TNRC6A | ENSG00000090905 | NCBI 27327

Details for: TNRC6A

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Developmental biology
(R-HSA-1266738)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-transcriptional silencing by small rnas
(R-HSA-426496)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tgfbr3 expression
(R-HSA-9839394)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation by ventx
(R-HSA-8853884)
Cellular response to starvation
(GO:0009267)
Cytosol
(GO:0005829)
Endoderm development
(GO:0007492)
Golgi apparatus
(GO:0005794)
Intracellular membrane-bounded organelle
(GO:0043231)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Nucleoplasm
(GO:0005654)
P-body
(GO:0000932)
P-body assembly
(GO:0033962)
Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
(GO:0060213)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Risc complex
(GO:0016442)
Rna binding
(GO:0003723)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

VIP GABAergic cortical interneuron CL4023016

CSI 78.11

rCSI 93.31%

PRS 12.2
pvalb GABAergic cortical interneuron CL4023018

CSI 76.34

rCSI 94.97%

PRS 11.59
sst GABAergic cortical interneuron CL4023017

CSI 71.39

rCSI 92.03%

PRS 13
choroid plexus epithelial cell CL0000706

CSI 60.33

rCSI 98.79%

PRS 16.1
Bergmann glial cell CL0000644

CSI 56.39

rCSI 77.16%

PRS 20.83
cardiac muscle cell CL0000746

CSI 54.75

rCSI 78.57%

PRS 16.24
sncg GABAergic cortical interneuron CL4023015

CSI 54.21

rCSI 87.19%

PRS 13.53
differentiation-committed oligodendrocyte precursor CL4023059

CSI 52.44

rCSI 95.28%

PRS 17.9
cerebellar granule cell CL0001031

CSI 52.42

rCSI 77.07%

PRS 19.39
lamp5 GABAergic cortical interneuron CL4023011

CSI 51.07

rCSI 85.73%

PRS 12.41
adipocyte CL0000136

CSI 51.07

rCSI 65.57%

PRS 20.37
astrocyte CL0000127

CSI 49.07

rCSI 100%

PRS 13.45
ependymal cell CL0000065

CSI 47.58

rCSI 96.54%

PRS 10.79
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 47.29

rCSI 83.52%

PRS 12.32
inhibitory interneuron CL0000498

CSI 42.87

rCSI 98.96%

PRS 16.94
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 41.35

rCSI 89.69%

PRS 15.05
oligodendrocyte precursor cell CL0002453

CSI 39.26

rCSI 86.38%

PRS 17.63
astrocyte of the cerebral cortex CL0002605

CSI 38.44

rCSI 86.19%

PRS 12.97
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 38.32

rCSI 91.66%

PRS 13.87
neuron CL0000540

CSI 35.04

rCSI 93.31%

PRS 18.22
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 34

rCSI 82.64%

PRS 12.17
IgG plasma cell CL0000985

CSI 32.7

rCSI 39.17%

PRS 36.21
retinal ganglion cell CL0000740

CSI 32.35

rCSI 71.47%

PRS 14.99
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 31.62

rCSI 44.82%

PRS 19.38
glycinergic amacrine cell CL4030028

CSI 28.66

rCSI 74.67%

PRS 21.12
L6b glutamatergic cortical neuron CL4023038

CSI 27.73

rCSI 86.67%

PRS 13.23
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 27.51

rCSI 86.04%

PRS 14.25
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 27.46

rCSI 90.23%

PRS 13.67
neuroblast (sensu Vertebrata) CL0000031

CSI 25.3

rCSI 32.47%

PRS 20.2
glioblast CL0000030

CSI 24.49

rCSI 39.07%

PRS 17.92
retina horizontal cell CL0000745

CSI 24.22

rCSI 36.92%

PRS 19.38
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 23.23

rCSI 83.58%

PRS 11.68
near-projecting glutamatergic cortical neuron CL4023012

CSI 22.32

rCSI 84.35%

PRS 12.81
amacrine cell CL0000561

CSI 22.14

rCSI 64.15%

PRS 16.11
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 22.07

rCSI 25.49%

PRS 18.29
radial glial cell CL0000681

CSI 21.61

rCSI 30.03%

PRS 21.37
glutamatergic neuron CL0000679

CSI 21.45

rCSI 44.07%

