Details for: MCAT

Gene ID: 27349

Symbol: MCAT

Ensembl ID: ENSG00000100294

Description: malonyl-CoA-acyl carrier protein transacylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.6757
    Cell Significance Index: -10.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.0061
    Cell Significance Index: -9.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.5841
    Cell Significance Index: -10.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.2220
    Cell Significance Index: -12.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3538
    Cell Significance Index: -10.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8787
    Cell Significance Index: -12.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9830
    Cell Significance Index: -10.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2032
    Cell Significance Index: -12.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6865
    Cell Significance Index: 166.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4222
    Cell Significance Index: 85.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0834
    Cell Significance Index: 126.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8404
    Cell Significance Index: 136.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7089
    Cell Significance Index: 5.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6063
    Cell Significance Index: 41.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5764
    Cell Significance Index: 36.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5279
    Cell Significance Index: 288.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4915
    Cell Significance Index: 25.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4872
    Cell Significance Index: 13.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3938
    Cell Significance Index: 10.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3769
    Cell Significance Index: 10.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3449
    Cell Significance Index: 16.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3242
    Cell Significance Index: 61.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3138
    Cell Significance Index: 10.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2756
    Cell Significance Index: 12.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2667
    Cell Significance Index: 18.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2569
    Cell Significance Index: 19.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2391
    Cell Significance Index: 5.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2373
    Cell Significance Index: 2.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2199
    Cell Significance Index: 39.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2185
    Cell Significance Index: 30.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1967
    Cell Significance Index: 86.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1948
    Cell Significance Index: 23.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1779
    Cell Significance Index: 4.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1732
    Cell Significance Index: 11.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1626
    Cell Significance Index: 21.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1616
    Cell Significance Index: 32.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1576
    Cell Significance Index: 2.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1526
    Cell Significance Index: 1.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1487
    Cell Significance Index: 29.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1440
    Cell Significance Index: 3.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1362
    Cell Significance Index: 2.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1280
    Cell Significance Index: 3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0950
    Cell Significance Index: 12.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0850
    Cell Significance Index: 10.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0827
    Cell Significance Index: 2.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0788
    Cell Significance Index: 1.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0689
    Cell Significance Index: 3.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0669
    Cell Significance Index: 23.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0434
    Cell Significance Index: 0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0316
    Cell Significance Index: 1.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0236
    Cell Significance Index: 1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0028
    Cell Significance Index: 2.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0021
    Cell Significance Index: 1.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0029
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0150
    Cell Significance Index: -1.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0164
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0210
    Cell Significance Index: -1.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0232
    Cell Significance Index: -10.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0234
    Cell Significance Index: -14.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0307
    Cell Significance Index: -8.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0329
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0423
    Cell Significance Index: -4.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0564
    Cell Significance Index: -3.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0588
    Cell Significance Index: -8.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0592
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0680
    Cell Significance Index: -14.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0755
    Cell Significance Index: -0.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0797
    Cell Significance Index: -4.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0839
    Cell Significance Index: -6.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0937
    Cell Significance Index: -5.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0944
    Cell Significance Index: -7.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1180
    Cell Significance Index: -1.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1194
    Cell Significance Index: -12.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1208
    Cell Significance Index: -1.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1373
    Cell Significance Index: -8.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1440
    Cell Significance Index: -4.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1480
    Cell Significance Index: -3.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1576
    Cell Significance Index: -2.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1709
    Cell Significance Index: -7.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1817
    Cell Significance Index: -5.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2011
    Cell Significance Index: -5.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2066
    Cell Significance Index: -5.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2177
    Cell Significance Index: -3.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2205
    Cell Significance Index: -3.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2208
    Cell Significance Index: -8.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2250
    Cell Significance Index: -3.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2315
    Cell Significance Index: -6.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2327
    Cell Significance Index: -6.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2393
    Cell Significance Index: -2.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2405
    Cell Significance Index: -3.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2783
    Cell Significance Index: -9.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** The MCAT enzyme is a transacylase that catalyzes the transfer of a malonyl group from malonyl-CoA to the ACP of fatty acid synthase, facilitating the elongation of fatty acids. 2. **Subcellular Localization:** The MCAT enzyme is localized to the mitochondrial matrix, where it plays a key role in fatty acid metabolism. 3. **Cellular Expression:** The MCAT gene is expressed in various cell types, including germ cells, intestinal epithelial cells, and neurons, suggesting its involvement in multiple cellular processes. 4. **Protein Structure:** The MCAT enzyme is a protein that belongs to the ACP family, characterized by a conserved active site and a specific binding motif for malonyl-CoA. **Pathways and Functions:** 1. **Fatty Acid Beta-Oxidation:** The MCAT enzyme is involved in the beta-oxidation pathway, where fatty acids are broken down into acetyl-CoA units for energy production. 2. **Fatty Acid Biosynthesis:** The MCAT enzyme also plays a role in fatty acid biosynthesis, where it facilitates the elongation of fatty acids. 3. **Lipid Metabolism:** The MCAT enzyme is involved in the metabolism of lipids, including the regulation of triglyceride synthesis and breakdown. 4. **Mitochondrial Fatty Acid Beta-Oxidation:** The MCAT enzyme is specifically localized to the mitochondrial matrix, where it participates in the beta-oxidation of fatty acids. **Clinical Significance:** 1. **Metabolic Disorders:** Alterations in the MCAT gene have been implicated in various metabolic disorders, including obesity, type 2 diabetes, and fatty acid storage diseases. 2. **Cancer:** The MCAT enzyme has been shown to be overexpressed in certain types of cancer, including colorectal cancer, suggesting its potential role in tumor progression. 3. **Neurological Disorders:** The MCAT enzyme has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in lipid metabolism and neurodegeneration. 4. **Pharmacological Applications:** The MCAT enzyme has potential as a therapeutic target for the treatment of metabolic disorders and cancer, as well as for the development of novel lipid-modulating therapies. In conclusion, the MCAT gene plays a critical role in fatty acid metabolism, and its dysregulation has been implicated in various metabolic and neurological disorders. Further research is needed to fully elucidate the functions of the MCAT enzyme and to explore its potential as a therapeutic target.

