Details for: TJP3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 9.7199
Cell Significance Index: -9.2800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 8.2470
Cell Significance Index: 112.5200 - Cell Name: precursor cell (CL0011115)
Fold Change: 5.5637
Cell Significance Index: 42.1900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.2033
Cell Significance Index: -11.2600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.7039
Cell Significance Index: 55.5000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.5905
Cell Significance Index: 248.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.0145
Cell Significance Index: 86.8600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.9817
Cell Significance Index: 135.1500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.8438
Cell Significance Index: 61.6100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.2985
Cell Significance Index: 119.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.9822
Cell Significance Index: 119.0000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5955
Cell Significance Index: 173.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2999
Cell Significance Index: -2.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1217
Cell Significance Index: 182.4300 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.0388
Cell Significance Index: 10.7200 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.7136
Cell Significance Index: 0.5100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7103
Cell Significance Index: 70.2600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5728
Cell Significance Index: 12.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5579
Cell Significance Index: 304.6600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5392
Cell Significance Index: 4.9700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5246
Cell Significance Index: 24.4600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.4801
Cell Significance Index: 8.0800 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.4697
Cell Significance Index: 5.0900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.4679
Cell Significance Index: 4.7200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4394
Cell Significance Index: 9.1200 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4040
Cell Significance Index: 4.5200 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.3885
Cell Significance Index: 5.5300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3719
Cell Significance Index: 9.9300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3167
Cell Significance Index: 11.1300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2910
Cell Significance Index: 9.3200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2808
Cell Significance Index: 55.7300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2495
Cell Significance Index: 44.9700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2466
Cell Significance Index: 222.6800 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.2464
Cell Significance Index: 2.4400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2209
Cell Significance Index: 10.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.2184
Cell Significance Index: 31.7400 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.2108
Cell Significance Index: 2.4500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1874
Cell Significance Index: 1.9400 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.1679
Cell Significance Index: 1.6800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1625
Cell Significance Index: 19.9900 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.1248
Cell Significance Index: 0.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1113
Cell Significance Index: 3.1100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1053
Cell Significance Index: 12.0300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1040
Cell Significance Index: 19.7900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0945
Cell Significance Index: 7.0400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0720
Cell Significance Index: 49.7800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0680
Cell Significance Index: 1.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0557
Cell Significance Index: 7.2000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0469
Cell Significance Index: 9.4100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0441
Cell Significance Index: 0.7600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0314
Cell Significance Index: 1.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0280
Cell Significance Index: 17.8000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0164
Cell Significance Index: 0.2300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0159
Cell Significance Index: 2.7200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0125
Cell Significance Index: 4.4900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0096
Cell Significance Index: 18.0700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0085
Cell Significance Index: 15.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0028
Cell Significance Index: 2.0900 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.0006
Cell Significance Index: 0.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0031
Cell Significance Index: -2.2400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0032
Cell Significance Index: -2.4000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0041
Cell Significance Index: -2.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0044
Cell Significance Index: -6.0000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0100
Cell Significance Index: -5.6200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0108
Cell Significance Index: -0.3000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.0171
Cell Significance Index: -0.1100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0178
Cell Significance Index: -5.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0197
Cell Significance Index: -8.9500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0206
Cell Significance Index: -9.1200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0207
Cell Significance Index: -4.3600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0228
Cell Significance Index: -0.5700 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.0307
Cell Significance Index: -0.3000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0382
Cell Significance Index: -4.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0386
Cell Significance Index: -4.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0502
Cell Significance Index: -5.1300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0622
Cell Significance Index: -8.5400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0822
Cell Significance Index: -8.5600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1022
Cell Significance Index: -12.0500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1039
Cell Significance Index: -3.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1045
Cell Significance Index: -8.2800 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.1048
Cell Significance Index: -0.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1194
Cell Significance Index: -8.0300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1209
Cell Significance Index: -9.2800 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.1230
Cell Significance Index: -1.1300 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1362
Cell Significance Index: -1.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1372
Cell Significance Index: -8.4100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1467
Cell Significance Index: -7.4200 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.1496
Cell Significance Index: -1.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1605
Cell Significance Index: -7.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1615
Cell Significance Index: -9.0600 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.1621
Cell Significance Index: -3.3800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1623
Cell Significance Index: -2.4000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1629
Cell Significance Index: -6.6800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1645
Cell Significance Index: -8.5700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1740
Cell Significance Index: -6.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1762
Cell Significance Index: -10.8300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1786
Cell Significance Index: -1.2100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1835
Cell Significance Index: -11.8400 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1943
Cell Significance Index: -1.2900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4190987444
Symbol: ZO3_HUMAN
Name: Tight junction protein ZO-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16129888
Title: PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.
PubMed ID: 16129888
DOI: 10.1242/jcs.02528
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 18823282
Title: Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).
PubMed ID: 18823282
DOI: 10.1042/bc20080072
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20434232
Title: Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule.
PubMed ID: 20434232
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21411630
Title: Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.
PubMed ID: 21411630
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22354024
Title: The Staphylococcus aureus alpha-toxin perturbs the barrier function in Caco-2 epithelial cell monolayers by altering junctional integrity.
PubMed ID: 22354024
DOI: 10.1128/iai.00001-12
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23608536
Title: Delineation of the key aspects in the regulation of epithelial monolayer formation.
PubMed ID: 23608536
DOI: 10.1128/mcb.01435-12
PubMed ID: 24314862
Title: Curcumin prevents leptin-induced tight junction dysfunction in intestinal Caco-2 BBe cells.
PubMed ID: 24314862
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 919
- Mass: 101397
- Checksum: D36EB684E7E4A6C8
- Sequence:
MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG RLQTGDHIVM VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT KASPSSPGRQ DSDEDDGPQR VEEVDQGRGY DGDSSSGSGR SWDERSRRPR PGRRGRAGSH GRRSPGGGSE ANGLALVSGF KRLPRQDVQM KPVKSVLVKR RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI NGVSSQNLSL NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE QRSELPRESS YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN DVGIFVSGVQ AGSPADGQGI QEGDQILQVN DVPFQNLTRE EAVQFLLGLP PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI RTHFELEPSP PSGLGFTRGD VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP NQSRAEQLAS LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS RTDSPSKIIK LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP ESRPALKALR QWLAPASRRS TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD TWYQELKAII REQQTRPIWT AEDQLDGSLE DNLDLPHHGL ADSSADLSCD SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP ALARSSEPVQ ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV HDAESSDEDG YDWGPATDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.