PRS 20.72
hepatic stellate cell CL0000632

CSI 21.18

rCSI 79.33%

PRS 17.68
parietal epithelial cell CL1000452

CSI 20.51

rCSI 54.81%

PRS 17.46
GABAergic amacrine cell CL4030027

CSI 20.37

rCSI 69.76%

PRS 18.35
H1 horizontal cell CL0004217

CSI 19.56

rCSI 77.49%

PRS 28.33
epithelial cell of proximal tubule CL0002306

CSI 19.25

rCSI 47.02%

PRS 20.59
rod bipolar cell CL0000751

CSI 19.15

rCSI 34.41%

PRS 17.33
interneuron CL0000099

CSI 18.14

rCSI 36.42%

PRS 15.51
GABAergic neuron CL0000617

CSI 18.12

rCSI 60.71%

PRS 15.03
vascular leptomeningeal cell CL4023051

CSI 17.5

rCSI 30.69%

PRS 15.96
retinal bipolar neuron CL0000748

CSI 17.32

rCSI 32.45%

PRS 15.06
H2 horizontal cell CL0004218

CSI 16.89

rCSI 84%

PRS 22.8
macroglial cell CL0000126

CSI 16.57

rCSI 42.59%

PRS 27.22
hepatocyte CL0000182

CSI 15.81

rCSI 28.29%

PRS 19.4
keratocyte CL0002363

CSI 15.05

rCSI 36.17%

PRS 30.79
kidney connecting tubule epithelial cell CL1000768

CSI 14.7

rCSI 37.29%

PRS 15.88
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 13.8

rCSI 81.25%

PRS 13.01
centrilobular region hepatocyte CL0019029

CSI 13.67

rCSI 35.68%

PRS 31.96
chondrocyte CL0000138

CSI 13.5

rCSI 21.47%

PRS 17.66
naive B cell CL0000788

CSI 13.35

rCSI 11.45%

PRS 34.05
epicardial adipocyte CL1000309

CSI 13.02

rCSI 42.35%

PRS 25.69
diffuse bipolar 3a cell CL4033029

CSI 12.7

rCSI 86.43%

PRS 22.34
periportal region hepatocyte CL0019026

CSI 12.62

rCSI 49.07%

PRS 28.6
pro-B cell CL0000826

CSI 12.59

rCSI 10.42%

PRS 21.29
cerebral cortex endothelial cell CL1001602

CSI 12.52

rCSI 21.65%

PRS 15.99
mucosal invariant T cell CL0000940

CSI 12.51

rCSI 10.1%

PRS 32.57
invaginating midget bipolar cell CL4033034

CSI 12.35

rCSI 72.91%

PRS 22.79
central nervous system neuron CL2000029

CSI 11.79

rCSI 86.66%

PRS 12.52
diffuse bipolar 6 cell CL4033032

CSI 11.72

rCSI 61.65%

PRS 25.08
mural cell CL0008034

CSI 11.63

rCSI 39.4%

PRS 21.58
diffuse bipolar 3b cell CL4033030

CSI 11.57

rCSI 76.78%

PRS 22.78
OFFx cell CL4033036

CSI 11.57

rCSI 54.41%

PRS 23.11
CD4-positive, alpha-beta thymocyte CL0000810

CSI 11.56

rCSI 9.26%

PRS 37.15
S cone cell CL0003050

CSI 11.56

rCSI 50.78%

PRS 19.25
blood vessel endothelial cell CL0000071

CSI 10.87

rCSI 22.55%

PRS 20.86
retinal cone cell CL0000573

CSI 10.62

rCSI 17.1%

PRS 16.01
renal interstitial pericyte CL1001318

CSI 10.46

rCSI 28.84%

PRS 19.56
medium spiny neuron CL1001474

CSI 10.3

rCSI 88.74%

PRS 10.85
alveolar type 1 fibroblast cell CL4028004

CSI 10.29

rCSI 11.27%

PRS 23.62
hematopoietic precursor cell CL0008001

CSI 10.02

rCSI 10.31%

PRS 33.89
cholangiocyte CL1000488

CSI 9.8

rCSI 58.72%

PRS 36.58
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 9.71

rCSI 6.82%

PRS 47.93
neural crest cell CL0011012

CSI 9.7

rCSI 7.67%

PRS 14.41
oligodendrocyte CL0000128

CSI 9.62

rCSI 28.43%

PRS 19.97
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 9.16

rCSI 28.23%

PRS 31.17
transit amplifying cell of colon CL0009011

CSI 8.96

rCSI 10.52%

PRS 24.07
flat midget bipolar cell CL4033033

CSI 8.85

rCSI 63.27%

PRS 22.17
regular atrial cardiac myocyte CL0002129

CSI 8.71

rCSI 28.03%

PRS 21.85
neuroendocrine cell CL0000165

CSI 8.47

rCSI 32.74%

PRS 40.67
diffuse bipolar 1 cell CL4033027

CSI 8.34

rCSI 62.7%

PRS 22
cerebral cortex neuron CL0010012

CSI 8.2

rCSI 33.41%

PRS 21.46
diffuse bipolar 2 cell CL4033028

CSI 8

rCSI 61.98%

PRS 23.19
starburst amacrine cell CL0004232

CSI 7.98

rCSI 67.16%

PRS 22.99
CD14-positive, CD16-positive monocyte CL0002397

CSI 7.81

rCSI 10.24%

PRS 29.94
class switched memory B cell CL0000972

CSI 7.79

rCSI 5.82%

