Details for: DISC1

Gene ID: 27185

Symbol: DISC1

Ensembl ID: ENSG00000162946

Description: DISC1 scaffold protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.3258
    Cell Significance Index: -26.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.3735
    Cell Significance Index: -26.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.8662
    Cell Significance Index: -26.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.6259
    Cell Significance Index: -32.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9707
    Cell Significance Index: -26.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8841
    Cell Significance Index: -27.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.6246
    Cell Significance Index: 43.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1147
    Cell Significance Index: 239.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0371
    Cell Significance Index: 128.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5037
    Cell Significance Index: 92.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3583
    Cell Significance Index: 269.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2318
    Cell Significance Index: 26.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2045
    Cell Significance Index: 833.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0443
    Cell Significance Index: 15.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7111
    Cell Significance Index: 19.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6024
    Cell Significance Index: 114.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5745
    Cell Significance Index: 38.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4964
    Cell Significance Index: 178.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3780
    Cell Significance Index: 54.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3348
    Cell Significance Index: 33.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3095
    Cell Significance Index: 8.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2933
    Cell Significance Index: 18.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2499
    Cell Significance Index: 225.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2315
    Cell Significance Index: 46.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1824
    Cell Significance Index: 6.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1798
    Cell Significance Index: 5.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1713
    Cell Significance Index: 27.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1605
    Cell Significance Index: 3.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1180
    Cell Significance Index: 6.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0874
    Cell Significance Index: 15.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0745
    Cell Significance Index: 0.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0585
    Cell Significance Index: 3.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0138
    Cell Significance Index: 25.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0124
    Cell Significance Index: 0.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0066
    Cell Significance Index: 3.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0040
    Cell Significance Index: 0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0132
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0159
    Cell Significance Index: -21.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0320
    Cell Significance Index: -23.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0332
    Cell Significance Index: -24.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0374
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0408
    Cell Significance Index: -18.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0408
    Cell Significance Index: -30.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0513
    Cell Significance Index: -32.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0676
    Cell Significance Index: -29.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0750
    Cell Significance Index: -21.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0816
    Cell Significance Index: -3.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0854
    Cell Significance Index: -11.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1106
    Cell Significance Index: -7.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1185
    Cell Significance Index: -1.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1244
    Cell Significance Index: -14.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1255
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1280
    Cell Significance Index: -21.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1296
    Cell Significance Index: -4.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1332
    Cell Significance Index: -2.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1405
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1476
    Cell Significance Index: -31.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1672
    Cell Significance Index: -17.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1688
    Cell Significance Index: -3.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1995
    Cell Significance Index: -25.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2147
    Cell Significance Index: -10.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2247
    Cell Significance Index: -3.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2269
    Cell Significance Index: -26.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2385
    Cell Significance Index: -3.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2403
    Cell Significance Index: -15.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2416
    Cell Significance Index: -25.1600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2456
    Cell Significance Index: -2.9500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2516
    Cell Significance Index: -3.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2518
    Cell Significance Index: -6.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2549
    Cell Significance Index: -32.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2598
    Cell Significance Index: -29.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2790
    Cell Significance Index: -4.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3244
    Cell Significance Index: -16.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3518
    Cell Significance Index: -26.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3559
    Cell Significance Index: -18.4900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.3662
    Cell Significance Index: -4.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4062
    Cell Significance Index: -18.9400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4063
    Cell Significance Index: -5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4479
    Cell Significance Index: -31.6800
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.4505
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4541
    Cell Significance Index: -23.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5154
    Cell Significance Index: -22.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5319
    Cell Significance Index: -15.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5963
    Cell Significance Index: -22.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.6014
    Cell Significance Index: -8.4400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6158
    Cell Significance Index: -7.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6249
    Cell Significance Index: -13.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6495
    Cell Significance Index: -17.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6505
    Cell Significance Index: -22.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6512
    Cell Significance Index: -14.0700
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.6550
    Cell Significance Index: -8.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6679
    Cell Significance Index: -29.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6707
    Cell Significance Index: -23.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6726
    Cell Significance Index: -16.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6739
    Cell Significance Index: -24.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DISC1 is a 145-kDa protein that belongs to the 4.1 protein family, which is characterized by its ability to bind to multiple proteins and regulate their interactions. DISC1 is highly expressed in the central nervous system (CNS), particularly in neurons, glial cells, and microglia. It is also expressed in various other cell types, including cardiac myocytes, macrophages, and oligodendrocyte precursor cells. **Pathways and Functions** DISC1 interacts with multiple signaling pathways, including: 1. **Canonical Wnt pathway**: DISC1 regulates the Wnt/β-catenin signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Cytoskeleton organization**: DISC1 interacts with microtubules and regulates their organization, which is essential for cell migration, division, and axon extension. 3. **Protein localization**: DISC1 regulates the localization of proteins to specific cellular compartments, such as the centrosome, ciliary base, and postsynaptic density. 4. **Synaptic transmission**: DISC1 regulates synaptic transmission by interacting with glutamatergic and GABAergic receptors and regulating the release of neurotransmitters. **Clinical Significance** DISC1 has been implicated in various neurological disorders, including: 1. **Schizophrenia**: DISC1 has been associated with schizophrenia, a complex psychiatric disorder characterized by cognitive impairment, hallucinations, and delusions. 2. **Bipolar disorder**: DISC1 has been linked to bipolar disorder, a mood disorder characterized by episodes of mania and depression. 3. **Neurodegenerative diseases**: DISC1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Neuroinflammation**: DISC1 has been shown to regulate neuroinflammation, which is a key component of various neurological disorders. In conclusion, DISC1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell proliferation, migration, and differentiation. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of DISC1 in neuroimmunology. Further research is needed to elucidate the mechanisms by which DISC1 regulates cellular processes and to understand its role in neurological disorders.

