Details for: RBMS3

Gene ID: 27303

Symbol: RBMS3

Ensembl ID: ENSG00000144642

Description: RNA binding motif single stranded interacting protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 266.8313
    Cell Significance Index: -67.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 137.3796
    Cell Significance Index: -64.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.3924
    Cell Significance Index: -54.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.4748
    Cell Significance Index: -67.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.8757
    Cell Significance Index: -74.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 23.3635
    Cell Significance Index: 158.3000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 18.2748
    Cell Significance Index: 162.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8548
    Cell Significance Index: -66.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 9.6843
    Cell Significance Index: 207.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 7.5514
    Cell Significance Index: 2708.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.9431
    Cell Significance Index: 135.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.6784
    Cell Significance Index: 81.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.4823
    Cell Significance Index: 420.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 5.3372
    Cell Significance Index: 328.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.0976
    Cell Significance Index: 98.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.4087
    Cell Significance Index: 87.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.2472
    Cell Significance Index: 32.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1953
    Cell Significance Index: 83.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1038
    Cell Significance Index: 1455.0900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 1.9044
    Cell Significance Index: 8.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7185
    Cell Significance Index: 76.0200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.0324
    Cell Significance Index: 13.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9792
    Cell Significance Index: 49.4900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.8855
    Cell Significance Index: 7.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5424
    Cell Significance Index: 14.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5287
    Cell Significance Index: 106.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5153
    Cell Significance Index: 327.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5147
    Cell Significance Index: 969.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4273
    Cell Significance Index: 52.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3431
    Cell Significance Index: 155.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2084
    Cell Significance Index: 4.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1706
    Cell Significance Index: 4.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1159
    Cell Significance Index: 0.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0928
    Cell Significance Index: 16.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0823
    Cell Significance Index: 2.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0637
    Cell Significance Index: 6.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0225
    Cell Significance Index: -9.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0300
    Cell Significance Index: -55.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0359
    Cell Significance Index: -55.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0369
    Cell Significance Index: -20.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0435
    Cell Significance Index: -59.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0819
    Cell Significance Index: -16.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0824
    Cell Significance Index: -60.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0868
    Cell Significance Index: -65.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0893
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0907
    Cell Significance Index: -67.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1130
    Cell Significance Index: -70.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1191
    Cell Significance Index: -67.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1231
    Cell Significance Index: -6.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1281
    Cell Significance Index: -1.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1477
    Cell Significance Index: -20.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1643
    Cell Significance Index: -23.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2045
    Cell Significance Index: -58.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3150
    Cell Significance Index: -4.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3182
    Cell Significance Index: -5.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3260
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3322
    Cell Significance Index: -69.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3377
    Cell Significance Index: -57.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3480
    Cell Significance Index: -7.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4070
    Cell Significance Index: -9.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4366
    Cell Significance Index: -24.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4627
    Cell Significance Index: -59.7800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4830
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5162
    Cell Significance Index: -59.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5374
    Cell Significance Index: -63.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5572
    Cell Significance Index: -64.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5591
    Cell Significance Index: -57.1100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5867
    Cell Significance Index: -3.6200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6236
    Cell Significance Index: -6.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6678
    Cell Significance Index: -10.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7484
    Cell Significance Index: -16.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7640
    Cell Significance Index: -60.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7909
    Cell Significance Index: -37.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8122
    Cell Significance Index: -60.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8346
    Cell Significance Index: -14.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8846
    Cell Significance Index: -17.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8910
    Cell Significance Index: -59.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9034
    Cell Significance Index: -63.8900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9357
    Cell Significance Index: -11.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9499
    Cell Significance Index: -61.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0784
    Cell Significance Index: -56.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1208
    Cell Significance Index: -70.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1382
    Cell Significance Index: -59.7600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.1405
    Cell Significance Index: -11.8800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.1528
    Cell Significance Index: -11.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1895
    Cell Significance Index: -15.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2101
    Cell Significance Index: -56.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2219
    Cell Significance Index: -32.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3773
    Cell Significance Index: -62.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4401
    Cell Significance Index: -50.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4891
    Cell Significance Index: -47.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4899
    Cell Significance Index: -48.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.5416
    Cell Significance Index: -53.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.5457
    Cell Significance Index: -32.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5565
    Cell Significance Index: -32.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.6271
    Cell Significance Index: -20.2900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.6317
    Cell Significance Index: -21.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6546
    Cell Significance Index: -60.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.7005
    Cell Significance Index: -41.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RBMS3 is a member of the RNA-binding motif single-stranded interacting protein family, which is characterized by the presence of an RNA-binding motif (RBM) domain. This domain allows RBMS3 to interact with single-stranded RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs), and other non-coding RNAs. RBMS3's ability to bind to these RNAs enables it to regulate their activity, thereby influencing gene expression and cellular behavior. RBMS3 has been implicated in various cellular processes, including: 1. **Negative regulation of canonical Wnt signaling pathway**: RBMS3 has been shown to interact with and inhibit the activity of β-catenin, a key component of the canonical Wnt signaling pathway. 2. **Regulation of gene expression**: RBMS3 can bind to and stabilize specific mRNAs, influencing their translation and contributing to the regulation of gene expression. 3. **Modulation of RNA stability**: RBMS3 can interact with RNAs, influencing their stability and decay rates. **Pathways and Functions** RBMS3's interactions with RNAs and its regulation of gene expression have significant implications for various cellular processes, including: 1. **Defense response to tumor cells**: RBMS3 has been implicated in the regulation of gene expression in response to tumor cells, suggesting its potential role in cancer prevention and therapy. 2. **Negative regulation of canonical Wnt signaling pathway**: RBMS3's inhibition of β-catenin activity can contribute to the regulation of cell proliferation, differentiation, and survival. 3. **Regulation of gene expression**: RBMS3's ability to bind to and stabilize specific mRNAs can influence the expression of genes involved in various cellular processes, including development, differentiation, and response to environmental stimuli. **Clinical Significance** The study of RBMS3 and its functions has significant implications for the understanding and treatment of various diseases, including: 1. **Cancer**: RBMS3's role in regulating gene expression and modulating the Wnt signaling pathway suggests its potential as a therapeutic target in cancer prevention and therapy. 2. **Neurological disorders**: RBMS3's expression in neurons and its involvement in the regulation of gene expression and RNA stability suggest its potential role in neurological disorders, such as neurodegenerative diseases and neuropsychiatric disorders. 3. **Regenerative medicine**: RBMS3's ability to regulate gene expression and modulate cellular responses to external stimuli makes it a potential candidate for the development of regenerative therapies. In conclusion, RBMS3 is a protein with a complex and multifaceted role in regulating gene expression and modulating cellular responses to external stimuli. Further research on RBMS3's functions and clinical significance is needed to fully understand its potential implications for human health and disease.

Genular Protein ID: 501641016

Symbol: RBMS3_HUMAN

Name: RNA-binding motif, single-stranded-interacting protein 3

UniProtKB Accession Codes:

Q6XE24 A8K9S4 B7ZL17 G5E9J9 O75876 Q17RI0 Q6XE23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10675610

Title: Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins.

PubMed ID: 10675610

DOI: 10.1016/s0378-1119(99)00515-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 437
  • Mass: 47840
  • Checksum: 7EFC2ECFE24E323C
  • Sequence:
    • MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 
TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 
SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 
GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 
RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL 
HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV 
DTSNEHAPAY SYQQSKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.