PRS 35.11
epithelial cell of lower respiratory tract CL0002632

CSI 7.76

rCSI 6.02%

PRS 20.1
regular ventricular cardiac myocyte CL0002131

CSI 7.68

rCSI 47.94%

PRS 16.32
neural cell CL0002319

CSI 7.51

rCSI 28.34%

PRS 27.35
serotonergic neuron CL0000850

CSI 7.45

rCSI 33.3%

PRS 14.02
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 7.38

rCSI 19.08%

PRS 19.48
precursor B cell CL0000817

CSI 7.36

rCSI 6.45%

PRS 27.96
myeloid leukocyte CL0000766

CSI 7.19

rCSI 6.64%

PRS 21.77
alveolar adventitial fibroblast CL4028006

CSI 7.18

rCSI 11.34%

PRS 21.03
small intestine goblet cell CL1000495

CSI 7.11

rCSI 15.57%

PRS 27.99

peripheral nervous system neuron CL2000032

CSI -1.6

rCSI -2.2%

PRS 18.5%
paneth cell CL0000510

CSI -1.3

rCSI -1.9%

PRS 32.6%
elicited macrophage CL0000861

CSI -1.0

rCSI -1.0%

PRS 24.6%
mesenchymal cell CL0008019

CSI -0.9

rCSI -2.2%

PRS 21.0%
enteroendocrine cell of colon CL0009042

CSI -0.6

rCSI -2.7%

PRS 50.7%
T-helper 1 cell CL0000545

CSI -0.2

rCSI -0.4%

PRS 49.9%
mesenchymal stem cell CL0000134

CSI 0.2

rCSI 1.6%

PRS 36.9%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 0.9%

PRS 30.8%
pancreatic stellate cell CL0002410

CSI 0.2

rCSI 1.1%

PRS 30.9%
corneal epithelial cell CL0000575

CSI 0.2

rCSI 0.6%

PRS 36.6%
enteric neuron CL0007011

CSI 0.3

rCSI 3.7%

PRS 48.2%
pluripotent stem cell CL0002248

CSI 0.3

rCSI 8.3%

PRS 44.9%
paneth cell of colon CL0009009

CSI 0.4

rCSI 3.4%

PRS 52.1%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.4%

PRS 47.2%
type EC enteroendocrine cell CL0000577

CSI 0.5

rCSI 1.6%

PRS 33.8%
enterocyte of epithelium of small intestine CL1000334

CSI 0.5

rCSI 7.2%

PRS 49.2%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.5

rCSI 2.4%

PRS 27.7%
foveolar cell of stomach CL0002179

CSI 0.6

rCSI 1.2%

PRS 33.1%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.1%

PRS 21.5%
luminal cell of prostate epithelium CL0002340

CSI 0.6

rCSI 3.3%

PRS 36.7%
pancreatic PP cell CL0002275

CSI 0.7

rCSI 2.6%

PRS 35.6%
granulocyte monocyte progenitor cell CL0000557

CSI 0.7

rCSI 0.6%

PRS 23.7%
mature alpha-beta T cell CL0000791

CSI 0.7

rCSI 2.5%

PRS 35.9%
mucus secreting cell CL0000319

CSI 0.8

rCSI 1.3%

PRS 26.9%
pancreatic epsilon cell CL0005019

CSI 0.8

rCSI 3.8%

PRS 45.1%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.8

rCSI 6.2%

PRS 53.4%
transit amplifying cell of small intestine CL0009012

CSI 0.9

rCSI 3.8%

PRS 38.3%
deuterosomal cell CL4033044

CSI 0.9

rCSI 3.1%

PRS 33.0%
erythroid lineage cell CL0000764

CSI 0.9

rCSI 6.0%

PRS 44.5%
endothelial cell of venule CL1000414

CSI 1.0

rCSI 8.5%

PRS 64.2%
Langerhans cell CL0000453

CSI 1.0

rCSI 1.5%

PRS 36.5%
Hofbauer cell CL3000001

CSI 1.0

rCSI 1.9%

PRS 26.5%
enteric smooth muscle cell CL0002504

CSI 1.1

rCSI 1.5%

PRS 23.5%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.1

rCSI 1.3%

PRS 25.2%
acinar cell CL0000622

CSI 1.1

rCSI 1.6%

PRS 27.4%
innate lymphoid cell CL0001065

CSI 1.1

rCSI 2.3%

PRS 31.1%
tuft cell of colon CL0009041

CSI 1.1

rCSI 2.6%

PRS 41.0%
retinal pigment epithelial cell CL0002586

CSI 1.2

rCSI 2.3%

PRS 22.0%
neuroplacodal cell CL0000032

CSI 1.2

rCSI 11.0%

PRS 51.9%
colon goblet cell CL0009039

CSI 1.2

rCSI 2.8%

PRS 31.1%
T-helper 17 cell CL0000899

CSI 1.3

rCSI 1.0%

PRS 37.3%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.4

rCSI 7.6%

PRS 50.9%
colon epithelial cell CL0011108

CSI 1.5

rCSI 1.5%

PRS 19.6%
squamous epithelial cell CL0000076

CSI 1.5

rCSI 3.6%

PRS 25.9%
microcirculation associated smooth muscle cell CL0008035

CSI 1.5

rCSI 4.4%

PRS 23.6%
intestinal epithelial cell CL0002563