Genular Protein ID: 3726017077

Symbol: DISC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NRI5 A6NLH2 C4P091 C4P095 C4P0A1 C4P0A3 C4P0B3 C4P0B6 C4P0C1 C9J6D0 O75045 Q5VT44 Q5VT45 Q8IXJ0 Q8IXJ1 Q9BX19 Q9NRI3 Q9NRI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 11 CORUM 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 32 Ensembl 13 ExpressionAtlas 1 GO 46 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 RefSeq 12 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10814723

Title: Disruption of two novel genes by a translocation co-segregating with schizophrenia.

PubMed ID: 10814723

DOI: 10.1093/hmg/9.9.1415

PubMed ID: 12573262

Title: Evolutionary constraints on the Disrupted in Schizophrenia locus.

PubMed ID: 12573262

DOI: 10.1016/s0888-7543(02)00026-5

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 19805229

Title: DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.

PubMed ID: 19805229

DOI: 10.1073/pnas.0903413106

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11468279

Title: Chromosome 1 loci in Finnish schizophrenia families.

PubMed ID: 11468279

DOI: 10.1093/hmg/10.15.1611

PubMed ID: 12812986

Title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

PubMed ID: 12812986

DOI: 10.1093/hmg/ddg162

PubMed ID: 14532331

Title: Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.

PubMed ID: 14532331

DOI: 10.1093/hmg/ddg341

PubMed ID: 12506198

Title: Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.

PubMed ID: 12506198

DOI: 10.1073/pnas.0136913100

PubMed ID: 15386212

Title: Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.

PubMed ID: 15386212

DOI: 10.1086/425586

PubMed ID: 14962739

Title: Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.

PubMed ID: 14962739

DOI: 10.1016/j.mcn.2003.09.009

PubMed ID: 15797709

Title: Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

PubMed ID: 15797709

DOI: 10.1016/j.mcn.2004.11.003

PubMed ID: 15939883

Title: Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.

PubMed ID: 15939883

DOI: 10.1073/pnas.0500515102

PubMed ID: 16510495

Title: Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.

PubMed ID: 16510495

DOI: 10.1093/hmg/ddl040

PubMed ID: 17035248

Title: DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.

PubMed ID: 17035248

DOI: 10.1093/hmg/ddl407

PubMed ID: 17519386

Title: PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

PubMed ID: 17519386

DOI: 10.1124/jpet.107.122218

PubMed ID: 17389905

Title: A novel DISC1-interacting partner DISC1-binding zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.

PubMed ID: 17389905

DOI: 10.1038/sj.mp.4001945

PubMed ID: 18955030

Title: DISC1-kendrin interaction is involved in centrosomal microtubule network formation.

PubMed ID: 18955030

DOI: 10.1016/j.bbrc.2008.10.100

PubMed ID: 19502360

Title: Disc1 regulates granule cell migration in the developing hippocampus.

PubMed ID: 19502360

DOI: 10.1093/hmg/ddp266

PubMed ID: 19303846

Title: Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

PubMed ID: 19303846

DOI: 10.1016/j.cell.2008.12.044

PubMed ID: 22228767

Title: CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.

PubMed ID: 22228767

DOI: 10.1074/jbc.m111.277103

PubMed ID: 28727686

Title: FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.

