Details for: C5AR2

Gene ID: 27202

Symbol: C5AR2

Ensembl ID: ENSG00000134830

Description: complement C5a receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.0380
    Cell Significance Index: -5.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.3686
    Cell Significance Index: -5.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 11.2562
    Cell Significance Index: -5.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.4122
    Cell Significance Index: -5.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.6527
    Cell Significance Index: 25.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8561
    Cell Significance Index: 12.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6485
    Cell Significance Index: 14.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4044
    Cell Significance Index: 7.4800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3897
    Cell Significance Index: 4.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2652
    Cell Significance Index: 3.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2160
    Cell Significance Index: 41.1000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0884
    Cell Significance Index: 0.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0884
    Cell Significance Index: 8.7500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0842
    Cell Significance Index: 0.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0822
    Cell Significance Index: 74.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0661
    Cell Significance Index: 3.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0525
    Cell Significance Index: 5.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0510
    Cell Significance Index: 8.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0448
    Cell Significance Index: 5.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0261
    Cell Significance Index: 0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0234
    Cell Significance Index: 4.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0151
    Cell Significance Index: 0.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0142
    Cell Significance Index: 1.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0126
    Cell Significance Index: 0.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0102
    Cell Significance Index: 3.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0045
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0021
    Cell Significance Index: 1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0073
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0083
    Cell Significance Index: -3.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0089
    Cell Significance Index: -1.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0097
    Cell Significance Index: -1.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0122
    Cell Significance Index: -1.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0143
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0281
    Cell Significance Index: -4.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0287
    Cell Significance Index: -3.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0290
    Cell Significance Index: -1.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0290
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0297
    Cell Significance Index: -5.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0320
    Cell Significance Index: -4.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0360
    Cell Significance Index: -4.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0364
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0381
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0440
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0445
    Cell Significance Index: -5.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0451
    Cell Significance Index: -0.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0516
    Cell Significance Index: -6.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0528
    Cell Significance Index: -5.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0559
    Cell Significance Index: -1.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0581
    Cell Significance Index: -4.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0614
    Cell Significance Index: -4.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0633
    Cell Significance Index: -3.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0676
    Cell Significance Index: -5.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0797
    Cell Significance Index: -5.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0902
    Cell Significance Index: -4.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0916
    Cell Significance Index: -4.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0916
    Cell Significance Index: -2.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0970
    Cell Significance Index: -5.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0993
    Cell Significance Index: -5.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1014
    Cell Significance Index: -4.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1055
    Cell Significance Index: -5.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1097
    Cell Significance Index: -3.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1140
    Cell Significance Index: -3.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1225
    Cell Significance Index: -5.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1356
    Cell Significance Index: -4.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1374
    Cell Significance Index: -5.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1410
    Cell Significance Index: -1.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1470
    Cell Significance Index: -6.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1475
    Cell Significance Index: -1.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1482
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1486
    Cell Significance Index: -5.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1497
    Cell Significance Index: -4.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1501
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1506
    Cell Significance Index: -2.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1509
    Cell Significance Index: -3.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1538
    Cell Significance Index: -2.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1668
    Cell Significance Index: -4.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1678
    Cell Significance Index: -4.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1685
    Cell Significance Index: -6.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1718
    Cell Significance Index: -5.0600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1766
    Cell Significance Index: -2.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1784
    Cell Significance Index: -4.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1806
    Cell Significance Index: -5.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1806
    Cell Significance Index: -3.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1877
    Cell Significance Index: -4.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1885
    Cell Significance Index: -4.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1933
    Cell Significance Index: -3.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C5AR2 exhibits several distinctive features that underscore its importance in immune regulation: 1. **High-affinity ligand binding**: C5AR2 has a high affinity for C5a, allowing for efficient recruitment of immune cells to sites of inflammation. 2. **Diverse expression patterns**: C5AR2 is expressed on a wide range of cell types, including innate lymphoid cells, monocytes, epithelial cells, and neurons, indicating its involvement in various immune and non-immune processes. 3. **Regulation of immune responses**: C5AR2 mediates both pro-inflammatory and anti-inflammatory responses, depending on the context and cell type. 4. **Cross-talk with other signaling pathways**: C5AR2 interacts with multiple signaling pathways, including phospholipase C-activating G protein-coupled receptor signaling and G protein-coupled receptor activity. **Pathways and Functions:** C5AR2's involvement in immune regulation is mediated through the following pathways and functions: 1. **Complement cascade**: C5AR2 regulates the complement cascade by modulating the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-α. 2. **Immune cell recruitment**: C5AR2 facilitates the recruitment of immune cells, including neutrophils and monocytes, to sites of inflammation. 3. **Neuroinflammation**: C5AR2 is expressed on GABAergic interneurons and regulates neuroinflammation by modulating the production of pro-inflammatory cytokines. 4. **Tissue repair**: C5AR2 plays a role in tissue repair by regulating the production of anti-inflammatory cytokines and promoting the migration of stem cells. **Clinical Significance:** The dysregulation of C5AR2 has been implicated in various diseases, including: 1. **Inflammatory disorders**: C5AR2's role in mediating inflammation makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 2. **Autoimmune diseases**: C5AR2's involvement in the regulation of immune responses makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and lupus. 3. **Cancer**: C5AR2's expression on tumor cells and its role in promoting angiogenesis and tumor growth make it a potential target for cancer therapy. 4. **Neurological disorders**: C5AR2's involvement in neuroinflammation and its expression on GABAergic interneurons make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, C5AR2 is a critical component of the immune system, playing a pivotal role in the regulation of inflammation, tissue repair, and immune homeostasis. Its dysregulation has been implicated in various diseases, highlighting the potential for therapeutic targeting of this receptor.

Genular Protein ID: 624307845

Symbol: C5AR2_HUMAN

Name: C5a anaphylatoxin chemotactic receptor 2

UniProtKB Accession Codes:

Q9P296 B2RA09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11090875

Title: A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.

PubMed ID: 11090875

DOI: 10.1016/s0161-5890(00)00067-5

PubMed ID: 11165367

Title: Identification of four novel human G protein-coupled receptors expressed in the brain.

PubMed ID: 11165367

DOI: 10.1016/s0169-328x(00)00242-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11773063

Title: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74).

PubMed ID: 11773063

DOI: 10.1074/jbc.c100714200

PubMed ID: 12540846

Title: The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.

PubMed ID: 12540846

DOI: 10.1074/jbc.m206169200

PubMed ID: 15833747

Title: C5L2 is a functional receptor for acylation-stimulating protein.

PubMed ID: 15833747

DOI: 10.1074/jbc.m406921200

PubMed ID: 19615750

Title: C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

PubMed ID: 19615750

DOI: 10.1016/j.molimm.2009.06.007

PubMed ID: 16627811

Title: Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia.

PubMed ID: 16627811

DOI: 10.1161/01.atv.0000222907.72985.0b

PubMed ID: 21698200

Title: Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease.

PubMed ID: 21698200

DOI: 10.1371/journal.pone.0020984

Sequence Information:

  • Length: 337
  • Mass: 36080
  • Checksum: 53AF41B129FE8FE6
  • Sequence:
    • MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV PGNAMVAWVA 
GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW PYGAVGCRAL PSIILLTMYA 
SVLLLAALSA DLCFLALGPA WWSTVQRACG VQVACGAAWT LALLLTVPSA IYRRLHQEHF 
PARLQCVVDY GGSSSTENAV TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV 
GFFVCWAPYH LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR 
RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.