Details for: STK39

Gene ID: 27347

Symbol: STK39

Ensembl ID: ENSG00000198648

Description: serine/threonine kinase 39

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 384.9041
    Cell Significance Index: -59.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.0939
    Cell Significance Index: -59.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.8116
    Cell Significance Index: -57.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.0196
    Cell Significance Index: -44.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.6149
    Cell Significance Index: -59.9400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 28.8948
    Cell Significance Index: 20.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7103
    Cell Significance Index: -55.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5915
    Cell Significance Index: -50.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.2102
    Cell Significance Index: -60.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2238
    Cell Significance Index: -31.1300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 3.3256
    Cell Significance Index: 33.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3093
    Cell Significance Index: 185.7000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.8592
    Cell Significance Index: 25.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.7420
    Cell Significance Index: 210.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5348
    Cell Significance Index: 508.4700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.3210
    Cell Significance Index: 14.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2012
    Cell Significance Index: 102.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8811
    Cell Significance Index: 674.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8659
    Cell Significance Index: 184.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8538
    Cell Significance Index: 70.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2863
    Cell Significance Index: 86.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2638
    Cell Significance Index: 30.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2357
    Cell Significance Index: 54.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2059
    Cell Significance Index: 239.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2002
    Cell Significance Index: 34.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1542
    Cell Significance Index: 69.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1417
    Cell Significance Index: 32.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1312
    Cell Significance Index: 123.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0991
    Cell Significance Index: 49.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9757
    Cell Significance Index: 59.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9519
    Cell Significance Index: 49.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9365
    Cell Significance Index: 647.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9188
    Cell Significance Index: 417.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9009
    Cell Significance Index: 146.5300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8624
    Cell Significance Index: 8.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6685
    Cell Significance Index: 908.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6459
    Cell Significance Index: 116.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6332
    Cell Significance Index: 402.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6205
    Cell Significance Index: 17.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5396
    Cell Significance Index: 11.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4813
    Cell Significance Index: 59.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3880
    Cell Significance Index: 6.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3289
    Cell Significance Index: 6.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2532
    Cell Significance Index: 389.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2268
    Cell Significance Index: 7.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1869
    Cell Significance Index: 2.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1285
    Cell Significance Index: 70.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1110
    Cell Significance Index: 21.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0986
    Cell Significance Index: 185.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0748
    Cell Significance Index: 4.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0611
    Cell Significance Index: 10.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0524
    Cell Significance Index: 96.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0128
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0365
    Cell Significance Index: -16.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0438
    Cell Significance Index: -32.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0755
    Cell Significance Index: -57.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0812
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0817
    Cell Significance Index: -46.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1165
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1274
    Cell Significance Index: -18.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1521
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1634
    Cell Significance Index: -34.4100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1677
    Cell Significance Index: -0.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1686
    Cell Significance Index: -48.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2060
    Cell Significance Index: -24.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2118
    Cell Significance Index: -29.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2120
    Cell Significance Index: -5.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2186
    Cell Significance Index: -22.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2366
    Cell Significance Index: -24.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2699
    Cell Significance Index: -2.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2790
    Cell Significance Index: -35.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2854
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3072
    Cell Significance Index: -35.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3196
    Cell Significance Index: -37.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3256
    Cell Significance Index: -7.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3593
    Cell Significance Index: -4.4800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3936
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4038
    Cell Significance Index: -52.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4122
    Cell Significance Index: -47.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4641
    Cell Significance Index: -9.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5042
    Cell Significance Index: -6.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5193
    Cell Significance Index: -11.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5637
    Cell Significance Index: -7.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5898
    Cell Significance Index: -46.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6187
    Cell Significance Index: -46.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6560
    Cell Significance Index: -30.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7380
    Cell Significance Index: -38.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7626
    Cell Significance Index: -53.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7658
    Cell Significance Index: -24.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7696
    Cell Significance Index: -24.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7929
    Cell Significance Index: -19.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8124
    Cell Significance Index: -18.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8544
    Cell Significance Index: -12.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8797
    Cell Significance Index: -28.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9310
    Cell Significance Index: -57.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9698
    Cell Significance Index: -50.9200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9702
    Cell Significance Index: -14.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0032
    Cell Significance Index: -20.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STK39 is a member of the STE20/SPS1-related protein kinase family, characterized by its ability to phosphorylate serine and threonine residues on target proteins. The enzyme has a unique catalytic domain and a regulatory N-terminal domain that interacts with other proteins to modulate its activity. STK39 is also known for its involvement in various signaling pathways, including the chemokine signaling pathway, the p38MAPK cascade, and the regulation of ion transport across cellular membranes. **Pathways and Functions:** STK39 is involved in a wide range of cellular processes, including: 1. **Cell Signaling:** STK39 regulates the activity of various signaling pathways, including the chemokine signaling pathway, the p38MAPK cascade, and the regulation of ion transport across cellular membranes. 2. **Cell Homeostasis:** STK39 is involved in maintaining cellular homeostasis by regulating the activity of ion transporters and pumps, including potassium and sodium channels. 3. **Inflammation:** STK39 modulates the inflammatory response by regulating the activity of immune cells, including macrophages and T cells. 4. **Ion Transport:** STK39 regulates the activity of ion transporters and pumps, including potassium and sodium channels, to maintain cellular homeostasis. 5. **Cell Growth and Differentiation:** STK39 is involved in regulating cell growth and differentiation by modulating the activity of signaling pathways involved in these processes. **Clinical Significance:** Dysregulation of STK39 has been implicated in various diseases, including: 1. **Hypertension:** STK39 is involved in regulating blood pressure by modulating the activity of ion transporters and pumps. 2. **Inflammatory Disorders:** STK39 modulates the inflammatory response by regulating the activity of immune cells. 3. **Neurological Disorders:** STK39 is involved in regulating neuronal function and plasticity, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** STK39 is involved in regulating cell growth and differentiation, and its dysregulation has been implicated in cancer development and progression. In conclusion, STK39 is a multifaceted gene that plays a crucial role in regulating cellular homeostasis, signaling pathways, and response to environmental stimuli. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of STK39 and its potential as a therapeutic target.

