TNRC6A | ENSG00000090905 | NCBI 27327

Details for: TNRC6A

Gene ID: 27327

Symbol: TNRC6A

Ensembl ID: ENSG00000090905

Description: trinucleotide repeat containing adaptor 6A

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Developmental biology
(R-HSA-1266738)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-transcriptional silencing by small rnas
(R-HSA-426496)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tgfbr3 expression
(R-HSA-9839394)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation by ventx
(R-HSA-8853884)
Cellular response to starvation
(GO:0009267)
Cytosol
(GO:0005829)
Endoderm development
(GO:0007492)
Golgi apparatus
(GO:0005794)
Intracellular membrane-bounded organelle
(GO:0043231)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Nucleoplasm
(GO:0005654)
P-body
(GO:0000932)
P-body assembly
(GO:0033962)
Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
(GO:0060213)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Risc complex
(GO:0016442)
Rna binding
(GO:0003723)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 713.5545
Cell Significance Index: -110.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 438.7656
Cell Significance Index: -111.2900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 302.9026
Cell Significance Index: -124.7800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 236.5487
Cell Significance Index: -111.6800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 211.4424
Cell Significance Index: -85.9000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 197.1091
Cell Significance Index: -101.3900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 92.4283
Cell Significance Index: -113.9600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 90.2913
Cell Significance Index: -86.2100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 37.8930
Cell Significance Index: -101.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 36.1360
Cell Significance Index: -110.9900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 29.0240
Cell Significance Index: -114.5300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.6350
Cell Significance Index: -47.3500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.5715
Cell Significance Index: 1998.3900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 4.1831
Cell Significance Index: 89.4200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 4.1431
Cell Significance Index: 7800.9800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 3.8985
Cell Significance Index: 2696.3500
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.8982
Cell Significance Index: 54.5100
Cell Name: preadipocyte (CL0002334)
Fold Change: 3.8915
Cell Significance Index: 75.9500
Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.8119
Cell Significance Index: 91.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.6873
Cell Significance Index: 206.9100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.5894
Cell Significance Index: 220.6200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.5836
Cell Significance Index: 275.0000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.2648
Cell Significance Index: 123.6300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.2273
Cell Significance Index: 142.7500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.2060
Cell Significance Index: 636.2400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.0359
Cell Significance Index: 51.1400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.9464
Cell Significance Index: 198.1200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8401
Cell Significance Index: 569.7300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.9763
Cell Significance Index: 50.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.8408
Cell Significance Index: 1169.1100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6043
Cell Significance Index: 44.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.4482
Cell Significance Index: 657.2900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.1732
Cell Significance Index: 33.4800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0229
Cell Significance Index: 125.7800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.8718
Cell Significance Index: 14.9400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8651
Cell Significance Index: 155.9500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7397
Cell Significance Index: 667.9000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6641
Cell Significance Index: 91.2000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6241
Cell Significance Index: 67.8800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.5874
Cell Significance Index: 1083.3600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5814
Cell Significance Index: 895.0500
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.5594
Cell Significance Index: 8.5100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5380
Cell Significance Index: 87.5000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5017
Cell Significance Index: 10.8700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4355
Cell Significance Index: 192.5600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4049
Cell Significance Index: 21.0900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2874
Cell Significance Index: 156.9500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2251
Cell Significance Index: 306.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.1589
Cell Significance Index: 16.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0370
Cell Significance Index: 1.3000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0324
Cell Significance Index: 6.1700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0267
Cell Significance Index: -1.8500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0566
Cell Significance Index: -41.5100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1008
Cell Significance Index: -12.9300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1220
Cell Significance Index: -90.3800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1394
Cell Significance Index: -105.5400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1986
Cell Significance Index: -112.0200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2150
Cell Significance Index: -134.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2184
Cell Significance Index: -37.3000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2815
