Details for: DMAC2L

Gene ID: 27109

Symbol: DMAC2L

Ensembl ID: ENSG00000125375

Description: distal membrane arm assembly component 2 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.9698
    Cell Significance Index: -21.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.5569
    Cell Significance Index: -20.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.5651
    Cell Significance Index: -23.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.2052
    Cell Significance Index: -27.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.5761
    Cell Significance Index: -26.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.9491
    Cell Significance Index: -23.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3154
    Cell Significance Index: -23.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2875
    Cell Significance Index: -24.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6826
    Cell Significance Index: -26.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6065
    Cell Significance Index: -17.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4901
    Cell Significance Index: 404.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5762
    Cell Significance Index: 183.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3745
    Cell Significance Index: 86.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0884
    Cell Significance Index: 56.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8560
    Cell Significance Index: 154.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8166
    Cell Significance Index: 7.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8129
    Cell Significance Index: 9.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6844
    Cell Significance Index: 84.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6473
    Cell Significance Index: 38.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5958
    Cell Significance Index: 38.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5386
    Cell Significance Index: 108.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5384
    Cell Significance Index: 38.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5123
    Cell Significance Index: 23.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5089
    Cell Significance Index: 60.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4916
    Cell Significance Index: 13.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4690
    Cell Significance Index: 10.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4326
    Cell Significance Index: 390.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4264
    Cell Significance Index: 19.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4154
    Cell Significance Index: 28.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4112
    Cell Significance Index: 56.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4100
    Cell Significance Index: 181.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3550
    Cell Significance Index: 127.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3520
    Cell Significance Index: 192.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3466
    Cell Significance Index: 68.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2950
    Cell Significance Index: 8.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2838
    Cell Significance Index: 21.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2779
    Cell Significance Index: 35.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2444
    Cell Significance Index: 6.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2111
    Cell Significance Index: 27.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1726
    Cell Significance Index: 1.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1702
    Cell Significance Index: 32.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1695
    Cell Significance Index: 9.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1493
    Cell Significance Index: 14.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1353
    Cell Significance Index: 15.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0912
    Cell Significance Index: 63.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0844
    Cell Significance Index: 5.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0615
    Cell Significance Index: 2.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0491
    Cell Significance Index: 1.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0478
    Cell Significance Index: 3.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0442
    Cell Significance Index: 2.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0287
    Cell Significance Index: 21.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0283
    Cell Significance Index: 4.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0165
    Cell Significance Index: 22.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0150
    Cell Significance Index: 28.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0032
    Cell Significance Index: 4.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0025
    Cell Significance Index: 1.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0157
    Cell Significance Index: -0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0233
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0334
    Cell Significance Index: -1.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0342
    Cell Significance Index: -4.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0369
    Cell Significance Index: -16.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0403
    Cell Significance Index: -22.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0486
    Cell Significance Index: -30.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0718
    Cell Significance Index: -2.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0754
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0764
    Cell Significance Index: -21.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1038
    Cell Significance Index: -2.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1152
    Cell Significance Index: -6.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1213
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1374
    Cell Significance Index: -28.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1574
    Cell Significance Index: -2.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1730
    Cell Significance Index: -5.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1816
    Cell Significance Index: -1.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1840
    Cell Significance Index: -2.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2034
    Cell Significance Index: -16.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2190
    Cell Significance Index: -7.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2315
    Cell Significance Index: -5.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2371
    Cell Significance Index: -24.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2597
    Cell Significance Index: -5.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2853
    Cell Significance Index: -4.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3002
    Cell Significance Index: -3.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3008
    Cell Significance Index: -15.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3076
    Cell Significance Index: -7.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3456
    Cell Significance Index: -4.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4064
    Cell Significance Index: -10.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4078
    Cell Significance Index: -27.4200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4254
    Cell Significance Index: -4.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4433
    Cell Significance Index: -27.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4553
    Cell Significance Index: -10.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4711
    Cell Significance Index: -9.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4765
    Cell Significance Index: -13.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4944
    Cell Significance Index: -15.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4983
    Cell Significance Index: -9.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5130
    Cell Significance Index: -15.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5193
    Cell Significance Index: -8.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5243
    Cell Significance Index: -7.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DMAC2L is a relatively novel gene, with limited information available on its structure, expression, and function. However, its significant expression in various cell types and its association with multiple cellular processes suggest that it may be a key regulator of mitochondrial function. Notably, DMAC2L is co-expressed with ATP synthase-coupling factor B (ATP5S_HUMAN), a critical component of the mitochondrial proton-transporting ATP synthase complex. This association implies that DMAC2L may play a role in regulating ATP production and energy metabolism. **Pathways and Functions:** DMAC2L is implicated in several key cellular pathways, including: 1. **Mitochondrial biogenesis and maintenance**: DMAC2L is required for the proper assembly and function of the mitochondrial inner membrane, which is essential for maintaining mitochondrial integrity and function. 2. **Energy metabolism**: DMAC2L regulates ATP production through its interaction with the ATP synthase-coupling factor B complex, which is critical for the chemiosmotic coupling of proton transport and ATP synthesis. 3. **Cellular stress responses**: DMAC2L modulates cellular stress responses, including heat production by uncoupling proteins, which is essential for maintaining cellular homeostasis under conditions of oxidative stress. 4. **Metabolic regulation**: DMAC2L is involved in regulating metabolic pathways, including the citric acid cycle and respiratory electron transport, which are critical for maintaining energy homeostasis. **Clinical Significance:** The discovery of DMAC2L's role in mitochondrial function and disease pathogenesis has significant implications for the treatment of various diseases, including: 1. **Mitochondrial disorders**: DMAC2L dysfunction may contribute to the development of mitochondrial disorders, such as mitochondrial myopathies and neurodegenerative diseases. 2. **Cancer**: DMAC2L's role in regulating energy metabolism and cellular stress responses may make it a potential target for cancer therapy. 3. **Inflammatory diseases**: DMAC2L's expression in immune cells suggests that it may play a role in regulating inflammatory responses and modulating immune cell function. In conclusion, DMAC2L is a novel gene that plays a critical role in mitochondrial function, energy metabolism, and cellular homeostasis. Further research is needed to fully elucidate its mechanisms of action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 3435464931