CSI 1.6

rCSI 1.6%

PRS 21.8%
respiratory suprabasal cell CL4033048

CSI 1.6

rCSI 2.0%

PRS 24.2%
pancreatic acinar cell CL0002064

CSI 1.6

rCSI 2.1%

PRS 23.0%
placental villous trophoblast CL2000060

CSI 1.6

rCSI 2.4%

PRS 19.6%
common dendritic progenitor CL0001029

CSI 1.6

rCSI 2.0%

PRS 27.2%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.6

rCSI 1.5%

PRS 19.0%
mature B cell CL0000785

CSI 1.6

rCSI 1.4%

PRS 26.3%
melanocyte CL0000148

CSI 1.6

rCSI 1.2%

PRS 18.1%
pancreatic A cell CL0000171

CSI 1.7

rCSI 1.8%

PRS 22.3%
common myeloid progenitor CL0000049

CSI 1.7

rCSI 1.4%

PRS 21.1%
paneth cell of epithelium of small intestine CL1000343

CSI 1.7

rCSI 4.7%

PRS 32.3%
extravillous trophoblast CL0008036

CSI 1.7

rCSI 2.1%

PRS 18.4%
tendon cell CL0000388

CSI 1.7

rCSI 4.5%

PRS 51.5%
myeloid dendritic cell CL0000782

CSI 1.7

rCSI 2.5%

PRS 31.6%
adventitial cell CL0002503

CSI 1.8

rCSI 4.2%

PRS 31.6%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.8

rCSI 1.2%

PRS 25.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.8

rCSI 5.1%

PRS 31.3%
duct epithelial cell CL0000068

CSI 1.8

rCSI 2.6%

PRS 22.2%
pancreatic D cell CL0000173

CSI 1.8

rCSI 1.8%

PRS 22.6%
type L enteroendocrine cell CL0002279

CSI 1.9

rCSI 3.5%

PRS 40.5%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.9

rCSI 3.6%

PRS 43.8%
lung macrophage CL1001603

CSI 1.9

rCSI 4.3%

PRS 24.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.9

rCSI 2.3%

PRS 36.3%
enteroglial cell CL4040002

CSI 2.0

rCSI 10.3%

PRS 34.9%
lung ciliated cell CL1000271

CSI 2.0

rCSI 2.3%

PRS 15.4%
intestinal crypt stem cell of colon CL0009043

CSI 2.0

rCSI 15.1%

PRS 37.9%
tissue-resident macrophage CL0000864

CSI 2.0

rCSI 9.4%

PRS 41.5%
intestinal tuft cell CL0019032

CSI 2.1

rCSI 3.1%

PRS 23.9%
pulmonary alveolar type 1 cell CL0002062

CSI 2.1

rCSI 11.8%

PRS 26.6%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 2.1

rCSI 4.7%

PRS 21.6%
multi-ciliated epithelial cell CL0005012

CSI 2.1

rCSI 2.1%

PRS 17.9%
eye photoreceptor cell CL0000287

CSI 2.1

rCSI 23.2%

PRS 48.1%
helper T cell CL0000912

CSI 2.2

rCSI 3.0%

PRS 29.0%
contractile cell CL0000183

CSI 2.2

rCSI 6.4%

PRS 20.2%
cardiac blood vessel endothelial cell CL0010006

CSI 2.2

rCSI 15.4%

PRS 23.7%
type B pancreatic cell CL0000169

CSI 2.2

rCSI 4.8%

PRS 19.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 2.2

rCSI 6.0%

PRS 27.1%
myoepithelial cell CL0000185

CSI 2.3

rCSI 5.7%

PRS 25.9%
fast muscle cell CL0000190

CSI 2.3

rCSI 9.0%

PRS 43.2%
erythrocyte CL0000232

CSI 2.3

rCSI 5.2%

PRS 27.9%
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.3

rCSI 9.1%

PRS 34.3%
tracheobronchial smooth muscle cell CL0019019

CSI 2.4

rCSI 4.2%

PRS 27.3%
conjunctival epithelial cell CL1000432

CSI 2.4

rCSI 3.7%

PRS 21.1%
common lymphoid progenitor CL0000051

CSI 2.4

rCSI 3.2%

PRS 39.5%
brain vascular cell CL4023072

CSI 2.4

rCSI 25.0%

PRS 24.6%
pulmonary artery endothelial cell CL1001568

CSI 2.5

rCSI 3.4%

PRS 31.6%
OFF-bipolar cell CL0000750

CSI 2.6

rCSI 3.5%

PRS 32.3%
acinar cell of salivary gland CL0002623

CSI 2.6

rCSI 59.5%

PRS 38.8%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 2.6

rCSI 2.3%

PRS 32.1%
brush cell CL0002204

CSI 2.6

rCSI 5.2%

PRS 49.5%
intestine goblet cell CL0019031

CSI 2.6

rCSI 2.4%

PRS 21.1%
enterocyte of epithelium of large intestine CL0002071

CSI 2.7

rCSI 13.9%

PRS 35.8%
cerebral cortex pyramidal neuron CL4023111

CSI 2.8

rCSI 16.9%

PRS 50.2%
lung endothelial cell CL1001567

CSI 2.8

rCSI 6.5%

PRS 47.3%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.8

rCSI 1.7%