Cell Significance Index: -3.5100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2868
Cell Significance Index: -41.6900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3212
Cell Significance Index: -9.2600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3292
Cell Significance Index: -8.8200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3395
Cell Significance Index: -97.6900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4451
Cell Significance Index: -45.4700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5260
Cell Significance Index: -62.0300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5745
Cell Significance Index: -27.0000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5752
Cell Significance Index: -8.2600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.5775
Cell Significance Index: -74.6100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5987
Cell Significance Index: -126.1100
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.6007
Cell Significance Index: -7.7900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6213
Cell Significance Index: -9.1700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6481
Cell Significance Index: -75.5300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6611
Cell Significance Index: -41.6700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6746
Cell Significance Index: -9.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.7167
Cell Significance Index: -70.9000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7625
Cell Significance Index: -34.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7763
Cell Significance Index: -50.0900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8321
Cell Significance Index: -43.6900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8338
Cell Significance Index: -95.5200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8459
Cell Significance Index: -39.4400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.9181
Cell Significance Index: -64.9300
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.9706
Cell Significance Index: -12.2500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9846
Cell Significance Index: -26.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9991
Cell Significance Index: -51.9000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.0333
Cell Significance Index: -77.0100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1294
Cell Significance Index: -89.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1523
Cell Significance Index: -28.8100
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -1.2190
Cell Significance Index: -15.3500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.2239
Cell Significance Index: -24.2000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4074
Cell Significance Index: -86.2900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.4827
Cell Significance Index: -32.4700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.5548
Cell Significance Index: -33.0000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.5615
Cell Significance Index: -38.1000
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.6111
Cell Significance Index: -19.2100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.6420
Cell Significance Index: -57.0600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.6826
Cell Significance Index: -55.0900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.7865
Cell Significance Index: -56.9000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.8215
Cell Significance Index: -36.5700
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.9942
Cell Significance Index: -34.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TNRC6A is characterized by its unique trinucleotide repeat sequence, which is thought to play a role in its function. The gene is highly expressed in various cell types and is involved in regulating a wide range of cellular processes, including: * Cell-cell communication: TNRC6A is involved in regulating adherens junctions and cell-cell communication. * Signaling pathways: The gene is involved in regulating various signaling pathways, including Wnt signaling, Notch signaling, and MAPK signaling. * Gene regulation: TNRC6A is involved in regulating gene expression, including transcriptional regulation and post-transcriptional gene silencing. * Protein translation: The gene is involved in regulating protein translation, including the regulation of Pten translation. * Cellular senescence: TNRC6A is involved in regulating cellular senescence, including the regulation of TP53 and p21 expression. **Pathways and Functions** TNRC6A is involved in regulating a wide range of cellular pathways, including: * Adherens junctions interactions: TNRC6A is involved in regulating adherens junctions and cell-cell communication. * Beta-catenin independent Wnt signaling: The gene is involved in regulating Wnt signaling pathways, independent of beta-catenin. * Ca2+ pathway: TNRC6A is involved in regulating the Ca2+ pathway, which is critical for cellular signaling. * Cell-cell communication: The gene is involved in regulating cell-cell communication, including the regulation of cadherins and junctional proteins. * Cellular responses to stimuli: TNRC6A is involved in regulating cellular responses to stimuli, including the regulation of MAPK signaling. * Cellular senescence: The gene is involved in regulating cellular senescence, including the regulation of TP53 and p21 expression. **Clinical Significance** TNRC6A has been implicated in various diseases, including: * Neurological disorders: TNRC6A has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. * Cancer: The gene has been implicated in cancer, including the regulation of cell proliferation and survival. * Cardiovascular disease: TNRC6A has been implicated in cardiovascular disease, including the regulation of cardiac function and cell-cell communication. * Neurodevelopmental disorders: The gene has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, TNRC6A is a complex gene that plays a critical role in various cellular processes, including cell-cell communication, signaling pathways, and gene regulation. Further research is needed to fully understand the function and clinical significance of TNRC6A.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Trinucleotide repeat-containing gene 6A protein

