Details for: CHMP2A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 353.7235
Cell Significance Index: -55.0200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 234.8967
Cell Significance Index: -59.5800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 162.5935
Cell Significance Index: -66.9800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 146.7415
Cell Significance Index: -69.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 143.8498
Cell Significance Index: -58.4400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.5892
Cell Significance Index: -65.6300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 103.0815
Cell Significance Index: -69.1700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 61.9224
Cell Significance Index: -59.1200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 54.0246
Cell Significance Index: -66.6100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.4868
Cell Significance Index: -72.9500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.4775
Cell Significance Index: -50.6100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.3629
Cell Significance Index: -41.1600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.4342
Cell Significance Index: 160.1200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.0938
Cell Significance Index: 28.4900 - Cell Name: peg cell (CL4033014)
Fold Change: 3.0840
Cell Significance Index: 71.2500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.9391
Cell Significance Index: 203.2500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.6426
Cell Significance Index: 71.9300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3757
Cell Significance Index: 177.0600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2705
Cell Significance Index: 409.3000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1910
Cell Significance Index: 269.4100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.0936
Cell Significance Index: 227.7200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.0891
Cell Significance Index: 1140.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.0434
Cell Significance Index: 96.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.9444
Cell Significance Index: 267.0200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.7948
Cell Significance Index: 52.7100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.7466
Cell Significance Index: 123.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6948
Cell Significance Index: 88.0400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.6878
Cell Significance Index: 746.2300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.6112
Cell Significance Index: 29.7800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5677
Cell Significance Index: 17.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.5396
Cell Significance Index: 198.9000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.3514
Cell Significance Index: 20.2500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3463
Cell Significance Index: 86.8600 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.3295
Cell Significance Index: 170.4300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.2057
Cell Significance Index: 7.4200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1546
Cell Significance Index: 60.1400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7999
Cell Significance Index: 14.1400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7720
Cell Significance Index: 20.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7284
Cell Significance Index: 20.9900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6766
Cell Significance Index: 79.8000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5582
Cell Significance Index: 29.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4912
Cell Significance Index: 48.5900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4906
Cell Significance Index: 30.9200 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.4800
Cell Significance Index: 7.2900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4640
Cell Significance Index: 12.3900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4539
Cell Significance Index: 77.5100 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.4002
Cell Significance Index: 3.1900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3859
Cell Significance Index: 23.1700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3717
Cell Significance Index: 7.7800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3651
Cell Significance Index: 16.5500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1693
Cell Significance Index: 32.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1568
Cell Significance Index: 118.6900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1122
Cell Significance Index: 82.3000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0387
Cell Significance Index: 7.7700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0365
Cell Significance Index: 1.2700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0164
Cell Significance Index: 3.2500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0198
Cell Significance Index: -14.6800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0247
Cell Significance Index: -46.4200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0257
Cell Significance Index: -2.6300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0445
Cell Significance Index: -82.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0529
Cell Significance Index: -0.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0542
Cell Significance Index: -83.4400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0600
Cell Significance Index: -37.4600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0613
Cell Significance Index: -21.9900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0640
Cell Significance Index: -87.0400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0756
Cell Significance Index: -42.6300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0767
Cell Significance Index: -2.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0834
Cell Significance Index: -52.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1302
Cell Significance Index: -27.4200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1346
Cell Significance Index: -61.1000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1413
Cell Significance Index: -16.1900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1440
Cell Significance Index: -3.0700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1687
Cell Significance Index: -19.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2130
Cell Significance Index: -61.3000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2911
Cell Significance Index: -23.0600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3683
Cell Significance Index: -9.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3812
Cell Significance Index: -12.2100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3941
Cell Significance Index: -11.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4083
Cell Significance Index: -59.3600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4853
Cell Significance Index: -55.4000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4859
Cell Significance Index: -6.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5119
Cell Significance Index: -11.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6134
Cell Significance Index: -37.7000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6350
Cell Significance Index: -16.9900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6961
Cell Significance Index: -72.4900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7712
Cell Significance Index: -20.6700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8975
Cell Significance Index: -68.8800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.9512
Cell Significance Index: -63.9600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9777
Cell Significance Index: -54.8700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.0095
Cell Significance Index: -8.4800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.1066
Cell Significance Index: -11.4600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1148
Cell Significance Index: -68.3500 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.1588
Cell Significance Index: -7.2000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.2181
Cell Significance Index: -14.5200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.2219
Cell Significance Index: -35.9900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -1.3634
Cell Significance Index: -19.1100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.4240
Cell Significance Index: -58.3500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.4416
Cell Significance Index: -8.7100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.4800
Cell Significance Index: -16.0900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.5089
Cell Significance Index: -55.3900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1653222996
Symbol: CHM2A_HUMAN
Name: Charged multivesicular body protein 2a
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16533400
Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.
PubMed ID: 16533400
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 11559748
Title: CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.
PubMed ID: 11559748
PubMed ID: 14505570
PubMed ID: 14519844
Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
PubMed ID: 14519844
PubMed ID: 16730941
Title: A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
PubMed ID: 16730941
PubMed ID: 17853893
Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
PubMed ID: 17853893
PubMed ID: 17547705
Title: Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain.
PubMed ID: 17547705
PubMed ID: 18385515
Title: Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.
PubMed ID: 18385515
PubMed ID: 18687924
Title: Helical structures of ESCRT-III are disassembled by VPS4.
PubMed ID: 18687924
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21543490
Title: Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
PubMed ID: 21543490
DOI: 10.1128/jvi.02610-10
PubMed ID: 21310966
Title: Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.
PubMed ID: 21310966
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26040712
Title: Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
PubMed ID: 26040712
DOI: 10.1038/nature14408
PubMed ID: 28242692
Title: LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
PubMed ID: 28242692
Sequence Information:
- Length: 222
- Mass: 25104
- Checksum: F2B86C623829E32E
- Sequence:
MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD
Genular Protein ID: 2334126450
Symbol: M0R1T5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 265
- Mass: 29604
- Checksum: F18F9FA8E242551A
- Sequence:
MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS SECSKSWTPF PTQGPATAPS PPFPCITPLR CLTPPAQTPT FSADLPSTGG SLSVAAGGKK AEAAASALAD ADADLEERLK NLRRD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.