Details for: GPKOW

Gene ID: 27238

Symbol: GPKOW

Ensembl ID: ENSG00000068394

Description: G-patch domain and KOW motifs

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.6120
    Cell Significance Index: -11.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.8444
    Cell Significance Index: -13.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 37.2135
    Cell Significance Index: -15.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.5901
    Cell Significance Index: -17.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.3533
    Cell Significance Index: -13.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.1537
    Cell Significance Index: -16.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2237
    Cell Significance Index: -13.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9574
    Cell Significance Index: -13.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3829
    Cell Significance Index: -14.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8266
    Cell Significance Index: -15.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0588
    Cell Significance Index: -9.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2222
    Cell Significance Index: 198.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0211
    Cell Significance Index: 61.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6878
    Cell Significance Index: 80.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6195
    Cell Significance Index: 32.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4857
    Cell Significance Index: 14.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4749
    Cell Significance Index: 32.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4660
    Cell Significance Index: 29.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4495
    Cell Significance Index: 310.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4302
    Cell Significance Index: 11.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3987
    Cell Significance Index: 5.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3045
    Cell Significance Index: 8.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2866
    Cell Significance Index: 6.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2690
    Cell Significance Index: 48.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2647
    Cell Significance Index: 32.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2615
    Cell Significance Index: 6.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2043
    Cell Significance Index: 9.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1669
    Cell Significance Index: 91.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1628
    Cell Significance Index: 32.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1577
    Cell Significance Index: 69.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1495
    Cell Significance Index: 6.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1454
    Cell Significance Index: 4.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1408
    Cell Significance Index: 19.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1398
    Cell Significance Index: 7.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1262
    Cell Significance Index: 12.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1208
    Cell Significance Index: 23.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1149
    Cell Significance Index: 14.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1083
    Cell Significance Index: 7.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1047
    Cell Significance Index: 6.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0936
    Cell Significance Index: 2.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0910
    Cell Significance Index: 17.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0872
    Cell Significance Index: 6.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0796
    Cell Significance Index: 1.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0762
    Cell Significance Index: 9.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0716
    Cell Significance Index: 8.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0638
    Cell Significance Index: 3.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0528
    Cell Significance Index: 18.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0488
    Cell Significance Index: 5.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0460
    Cell Significance Index: 1.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0309
    Cell Significance Index: 27.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0306
    Cell Significance Index: 0.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0306
    Cell Significance Index: 1.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0264
    Cell Significance Index: 0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0105
    Cell Significance Index: 1.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0027
    Cell Significance Index: 0.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0103
    Cell Significance Index: -7.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0211
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0215
    Cell Significance Index: -12.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0268
    Cell Significance Index: -12.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0318
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0327
    Cell Significance Index: -20.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0419
    Cell Significance Index: -1.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0551
    Cell Significance Index: -15.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0813
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0833
    Cell Significance Index: -17.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0881
    Cell Significance Index: -1.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0963
    Cell Significance Index: -2.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0973
    Cell Significance Index: -1.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0988
    Cell Significance Index: -0.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1014
    Cell Significance Index: -4.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1078
    Cell Significance Index: -6.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1201
    Cell Significance Index: -9.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1207
    Cell Significance Index: -3.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1396
    Cell Significance Index: -2.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1443
    Cell Significance Index: -15.0300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1446
    Cell Significance Index: -0.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1490
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1630
    Cell Significance Index: -12.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1948
    Cell Significance Index: -3.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2047
    Cell Significance Index: -6.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2066
    Cell Significance Index: -5.3100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2224
    Cell Significance Index: -1.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2519
    Cell Significance Index: -8.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2651
    Cell Significance Index: -3.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2670
    Cell Significance Index: -16.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2769
    Cell Significance Index: -12.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2966
    Cell Significance Index: -10.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3090
    Cell Significance Index: -7.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3153
    Cell Significance Index: -11.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3204
    Cell Significance Index: -10.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The GPKOW gene is characterized by its unique G-patch domain and KOW motifs, which are essential for its function. The G-patch domain is a conserved structural motif found in various proteins, including RNA-binding proteins, and is involved in protein-protein interactions. The KOW motifs, on the other hand, are involved in recognizing and binding to specific RNA sequences. These motifs work together to facilitate the protein's role in RNA processing and cell signaling. **Pathways and Functions:** The GPKOW protein is involved in several key pathways, including: 1. **RNA processing:** GPKOW is a component of the spliceosome complex, which is responsible for splicing pre-mRNA transcripts into mature mRNAs. The protein's G-patch domain and KOW motifs work together to recognize and bind to specific RNA sequences, facilitating the splicing process. 2. **Protein binding:** GPKOW interacts with various proteins, including RNA-binding proteins and other signaling molecules, to regulate cellular processes. 3. **Cell signaling:** The protein's ability to bind to specific RNA sequences and interact with signaling molecules makes it a key component in cell signaling pathways, influencing cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of the GPKOW gene has been implicated in various diseases, including: 1. **Neurological disorders:** Alterations in GPKOW expression have been linked to neurological disorders, such as schizophrenia and autism spectrum disorder, highlighting its role in neuronal function and development. 2. **Cancer:** Aberrant expression of GPKOW has been observed in certain types of cancer, including colon cancer, suggesting its potential as a biomarker or therapeutic target. 3. **Immune system dysfunction:** GPKOW's role in regulating immune responses makes it an important component in understanding immune system dysfunction, such as in autoimmune diseases. In conclusion, the GPKOW gene is a critical regulator of RNA processing, protein binding, and cell signaling, with implications for various diseases. Further research is needed to fully understand the functions of this gene and its potential therapeutic applications.

Genular Protein ID: 1530852209

Symbol: GPKOW_HUMAN

Name: G-patch domain and KOW motifs-containing protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8938429

Title: Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval.

PubMed ID: 8938429

DOI: 10.1101/gr.6.11.1056

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16271871

Title: MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana.

PubMed ID: 16271871

DOI: 10.1016/j.cub.2005.09.038

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16491121

Title: Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.

PubMed ID: 16491121

DOI: 10.1038/sj.onc.1209436

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21880142

Title: G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.

PubMed ID: 21880142

DOI: 10.1186/1750-2187-6-10

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25296192

Title: GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo.

PubMed ID: 25296192

DOI: 10.1042/bsr20140142

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 476
  • Mass: 52229
  • Checksum: 36F1C5771969897D
  • Sequence:
  • MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV 
    KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE 
    NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG 
    EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG 
    LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN 
    TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR 
    DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD 
    RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.