PubMed ID: 28727686

DOI: 10.1038/mp.2017.138

Sequence Information:

  • Length: 854
  • Mass: 93611
  • Checksum: 63C3FDF2F59830C6
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 
ETIRSLQERI KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH 
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR REVEHQETAY 
ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL LIQSLQLQEA RGSLSVEDER 
QMDDLEGAAP PIPPRLHSED KRKTPLKVLE EWKTHLIPSL HCAGGEQKEE SYILSAELGE 
KCEDIGKKLL YLEDQLHTAI HSHDEDLIQS LRRELQMVKE TLQAMILQLQ PAKEAGEREA 
AASCMTAGVH EAQA

Genular Protein ID: 3958403936

Symbol: C4P098_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P098

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 803
  • Mass: 87777
  • Checksum: 7F85A2BDA22E2F24
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 
ETIRSLQERI KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH 
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR REVEHQETAY 
ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL LIQSLQLQEA RGSLSVEDER 
QMDDLEGAAP PIPPRLHSED KRKTPLKVLE EWKTHLIPSL HCAGGEQKEV CPFHMASRGD 
PYSKGCFGTM LQMGTINIGK ASH

Genular Protein ID: 3592249942

Symbol: C4P0D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0D1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 387
  • Mass: 40564
  • Checksum: 33CABF4B19DA4FAE
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKGLLEEVAT SHLTLHT

Genular Protein ID: 4277798593

Symbol: C4P0C4_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0C4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SMR 1

Sequence Information:

  • Length: 547
  • Mass: 58908
  • Checksum: 4F05E7A07D20F09F
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 
ETIRRYC

Genular Protein ID: 1939714959

Symbol: C4P0D3_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0D3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 375
  • Mass: 39295
  • Checksum: D4FCFAA142D146D6
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKGEF

Genular Protein ID: 3523099149

Symbol: C4P0D2_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0D2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 429
  • Mass: 45385
  • Checksum: CB8AD16E84A5A08C
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKGSHWKGYI FIWGEQQLWI RIMKIDNGKW ACHSGTFPSF FPEPAGTNCF 
GSTMEASTS

Genular Protein ID: 39396717

Symbol: C4P0D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0D0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 387
  • Mass: 40407
  • Checksum: 2B40BA509C9CDB24
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAGTNCFGS TMEASTS

Genular Protein ID: 3301935623

Symbol: C4P0A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0A5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SMR 1

Sequence Information:

  • Length: 551
  • Mass: 59299
  • Checksum: 23BC3EE366CD87A0
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 
ETIRRKPFLD G

Genular Protein ID: 3373413174

Symbol: C4P094_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P094

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 2 SMR 1

Sequence Information:

  • Length: 732
  • Mass: 79702
  • Checksum: 5E5CBC2A25EAE6F9
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQHLQERIKS LNLSLKEITT KVCMSEKFCS TLRKKVNDIE TQLPALLEAK MHAISGNHFW 
TAKDLTEEIR SLTSEREGLE GLLSKLLVLS SRNVKKLGSV KEDYNRLRRE VEHQETAYET 
SVKENTMKYM ETLKNKLCSC KCPLLGKVWE ADLEACRLLI QSLQLQEARG SLSVEDERQM 
DDLEGAAPPI PPRLHSEDKR KTPLKVLEEW KTHLIPSLHC AGGEQKEESY ILSAELGEKC 
EDIGKKLLYL EDQLHTAIHS HDEDLIQSLR RELQMVKETL QAMILQLQPA KEAGEREAAA 
SCMTAGVHEA QA

Genular Protein ID: 1649235502

Symbol: C4P0A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0A4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 681
  • Mass: 74329
  • Checksum: 5852E0DA9131A1DD
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 
ETIRSLQERI KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH 
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR REVEHQETAY 
ETSVKENTMK YMETLKNKLC R

Genular Protein ID: 2837217389

Symbol: C4P096_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P096

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 1 SAM 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 886
  • Mass: 96783
  • Checksum: BA975D556FA14B5A
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKVETGFHYV GQAGLELLTS SNPPASASQS AGITAETLQQ RLEDLEQEKI 
SLHFQLPSRQ PALSSFLGHL AAQVQAALRR GATQQASGDD THTPLRMEPR LLEPTAQDSL 
HVSITRRDWL LQEKQQLQKE IEALQARMFV LEAKDQQLRR EIEEQEQQLQ WQGCDLTPLV 
GQLSLGQLQE VSKALQDTLA SAGQIPFHAE PPETIRSLQE RIKSLNLSLK EITTKVCMSE 
KFCSTLRKKV NDIETQLPAL LEAKMHAISG NHFWTAKDLT EEIRSLTSER EGLEGLLSKL 
LVLSSRNVKK LGSVKEDYNR LRREVEHQET AYETSVKENT MKYMETLKNK LCSCKCPLLG 
KVWEADLEAC RLLIQSLQLQ EARGSLSVED ERQMDDLEGA APPIPPRLHS EDKRKTPLKV 
LEEWKTHLIP SLHCAGGEQK EESYILSAEL GEKCEDIGKK LLYLEDQLHT AIHSHDEDLI 
QSLRRELQMV KETLQAMILQ LQPAKEAGER EAAASCMTAG VHEAQA

Genular Protein ID: 1035709701

Symbol: C4P0C8_HUMAN

Name: N/A

UniProtKB Accession Codes:

C4P0C8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SMR 1

Sequence Information:

  • Length: 423
  • Mass: 44655
  • Checksum: 9BE445052FCFF7FA
  • Sequence:
    • MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 
TQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.