Details for: RRP7A

Gene ID: 27341

Symbol: RRP7A

Ensembl ID: ENSG00000189306

Description: ribosomal RNA processing 7 homolog A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.6601
    Cell Significance Index: -23.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.8105
    Cell Significance Index: -28.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.6140
    Cell Significance Index: -31.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.7621
    Cell Significance Index: -31.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.0441
    Cell Significance Index: -35.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.8674
    Cell Significance Index: -34.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.9938
    Cell Significance Index: -35.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5784
    Cell Significance Index: -32.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6608
    Cell Significance Index: -25.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8037
    Cell Significance Index: -34.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2690
    Cell Significance Index: 32.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1815
    Cell Significance Index: 32.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9978
    Cell Significance Index: 64.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9335
    Cell Significance Index: 48.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8268
    Cell Significance Index: 57.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7749
    Cell Significance Index: 91.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7212
    Cell Significance Index: 53.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6666
    Cell Significance Index: 31.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6201
    Cell Significance Index: 85.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5977
    Cell Significance Index: 12.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5949
    Cell Significance Index: 27.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5819
    Cell Significance Index: 317.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5815
    Cell Significance Index: 16.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5533
    Cell Significance Index: 110.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5530
    Cell Significance Index: 16.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5468
    Cell Significance Index: 14.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5344
    Cell Significance Index: 106.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5166
    Cell Significance Index: 66.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5078
    Cell Significance Index: 5.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4815
    Cell Significance Index: 86.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4676
    Cell Significance Index: 206.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4383
    Cell Significance Index: 53.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3582
    Cell Significance Index: 25.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3381
    Cell Significance Index: 15.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3148
    Cell Significance Index: 6.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3030
    Cell Significance Index: 2.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3002
    Cell Significance Index: 7.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2508
    Cell Significance Index: 32.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2491
    Cell Significance Index: 89.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2101
    Cell Significance Index: 5.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1755
    Cell Significance Index: 33.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1745
    Cell Significance Index: 29.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1667
    Cell Significance Index: 2.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1603
    Cell Significance Index: 144.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1323
    Cell Significance Index: 21.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0935
    Cell Significance Index: 0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0843
    Cell Significance Index: 2.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0801
    Cell Significance Index: 1.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0778
    Cell Significance Index: 53.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0645
    Cell Significance Index: 2.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0608
    Cell Significance Index: 1.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0437
    Cell Significance Index: 0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0410
    Cell Significance Index: 1.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0093
    Cell Significance Index: 17.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0206
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0244
    Cell Significance Index: -33.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0251
    Cell Significance Index: -18.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0260
    Cell Significance Index: -2.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0322
    Cell Significance Index: -20.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0543
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0566
    Cell Significance Index: -0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0610
    Cell Significance Index: -27.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0775
    Cell Significance Index: -0.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0788
    Cell Significance Index: -7.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0797
    Cell Significance Index: -3.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0901
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0917
    Cell Significance Index: -19.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0957
    Cell Significance Index: -10.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0960
    Cell Significance Index: -27.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1038
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1110
    Cell Significance Index: -12.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1158
    Cell Significance Index: -16.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1172
    Cell Significance Index: -3.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1674
    Cell Significance Index: -6.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2035
    Cell Significance Index: -15.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2087
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2104
    Cell Significance Index: -24.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2176
    Cell Significance Index: -5.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2313
    Cell Significance Index: -25.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2514
    Cell Significance Index: -3.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2786
    Cell Significance Index: -18.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2992
    Cell Significance Index: -16.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3148
    Cell Significance Index: -19.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3260
    Cell Significance Index: -33.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3759
    Cell Significance Index: -29.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4525
    Cell Significance Index: -2.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4850
    Cell Significance Index: -8.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5758
    Cell Significance Index: -35.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5803
    Cell Significance Index: -30.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5989
    Cell Significance Index: -17.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6081
    Cell Significance Index: -14.0500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6236
    Cell Significance Index: -8.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6283
    Cell Significance Index: -16.1500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6730
    Cell Significance Index: -9.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRP7A is a RNA-binding protein that belongs to the RRP family of proteins, which are involved in the processing of ribosomal RNAs (rRNAs) in the nucleolus and cytosol. The gene is highly conserved across species, suggesting its essential role in ribosome biogenesis. RRP7A is a 34-kDa protein that contains two RNA-binding domains and is primarily localized to the nucleolus and cytosol. Its expression is tightly regulated during cell cycle progression, with peak expression observed during the G1 phase. **Pathways and Functions:** RRP7A is involved in several cellular pathways, including: 1. **Ribosome biogenesis:** RRP7A is essential for the processing of rRNAs in the nucleolus and cytosol, which is critical for ribosome assembly and function. 2. **Cell cycle regulation:** RRP7A is involved in the regulation of cell cycle progression, particularly during the G1 phase, where it modulates the expression of cyclin-dependent kinases. 3. **Apoptosis:** RRP7A has been shown to modulate apoptosis, particularly in hematopoietic cells, where it prevents premature apoptosis during development. 4. **Immune response:** RRP7A has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases, where it modulates the expression of immune-related genes. **Clinical Significance:** Dysregulation of RRP7A has been implicated in various diseases, including: 1. **Anemia:** Mutations in RRP7A have been associated with anemia, particularly in the context of erythropoiesis, where it regulates the expression of erythroid-specific genes. 2. **Cancer:** RRP7A has been shown to modulate the expression of oncogenes and tumor suppressor genes, leading to cancer development and progression. 3. **Autoimmune diseases:** RRP7A has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurological disorders:** RRP7A has been shown to modulate the expression of genes involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RRP7A is a multifunctional protein that plays a critical role in ribosome biogenesis, cell cycle regulation, apoptosis, and immune response modulation. Its dysregulation has been implicated in various diseases, highlighting the importance of RRP7A in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which RRP7A regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4074633681

Symbol: RRP7A_HUMAN

Name: Ribosomal RNA-processing protein 7 homolog A

UniProtKB Accession Codes:

Q9Y3A4 A4FTX2 B2RBG4 Q0VAD0 Q5JZ94 Q6P4B5 Q8IVR9 Q8IVY0 Q8N5Q3 Q8NEY6 Q9Y3H5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12087473

Title: Serological identification and expression analysis of gastric cancer-associated genes.

PubMed ID: 12087473

DOI: 10.1038/sj.bjc.6600321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 33199730

Title: RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis.

PubMed ID: 33199730

DOI: 10.1038/s41467-020-19658-0

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 280
  • Mass: 32334
  • Checksum: 3625D609B0FF2F76
  • Sequence:
    • MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG TKSTWPQKRT 
LFVLNVPPYC TEESLSRLLS TCGLVQSVEL QEKPDLAESP KESRSKFFHP KPVPGFQVAY 
VVFQKPSGVS AALALKGPLL VSTESHPVKS GIHKWISDYA DSVPDPEALR VEVDTFMEAY 
DQKIAEEEAK AKEEEGVPDE EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRSRKELLN 
FYAWQHRESK MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.