Symbol: ATP5S_HUMAN

Name: ATP synthase-coupling factor B

UniProtKB Accession Codes:

Q99766 A0A2R8YDJ1 A0A5K1VW60 A8K1U3 D9N156 Q8WWX3 Q96F77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 9 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 11744738

Title: Factor B and the mitochondrial ATP synthase complex.

PubMed ID: 11744738

DOI: 10.1074/jbc.m111256200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 200
  • Mass: 23226
  • Checksum: D850F7B6485D0591
  • Sequence:
    • MMPFGKISQQ LCGVKKLPWS CDSRYFWGWL NAVFNKVDYD RIRDVGPDRA ASEWLLRCGA 
MVRYHGQERW QKDYNHLPTG PLDKYKIQAI DATDSCIMSI GFDHMEGLEH VEKIRLCKCH 
YIEDDCLLRL SQLENLQKTI LEMEIISCGN ITDKGIIALR HLRNLKYLLL SDLPGVREKE 
NLVQAFKTAL PSLELKLQLK

Genular Protein ID: 3283946178

Symbol: A0A5F9ZGZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A5F9ZGZ2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 ExpressionAtlas 1 Gene3D 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 112
  • Mass: 13027
  • Checksum: E83CFBB26F73BFC2
  • Sequence:
    • MMPFGKISQQ LCGVKKLPWS CDSRYFWGWL NAVFNKVDYD RIRDVGPDRA ASEWLLRCGA 
MVRYHGQERW QKDYNHLPTG PLDKYKIQAI DATDSCIMSI GFDHMETSNI CC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.