Genular Protein ID: 1536292160

Symbol: STK39_HUMAN

Name: STE20/SPS1-related proline-alanine-rich protein kinase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10980603

Title: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.

PubMed ID: 10980603

DOI: 10.1038/sj.onc.1203784

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 12740379

Title: PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).

PubMed ID: 12740379

DOI: 10.1074/jbc.m301899200

PubMed ID: 14988727

Title: SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.

PubMed ID: 14988727

DOI: 10.1038/sj.emboj.7600125

PubMed ID: 16669787

Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

PubMed ID: 16669787

DOI: 10.1042/bj20060220

PubMed ID: 16832045

Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

PubMed ID: 16832045

DOI: 10.1073/pnas.0604607103

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17190791

Title: Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.

PubMed ID: 17190791

DOI: 10.1083/jcb.200605093

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19665974

Title: Sites of regulated phosphorylation that control K-Cl cotransporter activity.

PubMed ID: 19665974

DOI: 10.1016/j.cell.2009.05.031

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 18270262

Title: Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

PubMed ID: 18270262

DOI: 10.1242/jcs.025312

PubMed ID: 20385770

Title: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

PubMed ID: 20385770

DOI: 10.1128/mcb.01560-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21321328

Title: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

PubMed ID: 21321328

DOI: 10.1242/jcs.077230

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34289367

Title: Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.

PubMed ID: 34289367

DOI: 10.1016/j.celrep.2021.109416

Sequence Information:

  • Length: 545
  • Mass: 59474
  • Checksum: 35E68F400A38A861
  • Sequence:
  • MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR 
    DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN 
    VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL 
    DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA 
    PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK 
    EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR 
    AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS 
    TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD 
    GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA 
    QLSVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.