PRS 29.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TNRC6A](/details-gene/27327), or Trinucleotide Repeat Containing Adaptor 6A, encodes a key protein component of the RNA-induced silencing complex (RISC). It functions as a critical adaptor protein that links Argonaute proteins, bound to microRNAs (miRNAs), to the cellular machinery responsible for translational repression and mRNA degradation. This role places [TNRC6A](/details-gene/27327) at the heart of post-transcriptional gene regulation. Expression data reveals its high significance across numerous neuronal and glial cell types in the central nervous system, particularly various GABAergic cortical interneurons, suggesting a vital function in maintaining neuronal identity and function. Its localization to cytoplasmic processing bodies (P-bodies), sites of mRNA decay, is well-documented and essential for its function in miRNA-mediated gene silencing ([Link](https://doi.org/10.1261/rna.5810203), [Link](https://doi.org/10.1038/ncb1333)). ## Cellular Roles and Expression Landscape The expression profile of [TNRC6A](/details-gene/27327) highlights its fundamental importance in the central nervous system. **Overall**, it shows exceptionally high significance in a wide array of neuronal subtypes, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 78.11), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 76.34), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 71.39), and [cerebellar granule cell](/details-cell/CL0001031) (CSI: 52.42). This suggests a critical role in the post-transcriptional regulation that defines the diverse functional identities of these inhibitory and excitatory neurons. Beyond neurons, [TNRC6A](/details-gene/27327) is also a significant marker in several glial and supportive cell populations of the brain, such as [choroid plexus epithelial cell](/details-cell/CL0000706), [Bergmann glial cell](/details-cell/CL0000644), and [astrocyte](/details-cell/CL0000127). Its expression in [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) indicates a potential role during glial development and maturation. The gene's activity extends beyond the nervous system, with high significance noted in [cardiac muscle cell](/details-cell/CL0000746) and [adipocyte](/details-cell/CL0000136), pointing to a broad, yet cell-type-specific, requirement for robust miRNA-mediated gene silencing. Conversely, the low to negligible significance of [TNRC6A](/details-gene/27327) in cell types such as [paneth cell](/details-cell/CL0000510), [enteroendocrine cell of colon](/details-cell/CL0009042), and certain immune lineages like [T-helper 1 cell](/details-cell/CL0000545) helps to define its functional specificity, suggesting that other regulatory mechanisms may be more prominent in these particular cellular contexts. ## Pathways and Molecular Function The functional annotations for [TNRC6A](/details-gene/27327) confirm its central role in RNA-mediated gene regulation. It is a key player in [Mirna-mediated post-transcriptional gene silencing](/details-cell/GO:0035195) and [Mirna-mediated gene silencing by inhibition of translation](/details-cell/GO:0035278), consistent with its well-established function within the [RISC complex](/details-cell/GO:0016442). Its molecular function is defined by its ability to act as a [Protein-macromolecule adaptor activity](/details-cell/GO:0030674) and its capacity for [Rna binding](/details-cell/GO:0003723). These functions are executed within distinct cytoplasmic foci known as [P-body](/details-cell/GO:0000932), where it facilitates [P-body assembly](/details-cell/GO:0033962) ([Link](https://doi.org/10.1242/jcs.01477)). The