Details for: GK2

Gene ID: 2712

Symbol: GK2

Ensembl ID: ENSG00000196475

Description: glycerol kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.35
    Marker Score: 103061
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.35
    Marker Score: 7850
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30388
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.52
    Marker Score: 6416
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3158
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 2.39
    Marker Score: 690
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.31
    Marker Score: 743
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 2.25
    Marker Score: 712
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.63
    Marker Score: 745
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.63
    Marker Score: 681
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.46
    Marker Score: 851
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.41
    Marker Score: 625
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.36
    Marker Score: 714
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.33
    Marker Score: 714
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.21
    Marker Score: 704
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.19
    Marker Score: 567
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.16
    Marker Score: 613
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.14
    Marker Score: 714
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.06
    Marker Score: 698
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.03
    Marker Score: 680
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71136
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.98
    Marker Score: 47361
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30321
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1556
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.95
    Marker Score: 542
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1790
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 706
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.92
    Marker Score: 709
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5243
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 711
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.79
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.79
    Marker Score: 407
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.75
    Marker Score: 418
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.75
    Marker Score: 713
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.74
    Marker Score: 712
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1490
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 428
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.7
    Marker Score: 709
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 553
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 399
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.64
    Marker Score: 678
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 711
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.6
    Marker Score: 702
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.55
    Marker Score: 708
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.5
    Marker Score: 711
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.49
    Marker Score: 707
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7099
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.41
    Marker Score: 713
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 707
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.4
    Marker Score: 733
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4
    Marker Score: 2384
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.35
    Marker Score: 481
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 689
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.29
    Marker Score: 599
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.26
    Marker Score: 692
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.21
    Marker Score: 738
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 733
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.06
    Marker Score: 632
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 687

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Other Information

**Key characteristics:** - It is a serine/threonine kinase. - It is a multi-functional enzyme that can act as a kinase or a phosphatase. - It is involved in the regulation of lipid metabolism, cell signaling, and inflammation. **Pathways and functions:** - The GK2 gene is involved in the following pathways and functions: - Glycerol catabolic process: GK2 is a key enzyme in the glycerol catabolic process, which breaks down glycerol into smaller molecules that can be used for energy or stored for future use. - Glycerol metabolic process: GK2 is also involved in the regulation of glycerol metabolism, including the synthesis of triglycerides and the breakdown of glycerol to produce energy. - Mitochondrial outer membrane: GK2 is a component of the mitochondrial outer membrane, where it helps to maintain the integrity of the mitochondrial inner membrane. **Clinical significance:** - Mutations in the GK2 gene have been linked to several human diseases, including: - Glycerol kinase deficiency: This disorder is caused by mutations in the GK2 gene and is characterized by a deficiency of glycerol kinase activity. Symptoms include intellectual disability, seizures, and developmental delays. - Obesity: GK2 is involved in the regulation of lipid metabolism, and mutations in the GK2 gene have been linked to obesity. - Diabetes: GK2 is involved in the regulation of glucose metabolism, and mutations in the GK2 gene have been linked to diabetes.

Genular Protein ID: 1553876210

Symbol: GLPK2_HUMAN

Name: Glycerol kinase 2

UniProtKB Accession Codes:

Q14410 A8K876 Q6PD73 Q86XV8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7987308

Title: The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.

PubMed ID: 7987308

DOI: 10.1093/hmg/3.8.1317

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28852571

Title: Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.

PubMed ID: 28852571

DOI: 10.1038/celldisc.2017.30

PubMed ID: 33536340

Title: ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.

PubMed ID: 33536340

DOI: 10.1073/pnas.2018355118

Sequence Information:

  • Length: 553
  • Mass: 60594
  • Checksum: 8CE43A0686BC4AD6
  • Sequence:
    • MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE GWVEQDPKEI 
LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW DKLTGEPLYN AVVWLDLRTQ 
TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS AVKLRWMLDN VRNVQKAVEE GRALFGTIDS 
WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY 
GLIKTGALEG VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL 
LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK EVGTSYGCYF 
VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV CFQTREILEA MNRDCGIPLR 
HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF MPETTALGAA MAAGAAEGVS VWSLEPQALS 
VLRMERFEPQ IQATESEIRY ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM 
VMLIGARYIS GVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.