5 extratelencephalic projecting glutamatergic cortical neuron. **Pathways and functions:** - **ATP binding:** GK binds to ATP and undergoes autophosphorylation, leading to the formation of a phosphate-activated GK (GK-P). - **Glycerol catabolic process:** GK-P is involved in the regulation of fatty acid oxidation. It phosphorylates glycerol-3-phosphate to 3-phosphoglycerate, which can be used in the citric acid cycle. - **Glycerol metabolic process:** GK is also involved in the regulation of lipid metabolism. It phosphorylates glycerol to 3-phosphoglycerate, which can be used to synthesize new lipids. - **Glycerol kinase activity:** GK activity is regulated by various factors, including changes in ATP concentration, calcium ions, and hormones. **Clinical significance:** - Dysregulation of GK has been linked to various diseases, including obesity, metabolic syndrome, and cancer. - Inhibition of GK has been shown to improve insulin sensitivity and reduce inflammation, suggesting that it may be a potential therapeutic target for type 2 diabetes and other metabolic disorders. - Overexpression of GK has been observed in some types of cancer, indicating that it may play a role in tumor growth and metastasis.

Genular Protein ID: 2479660992

Symbol: GLPK_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32189 A6NJP5 B2R833 Q6IQ27 Q8IVR5 Q9UMP0 Q9UMP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 71 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8401584

Title: Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene.

PubMed ID: 8401584

DOI: 10.1038/ng0893-367

PubMed ID: 7987308

Title: The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.

PubMed ID: 7987308

DOI: 10.1093/hmg/3.8.1317

PubMed ID: 10851254

Title: Five cases of isolated glycerol kinase deficiency, including two families: failure to find genotype:phenotype correlation.

PubMed ID: 10851254

DOI: 10.1136/jmg.37.6.434

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8499912

Title: Cloning of the X-linked glycerol kinase deficiency gene and its identification by sequence comparison to the Bacillus subtilis homologue.

PubMed ID: 8499912

DOI: 10.1093/hmg/2.2.97

PubMed ID: 8499898

Title: Isolation of the human Xp21 glycerol kinase gene by positional cloning.

PubMed ID: 8499898

DOI: 10.1093/hmg/2.2.107

PubMed ID: 15845384

Title: Human and murine glycerol kinase: influence of exon 18 alternative splicing on function.

PubMed ID: 15845384

DOI: 10.1016/j.bbrc.2005.03.143

PubMed ID: 37021775

Title: Expression and characterisation of human glycerol kinase: the role of solubilising agents and molecular chaperones.

PubMed ID: 37021775

DOI: 10.1042/bsr20222258

PubMed ID: 8651297

Title: Mutations and phenotype in isolated glycerol kinase deficiency.

PubMed ID: 8651297

PubMed ID: 9719371

Title: Clinical heterogeneity and novel mutations in the glycerol kinase gene in three families with isolated glycerol kinase deficiency.

PubMed ID: 9719371

DOI: 10.1136/jmg.35.8.650

PubMed ID: 10736265

Title: Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait.

PubMed ID: 10736265

DOI: 10.1086/302903

Sequence Information:

  • Length: 559
  • Mass: 61245
  • Checksum: 18268B7A4C6A09F3
  • Sequence:
    • MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 
LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ 
STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS 
WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PNVRSSSEIY 
GLMKISHSVK AGALEGVPIS GCLGDQSAAL VGQMCFQIGQ AKNTYGTGCF LLCNTGHKCV 
FSDHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKTSEE IEKLAKEVGT 
SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF AALEAVCFQT REILDAMNRD 
CGIPLSHLQV DGGMTSNKIL MQLQADILYI PVVKPSMPET TALGAAMAAG AAEGVGVWSL 
EPEDLSAVTM ERFEPQINAE ESEIRYSTWK KAVMKSMGWV TTQSPESGDP SIFCSLPLGF 
FIVSSMVMLI GARYISGIP

Genular Protein ID: 2848611351

Symbol: A0A8I5KXY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KXY7

Database IDs:

ARBA 12 CDD 1 CTD 1 EMBL 3 EPD 1 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 7 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PIRSF 1 PROSITE 2 Pfam 4 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 581
  • Mass: 63034
  • Checksum: FA3D439846CAE072
  • Sequence:
    • MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 
LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKITGEPLYN AVAAPVSPGP 
SVPVAVVPSG SSVPAPGTSS VWLDLRTQST VESLSKRIPG NNNFVKSKTG LPLSTYFSAV 
KLRWLLDNVR KVQKAVEEKR ALFGTIDSWL IWSLTGGVNG GVHCTDVTNA SRTMLFNIHS 
LEWDKQLCEF FGIPMEILPN VRSSSEIYGL MKAGALEGVP ISGCLGDQSA ALVGQMCFQI 
GQAKNTYGTG CFLLCNTGHK CVFSDHGLLT TVAYKLGRDK PVYYALEGSV AIAGAVIRWL 
RDNLGIIKTS EEIEKLAKEV GTSYGCYFVP AFSGLYAPYW EPSARGIICG LTQFTNKCHI 
AFAALEAVCF QTREILDAMN RDCGIPLSHL QVDGGMTSNK ILMQLQADIL YIPVVKPSMP 
ETTALGAAMA AGAAEGVGVW SLEPEDLSAV TMERFEPQIN AEESEIRYST WKKAVMKSMG 
WVTTQSPESG DPSIFCSLPL GFFIVSSMVM LIGARYISGI P

Genular Protein ID: 3520631817

Symbol: B4DH54_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DH54

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 4 RuleBase 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 354
  • Mass: 38438
  • Checksum: ABA2812D88487FC8
  • Sequence:
    • MLFNIHSLEW DKQLCEFFGI PMEILPNVRS SSEIYGLMKI SHSVKAGALE GVPISGCLGD 
QSAALVGQMC FQIGQAKNTY GTGCFLLCNT GHKCVFSDHG LLTTVAYKLG RDKPVYYALE 
GSVAIAGAVI RWLRDNLGII KTSEEIEKLA KEVGTSYGCY FVPAFSGLYA PYWEPSARGI 
ICGLTQFTNK CHIAFAALEA VCFQTRETLD AMNRDCGIPL SHLQVDGGMT SNKILMQLQA 
DILYIPVVKP SMPETTALGA AMAAGAAEGV GVWSLEPEDL SAVTMERFEP QINAEESEIR 
YSTWKKAVMK SMGWVTTQSP ESGDPSIFCS LPLGFFIVSS MVMLIGARYI SGIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.