Details for: CHMP2A

Gene ID: 27243

Symbol: CHMP2A

Ensembl ID: ENSG00000130724

Description: charged multivesicular body protein 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 353.7235
    Cell Significance Index: -55.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.8967
    Cell Significance Index: -59.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 162.5935
    Cell Significance Index: -66.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 146.7415
    Cell Significance Index: -69.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.8498
    Cell Significance Index: -58.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.5892
    Cell Significance Index: -65.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 103.0815
    Cell Significance Index: -69.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.9224
    Cell Significance Index: -59.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.0246
    Cell Significance Index: -66.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.4868
    Cell Significance Index: -72.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4775
    Cell Significance Index: -50.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3629
    Cell Significance Index: -41.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4342
    Cell Significance Index: 160.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0938
    Cell Significance Index: 28.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0840
    Cell Significance Index: 71.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9391
    Cell Significance Index: 203.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6426
    Cell Significance Index: 71.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3757
    Cell Significance Index: 177.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2705
    Cell Significance Index: 409.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1910
    Cell Significance Index: 269.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0936
    Cell Significance Index: 227.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0891
    Cell Significance Index: 1140.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0434
    Cell Significance Index: 96.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9444
    Cell Significance Index: 267.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7948
    Cell Significance Index: 52.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7466
    Cell Significance Index: 123.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6948
    Cell Significance Index: 88.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6878
    Cell Significance Index: 746.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6112
    Cell Significance Index: 29.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5677
    Cell Significance Index: 17.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5396
    Cell Significance Index: 198.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3514
    Cell Significance Index: 20.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3463
    Cell Significance Index: 86.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3295
    Cell Significance Index: 170.4300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2057
    Cell Significance Index: 7.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1546
    Cell Significance Index: 60.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7999
    Cell Significance Index: 14.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7720
    Cell Significance Index: 20.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7284
    Cell Significance Index: 20.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6766
    Cell Significance Index: 79.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5582
    Cell Significance Index: 29.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4912
    Cell Significance Index: 48.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4906
    Cell Significance Index: 30.9200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.4800
    Cell Significance Index: 7.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4640
    Cell Significance Index: 12.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4539
    Cell Significance Index: 77.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4002
    Cell Significance Index: 3.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3859
    Cell Significance Index: 23.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3717
    Cell Significance Index: 7.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3651
    Cell Significance Index: 16.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1693
    Cell Significance Index: 32.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1568
    Cell Significance Index: 118.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1122
    Cell Significance Index: 82.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0387
    Cell Significance Index: 7.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0365
    Cell Significance Index: 1.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0164
    Cell Significance Index: 3.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0247
    Cell Significance Index: -46.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0257
    Cell Significance Index: -2.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0445
    Cell Significance Index: -82.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0529
    Cell Significance Index: -0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0542
    Cell Significance Index: -83.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0600
    Cell Significance Index: -37.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0613
    Cell Significance Index: -21.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0640
    Cell Significance Index: -87.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0756
    Cell Significance Index: -42.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0767
    Cell Significance Index: -2.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0834
    Cell Significance Index: -52.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1302
    Cell Significance Index: -27.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1346
    Cell Significance Index: -61.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1413
    Cell Significance Index: -16.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1440
    Cell Significance Index: -3.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1687
    Cell Significance Index: -19.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2130
    Cell Significance Index: -61.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2911
    Cell Significance Index: -23.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3683
    Cell Significance Index: -9.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3812
    Cell Significance Index: -12.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3941
    Cell Significance Index: -11.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4083
    Cell Significance Index: -59.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4853
    Cell Significance Index: -55.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4859
    Cell Significance Index: -6.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5119
    Cell Significance Index: -11.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6134
    Cell Significance Index: -37.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6350
    Cell Significance Index: -16.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6961
    Cell Significance Index: -72.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7712
    Cell Significance Index: -20.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8975
    Cell Significance Index: -68.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9512
    Cell Significance Index: -63.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9777
    Cell Significance Index: -54.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0095
    Cell Significance Index: -8.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1066
    Cell Significance Index: -11.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1148
    Cell Significance Index: -68.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1588
    Cell Significance Index: -7.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2181
    Cell Significance Index: -14.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2219
    Cell Significance Index: -35.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.3634
    Cell Significance Index: -19.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.4240
    Cell Significance Index: -58.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4416
    Cell Significance Index: -8.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4800
    Cell Significance Index: -16.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5089
    Cell Significance Index: -55.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHMP2A is a member of the ESCRT complex, which is responsible for the sorting and degradation of proteins and lipids within the endosomal system. CHMP2A is a key player in the ESCRT-III complex, which is involved in the formation of multivesicular bodies (MVBs) and the budding of viruses such as HIV. CHMP2A has also been implicated in the regulation of autophagy, a process essential for cellular survival and immune response. **Pathways and Functions:** CHMP2A is involved in various cellular processes, including: 1. **Autophagy:** CHMP2A regulates the formation of autophagosomes and the degradation of cellular components, which is essential for maintaining cellular homeostasis. 2. **Endosomal sorting:** CHMP2A is involved in the sorting of proteins and lipids within the endosomal system, which is critical for maintaining cellular homeostasis and regulating immune responses. 3. **Viral budding:** CHMP2A is essential for the budding of viruses such as HIV, which is a critical step in the viral life cycle. 4. **Cell cycle regulation:** CHMP2A regulates the cell cycle, particularly during the G2/M phase, which is essential for maintaining cellular homeostasis. 5. **Immune response:** CHMP2A is involved in the regulation of immune responses, particularly during the early stages of viral infection. **Clinical Significance:** CHMP2A has significant implications in various diseases, including: 1. **COVID-19:** CHMP2A has been implicated in the regulation of immune responses during SARS-CoV-2 infection, which is essential for understanding the pathogenesis of COVID-19. 2. **Cancer:** CHMP2A has been implicated in the regulation of autophagy and endosomal sorting, which is critical for maintaining cellular homeostasis and preventing cancer. 3. **Neurodegenerative diseases:** CHMP2A has been implicated in the regulation of autophagy and endosomal sorting, which is essential for maintaining cellular homeostasis and preventing neurodegenerative diseases. In conclusion, CHMP2A is a complex protein that plays a critical role in various cellular processes, including autophagy, endosomal sorting, and viral budding. Its implications in diseases such as COVID-19, cancer, and neurodegenerative diseases highlight the importance of understanding the function and regulation of CHMP2A in maintaining cellular homeostasis and regulating immune responses.

