Details for: PDCD4

Gene ID: 27250

Symbol: PDCD4

Ensembl ID: ENSG00000150593

Description: programmed cell death 4

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
    (R-HSA-8950505)
  • Immune system
    (R-HSA-168256)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Signaling by interleukins
    (R-HSA-449147)
  • Apoptotic process
    (GO:0006915)
  • Bmp signaling pathway
    (GO:0030509)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Epithelial to mesenchymal transition involved in cardiac fibroblast development
    (GO:0060940)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of jun kinase activity
    (GO:0043508)
  • Negative regulation of myofibroblast differentiation
    (GO:1904761)
  • Negative regulation of vascular associated smooth muscle cell differentiation
    (GO:1905064)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Protein binding
    (GO:0005515)
  • Response to alkaloid
    (GO:0043279)
  • Response to hormone
    (GO:0009725)
  • Rna binding
    (GO:0003723)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 369.0888
    Cell Significance Index: -57.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 227.3270
    Cell Significance Index: -57.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 167.7398
    Cell Significance Index: -69.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.2988
    Cell Significance Index: -62.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 149.1985
    Cell Significance Index: -70.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 138.6898
    Cell Significance Index: -71.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.6698
    Cell Significance Index: -63.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.9946
    Cell Significance Index: -65.3400
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 37.2353
    Cell Significance Index: 18.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4739
    Cell Significance Index: -46.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1564
    Cell Significance Index: -67.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.6673
    Cell Significance Index: -45.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.9862
    Cell Significance Index: -30.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.2859
    Cell Significance Index: 114.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1809
    Cell Significance Index: 148.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2817
    Cell Significance Index: 280.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2196
    Cell Significance Index: 51.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9839
    Cell Significance Index: 57.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9031
    Cell Significance Index: 261.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8785
    Cell Significance Index: 88.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.8546
    Cell Significance Index: 46.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8335
    Cell Significance Index: 235.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7524
    Cell Significance Index: 47.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6997
    Cell Significance Index: 306.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.6073
    Cell Significance Index: 101.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5459
    Cell Significance Index: 109.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4768
    Cell Significance Index: 190.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4567
    Cell Significance Index: 644.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.4439
    Cell Significance Index: 246.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4157
    Cell Significance Index: 37.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2296
    Cell Significance Index: 26.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2240
    Cell Significance Index: 18.3400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.1968
    Cell Significance Index: 24.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1737
    Cell Significance Index: 232.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1603
    Cell Significance Index: 31.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1525
    Cell Significance Index: 231.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1153
    Cell Significance Index: 31.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0517
    Cell Significance Index: 47.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0088
    Cell Significance Index: 99.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9321
    Cell Significance Index: 334.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8014
    Cell Significance Index: 44.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6907
    Cell Significance Index: 13.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6003
    Cell Significance Index: 327.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5663
    Cell Significance Index: 5.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4725
    Cell Significance Index: 36.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4618
    Cell Significance Index: 34.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4532
    Cell Significance Index: 853.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3808
    Cell Significance Index: 72.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3672
    Cell Significance Index: 565.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2970
    Cell Significance Index: 547.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2535
    Cell Significance Index: 27.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2463
    Cell Significance Index: 170.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2429
    Cell Significance Index: 14.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2323
    Cell Significance Index: 147.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2188
    Cell Significance Index: 35.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1895
    Cell Significance Index: 6.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1783
    Cell Significance Index: 11.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0991
    Cell Significance Index: 5.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0806
    Cell Significance Index: 4.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0395
    Cell Significance Index: 53.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0101
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0228
    Cell Significance Index: -14.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0273
    Cell Significance Index: -19.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0344
    Cell Significance Index: -31.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0448
    Cell Significance Index: -2.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0477
    Cell Significance Index: -6.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0482
    Cell Significance Index: -21.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0704
    Cell Significance Index: -4.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0747
    Cell Significance Index: -56.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0842
    Cell Significance Index: -47.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1358
    Cell Significance Index: -13.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1520
    Cell Significance Index: -32.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1560
    Cell Significance Index: -1.8600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1714
    Cell Significance Index: -1.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1777
    Cell Significance Index: -5.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1929
    Cell Significance Index: -55.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2086
    Cell Significance Index: -10.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2389
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2463
    Cell Significance Index: -28.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2474
    Cell Significance Index: -29.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2479
    Cell Significance Index: -28.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3567
    Cell Significance Index: -5.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3722
    Cell Significance Index: -19.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4068
    Cell Significance Index: -47.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4096
    Cell Significance Index: -18.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4433
    Cell Significance Index: -46.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4645
    Cell Significance Index: -17.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5095
    Cell Significance Index: -13.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5310
    Cell Significance Index: -9.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5339
    Cell Significance Index: -7.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6365
    Cell Significance Index: -44.0200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.6387
    Cell Significance Index: -1.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6844
    Cell Significance Index: -20.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7241
    Cell Significance Index: -57.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9305
    Cell Significance Index: -57.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0553
    Cell Significance Index: -26.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1767
    Cell Significance Index: -33.7300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.2262
    Cell Significance Index: -12.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2319
    Cell Significance Index: -26.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PDCD4 is a protein-coding gene that belongs to the programmed cell death 4 family. It is a negative regulator of apoptosis, which is the process of programmed cell death. PDCD4 also regulates cytokine production, myofibroblast differentiation, and vascular associated smooth muscle cell proliferation. It interacts with various signaling pathways, including the BMP signaling pathway, cytokine signaling in the immune system, and interleukin-12 signaling. PDCD4 is highly expressed in epithelial cells, which are the primary site of cell-cell interactions and tissue organization. **Pathways and Functions** PDCD4 is involved in several key pathways, including: 1. **Apoptotic Process**: PDCD4 is a negative regulator of apoptosis, preventing excessive cell death and maintaining tissue homeostasis. 2. **BMP Signaling Pathway**: PDCD4 interacts with the BMP signaling pathway, regulating cell proliferation, differentiation, and apoptosis. 3. **Cytokine Signaling in Immune System**: PDCD4 regulates cytokine production, modulating the immune response and preventing excessive inflammation. 4. **Cytoplasm and Nucleus**: PDCD4 is localized to the cytoplasm and nucleus, where it regulates various cellular processes, including transcription and translation. 5. **Epithelial to Mesenchymal Transition**: PDCD4 regulates the transition of epithelial cells to mesenchymal cells, a process involved in tissue repair and fibrosis. 6. **Interleukin-12 Signaling**: PDCD4 interacts with the interleukin-12 signaling pathway, regulating immune response and inflammation. **Clinical Significance** Dysregulation of PDCD4 has been implicated in various diseases, including: 1. **Cancer**: PDCD4 is a tumor suppressor gene that is frequently downregulated in cancer cells, leading to increased cell proliferation and survival. 2. **Inflammatory Disorders**: PDCD4 regulates cytokine production and inflammation, making it a potential therapeutic target for inflammatory diseases. 3. **Cardiovascular Diseases**: PDCD4 regulates vascular associated smooth muscle cell proliferation and apoptosis, making it a potential therapeutic target for cardiovascular diseases. 4. **Autoimmune Diseases**: PDCD4 regulates immune response and cytokine production, making it a potential therapeutic target for autoimmune diseases. In conclusion, PDCD4 is a critical gene that regulates various cellular processes, including apoptosis, inflammation, and immune response. Its dysregulation has been implicated in various diseases, making it a potential therapeutic target for cancer, inflammatory disorders, cardiovascular diseases, and autoimmune diseases.

