Details for: GPR162

Gene ID: 27239

Symbol: GPR162

Ensembl ID: ENSG00000250510

Description: G protein-coupled receptor 162

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.8119
    Cell Significance Index: -11.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.6583
    Cell Significance Index: -10.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.7566
    Cell Significance Index: -9.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.6754
    Cell Significance Index: 67.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.3846
    Cell Significance Index: 125.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7984
    Cell Significance Index: 30.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9438
    Cell Significance Index: 189.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8487
    Cell Significance Index: 24.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7464
    Cell Significance Index: 50.1900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.7070
    Cell Significance Index: 8.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7045
    Cell Significance Index: 5.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4321
    Cell Significance Index: 154.9900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3973
    Cell Significance Index: 5.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3218
    Cell Significance Index: 222.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.2787
    Cell Significance Index: -0.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2470
    Cell Significance Index: 12.8700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1362
    Cell Significance Index: 1.2000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1081
    Cell Significance Index: 1.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0975
    Cell Significance Index: 5.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0513
    Cell Significance Index: 7.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0315
    Cell Significance Index: 4.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0129
    Cell Significance Index: 24.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0098
    Cell Significance Index: 6.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0050
    Cell Significance Index: 2.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0063
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0129
    Cell Significance Index: -0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0132
    Cell Significance Index: -2.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0180
    Cell Significance Index: -10.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0221
    Cell Significance Index: -10.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0231
    Cell Significance Index: -0.4900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0252
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0266
    Cell Significance Index: -4.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0314
    Cell Significance Index: -0.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0378
    Cell Significance Index: -4.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0386
    Cell Significance Index: -11.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0394
    Cell Significance Index: -0.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0440
    Cell Significance Index: -1.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0479
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0583
    Cell Significance Index: -1.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0620
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0639
    Cell Significance Index: -7.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0654
    Cell Significance Index: -1.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0666
    Cell Significance Index: -4.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0673
    Cell Significance Index: -6.8700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0686
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0698
    Cell Significance Index: -11.9200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0744
    Cell Significance Index: -0.8400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0794
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0810
    Cell Significance Index: -2.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0834
    Cell Significance Index: -10.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0859
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0897
    Cell Significance Index: -10.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0955
    Cell Significance Index: -1.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0993
    Cell Significance Index: -10.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1000
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1002
    Cell Significance Index: -11.4800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1024
    Cell Significance Index: -1.1300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1049
    Cell Significance Index: -1.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1060
    Cell Significance Index: -2.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1124
    Cell Significance Index: -5.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1158
    Cell Significance Index: -3.7900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1208
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1269
    Cell Significance Index: -10.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1284
    Cell Significance Index: -9.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1558
    Cell Significance Index: -5.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1646
    Cell Significance Index: -10.6200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1690
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1838
    Cell Significance Index: -6.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1854
    Cell Significance Index: -2.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1859
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1876
    Cell Significance Index: -8.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1984
    Cell Significance Index: -4.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2004
    Cell Significance Index: -5.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2024
    Cell Significance Index: -4.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2046
    Cell Significance Index: -4.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2115
    Cell Significance Index: -9.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2318
    Cell Significance Index: -6.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2372
    Cell Significance Index: -3.3700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2382
    Cell Significance Index: -2.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2389
    Cell Significance Index: -11.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2468
    Cell Significance Index: -9.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2484
    Cell Significance Index: -11.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2512
    Cell Significance Index: -2.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2584
    Cell Significance Index: -2.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2674
    Cell Significance Index: -3.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2689
    Cell Significance Index: -4.9700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2877
    Cell Significance Index: -3.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2964
    Cell Significance Index: -2.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3020
    Cell Significance Index: -3.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3089
    Cell Significance Index: -6.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3095
    Cell Significance Index: -3.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR162 is a transmembrane receptor belonging to the class C GPCR family. It exhibits a characteristic seven-transmembrane domain structure, characteristic of GPCRs, and is predicted to bind to various ligands, including neurotransmitters and hormones. Notably, GPR162 is highly expressed in neurons, particularly in glycinergic and GABAergic neurons, as well as in ciliated cells of the tracheobronchial tree. Its expression pattern suggests a role in regulating neurotransmission and airway function. **Pathways and Functions:** GPR162 is predicted to activate G-protein coupled signaling pathways, which are crucial for regulating various cellular processes, including ion channel activity, gene expression, and cell proliferation. The receptor's signaling mechanisms are likely to involve the activation of G-proteins, which in turn modulate downstream effectors, such as adenylyl cyclase, phospholipase C, and protein kinases. The functional consequences of GPR162 activation are not yet fully understood, but it is likely to play a role in modulating neurotransmitter release, synaptic plasticity, and airway tone. **Clinical Significance:** GPR162 has been implicated in various diseases, including neurological disorders and respiratory conditions. Its dysregulation has been linked to conditions such as epilepsy, anxiety disorders, and asthma. The receptor's expression in neurons and respiratory cells suggests a potential role in regulating mood, anxiety, and airway function. Further research is needed to elucidate the clinical significance of GPR162 and its potential as a therapeutic target. In conclusion, GPR162 is a novel GPCR with a complex expression pattern and signaling mechanisms. Further research is necessary to fully elucidate its functional significance and clinical implications. As a potential therapeutic target, GPR162 holds promise for the treatment of various diseases, including neurological disorders and respiratory conditions. **Future Directions:** To further understand the biology of GPR162, future studies should focus on: 1. Functional characterization of GPR162 using in vitro and in vivo models. 2. Elucidation of its signaling mechanisms and downstream effectors. 3. Investigation of its clinical significance in various diseases. 4. Development of GPR162-targeting therapies for neurological and respiratory disorders. By shedding light on the mysteries of GPR162, we may uncover new insights into the regulation of neurotransmission and airway function, ultimately leading to the development of novel treatments for various diseases.

Genular Protein ID: 3679623612

Symbol: GP162_HUMAN

Name: Probable G-protein coupled receptor 162

UniProtKB Accession Codes:

Q16538 Q16664 Q59EH5 Q66K56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8723724

Title: A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

PubMed ID: 8723724

DOI: 10.1101/gr.6.4.314

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 588
  • Mass: 63930
  • Checksum: 746BBE0BD83C8566
  • Sequence:
    • MARGGAGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL LLCFLAGTHI 
LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL ALATCFTVAS LSYHRMWMVR 
WPVNYRLSNA KKQALHAVMG IWMVSFILST LPSIGWHNNG ERYYARGCQF IVSKIGLGFG 
VCFSLLLLGG IVMGLVCVAI TFYQTLWARP RRARQARRVG GGGGTKAGGP GALGTRPAFE 
VPAIVVEDAR GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS 
APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEEDG DDDGGCDDYA 
EGRVCKVRFD ANGATGPGSR DPAQVKLLPG RHMLFPPLER VHYLQVPLSR RLSHDETNIF 
STPREPGSFL HKWSSSDDIR VLPAQSRALG GPPEYLGQRH RLEDEEDEEE AEGGGLASLR 
QFLESGVLGS GGGPPRGPGF FREEITTFID ETPLPSPTAS PGHSPRRPRP LGLSPRRLSL 
GSPESRAVGL PLGLSAGRRC SLTGGEESAR AWGGSWGPGN PIFPQLTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.