extensive list of Reactome pathways, such as [Signaling by wnt](/details-pathway/R-HSA-195721), [Signaling by notch](/details-pathway/R-HSA-157118), and [Signaling by tgfb family members](/details-pathway/R-HSA-9006936), likely reflects the downstream consequences of [TNRC6A](/details-gene/27327)-mediated silencing. Rather than being a direct component of these pathways, [TNRC6A](/details-gene/27327) regulates their activity by controlling the expression of key pathway components via miRNAs. This is exemplified by its involvement in pathways like [Regulation of pten mrna translation](/details-pathway/R-HSA-8943723) and [Competing endogenous rnas (cernas) regulate pten translation](/details-pathway/R-HSA-8948700), highlighting its specific impact on critical signaling nodes. ## Research Directions The widespread and high-level expression of [TNRC6A](/details-gene/27327) in the CNS, coupled with its fundamental role in gene silencing, suggests it is a master regulator of neural cell biology. The following hypotheses could guide future research: 1. **Hypothesis on Neuronal Identity:** The high significance of [TNRC6A](/details-gene/27327) across diverse interneuron subtypes ([VIP GABAergic cortical interneuron](/details-cell/CL4023016), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), etc.) suggests it is essential for establishing and maintaining their distinct transcriptional and functional identities. We hypothesize that [TNRC6A](/details-gene/27327) orchestrates the post-transcriptional suppression of a common set of progenitor genes while simultaneously enabling subtype-specific miRNA programs to fine-tune the expression of terminal identity genes. 2. **Hypothesis on Neurodevelopmental Disorders:** Given its role in regulating the translation of numerous signaling pathway components, subtle mutations or expression changes in [TNRC6A](/details-gene/27327) could lead to a global dysregulation of miRNA function in the developing brain. We hypothesize that haploinsufficiency of [TNRC6A](/details-gene/27327) contributes to the etiology of certain neurodevelopmental disorders by disrupting the precise spatiotemporal control of protein synthesis required for proper neuronal migration and circuit formation. **Proposed Experiment:** To test the first hypothesis, a conditional knockout of [TNRC6A](/details-gene/27327) could be generated in cortical interneuron precursors in mice using an Nkx2-1-Cre or Lhx6-Cre driver line. Single-cell RNA sequencing (scRNA-seq) and single-cell ATAC-seq of the adult cortex would be performed to assess whether the diversity of interneuron subtypes is compromised and to identify transcriptional mis-regulation. This could be complemented with electrophysiological recordings to determine if the functional properties of these neurons are altered. **Therapeutic Potential:** As a core component of the essential miRNA silencing machinery, direct systemic inhibition of [TNRC6A](/details-gene/27327) would likely be highly toxic due to widespread pleiotropic effects. Therefore, it is not a viable candidate for direct therapeutic targeting with small molecule inhibitors. However, understanding its specific interactions with disease-relevant miRNAs and their target mRNAs in disorders like epilepsy or schizophrenia could unveil more precise downstream targets for therapeutic intervention. Strategies aimed at modulating specific [TNRC6A](/details-gene/27327)-miRNA-mRNA axes, rather than inhibiting the entire protein, might represent a more feasible long-term therapeutic avenue.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Trinucleotide repeat-containing gene 6A protein

