Details for: TJP3

Gene ID: 27134

Symbol: TJP3

Ensembl ID: ENSG00000105289

Description: tight junction protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.7199
    Cell Significance Index: -9.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 8.2470
    Cell Significance Index: 112.5200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.5637
    Cell Significance Index: 42.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2033
    Cell Significance Index: -11.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7039
    Cell Significance Index: 55.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5905
    Cell Significance Index: 248.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.0145
    Cell Significance Index: 86.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9817
    Cell Significance Index: 135.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8438
    Cell Significance Index: 61.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2985
    Cell Significance Index: 119.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9822
    Cell Significance Index: 119.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5955
    Cell Significance Index: 173.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2999
    Cell Significance Index: -2.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1217
    Cell Significance Index: 182.4300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.0388
    Cell Significance Index: 10.7200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.7136
    Cell Significance Index: 0.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7103
    Cell Significance Index: 70.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5728
    Cell Significance Index: 12.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5579
    Cell Significance Index: 304.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5392
    Cell Significance Index: 4.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5246
    Cell Significance Index: 24.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4801
    Cell Significance Index: 8.0800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4697
    Cell Significance Index: 5.0900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4679
    Cell Significance Index: 4.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4394
    Cell Significance Index: 9.1200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4040
    Cell Significance Index: 4.5200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3885
    Cell Significance Index: 5.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3719
    Cell Significance Index: 9.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3167
    Cell Significance Index: 11.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2910
    Cell Significance Index: 9.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2808
    Cell Significance Index: 55.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2495
    Cell Significance Index: 44.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2466
    Cell Significance Index: 222.6800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2464
    Cell Significance Index: 2.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2209
    Cell Significance Index: 10.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2184
    Cell Significance Index: 31.7400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2108
    Cell Significance Index: 2.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1874
    Cell Significance Index: 1.9400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1679
    Cell Significance Index: 1.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1625
    Cell Significance Index: 19.9900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.1248
    Cell Significance Index: 0.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1113
    Cell Significance Index: 3.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1053
    Cell Significance Index: 12.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1040
    Cell Significance Index: 19.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0945
    Cell Significance Index: 7.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0720
    Cell Significance Index: 49.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0680
    Cell Significance Index: 1.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0557
    Cell Significance Index: 7.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0469
    Cell Significance Index: 9.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0441
    Cell Significance Index: 0.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0314
    Cell Significance Index: 1.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0280
    Cell Significance Index: 17.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0164
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0159
    Cell Significance Index: 2.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0125
    Cell Significance Index: 4.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0096
    Cell Significance Index: 18.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0028
    Cell Significance Index: 2.0900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0006
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0041
    Cell Significance Index: -2.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0100
    Cell Significance Index: -5.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0108
    Cell Significance Index: -0.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0171
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0178
    Cell Significance Index: -5.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0206
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0207
    Cell Significance Index: -4.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0307
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0386
    Cell Significance Index: -4.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0502
    Cell Significance Index: -5.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0622
    Cell Significance Index: -8.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0822
    Cell Significance Index: -8.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1022
    Cell Significance Index: -12.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1039
    Cell Significance Index: -3.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1045
    Cell Significance Index: -8.2800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1048
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1194
    Cell Significance Index: -8.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1209
    Cell Significance Index: -9.2800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1230
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1362
    Cell Significance Index: -1.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1372
    Cell Significance Index: -8.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1467
    Cell Significance Index: -7.4200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1496
    Cell Significance Index: -1.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1605
    Cell Significance Index: -7.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1615
    Cell Significance Index: -9.0600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1621
    Cell Significance Index: -3.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1623
    Cell Significance Index: -2.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1629
    Cell Significance Index: -6.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1645
    Cell Significance Index: -8.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1740
    Cell Significance Index: -6.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1762
    Cell Significance Index: -10.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1786
    Cell Significance Index: -1.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1835
    Cell Significance Index: -11.8400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1943
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TJP3 is a type of transmembrane protein that localizes to the tight junction complex, where it interacts with other proteins to regulate the permeability of epithelial barriers. Its key characteristics include: 1. **Transmembrane localization**: TJP3 is embedded in the plasma membrane, where it interacts with other proteins to regulate the tight junction complex. 2. **Tight junction localization**: TJP3 localizes to the tight junction complex, where it plays a critical role in regulating the permeability of epithelial barriers. 3. **Cell-cell adhesion**: TJP3 is involved in regulating cell-cell adhesion, which is essential for maintaining the integrity of epithelial barriers. 4. **Protein binding**: TJP3 interacts with other proteins, including ZO-1 and occludin, to regulate the tight junction complex. **Pathways and Functions** TJP3 is involved in various pathways that regulate the function of epithelial barriers, including: 1. **Bicellular tight junction**: TJP3 is essential for the establishment and maintenance of bicellular tight junctions, which are critical for regulating the permeability of epithelial barriers. 2. **Cell-cell adhesion**: TJP3 regulates cell-cell adhesion, which is essential for maintaining the integrity of epithelial barriers. 3. **Cell junction organization**: TJP3 is involved in regulating the organization of tight junctions, which is critical for maintaining the integrity of epithelial barriers. 4. **Endothelial intestinal barrier**: TJP3 is essential for maintaining the integrity of the endothelial intestinal barrier, which is critical for regulating the permeability of the gut. 5. **Blood-brain barrier**: TJP3 is involved in regulating the permeability of the blood-brain barrier, which is critical for maintaining the integrity of the central nervous system. **Clinical Significance** Dysregulation of TJP3 has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: TJP3 is essential for maintaining the integrity of the intestinal barrier, and dysregulation of TJP3 has been implicated in inflammatory bowel disease. 2. **Neurological disorders**: TJP3 is involved in regulating the permeability of the blood-brain barrier, and dysregulation of TJP3 has been implicated in various neurological disorders, including multiple sclerosis and Alzheimer's disease. 3. **Cancer**: TJP3 is involved in regulating cell-cell adhesion, and dysregulation of TJP3 has been implicated in various types of cancer, including colorectal cancer and breast cancer. In conclusion, TJP3 is a critical component of tight junction protein family that plays a pivotal role in maintaining the integrity of various epithelial barriers, including the intestinal and blood-brain barriers. Dysregulation of TJP3 has been implicated in various diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 4190987444