Genular Protein ID: 1653222996

Symbol: CHM2A_HUMAN

Name: Charged multivesicular body protein 2a

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16533400

Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.

PubMed ID: 16533400

DOI: 10.1186/1471-2164-7-48

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11559748

Title: CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.

PubMed ID: 11559748

DOI: 10.1242/jcs.114.13.2395

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 16730941

Title: A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.

PubMed ID: 16730941

DOI: 10.1016/j.ygeno.2006.04.003

PubMed ID: 17853893

Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PubMed ID: 17853893

DOI: 10.1038/sj.emboj.7601850

PubMed ID: 17547705

Title: Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain.

PubMed ID: 17547705

DOI: 10.1111/j.1600-0854.2007.00584.x

PubMed ID: 18385515

Title: Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.

PubMed ID: 18385515

DOI: 10.1091/mbc.e07-12-1263

PubMed ID: 18687924

Title: Helical structures of ESCRT-III are disassembled by VPS4.

PubMed ID: 18687924

DOI: 10.1126/science.1161070

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21543490

Title: Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.

PubMed ID: 21543490

DOI: 10.1128/jvi.02610-10

PubMed ID: 21310966

Title: Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.

PubMed ID: 21310966

DOI: 10.1126/science.1201847

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26040712

Title: Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.

PubMed ID: 26040712

DOI: 10.1038/nature14408

PubMed ID: 28242692

Title: LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

PubMed ID: 28242692

DOI: 10.1073/pnas.1613916114

Sequence Information:

  • Length: 222
  • Mass: 25104
  • Checksum: F2B86C623829E32E
  • Sequence:
  • MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR 
    IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP 
    QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS 
    NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD

Genular Protein ID: 2334126450

Symbol: M0R1T5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 265
  • Mass: 29604
  • Checksum: F18F9FA8E242551A
  • Sequence:
  • MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR 
    IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP 
    QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS 
    SECSKSWTPF PTQGPATAPS PPFPCITPLR CLTPPAQTPT FSADLPSTGG SLSVAAGGKK 
    AEAAASALAD ADADLEERLK NLRRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.