Details for: STK39
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 384.9041
Cell Significance Index: -59.8700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 235.0939
Cell Significance Index: -59.6300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 121.8116
Cell Significance Index: -57.5100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 109.0196
Cell Significance Index: -44.2900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 48.6149
Cell Significance Index: -59.9400 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 28.8948
Cell Significance Index: 20.6500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.7103
Cell Significance Index: -55.4800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.5915
Cell Significance Index: -50.9600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.2102
Cell Significance Index: -60.0200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.2238
Cell Significance Index: -31.1300 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 3.3256
Cell Significance Index: 33.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.3093
Cell Significance Index: 185.7000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.8592
Cell Significance Index: 25.3800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.7420
Cell Significance Index: 210.4200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5348
Cell Significance Index: 508.4700 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.3210
Cell Significance Index: 14.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.2012
Cell Significance Index: 102.6300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.8811
Cell Significance Index: 674.7000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.8659
Cell Significance Index: 184.5800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.8538
Cell Significance Index: 70.2000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2863
Cell Significance Index: 86.4900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.2638
Cell Significance Index: 30.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2357
Cell Significance Index: 54.6600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2059
Cell Significance Index: 239.3200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2002
Cell Significance Index: 34.5800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1542
Cell Significance Index: 69.2900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.1417
Cell Significance Index: 32.5800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1312
Cell Significance Index: 123.0400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0991
Cell Significance Index: 49.8200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.9757
Cell Significance Index: 59.9700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9519
Cell Significance Index: 49.4500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9365
Cell Significance Index: 647.7500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.9188
Cell Significance Index: 417.0200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9009
Cell Significance Index: 146.5300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.8624
Cell Significance Index: 8.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.6685
Cell Significance Index: 908.9200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6459
Cell Significance Index: 116.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6332
Cell Significance Index: 402.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6205
Cell Significance Index: 17.3400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5396
Cell Significance Index: 11.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4813
Cell Significance Index: 59.1900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3880
Cell Significance Index: 6.6500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3289
Cell Significance Index: 6.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2532
Cell Significance Index: 389.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2268
Cell Significance Index: 7.9700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1869
Cell Significance Index: 2.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1285
Cell Significance Index: 70.1700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1110
Cell Significance Index: 21.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0986
Cell Significance Index: 185.5700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0748
Cell Significance Index: 4.7200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0611
Cell Significance Index: 10.4300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0524
Cell Significance Index: 96.5700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0128
Cell Significance Index: -11.5200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0295
Cell Significance Index: -21.8300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0300
Cell Significance Index: -18.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0365
Cell Significance Index: -16.1200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0438
Cell Significance Index: -32.1400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0755
Cell Significance Index: -57.1900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0812
Cell Significance Index: -1.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0817
Cell Significance Index: -46.1000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1165
Cell Significance Index: -1.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1274
Cell Significance Index: -18.5200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1521
Cell Significance Index: -9.8100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1634
Cell Significance Index: -34.4100 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.1677
Cell Significance Index: -0.7300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1686
Cell Significance Index: -48.5200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2060
Cell Significance Index: -24.2900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2118
Cell Significance Index: -29.0800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2120
Cell Significance Index: -5.7700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2186
Cell Significance Index: -22.3400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2366
Cell Significance Index: -24.6400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2699
Cell Significance Index: -2.4900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2790
Cell Significance Index: -35.7700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2854
Cell Significance Index: -5.9200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3072
Cell Significance Index: -35.1900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3196
Cell Significance Index: -37.2400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3256
Cell Significance Index: -7.1300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3593
Cell Significance Index: -4.4800 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.3936
Cell Significance Index: -4.1000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4038
Cell Significance Index: -52.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4122
Cell Significance Index: -47.0500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4641
Cell Significance Index: -9.8500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5042
Cell Significance Index: -6.0100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5193
Cell Significance Index: -11.2500 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.5637
Cell Significance Index: -7.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5898
Cell Significance Index: -46.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6187
Cell Significance Index: -46.1100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6560
Cell Significance Index: -30.8300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7380
Cell Significance Index: -38.4400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.7626
Cell Significance Index: -53.9400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7658
Cell Significance Index: -24.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7696
Cell Significance Index: -24.6500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7929
Cell Significance Index: -19.8200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.8124
Cell Significance Index: -18.7700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.8544
Cell Significance Index: -12.2700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8797
Cell Significance Index: -28.8000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9310
Cell Significance Index: -57.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9698
Cell Significance Index: -50.9200 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.9702
Cell Significance Index: -14.7600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.0032
Cell Significance Index: -20.1400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1536292160
Symbol: STK39_HUMAN
Name: STE20/SPS1-related proline-alanine-rich protein kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10980603
Title: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
PubMed ID: 10980603
PubMed ID: 24722188
Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
PubMed ID: 24722188
DOI: 10.1038/ncomms4650
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 12740379
Title: PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).
PubMed ID: 12740379
PubMed ID: 14988727
Title: SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.
PubMed ID: 14988727
PubMed ID: 16669787
Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
PubMed ID: 16669787
DOI: 10.1042/bj20060220
PubMed ID: 16832045
Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
PubMed ID: 16832045
PubMed ID: 17487921
Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
PubMed ID: 17487921
PubMed ID: 17190791
Title: Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
PubMed ID: 17190791
PubMed ID: 18088087
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19665974
Title: Sites of regulated phosphorylation that control K-Cl cotransporter activity.
PubMed ID: 19665974
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 18270262
Title: Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
PubMed ID: 18270262
DOI: 10.1242/jcs.025312
PubMed ID: 20385770
Title: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.
PubMed ID: 20385770
DOI: 10.1128/mcb.01560-09
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21321328
Title: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
PubMed ID: 21321328
DOI: 10.1242/jcs.077230
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 34289367
Title: Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.
PubMed ID: 34289367
Sequence Information:
- Length: 545
- Mass: 59474
- Checksum: 35E68F400A38A861
- Sequence:
MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA QLSVS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.