Genular Protein ID: 2715940605

Symbol: TNR6A_HUMAN

Name: Trinucleotide repeat-containing gene 6A protein

UniProtKB Accession Codes:

Q8NDV7 C9JAR8 O15408 Q658L5 Q6NVB5 Q8NEZ0 Q8TBT8 Q8TCR0 Q9NV59 Q9P268

Database IDs:

Citations:

PubMed ID: 11950943

Title: A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

PubMed ID: 11950943

DOI: 10.1091/mbc.01-11-0544

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9225980

Title: cDNAs with long CAG trinucleotide repeats from human brain.

PubMed ID: 9225980

DOI: 10.1007/s004390050476

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14598044

Title: Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182.

PubMed ID: 14598044

DOI: 10.1007/s00109-003-0495-y

PubMed ID: 13130130

Title: The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.

PubMed ID: 13130130

DOI: 10.1261/rna.5810203

PubMed ID: 15494374

Title: GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.

PubMed ID: 15494374

DOI: 10.1242/jcs.01477

PubMed ID: 15908945

Title: Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.

PubMed ID: 15908945

DOI: 10.1038/ncb1265

PubMed ID: 16284623

Title: A role for the P-body component GW182 in microRNA function.

PubMed ID: 16284623

DOI: 10.1038/ncb1333

PubMed ID: 16284622

Title: Disruption of GW bodies impairs mammalian RNA interference.

PubMed ID: 16284622

DOI: 10.1038/ncb1334

PubMed ID: 16906129

Title: Formation of GW bodies is a consequence of microRNA genesis.

PubMed ID: 16906129

DOI: 10.1038/sj.embor.7400783

PubMed ID: 17671087

Title: Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system.

