Details for: CYTH4

Gene ID: 27128

Symbol: CYTH4

Ensembl ID: ENSG00000100055

Description: cytohesin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.0112
    Cell Significance Index: -9.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.0923
    Cell Significance Index: -8.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.2426
    Cell Significance Index: -11.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.2036
    Cell Significance Index: -12.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.5320
    Cell Significance Index: -11.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7253
    Cell Significance Index: -9.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8809
    Cell Significance Index: -11.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.7175
    Cell Significance Index: 22.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5038
    Cell Significance Index: -9.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0154
    Cell Significance Index: 37.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6899
    Cell Significance Index: 109.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3754
    Cell Significance Index: 29.8000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.2580
    Cell Significance Index: 3.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7459
    Cell Significance Index: 141.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6187
    Cell Significance Index: 61.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5159
    Cell Significance Index: 15.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4893
    Cell Significance Index: 441.7900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.4129
    Cell Significance Index: 3.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2824
    Cell Significance Index: 45.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.2613
    Cell Significance Index: -0.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2559
    Cell Significance Index: 30.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2154
    Cell Significance Index: 23.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1503
    Cell Significance Index: 4.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0703
    Cell Significance Index: 4.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0034
    Cell Significance Index: 0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0038
    Cell Significance Index: -0.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -9.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0079
    Cell Significance Index: -5.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0088
    Cell Significance Index: -0.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0115
    Cell Significance Index: -0.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0117
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0162
    Cell Significance Index: -3.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0175
    Cell Significance Index: -9.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0183
    Cell Significance Index: -11.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0248
    Cell Significance Index: -4.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0249
    Cell Significance Index: -11.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0256
    Cell Significance Index: -1.1600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0310
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0423
    Cell Significance Index: -1.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0475
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0570
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0582
    Cell Significance Index: -9.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0658
    Cell Significance Index: -9.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0740
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0755
    Cell Significance Index: -10.9800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0795
    Cell Significance Index: -1.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0884
    Cell Significance Index: -11.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0896
    Cell Significance Index: -11.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0914
    Cell Significance Index: -9.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0916
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0916
    Cell Significance Index: -10.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0941
    Cell Significance Index: -10.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0987
    Cell Significance Index: -4.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1044
    Cell Significance Index: -8.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1075
    Cell Significance Index: -13.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1228
    Cell Significance Index: -5.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1341
    Cell Significance Index: -6.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1567
    Cell Significance Index: -11.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1575
    Cell Significance Index: -1.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1606
    Cell Significance Index: -2.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1607
    Cell Significance Index: -10.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1668
    Cell Significance Index: -10.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1693
    Cell Significance Index: -2.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1780
    Cell Significance Index: -10.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1794
    Cell Significance Index: -9.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1820
    Cell Significance Index: -2.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1929
    Cell Significance Index: -10.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1965
    Cell Significance Index: -9.1600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2210
    Cell Significance Index: -0.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2233
    Cell Significance Index: -9.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2295
    Cell Significance Index: -11.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2335
    Cell Significance Index: -8.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2379
    Cell Significance Index: -7.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2418
    Cell Significance Index: -7.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2475
    Cell Significance Index: -4.8400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2531
    Cell Significance Index: -1.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2548
    Cell Significance Index: -3.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2591
    Cell Significance Index: -9.8100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2724
    Cell Significance Index: -3.3700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2762
    Cell Significance Index: -2.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2783
    Cell Significance Index: -7.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2915
    Cell Significance Index: -7.8100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2982
    Cell Significance Index: -2.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3002
    Cell Significance Index: -11.0200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3080
    Cell Significance Index: -7.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3164
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional protein**: CYTH4 exhibits guanyl-nucleotide exchange factor activity, regulating the activation of small GTPases, such as ARF (ADP-ribosylation factor). 2. **Membrane trafficking**: CYTH4 is involved in the regulation of membrane trafficking pathways, including vesicle-mediated transport and intra-golgi traffic. 3. **Protein binding**: CYTH4 interacts with various proteins, including those involved in signaling, trafficking, and membrane dynamics. 4. **Cell type-specific expression**: CYTH4 is expressed in a wide range of cell types, including immune cells, epithelial cells, and stem cells. **Pathways and Functions:** 1. **Centriolar satellite formation**: CYTH4 is involved in the formation and maintenance of centriolar satellites, which are crucial for the regulation of cilia and flagella function. 2. **Regulation of ARF protein signal transduction**: CYTH4 modulates the activity of ARF proteins, influencing various cellular processes, including membrane trafficking, cell polarity, and signaling. 3. **Intra-golgi and retrograde Golgi-to-ER traffic**: CYTH4 regulates the transport of proteins and lipids within the Golgi apparatus and between the Golgi and the endoplasmic reticulum (ER). 4. **Guanyl-nucleotide exchange factor activity**: CYTH4 catalyzes the exchange of GDP for GTP on small GTPases, such as ARF, influencing their activity and downstream signaling. **Clinical Significance:** The clinical significance of CYTH4 in immunological disorders is still largely unknown. However, its role in regulating membrane trafficking and signaling pathways suggests that alterations in CYTH4 expression or function may contribute to various immune-related diseases, such as: 1. **Autoimmune disorders**: Dysregulation of CYTH4-mediated membrane trafficking and signaling may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer**: CYTH4's involvement in cell signaling and membrane trafficking pathways may influence tumor growth, invasion, and metastasis. 3. **Neurological disorders**: CYTH4's role in regulating centriolar satellite formation and ARF protein signal transduction may contribute to the pathogenesis of neurological disorders, such as neurodegenerative diseases or cognitive impairments. In conclusion, CYTH4 is a multifunctional protein that plays a crucial role in regulating membrane trafficking and signaling pathways in various cell types, including immune cells. Further research is needed to elucidate the specific functions and mechanisms of CYTH4 in the immune system and its clinical significance in immunological disorders.

