Details for: GPKOW
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 73.6120
Cell Significance Index: -11.4500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 51.8444
Cell Significance Index: -13.1500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 37.2135
Cell Significance Index: -15.3300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 36.5901
Cell Significance Index: -17.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.3533
Cell Significance Index: -13.5500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 31.1537
Cell Significance Index: -16.0300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.2237
Cell Significance Index: -13.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.9574
Cell Significance Index: -13.5100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.3829
Cell Significance Index: -14.4200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.8266
Cell Significance Index: -15.1000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.0588
Cell Significance Index: -9.4000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2222
Cell Significance Index: 198.7800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0211
Cell Significance Index: 61.3000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6878
Cell Significance Index: 80.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6195
Cell Significance Index: 32.1800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4857
Cell Significance Index: 14.2700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4749
Cell Significance Index: 32.8400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4660
Cell Significance Index: 29.3700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4495
Cell Significance Index: 310.9200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4302
Cell Significance Index: 11.7100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3987
Cell Significance Index: 5.4400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3045
Cell Significance Index: 8.1500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2866
Cell Significance Index: 6.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2690
Cell Significance Index: 48.5000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2647
Cell Significance Index: 32.5500 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2615
Cell Significance Index: 6.6800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2043
Cell Significance Index: 9.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1669
Cell Significance Index: 91.1700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1628
Cell Significance Index: 32.6500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1577
Cell Significance Index: 69.7300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1495
Cell Significance Index: 6.9700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1454
Cell Significance Index: 4.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1408
Cell Significance Index: 19.3400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1398
Cell Significance Index: 7.2800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1262
Cell Significance Index: 12.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1208
Cell Significance Index: 23.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1149
Cell Significance Index: 14.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1083
Cell Significance Index: 7.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1047
Cell Significance Index: 6.7600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0936
Cell Significance Index: 2.3400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0910
Cell Significance Index: 17.3100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0872
Cell Significance Index: 6.5000 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0796
Cell Significance Index: 1.1400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0762
Cell Significance Index: 9.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0716
Cell Significance Index: 8.2000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0638
Cell Significance Index: 3.3500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0528
Cell Significance Index: 18.9500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0488
Cell Significance Index: 5.7500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0460
Cell Significance Index: 1.6000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0309
Cell Significance Index: 27.8900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0306
Cell Significance Index: 0.6400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0306
Cell Significance Index: 1.5500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0264
Cell Significance Index: 0.3000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0105
Cell Significance Index: 1.7900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0027
Cell Significance Index: 0.0700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0012
Cell Significance Index: 0.0100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0011
Cell Significance Index: 2.0200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0075
Cell Significance Index: -13.8700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0081
Cell Significance Index: -12.5100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0103
Cell Significance Index: -7.5800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0105
Cell Significance Index: -14.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0117
Cell Significance Index: -8.8300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0157
Cell Significance Index: -9.9700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0159
Cell Significance Index: -11.7900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0211
Cell Significance Index: -2.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0215
Cell Significance Index: -12.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0268
Cell Significance Index: -12.1600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0318
Cell Significance Index: -0.8900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0327
Cell Significance Index: -20.4200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0419
Cell Significance Index: -1.9700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0509
Cell Significance Index: -7.4000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0551
Cell Significance Index: -15.8400 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0813
Cell Significance Index: -0.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0833
Cell Significance Index: -17.5500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0881
Cell Significance Index: -1.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0963
Cell Significance Index: -2.0500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0973
Cell Significance Index: -1.1600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0988
Cell Significance Index: -0.9100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1014
Cell Significance Index: -4.1600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1078
Cell Significance Index: -6.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1201
Cell Significance Index: -9.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1207
Cell Significance Index: -3.8700 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1396
Cell Significance Index: -2.1200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1443
Cell Significance Index: -15.0300 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1446
Cell Significance Index: -0.9600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1490
Cell Significance Index: -1.6200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1630
Cell Significance Index: -12.9100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1948
Cell Significance Index: -3.2600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2047
Cell Significance Index: -6.0300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2066
Cell Significance Index: -5.3100 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2224
Cell Significance Index: -1.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2519
Cell Significance Index: -8.8500 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.2651
Cell Significance Index: -3.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2670
Cell Significance Index: -16.3700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2769
Cell Significance Index: -12.2500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2966
Cell Significance Index: -10.3900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3090
Cell Significance Index: -7.1400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3153
Cell Significance Index: -11.9400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3204
Cell Significance Index: -10.4900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1530852209
Symbol: GPKOW_HUMAN
Name: G-patch domain and KOW motifs-containing protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8938429
Title: Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval.
PubMed ID: 8938429
DOI: 10.1101/gr.6.11.1056
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16271871
Title: MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana.
PubMed ID: 16271871
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16491121
Title: Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.
PubMed ID: 16491121
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21880142
Title: G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.
PubMed ID: 21880142
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25296192
Title: GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo.
PubMed ID: 25296192
DOI: 10.1042/bsr20140142
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 33509932
Title: Structure of the activated human minor spliceosome.
PubMed ID: 33509932
Sequence Information:
- Length: 476
- Mass: 52229
- Checksum: 36F1C5771969897D
- Sequence:
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.