Details for: IL17C

Gene ID: 27189

Symbol: IL17C

Ensembl ID: ENSG00000124391

Description: interleukin 17C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.0011
    Cell Significance Index: 13.8900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1991
    Cell Significance Index: 2.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1242
    Cell Significance Index: 67.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1006
    Cell Significance Index: 1.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0711
    Cell Significance Index: 44.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0569
    Cell Significance Index: 2.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0513
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0196
    Cell Significance Index: 2.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0183
    Cell Significance Index: 2.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0120
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0022
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0029
    Cell Significance Index: -0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0040
    Cell Significance Index: -1.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0058
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0076
    Cell Significance Index: -1.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0079
    Cell Significance Index: -0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0090
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0090
    Cell Significance Index: -1.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0105
    Cell Significance Index: -0.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0127
    Cell Significance Index: -0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0140
    Cell Significance Index: -1.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0149
    Cell Significance Index: -1.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0164
    Cell Significance Index: -1.0600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0166
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0176
    Cell Significance Index: -0.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0191
    Cell Significance Index: -0.2600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0209
    Cell Significance Index: -0.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0211
    Cell Significance Index: -1.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0240
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0250
    Cell Significance Index: -1.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0269
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0281
    Cell Significance Index: -0.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0288
    Cell Significance Index: -2.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0304
    Cell Significance Index: -1.8700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0323
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0335
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0358
    Cell Significance Index: -0.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0365
    Cell Significance Index: -1.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0374
    Cell Significance Index: -1.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0381
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0394
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0412
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0424
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0428
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0434
    Cell Significance Index: -1.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0450
    Cell Significance Index: -2.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0467
    Cell Significance Index: -1.1900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0486
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0489
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0490
    Cell Significance Index: -1.5600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0499
    Cell Significance Index: -0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0510
    Cell Significance Index: -1.9300
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.0510
    Cell Significance Index: -0.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0527
    Cell Significance Index: -0.3600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0565
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0565
    Cell Significance Index: -1.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0567
    Cell Significance Index: -1.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0597
    Cell Significance Index: -1.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0606
    Cell Significance Index: -1.7300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0627
    Cell Significance Index: -0.6500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0637
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0645
    Cell Significance Index: -0.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0658
    Cell Significance Index: -1.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0677
    Cell Significance Index: -1.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0692
    Cell Significance Index: -1.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0711
    Cell Significance Index: -1.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0711
    Cell Significance Index: -1.7700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0716
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0716
    Cell Significance Index: -1.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0729
    Cell Significance Index: -2.0900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0743
    Cell Significance Index: -0.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0744
    Cell Significance Index: -1.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0747
    Cell Significance Index: -1.5600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0750
    Cell Significance Index: -0.6200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0763
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0768
    Cell Significance Index: -1.3100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0773
    Cell Significance Index: -0.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0777
    Cell Significance Index: -1.5200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0778
    Cell Significance Index: -1.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0778
    Cell Significance Index: -0.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0794
    Cell Significance Index: -1.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0798
    Cell Significance Index: -0.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0801
    Cell Significance Index: -1.8500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0806
    Cell Significance Index: -1.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0813
    Cell Significance Index: -1.9500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0814
    Cell Significance Index: -0.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0815
    Cell Significance Index: -1.7300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0817
    Cell Significance Index: -1.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0849
    Cell Significance Index: -1.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0852
    Cell Significance Index: -1.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0858
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL17C is a secreted cytokine that belongs to the IL-17 family, which is characterized by its ability to induce inflammatory responses and modulate immune cell activity. IL17C is primarily produced by hematopoietic stem cells, granulocyte-monocyte progenitor cells, and endothelial cells. Its expression is also observed in other cell types, including absorptive cells and transit amplifying cells, highlighting its broad range of cellular sources. **Pathways and Functions:** IL17C exerts its effects through the IL-17 receptor, which is composed of two subunits, IL-17RA and IL-17RC. The binding of IL17C to its receptor triggers a signaling cascade that involves the activation of various transcription factors, including NF-κB and IRFs. This cascade ultimately leads to the production of pro-inflammatory cytokines, chemokines, and other molecules that contribute to the regulation of immune responses. IL17C plays a crucial role in the regulation of immune responses, including the induction of inflammation, the promotion of angiogenesis, and the maintenance of tissue homeostasis. Its functions can be broadly categorized into three main areas: 1. **Inflammation**: IL17C promotes the recruitment of immune cells to sites of inflammation, thereby exacerbating inflammatory responses. 2. **Angiogenesis**: IL17C stimulates the formation of new blood vessels, which is essential for tissue repair and regeneration. 3. **Tissue homeostasis**: IL17C helps maintain tissue homeostasis by regulating the activity of immune cells and promoting the repair of damaged tissues. **Clinical Significance:** IL17C has been implicated in various diseases, including: 1. **Inflammatory disorders**: IL17C has been associated with autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, where it contributes to the perpetuation of inflammation. 2. **Cancer**: IL17C has been shown to promote tumor growth, angiogenesis, and metastasis in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: IL17C has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to the development of cognitive impairments. 4. **Cardiovascular disease**: IL17C has been linked to cardiovascular disease, where it promotes the formation of atherosclerotic plaques and contributes to the development of cardiovascular complications. In conclusion, IL17C is a multifunctional cytokine that plays a critical role in various physiological and pathological processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the mechanisms of IL17C and its clinical significance.

Genular Protein ID: 3925728657

Symbol: IL17C_HUMAN

Name: Interleukin-17C

UniProtKB Accession Codes:

Q9P0M4 Q3MIG8 Q9HC75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10639155

Title: Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family.

PubMed ID: 10639155

DOI: 10.1073/pnas.97.2.773

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21993849

Title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.

PubMed ID: 21993849

DOI: 10.1038/ni.2155

PubMed ID: 21993848

Title: IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.

PubMed ID: 21993848

DOI: 10.1038/ni.2156

Sequence Information:

  • Length: 197
  • Mass: 21765
  • Checksum: BAE0152E18DE7D08
  • Sequence:
    • MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH LLARGAKWGQ 
ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD THQRSISPWR YRVDTDEDRY 
PQKLAFAECL CRGCIDARTG RETAALNSVR LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT 
EFIHVPVGCT CVLPRSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.