Genular Protein ID: 4287324935

Symbol: CYH4_HUMAN

Name: Cytohesin-4

UniProtKB Accession Codes:

Q9UIA0 Q5R3F9 Q9UGT6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10652308

Title: Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.

PubMed ID: 10652308

DOI: 10.1074/jbc.275.5.3221

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

Sequence Information:

  • Length: 394
  • Mass: 45672
  • Checksum: 0C9C8E8AD6890F34
  • Sequence:
    • MDLCHPEPAE LSSGETEELQ RIKWHRKQLL EDIQKLKDEI ADVFAQIDCF ESAEESRMAQ 
KEKELCIGRK KFNMDPAKGI QYFIEHKLLT PDVQDIARFL YKGEGLNKTA IGTYLGERDP 
INLQVLQAFV DCHEFANLNL VQALRQFLWS FRLPGEAQKI DRMMEAFATR YCLCNPGVFQ 
STDTCYVLSF SIIMLNTSLH NPNVRDRPPF ERFVSMNRGI NNGSDLPEDQ LRNLFDSIKS 
EPFSIPEDDG NDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR 
GIIPLENLSV QKVDDPKKPF CLELYNPSCR GQKIKACKTD GDGRVVEGKH ESYRISATSA 
EERDQWIESI RASITRVPFY DLVSTRKKKI ASKQ

Genular Protein ID: 2046492546

Symbol: B4E2V8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2V8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 3 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 2 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 337
  • Mass: 39004
  • Checksum: 4001B30400DF5C17
  • Sequence:
    • MAQKEKELCI GRKKFNMDPA KGIQYFIEHK LLTPDVQDIA RFLYKGEGLN KTAIGTYLGE 
RDPINLQVLQ AFVDCHEFAN LNLVQALRQF LWSFRLPGEA QKIDRMMEAF ATRYCLCNPG 
VFQSTDTCYV LSFSIIMLNT SLHNPNVRDR PPFERFVSMN RGINNGSDLP EDQLRNLFDS 
IKSEPFSIPE DDGNDLTHTF FNPDREGWLL KLGGRVKTWK RRWFILTDNC LYYFEFTTDK 
EPRGIIPLEN LSVQKVDDPK KPFCLELYNP SCRGQKIKAC KTDGDGRVVE GKHESYRISA 
TSAEERDQWI ESIRASITRV PFYDLVSTRK KKIASKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.