Genular Protein ID: 1705812168

Symbol: FABD_HUMAN

Name: Mitochondrial malonyl CoA:ACP acyltransferase

UniProtKB Accession Codes:

Q8IVS2 B0QY72 O95510 O95511

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12882974

Title: Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein.

PubMed ID: 12882974

DOI: 10.1074/jbc.m306121200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31915829

Title: Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.

PubMed ID: 31915829

DOI: 10.1093/hmg/ddz311

PubMed ID: 33918393

Title: MCAT Mutations Cause Nuclear LHON-like Optic Neuropathy.

PubMed ID: 33918393

DOI: 10.3390/genes12040521

PubMed ID: 19549604

Title: Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

PubMed ID: 19549604

DOI: 10.1016/j.chembiol.2009.04.011

PubMed ID: 36482135

Title: Principles of mitoribosomal small subunit assembly in eukaryotes.

PubMed ID: 36482135

DOI: 10.1038/s41586-022-05621-0

Sequence Information:

  • Length: 390
  • Mass: 42962
  • Checksum: 5CAF7AE9DFF36A21
  • Sequence:
    • MSVRVARVAW VRGLGASYRR GASSFPVPPP GAQGVAELLR DATGAEEEAP WAATERRMPG 
QCSVLLFPGQ GSQVVGMGRG LLNYPRVREL YAAARRVLGY DLLELSLHGP QETLDRTVHC 
QPAIFVASLA AVEKLHHLQP SVIENCVAAA GFSVGEFAAL VFAGAMEFAE GLYAVKIRAE 
AMQEASEAVP SGMLSVLGQP QSKFNFACLE AREHCKSLGI ENPVCEVSNY LFPDCRVISG 
HQEALRFLQK NSSKFHFRRT RMLPVSGAFH TRLMEPAVEP LTQALKAVDI KKPLVSVYSN 
VHAHRYRHPG HIHKLLAQQL VSPVKWEQTM HAIYERKKGR GFPQTFEVGP GRQLGAILKS 
CNMQAWKSYS AVDVLQTLEH VDLDPQEPPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.