Genular Protein ID: 2715940605

Symbol: TNR6A_HUMAN

Name: Trinucleotide repeat-containing gene 6A protein

UniProtKB Accession Codes:

Q8NDV7 C9JAR8 O15408 Q658L5 Q6NVB5 Q8NEZ0 Q8TBT8 Q8TCR0 Q9NV59 Q9P268

Database IDs:

Citations:

PubMed ID: 11950943

Title: A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

PubMed ID: 11950943

DOI: 10.1091/mbc.01-11-0544

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9225980

Title: cDNAs with long CAG trinucleotide repeats from human brain.

PubMed ID: 9225980

DOI: 10.1007/s004390050476

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14598044

Title: Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182.

PubMed ID: 14598044

DOI: 10.1007/s00109-003-0495-y

PubMed ID: 13130130

Title: The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.

PubMed ID: 13130130

DOI: 10.1261/rna.5810203

PubMed ID: 15494374

Title: GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.

PubMed ID: 15494374

DOI: 10.1242/jcs.01477

PubMed ID: 15908945

Title: Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.

PubMed ID: 15908945

DOI: 10.1038/ncb1265

PubMed ID: 16284623

Title: A role for the P-body component GW182 in microRNA function.

PubMed ID: 16284623

DOI: 10.1038/ncb1333

PubMed ID: 16284622

Title: Disruption of GW bodies impairs mammalian RNA interference.

PubMed ID: 16284622

DOI: 10.1038/ncb1334

PubMed ID: 16906129

Title: Formation of GW bodies is a consequence of microRNA genesis.

PubMed ID: 16906129

DOI: 10.1038/sj.embor.7400783

PubMed ID: 17671087

Title: Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system.

PubMed ID: 17671087

DOI: 10.1101/gad.1566707

PubMed ID: 17596515

Title: Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.

PubMed ID: 17596515

DOI: 10.1091/mbc.e07-01-0070

PubMed ID: 19056672

Title: Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing.

PubMed ID: 19056672

DOI: 10.1242/jcs.036905

PubMed ID: 18690212

Title: Prolyl 4-hydroxylation regulates Argonaute 2 stability.

PubMed ID: 18690212

DOI: 10.1038/nature07186

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18946079

Title: Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2.

PubMed ID: 18946079

DOI: 10.1091/mbc.e08-08-0796

PubMed ID: 19304925

Title: Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

PubMed ID: 19304925

DOI: 10.1261/rna.1448009

PubMed ID: 19324964

Title: The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

PubMed ID: 19324964

DOI: 10.1261/rna.1229409

PubMed ID: 19383768

Title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

PubMed ID: 19383768

DOI: 10.1261/rna.1606309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21981923

Title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

PubMed ID: 21981923

DOI: 10.1016/j.molcel.2011.09.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26134560

Title: Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradation.

PubMed ID: 26134560

DOI: 10.1074/jbc.m114.635870

PubMed ID: 28546213

Title: Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

PubMed ID: 28546213

DOI: 10.1126/science.aai9372

PubMed ID: 29507423

Title: Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

PubMed ID: 29507423

DOI: 10.1038/s41588-018-0067-2

PubMed ID: 29395067

Title: High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

PubMed ID: 29395067

DOI: 10.1016/j.molcel.2017.12.020

PubMed ID: 31400113

Title: KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.

PubMed ID: 31400113

DOI: 10.1093/nar/gkz683

Sequence Information:

Length: 1962
Mass: 210297
Checksum: 963C054628E18592
Sequence:

MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE QKIKVPEQIK 
PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ QQQPQQQQPQ QQPQPQPQQQ 
QPQQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN 
QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP 
SAPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS 
SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST 
LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW 
GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT 
GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ 
ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG 
WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG SATSQTNEQS 
SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN 
SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNGNDTSSV 
SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG 
DGQKSSQGWS VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN 
NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP 
ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN 
MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA 
WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG 
WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW 
INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG 
SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM 
QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL 
KYAPNNGGLN PLFGPQQVAM LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ 
DQQGRPLSVQ QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK 
GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL DQNSSKHGAI 
SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP NGSSSVNWPP EFRPGEPWKG 
YPNIDPETDP YVTPGSVINN LSINTVREVD HLRDRNSGSS SSLNTTLPST SAWSSIRASN 
YNVPLSSTAQ STSARNSDSK LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ 
KPPLSTWDNS PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL 
CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF ASEEEISRFF 
AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW NGAGLSGTNC GDLHGTSLWG 
TPHYSTSLWG PPSSSDPRGI SSPSPINAFL SVDHLGGGGE SM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TNRC6A

Associated with

Cells (max top 100)

Other Information

A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. PubMed ID: 11950943

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNAs with long CAG trinucleotide repeats from human brain. PubMed ID: 9225980

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. PubMed ID: 14598044

The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. PubMed ID: 13130130

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. PubMed ID: 15494374

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. PubMed ID: 15908945

A role for the P-body component GW182 in microRNA function. PubMed ID: 16284623

Disruption of GW bodies impairs mammalian RNA interference. PubMed ID: 16284622

Formation of GW bodies is a consequence of microRNA genesis. PubMed ID: 16906129

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. PubMed ID: 17671087

Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. PubMed ID: 17596515

Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. PubMed ID: 19056672

Prolyl 4-hydroxylation regulates Argonaute 2 stability. PubMed ID: 18690212

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2. PubMed ID: 18946079

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. PubMed ID: 19304925

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. PubMed ID: 19324964

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. PubMed ID: 19383768

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. PubMed ID: 21981923

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradation. PubMed ID: 26134560

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. PubMed ID: 28546213

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy. PubMed ID: 29507423

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. PubMed ID: 29395067

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. PubMed ID: 31400113