Details for: GLG1

Gene ID: 2734

Symbol: GLG1

Ensembl ID: ENSG00000090863

Description: golgi glycoprotein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 573.5952
    Cell Significance Index: -89.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 350.1373
    Cell Significance Index: -88.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 196.3049
    Cell Significance Index: -92.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.2644
    Cell Significance Index: -76.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 167.5204
    Cell Significance Index: -86.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.8019
    Cell Significance Index: -77.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.6580
    Cell Significance Index: -92.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.4914
    Cell Significance Index: -87.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.9714
    Cell Significance Index: -79.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.4665
    Cell Significance Index: -92.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.2250
    Cell Significance Index: -50.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.7668
    Cell Significance Index: 96.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6294
    Cell Significance Index: 521.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5031
    Cell Significance Index: 502.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4385
    Cell Significance Index: 874.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1476
    Cell Significance Index: 120.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6710
    Cell Significance Index: 128.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6149
    Cell Significance Index: 71.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5567
    Cell Significance Index: 58.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4882
    Cell Significance Index: 41.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4616
    Cell Significance Index: 1010.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3478
    Cell Significance Index: 185.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3177
    Cell Significance Index: 80.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3175
    Cell Significance Index: 35.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2707
    Cell Significance Index: 24.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2013
    Cell Significance Index: 195.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9813
    Cell Significance Index: 176.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9579
    Cell Significance Index: 94.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8657
    Cell Significance Index: 106.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8327
    Cell Significance Index: 454.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6979
    Cell Significance Index: 46.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6799
    Cell Significance Index: 40.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4833
    Cell Significance Index: 11.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4649
    Cell Significance Index: 205.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4315
    Cell Significance Index: 20.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4135
    Cell Significance Index: 11.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4031
    Cell Significance Index: 26.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3822
    Cell Significance Index: 8.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3430
    Cell Significance Index: 645.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3342
    Cell Significance Index: 63.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3215
    Cell Significance Index: 54.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2730
    Cell Significance Index: 35.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2665
    Cell Significance Index: 3.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2510
    Cell Significance Index: 462.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2410
    Cell Significance Index: 4.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2384
    Cell Significance Index: 108.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2297
    Cell Significance Index: 353.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2131
    Cell Significance Index: 135.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1639
    Cell Significance Index: 7.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1149
    Cell Significance Index: 2.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0827
    Cell Significance Index: 112.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0136
    Cell Significance Index: 9.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0199
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0558
    Cell Significance Index: -41.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0578
    Cell Significance Index: -36.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0889
    Cell Significance Index: -67.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1183
    Cell Significance Index: -66.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1371
    Cell Significance Index: -14.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1456
    Cell Significance Index: -4.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1588
    Cell Significance Index: -3.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1609
    Cell Significance Index: -18.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2399
    Cell Significance Index: -50.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2686
    Cell Significance Index: -3.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2822
    Cell Significance Index: -81.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2940
    Cell Significance Index: -31.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2957
    Cell Significance Index: -42.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3592
    Cell Significance Index: -46.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4332
    Cell Significance Index: -11.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4367
    Cell Significance Index: -45.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4416
    Cell Significance Index: -51.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4491
    Cell Significance Index: -31.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4592
    Cell Significance Index: -12.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4685
    Cell Significance Index: -22.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4789
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5193
    Cell Significance Index: -59.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5483
    Cell Significance Index: -62.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5873
    Cell Significance Index: -12.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6136
    Cell Significance Index: -31.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6165
    Cell Significance Index: -32.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6791
    Cell Significance Index: -50.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7321
    Cell Significance Index: -25.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9124
    Cell Significance Index: -22.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9125
    Cell Significance Index: -47.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9602
    Cell Significance Index: -28.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9866
    Cell Significance Index: -14.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9965
    Cell Significance Index: -78.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0741
    Cell Significance Index: -67.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1156
    Cell Significance Index: -31.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2256
    Cell Significance Index: -17.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.3282
    Cell Significance Index: -17.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4151
    Cell Significance Index: -30.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4820
    Cell Significance Index: -90.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5699
    Cell Significance Index: -32.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.5783
    Cell Significance Index: -42.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6217
    Cell Significance Index: -53.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6509
    Cell Significance Index: -52.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6630
    Cell Significance Index: -53.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.7251
    Cell Significance Index: -34.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.7424
    Cell Significance Index: -32.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.8245
    Cell Significance Index: -26.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** GLG1 is primarily localized to the Golgi apparatus, a complex organelle involved in protein modification, sorting, and packaging. 2. **Glycosylation:** GLG1 is a glycoprotein, meaning it is decorated with carbohydrate molecules (glycans) that play a critical role in its function and interaction with other molecules. 3. **Cell surface interactions:** GLG1 is involved in cell surface interactions, particularly at the vascular wall, where it may regulate blood vessel formation and maintenance. 4. **Protein processing:** GLG1 is also involved in the negative regulation of protein processing, which is essential for maintaining protein homeostasis and preventing protein misfolding. **Pathways and Functions:** 1. **Bone morphogenesis:** GLG1 is involved in the regulation of chondrocyte differentiation, which is critical for bone formation and development. 2. **Cell surface interactions at the vascular wall:** GLG1 plays a role in regulating blood vessel formation and maintenance, which is essential for tissue development and repair. 3. **Golgi apparatus:** GLG1 is localized to the Golgi apparatus, where it is involved in the modification and packaging of proteins for secretion or cellular use. 4. **Protein processing:** GLG1 is involved in the negative regulation of protein processing, which is essential for maintaining protein homeostasis and preventing protein misfolding. 5. **Transforming growth factor beta receptor signaling pathway:** GLG1 is involved in the negative regulation of this signaling pathway, which is critical for regulating cellular growth and differentiation. **Clinical Significance:** 1. **Neurological disorders:** GLG1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Respiratory diseases:** GLG1 is also involved in respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 3. **Cancer:** GLG1 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 4. **Vascular diseases:** GLG1 is involved in the regulation of blood vessel formation and maintenance, which is critical for preventing vascular diseases, such as atherosclerosis and stroke. In conclusion, GLG1 is a multifaceted gene that plays a critical role in various cellular processes, including cell surface interactions, protein processing, and signaling pathways. Its dysregulation has been implicated in various diseases, including neurological disorders, respiratory diseases, cancer, and vascular diseases. Further research is needed to fully understand the functions and clinical significance of GLG1.

Genular Protein ID: 718558842

Symbol: GSLG1_HUMAN

Name: Golgi apparatus protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8985126

Title: Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus.

PubMed ID: 8985126

DOI: 10.1089/dna.1996.15.1121

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2355176

Title: Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus.

PubMed ID: 2355176

DOI: 10.1177/38.7.2355176

PubMed ID: 9182700

Title: Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.

PubMed ID: 9182700

DOI: 10.1042/bj3240427

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1179
  • Mass: 134552
  • Checksum: 390F9923DC83C300
  • Sequence:
  • MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 
    QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 
    DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 
    KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 
    CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 
    LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 
    LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 
    GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 
    QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 
    DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 
    YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 
    QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 
    LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 
    STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 
    NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 
    LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 
    SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 
    AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 
    AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 
    SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.