Genular Protein ID: 1658077208

Symbol: PDCD4_HUMAN

Name: Programmed cell death protein 4

UniProtKB Accession Codes:

Q53EL6 B2RCV4 B5ME91 O15501 Q5VZS6 Q6PJI5 Q8TAR5 Q99834

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 9 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9759869

Title: Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells.

PubMed ID: 9759869

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10632927

Title: Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody.

PubMed ID: 10632927

DOI: 10.1046/j.1440-1827.1999.00995.x

PubMed ID: 12898601

Title: Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis.

PubMed ID: 12898601

DOI: 10.1002/path.1378

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16357133

Title: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.

PubMed ID: 16357133

DOI: 10.1158/0008-5472.can-05-3469

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16449643

Title: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.

PubMed ID: 16449643

DOI: 10.1128/mcb.26.4.1297-1306.2006

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17053147

Title: S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.

PubMed ID: 17053147

DOI: 10.1126/science.1130276

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18296639

Title: PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.

PubMed ID: 18296639

DOI: 10.1073/pnas.0712235105

PubMed ID: 19153607

Title: Structural basis for translational inhibition by the tumour suppressor Pdcd4.

PubMed ID: 19153607

DOI: 10.1038/emboj.2008.278

PubMed ID: 19204291

Title: Crystal structure of the eIF4A-PDCD4 complex.

PubMed ID: 19204291

DOI: 10.1073/pnas.0808275106

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 469
  • Mass: 51735
  • Checksum: 2CAE1D2055491177
  • Sequence:
    • MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK 
RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG 
KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD 
TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF 
DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV 
LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH 
HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP 
HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY

Genular Protein ID: 3939604089

Symbol: B4DKX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKX4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 455
  • Mass: 50229
  • Checksum: 3F965AFBA9D10FE4
  • Sequence:
    • MDVENEQILN VNPAENAGTE EVKNEINGNW ISASSINEAR INAKAKRRLR KNSSRDSGRG 
DSVSDSGSDA LRSGLTVPTS PKGRLLDRRS RSGKGRGLPK KGGAGGKGVW GTPGQVYDVE 
EVDVKDPNYD DDQENCVYET VVLPLDERAF EKTLTPIIQE YFEHGDTNEV AEMLRDLNLG 
EMKSGVPVLA VSLALEGKAS HREMTSKLLS DLCGTVMSTT DVEKSFDKLL KDLPELALDT 
PRAPQLVGQF IARAVGDGIL CNTYIDSYKG TVDCVQARAA LDKATVLLSM SKGGKRKDSV 
WGSGGGQQSV NHLVKEIDML LKEYLLSGDI SEAEHCLKEL EVPHFHHELV YEAIIMVLES 
TGESTFKMIL DLLKSLWKSS TITVDQMKRG YERIYNEIPD INLDVPHSYS VLERFVEECF 
QAGIISKQLR DLCPSRGRKR FVSEGDGGRL KPESY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.