Symbol: ZO3_HUMAN

Name: Tight junction protein ZO-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16129888

Title: PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.

PubMed ID: 16129888

DOI: 10.1242/jcs.02528

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 18823282

Title: Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).

PubMed ID: 18823282

DOI: 10.1042/bc20080072

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20434232

Title: Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule.

PubMed ID: 20434232

DOI: 10.1016/j.ejcb.2010.03.002

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21411630

Title: Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.

PubMed ID: 21411630

DOI: 10.1091/mbc.e10-08-0677

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354024

Title: The Staphylococcus aureus alpha-toxin perturbs the barrier function in Caco-2 epithelial cell monolayers by altering junctional integrity.

PubMed ID: 22354024

DOI: 10.1128/iai.00001-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23608536

Title: Delineation of the key aspects in the regulation of epithelial monolayer formation.

PubMed ID: 23608536

DOI: 10.1128/mcb.01435-12

PubMed ID: 24314862

Title: Curcumin prevents leptin-induced tight junction dysfunction in intestinal Caco-2 BBe cells.

PubMed ID: 24314862

DOI: 10.1016/j.jnutbio.2013.08.011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 919
  • Mass: 101397
  • Checksum: D36EB684E7E4A6C8
  • Sequence:
  • MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG RLQTGDHIVM 
    VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT KASPSSPGRQ DSDEDDGPQR 
    VEEVDQGRGY DGDSSSGSGR SWDERSRRPR PGRRGRAGSH GRRSPGGGSE ANGLALVSGF 
    KRLPRQDVQM KPVKSVLVKR RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI 
    NGVSSQNLSL NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE 
    LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE QRSELPRESS 
    YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN DVGIFVSGVQ AGSPADGQGI 
    QEGDQILQVN DVPFQNLTRE EAVQFLLGLP PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI 
    RTHFELEPSP PSGLGFTRGD VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP 
    NQSRAEQLAS LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR 
    QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS RTDSPSKIIK 
    LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP ESRPALKALR QWLAPASRRS 
    TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD TWYQELKAII REQQTRPIWT AEDQLDGSLE 
    DNLDLPHHGL ADSSADLSCD SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP 
    ALARSSEPVQ ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV 
    HDAESSDEDG YDWGPATDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.