Details for: SIGLEC9

Gene ID: 27180

Symbol: SIGLEC9

Ensembl ID: ENSG00000129450

Description: sialic acid binding Ig like lectin 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.0819
    Cell Significance Index: -7.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 12.0046
    Cell Significance Index: -6.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.3182
    Cell Significance Index: -7.7900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.7237
    Cell Significance Index: 7.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7493
    Cell Significance Index: 6.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7255
    Cell Significance Index: 13.4100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5433
    Cell Significance Index: 6.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4679
    Cell Significance Index: 10.2500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.4293
    Cell Significance Index: 6.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0067
    Cell Significance Index: -1.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0113
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0133
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0201
    Cell Significance Index: -7.2000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0226
    Cell Significance Index: -0.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0238
    Cell Significance Index: -4.7700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0241
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0248
    Cell Significance Index: -3.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0254
    Cell Significance Index: -4.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0276
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0340
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0365
    Cell Significance Index: -6.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0377
    Cell Significance Index: -2.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0424
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0437
    Cell Significance Index: -6.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0442
    Cell Significance Index: -5.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0485
    Cell Significance Index: -6.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0514
    Cell Significance Index: -6.0700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0520
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0544
    Cell Significance Index: -6.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0557
    Cell Significance Index: -0.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0582
    Cell Significance Index: -2.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0613
    Cell Significance Index: -3.1000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0674
    Cell Significance Index: -0.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0714
    Cell Significance Index: -1.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0744
    Cell Significance Index: -7.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0751
    Cell Significance Index: -3.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0787
    Cell Significance Index: -5.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0836
    Cell Significance Index: -6.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0848
    Cell Significance Index: -2.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0995
    Cell Significance Index: -4.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1060
    Cell Significance Index: -1.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1095
    Cell Significance Index: -8.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1170
    Cell Significance Index: -7.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1173
    Cell Significance Index: -7.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1245
    Cell Significance Index: -2.4400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1257
    Cell Significance Index: -1.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1307
    Cell Significance Index: -1.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1388
    Cell Significance Index: -6.4700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1425
    Cell Significance Index: -1.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1459
    Cell Significance Index: -3.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1559
    Cell Significance Index: -8.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1596
    Cell Significance Index: -2.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1627
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1672
    Cell Significance Index: -5.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1768
    Cell Significance Index: -3.4500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1783
    Cell Significance Index: -1.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1796
    Cell Significance Index: -6.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1810
    Cell Significance Index: -9.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1839
    Cell Significance Index: -5.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1925
    Cell Significance Index: -5.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1993
    Cell Significance Index: -5.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2023
    Cell Significance Index: -5.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2096
    Cell Significance Index: -9.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2159
    Cell Significance Index: -6.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2160
    Cell Significance Index: -6.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2166
    Cell Significance Index: -7.0900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2395
    Cell Significance Index: -3.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2445
    Cell Significance Index: -9.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2486
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2501
    Cell Significance Index: -5.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2521
    Cell Significance Index: -3.6100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2531
    Cell Significance Index: -2.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2614
    Cell Significance Index: -6.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2653
    Cell Significance Index: -6.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2658
    Cell Significance Index: -6.7900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2760
    Cell Significance Index: -2.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2814
    Cell Significance Index: -8.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2859
    Cell Significance Index: -7.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2912
    Cell Significance Index: -10.6900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2957
    Cell Significance Index: -4.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2966
    Cell Significance Index: -9.3800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2985
    Cell Significance Index: -3.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3005
    Cell Significance Index: -10.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3007
    Cell Significance Index: -4.8700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3044
    Cell Significance Index: -4.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3075
    Cell Significance Index: -4.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3124
    Cell Significance Index: -6.7500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3143
    Cell Significance Index: -4.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3185
    Cell Significance Index: -5.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3219
    Cell Significance Index: -7.7200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.3250
    Cell Significance Index: -4.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIGLEC9 is a type II transmembrane glycoprotein that belongs to the Ig-like lectin family. Its structure consists of a single Ig-like domain, which is responsible for binding sialic acid. This binding specificity allows SIGLEC9 to interact with a wide range of sialic acid-containing molecules, including pathogens, self-antigens, and other immune cells. SIGLEC9 is primarily expressed on the surface of immune cells, such as monocytes, neutrophils, and dendritic cells, as well as on epithelial cells and neural cells. **Pathways and Functions:** SIGLEC9's functions can be broadly categorized into three main areas: immune regulation, cell adhesion, and signaling. Immune regulation involves SIGLEC9's ability to modulate the activity of various immune cells, including monocytes, neutrophils, and dendritic cells. By binding sialic acid, SIGLEC9 can influence the production of cytokines, chemokines, and other immune mediators, ultimately regulating the intensity and duration of immune responses. SIGLEC9 also plays a role in cell adhesion, facilitating the interaction between immune cells and other cells, such as epithelial cells. SIGLEC9's signaling functions are mediated through its binding to sialic acid, which triggers a series of downstream signaling events. These events can activate various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, leading to changes in cell morphology, motility, and gene expression. Additionally, SIGLEC9 can interact with other molecules, such as integrins and selectins, to regulate cell adhesion and migration. **Clinical Significance:** SIGLEC9's dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and neurological conditions. For example, alterations in SIGLEC9 expression have been observed in patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and inflammation in the central nervous system. Additionally, SIGLEC9's role in cancer has been explored, with studies suggesting that its expression is altered in various types of tumors, including breast and lung cancer. In conclusion, SIGLEC9 is a multifunctional protein that plays a critical role in regulating the immune system and cell adhesion. Its unique ability to bind sialic acid positions it at the intersection of innate and adaptive immunity, making it an attractive target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the functions and clinical significance of SIGLEC9, but its importance in the regulation of immune responses and cell adhesion is already clear.

Genular Protein ID: 2926591292

Symbol: SIGL9_HUMAN

Name: Sialic acid-binding Ig-like lectin 9

UniProtKB Accession Codes:

Q9Y336 Q6GTU4 Q9BYI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10903842

Title: Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).

PubMed ID: 10903842

DOI: 10.1006/geno.2000.6208

PubMed ID: 10801862

Title: Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.

PubMed ID: 10801862

DOI: 10.1074/jbc.m002788200

PubMed ID: 10801860

Title: Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.

PubMed ID: 10801860

DOI: 10.1074/jbc.m002775200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 463
  • Mass: 50082
  • Checksum: 807BDCE0D18191F2
  • Sequence:
    • MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW IYPGPVVHGY 
WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK NCTLSIRDAR RSDAGRYFFR 
MEKGSIKWNY KHHRLSVNVT ALTHRPNILI PGTLESGCPQ NLTCSVPWAC EQGTPPMISW 
IGTSVSPLDP STTRSSVLTL IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT 
MTVFQGDGTV STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS 
NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV GGAGATALVF 
LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS QGPLTEPWAE DSPPDQPPPA 
SARSSVGEGE LQYASLSFQM VKPWDSRGQE ATDTEYSEIK IHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.