PubMed ID: 17671087

DOI: 10.1101/gad.1566707

PubMed ID: 17596515

Title: Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.

PubMed ID: 17596515

DOI: 10.1091/mbc.e07-01-0070

PubMed ID: 19056672

Title: Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing.

PubMed ID: 19056672

DOI: 10.1242/jcs.036905

PubMed ID: 18690212

Title: Prolyl 4-hydroxylation regulates Argonaute 2 stability.

PubMed ID: 18690212

DOI: 10.1038/nature07186

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18946079

Title: Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2.

PubMed ID: 18946079

DOI: 10.1091/mbc.e08-08-0796

PubMed ID: 19304925

Title: Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

PubMed ID: 19304925

DOI: 10.1261/rna.1448009

PubMed ID: 19324964

Title: The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

PubMed ID: 19324964

DOI: 10.1261/rna.1229409

PubMed ID: 19383768

Title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

PubMed ID: 19383768

DOI: 10.1261/rna.1606309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21981923

Title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

PubMed ID: 21981923

DOI: 10.1016/j.molcel.2011.09.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26134560

Title: Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradation.

PubMed ID: 26134560

DOI: 10.1074/jbc.m114.635870

PubMed ID: 28546213

Title: Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

PubMed ID: 28546213

DOI: 10.1126/science.aai9372

PubMed ID: 29507423

Title: Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

PubMed ID: 29507423

DOI: 10.1038/s41588-018-0067-2

PubMed ID: 29395067

Title: High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

PubMed ID: 29395067

DOI: 10.1016/j.molcel.2017.12.020

PubMed ID: 31400113

Title: KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.

PubMed ID: 31400113

DOI: 10.1093/nar/gkz683

Sequence Information:

Length: 1962
Mass: 210297
Checksum: 963C054628E18592
Sequence:

MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE QKIKVPEQIK 
PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ QQQPQQQQPQ QQPQPQPQQQ 
QPQQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN 
QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP 
SAPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS 
SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST 
LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW 
GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT 
GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ 
ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG 
WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG SATSQTNEQS 
SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN 
SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNGNDTSSV 
SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG 
DGQKSSQGWS VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN 
NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP 
ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN 
MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA 
WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG 
WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW 
INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG 
SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM 
QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL 
KYAPNNGGLN PLFGPQQVAM LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ 
DQQGRPLSVQ QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK 
GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL DQNSSKHGAI 
SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP NGSSSVNWPP EFRPGEPWKG 
YPNIDPETDP YVTPGSVINN LSINTVREVD HLRDRNSGSS SSLNTTLPST SAWSSIRASN 
YNVPLSSTAQ STSARNSDSK LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ 
KPPLSTWDNS PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL 
CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF ASEEEISRFF 
AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW NGAGLSGTNC GDLHGTSLWG 
TPHYSTSLWG PPSSSDPRGI SSPSPINAFL SVDHLGGGGE SM

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sclera UBERON0001773
	\|— Sclera Healthy UBERON0001773_PATO0000461
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: TNRC6A

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. PubMed ID: 11950943

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNAs with long CAG trinucleotide repeats from human brain. PubMed ID: 9225980

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. PubMed ID: 14598044

The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. PubMed ID: 13130130

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. PubMed ID: 15494374

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. PubMed ID: 15908945

A role for the P-body component GW182 in microRNA function. PubMed ID: 16284623

Disruption of GW bodies impairs mammalian RNA interference. PubMed ID: 16284622

Formation of GW bodies is a consequence of microRNA genesis. PubMed ID: 16906129

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. PubMed ID: 17671087

Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. PubMed ID: 17596515

Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. PubMed ID: 19056672

Prolyl 4-hydroxylation regulates Argonaute 2 stability. PubMed ID: 18690212

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2. PubMed ID: 18946079

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. PubMed ID: 19304925

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. PubMed ID: 19324964

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. PubMed ID: 19383768

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. PubMed ID: 21981923

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradation. PubMed ID: 26134560

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. PubMed ID: 28546213

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy. PubMed ID: 29507423

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. PubMed ID: 29395067

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. PubMed ID: 31400113