Details for: GLG1

Gene ID: 2734

Symbol: GLG1

Ensembl ID: ENSG00000090863

Description: golgi glycoprotein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.95
    Marker Score: 4151
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.92
    Marker Score: 98668
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.8
    Marker Score: 49704
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.7
    Marker Score: 12504
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.7
    Marker Score: 57683
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.65
    Marker Score: 11057
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.57
    Marker Score: 51053
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.57
    Marker Score: 3451
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.48
    Marker Score: 19034
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.47
    Marker Score: 36895
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.46
    Marker Score: 1273
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.44
    Marker Score: 10223
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.43
    Marker Score: 5345
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.43
    Marker Score: 92192
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.4
    Marker Score: 7867
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.37
    Marker Score: 4557
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.36
    Marker Score: 2855.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.35
    Marker Score: 2703
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.26
    Marker Score: 1319
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.25
    Marker Score: 83093
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.24
    Marker Score: 1180
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.23
    Marker Score: 703
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.22
    Marker Score: 5547
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.21
    Marker Score: 5302
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.2
    Marker Score: 9140
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.19
    Marker Score: 1894
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.19
    Marker Score: 1441
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.16
    Marker Score: 2330
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.14
    Marker Score: 2039
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.13
    Marker Score: 13867
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.12
    Marker Score: 8182
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.1
    Marker Score: 11263
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.09
    Marker Score: 1477
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.09
    Marker Score: 2602
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.09
    Marker Score: 10948
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.08
    Marker Score: 608
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.07
    Marker Score: 2290
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.07
    Marker Score: 46319
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19314
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.05
    Marker Score: 1776
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.04
    Marker Score: 856
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.02
    Marker Score: 1790
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 123132
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.99
    Marker Score: 2251
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.97
    Marker Score: 1370
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.97
    Marker Score: 1519
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.96
    Marker Score: 1109
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.92
    Marker Score: 949
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.92
    Marker Score: 488
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.92
    Marker Score: 5134
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.91
    Marker Score: 1120
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.91
    Marker Score: 540
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.89
    Marker Score: 546
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.87
    Marker Score: 1118
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19312
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.86
    Marker Score: 98465
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.85
    Marker Score: 457
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.85
    Marker Score: 18579
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17527
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.84
    Marker Score: 6523
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.82
    Marker Score: 7422
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15602
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.79
    Marker Score: 1817
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.79
    Marker Score: 411
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.77
    Marker Score: 23356
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.77
    Marker Score: 653.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.76
    Marker Score: 1159
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.76
    Marker Score: 13271
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.74
    Marker Score: 5829
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.73
    Marker Score: 1843
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.72
    Marker Score: 644
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.72
    Marker Score: 1296
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.72
    Marker Score: 697
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.71
    Marker Score: 2415
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.71
    Marker Score: 736
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.7
    Marker Score: 923
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.69
    Marker Score: 2838
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.68
    Marker Score: 678
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.68
    Marker Score: 1810
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.67
    Marker Score: 605
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.66
    Marker Score: 26700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.66
    Marker Score: 1262
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.65
    Marker Score: 12282
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.63
    Marker Score: 1341
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.63
    Marker Score: 3747.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.63
    Marker Score: 449
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.63
    Marker Score: 538
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.63
    Marker Score: 4258
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.63
    Marker Score: 4425
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.62
    Marker Score: 807
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.62
    Marker Score: 1490
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.62
    Marker Score: 9615.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.62
    Marker Score: 443
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.62
    Marker Score: 4080
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.61
    Marker Score: 781
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.6
    Marker Score: 838
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.6
    Marker Score: 5044
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.59
    Marker Score: 506
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.59
    Marker Score: 1968
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.59
    Marker Score: 1065

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Other Information

**Key characteristics:** * GLG1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It belongs to the Golgi apparatus protein family, which is responsible for sorting and packaging proteins for secretion or transport to other organelles. * GLG1 is a transmembrane protein with four immunoglobulin domains, each of which is responsible for a specific function. * It is expressed in high levels in cells that are involved in tissue development, differentiation, and homeostasis. **Pathways and functions:** * GLG1 plays a crucial role in bone morphogenesis by regulating the differentiation of mesenchymal cells into chondrocytes, which are cells that form the cartilage matrix. * It is also involved in cell surface interactions, as it is expressed on the surface of endothelial cells and immune cells. * GLG1 is a key regulator of extracellular matrix remodeling, as it facilitates the interaction between the extracellular matrix proteins collagen and proteoglycans and helps to maintain the integrity of the tissue. * It is also involved in inflammation, as it is expressed on activated macrophages and dendritic cells and can modulate their inflammatory responses. **Clinical significance:** * Mutations in GLG1 have been linked to several human diseases, including cancer, cardiovascular disease, and arthritis. * GLG1 inhibitors are being investigated as potential treatments for these diseases, as they could potentially block the abnormal cell behaviors associated with these conditions. **Additional notes:** * GLG1 is a highly conserved protein, with a similar gene found in mammals, birds, and fish. * It is a well-known target for cancer immunotherapy, as it is frequently expressed on tumor cells. * GLG1 is a promising immunotherapeutic target for the treatment of cancer and other diseases characterized by abnormal cell behavior.

Genular Protein ID: 718558842

Symbol: GSLG1_HUMAN

Name: Golgi apparatus protein 1

UniProtKB Accession Codes:

Q92896 B7Z8Y4 D3DUJ7 Q13221 Q6P9D1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8985126

Title: Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus.

PubMed ID: 8985126

DOI: 10.1089/dna.1996.15.1121

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2355176

Title: Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus.

PubMed ID: 2355176

DOI: 10.1177/38.7.2355176

PubMed ID: 9182700

Title: Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.

PubMed ID: 9182700

DOI: 10.1042/bj3240427

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1179
  • Mass: 134552
  • Checksum: 390F9923DC83C300
  • Sequence:
    • MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 
QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 
DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 
KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 
CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 
LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 
LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 
GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 
QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 
DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 
YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 
QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 
LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 
STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 
NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 
LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 
SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 
AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 
AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 
SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.