Details for: RND1

Gene ID: 27289

Symbol: RND1

Ensembl ID: ENSG00000172602

Description: Rho family GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.4624
    Cell Significance Index: -12.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.3606
    Cell Significance Index: -12.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.3534
    Cell Significance Index: -10.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0490
    Cell Significance Index: -12.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.4510
    Cell Significance Index: 114.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4123
    Cell Significance Index: -11.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2032
    Cell Significance Index: -12.6400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.2602
    Cell Significance Index: 13.9100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.9758
    Cell Significance Index: 14.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8186
    Cell Significance Index: 135.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3890
    Cell Significance Index: 40.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7937
    Cell Significance Index: 17.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5182
    Cell Significance Index: 18.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5070
    Cell Significance Index: 65.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4835
    Cell Significance Index: 7.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4739
    Cell Significance Index: 24.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4719
    Cell Significance Index: 94.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4700
    Cell Significance Index: 24.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3424
    Cell Significance Index: 15.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3171
    Cell Significance Index: 40.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3093
    Cell Significance Index: 14.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2581
    Cell Significance Index: 51.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2576
    Cell Significance Index: 49.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2438
    Cell Significance Index: 4.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1499
    Cell Significance Index: 3.1100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1495
    Cell Significance Index: 0.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1394
    Cell Significance Index: 13.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1358
    Cell Significance Index: 122.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1291
    Cell Significance Index: 6.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0958
    Cell Significance Index: 34.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0936
    Cell Significance Index: 1.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0681
    Cell Significance Index: 11.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0461
    Cell Significance Index: 25.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0423
    Cell Significance Index: 4.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0324
    Cell Significance Index: 0.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0245
    Cell Significance Index: 0.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0208
    Cell Significance Index: 1.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0207
    Cell Significance Index: 9.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0188
    Cell Significance Index: 1.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0159
    Cell Significance Index: 1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0114
    Cell Significance Index: 8.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0029
    Cell Significance Index: 0.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0043
    Cell Significance Index: -2.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0100
    Cell Significance Index: -6.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0229
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0254
    Cell Significance Index: -7.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0270
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0308
    Cell Significance Index: -3.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0344
    Cell Significance Index: -4.0100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0462
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0472
    Cell Significance Index: -6.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0474
    Cell Significance Index: -6.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0685
    Cell Significance Index: -7.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0767
    Cell Significance Index: -2.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0784
    Cell Significance Index: -2.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0799
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0806
    Cell Significance Index: -9.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0825
    Cell Significance Index: -2.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0834
    Cell Significance Index: -5.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0867
    Cell Significance Index: -2.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0945
    Cell Significance Index: -6.6900
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1056
    Cell Significance Index: -0.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1186
    Cell Significance Index: -4.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1223
    Cell Significance Index: -12.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1225
    Cell Significance Index: -7.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1326
    Cell Significance Index: -8.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1328
    Cell Significance Index: -1.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1347
    Cell Significance Index: -8.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1348
    Cell Significance Index: -2.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1368
    Cell Significance Index: -4.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1445
    Cell Significance Index: -9.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1592
    Cell Significance Index: -3.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1606
    Cell Significance Index: -7.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1667
    Cell Significance Index: -4.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1675
    Cell Significance Index: -12.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1800
    Cell Significance Index: -10.1000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1831
    Cell Significance Index: -1.1500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1921
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2088
    Cell Significance Index: -6.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2102
    Cell Significance Index: -7.9600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2106
    Cell Significance Index: -1.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2291
    Cell Significance Index: -7.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2486
    Cell Significance Index: -8.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2550
    Cell Significance Index: -9.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2568
    Cell Significance Index: -6.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2582
    Cell Significance Index: -1.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2640
    Cell Significance Index: -3.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2726
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2737
    Cell Significance Index: -7.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase activity**: RND1 belongs to the Rho GTPase family, which is characterized by its GTPase activity, enabling the conversion of GTP to GDP. 2. **Actin cytoskeleton regulation**: RND1 regulates the actin cytoskeleton organization, which is essential for cell migration, shape changes, and intracellular transport. 3. **Semaphorin signaling**: RND1 interacts with semaphorins, which are proteins that regulate axon guidance, cell migration, and differentiation. 4. **Cell migration**: RND1 regulates cell migration by modulating the actin cytoskeleton and semaphorin signaling pathways. 5. **Cell adhesion**: RND1 inhibits cell adhesion by regulating the expression of adhesion molecules and the actin cytoskeleton. **Pathways and Functions:** 1. **Actin cytoskeleton organization**: RND1 regulates the actin cytoskeleton organization by interacting with actin-binding proteins and modulating the activity of the Rho/Rac/ROCK pathway. 2. **Semaphorin signaling**: RND1 interacts with semaphorins, which regulate axon guidance, cell migration, and differentiation. 3. **Cell migration**: RND1 regulates cell migration by modulating the actin cytoskeleton and semaphorin signaling pathways. 4. **Neuron remodeling**: RND1 is involved in neuron remodeling by regulating the expression of genes involved in axon growth and guidance. 5. **Cytosol organization**: RND1 regulates the organization of the cytosol by interacting with other proteins and modulating the activity of the Rho/Rac/ROCK pathway. **Clinical Significance:** 1. **Neurological disorders**: RND1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 2. **Cancer**: RND1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been associated with tumor progression and metastasis. 3. **Vascular diseases**: RND1 is involved in vascular diseases, including atherosclerosis and hypertension, by regulating the expression of genes involved in cell migration and adhesion. 4. **Wound healing**: RND1 regulates wound healing by modulating the expression of genes involved in cell migration and tissue repair. 5. **Regenerative medicine**: RND1 has been identified as a potential target for regenerative medicine, with potential applications in tissue engineering and organ transplantation. In conclusion, RND1 is a multifaceted gene involved in regulating the actin cytoskeleton, semaphorin signaling, and cell migration. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the functions and clinical significance of RND1.

Genular Protein ID: 3179874368

Symbol: RND1_HUMAN

Name: Rho-related GTP-binding protein Rho6

UniProtKB Accession Codes:

Q92730 A8K9P7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9531558

Title: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.

PubMed ID: 9531558

DOI: 10.1083/jcb.141.1.187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11095956

Title: Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells.

PubMed ID: 11095956

DOI: 10.1006/bbrc.2000.3842

PubMed ID: 10664463

Title: Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.

PubMed ID: 10664463

DOI: 10.1016/s0014-5793(99)01530-6

PubMed ID: 11940653

Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

PubMed ID: 11940653

DOI: 10.1128/mcb.22.9.2952-2964.2002

PubMed ID: 12730235

Title: Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.

PubMed ID: 12730235

DOI: 10.1074/jbc.m303047200

PubMed ID: 19843518

Title: Structure and function of the intracellular region of the plexin-B1 transmembrane receptor.

PubMed ID: 19843518

DOI: 10.1074/jbc.m109.056275

Sequence Information:

  • Length: 232
  • Mass: 26056
  • Checksum: 9FD56ACB878FBCCA
  • Sequence:
    • MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR 
VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV 
LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF 
RTASMLCLNK PSPLPQKSPV RSLSKRLLHL PSRSELISST FKKEKAKSCS IM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.